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公开(公告)号：US12083258B2
公开(公告)日：2024-09-10
申请号：US17825918
申请日：2022-05-26
申请人： Fenwal, Inc.
CPC分类号： A61M1/3496 , A61M1/34 , A61M1/3403 , A61M1/3607 , A61M1/3609 , A61M1/3616 , A61M1/362262 , A61M1/362266 , A61M1/3643 , A61M1/3672 , A61M1/38 , A61M1/382 , A61M1/385 , G01N33/48 , G16H10/60 , G16H40/60 , A61M2202/0415 , A61M2205/33 , A61M2205/3334 , A61M2205/3379 , A61M2205/3393 , A61M2205/502 , A61M2205/505 , A61M2230/207
摘要： A system for collecting plasma comprises a separator to separate whole blood from a donor into a plasma product and red blood cells, an anticoagulant line to introduce anticoagulant to the whole blood, a touchscreen, and a controller. The controller is configured to receive donor parameters electronically from a donor management system. The controller is configured to use a target volume for plasma product and/or raw plasma which is based at least in part on donor height and weight used to calculate total donor blood volume, the target volume for plasma product and/or raw plasma based on the total donor blood volume. The controller is configured to control the system to operate at least three draw and return phases to withdraw whole blood from a donor and separate the whole blood into the plasma product and the red blood cells and to return the red blood cells to the donor.
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公开(公告)号：US20240198052A1
公开(公告)日：2024-06-20
申请号：US18589076
申请日：2024-02-27
IPC分类号： A61M25/01 , A61B17/22 , A61B18/00 , A61B18/22 , A61B18/24 , A61B18/26 , A61B90/30 , A61L27/20 , A61M25/00 , A61M25/09
CPC分类号： A61M25/0133 , A61B17/22 , A61B18/245 , A61B18/26 , A61L27/20 , A61M25/0009 , A61M25/0155 , A61M25/09 , A61B2017/22062 , A61B2018/0022 , A61B2018/00285 , A61B2018/2261 , A61B2018/2266 , A61B2018/2277 , A61B2018/2294 , A61B2018/263 , A61B2090/306 , A61L2400/12 , A61M2025/09008 , A61M2025/09183 , A61M2202/0415 , A61M2205/3592 , A61M2205/587
摘要： A catheter system for imparting pressure to induce fractures at a treatment site within or adjacent a blood vessel wall includes a catheter, a fortified balloon inflation fluid and a first light guide. The catheter includes an elongate shaft and a balloon that is coupled to the elongate shaft. The balloon has a balloon wall and can expand to a first expanded configuration to anchor the catheter in position relative. The fortified balloon inflation fluid can expand the balloon to the first expanded configuration. The fortified balloon inflation fluid includes a base inflation fluid and a fortification component. The fortification component reduces a threshold for inducing plasma formation in the fortified balloon inflation fluid compared to the base inflation fluid. The fortification component can include at least one of carbon and iron. The first light guide is disposed along the elongate shaft and is positioned at least partially within the balloon. The first light guide is in optical communication with a light source and the fortified balloon inflation fluid. The light source provides sub-millisecond pulses of a light to the first light guide so that plasma formation and rapid bubble formation occur in the fortified balloon inflation fluid, thereby imparting pressure waves upon the treatment site.
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公开(公告)号：US20240165380A1
公开(公告)日：2024-05-23
申请号：US18454673
申请日：2023-08-23
CPC分类号： A61M25/10188 , A61M5/1723 , A61M2005/1726 , A61M2025/0002 , A61M2025/1052 , A61M2202/0415 , A61M2202/0427 , A61M2202/0429
摘要： A method for automatically controlling an expandable member in a blood vessel of a subject may comprise obtaining, using a controller, proximal sensor data from a proximal pressure sensor and distal sensor data from a distal pressure sensor, comparing the obtained proximal sensor data to a proximal pressure threshold value, adjusting, using the controller, a volume of the expandable member based on the distal sensor data in response to determining that the proximal sensor data is above or at the proximal pressure threshold value, and adjusting, using the controller, the volume of the expandable member based on the proximal sensor data in response to determining that the proximal sensor data is below the proximal pressure threshold value.
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公开(公告)号：US20240139399A1
公开(公告)日：2024-05-02
申请号：US18407798
申请日：2024-01-09
申请人： Terumo BCT, Inc.
CPC分类号： A61M1/3696 , A61M1/024 , A61M1/0272 , A61M1/304 , A61M1/3496 , A61M1/3601 , A61M1/36224 , A61M1/362261 , A61M1/362262 , A61M1/362265 , A61M1/3627 , A61M1/3646 , A61M1/3693 , A61M1/382 , A61M1/30 , A61M1/3403 , A61M1/36222 , A61M1/3639 , A61M2202/0415 , A61M2205/12 , A61M2205/123 , A61M2205/331 , A61M2205/3334 , A61M2205/3379 , A61M2205/50
摘要： Described are embodiments that include methods and devices for separating components from multi-component fluids. Embodiments may involve use of separation vessels and movement of components into and out of separation vessels through ports. Embodiments may involve the separation of plasma from whole blood. Also described are embodiments that include methods and devices for positioning portions, e.g., loops, of disposables in medical devices. Embodiments may involve use of surfaces for automatically guiding loops to position them into a predetermined position.
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公开(公告)号：US11925771B2
公开(公告)日：2024-03-12
申请号：US18297913
申请日：2023-04-10
CPC分类号： A61M25/0084 , A61B17/1671 , A61K9/06 , A61M5/32 , A61M25/065 , A61M29/00 , A61M2025/0091 , A61M2025/09183 , A61M2202/0415 , A61M2202/0427 , A61M2202/0468 , A61M2202/09 , A61M2202/10 , A61M2205/0266 , A61M2210/1003
摘要： A method of delivering a therapeutic agent to a nucleus pulposus of an intervertebral disc is provided. The method comprises inserting a delivery tool containing the therapeutic agent through an anterior portion, a lateral portion, or an anterolateral portion of an annulus fibrosus and into the nucleus pulposus of the intervertebral disc; and delivering the therapeutic agent to the nucleus pulposus of the intervertebral disc. Devices and kits are also provided.
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公开(公告)号：US11925743B2
公开(公告)日：2024-03-12
申请号：US18103008
申请日：2023-01-30
申请人： Terumo BCT, Inc.
CPC分类号： A61M1/3696 , A61M1/024 , A61M1/0272 , A61M1/304 , A61M1/3496 , A61M1/3601 , A61M1/36224 , A61M1/362261 , A61M1/362262 , A61M1/362265 , A61M1/3627 , A61M1/3646 , A61M1/3693 , A61M1/382 , A61M1/30 , A61M1/3403 , A61M1/36222 , A61M1/3639 , A61M2202/0415 , A61M2205/12 , A61M2205/123 , A61M2205/331 , A61M2205/3334 , A61M2205/3379 , A61M2205/50
摘要： Described are embodiments that include methods and devices for separating components from multi-component fluids. Embodiments may involve use of separation vessels and movement of components into and out of separation vessels through ports. Embodiments may involve the separation of plasma from whole blood. Also described are embodiments that include methods and devices for positioning portions, e.g., loops, of disposables in medical devices. Embodiments may involve use of surfaces for automatically guiding loops to position them into a predetermined position.
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7.发明授权公开(公告)号：US11857714B2
公开(公告)日：2024-01-02
申请号：US18100023
申请日：2023-01-23
申请人： Fenwal, Inc.
发明人： Zahra R Ali , Lan T. Nguyen
CPC分类号： A61M1/3607 , A61M1/0209 , A61M1/361 , A61M1/3643 , A61M1/3672 , A61M1/3683 , A61M1/3693 , A61M1/3696 , A61M1/38 , A61M2202/0092 , A61M2202/0407 , A61M2202/0413 , A61M2202/0415 , A61M2202/0429 , A61M2202/0439 , A61M2202/0443 , A61M2205/3386 , A61M2205/50 , A61M2230/005 , A61M2230/207
摘要： Described is a method for controlling fluid volume balance. A controller is configured with a first set of inputs comprising a hematocrit, a total blood volume, and an ACD ratio. A maximum extracorporeal RBC amount during the procedure is estimated based on the first set of inputs. A fluid circuit is primed with a priming fluid. Whole blood is drawn from a blood source and separated into a RBC component, a target cell component, and a plasma component. The target cell component is directed to a product container. The product container comprising the target cell component is treated. A treated target cell component, a portion of the RBC component remaining in the fluid circuit, and/or a portion of the plasma component remaining in the fluid circuit are returned to the blood source. A first response action is provided if the maximum extracorporeal RBC amount estimated is above a programmed limit.
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公开(公告)号：US11814430B2
公开(公告)日：2023-11-14
申请号：US17175503
申请日：2021-02-12
申请人： IMMUNICOM, INC.
发明人： Thomas Emanuel Ichim , Steven Francis Josephs , Stephen Michael Prince , Amir Jafri , Robert Segal , David L. Schlotterbeck
CPC分类号： C07K16/2818 , A61M1/3496 , A61M1/3693 , C07K16/2827 , A61M2202/0415 , C07K2317/24 , C07K2317/76
摘要： The invention provides means, methods, and compositions of matter useful for enhancing tumor response to checkpoint inhibitors. In one embodiment, the invention teaches utilization of extracorporeal apheresis, specifically removal of various tumor derived, or tumor microenvironment derived immunological “blocking factors”. In one embodiment the invention provides the removal of soluble TNF-alpha receptors (sTNF-Rs) as a means of augmenting efficacy of immune checkpoint inhibitors. In one specific embodiment removal of sTNF-Rs is utilized to enhance efficacy of inhibitors of the PD-1/PD-L1 pathway, and/or the CD28/CTLA-4 pathway.
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公开(公告)号：US20230277810A1
公开(公告)日：2023-09-07
申请号：US18195233
申请日：2023-05-09
CPC分类号： A61M25/0133 , A61M25/09 , A61B18/26 , A61B17/22 , A61L27/20 , A61M25/0009 , A61M25/0155 , A61B18/245 , A61M2205/587 , A61M2202/0415 , A61M2025/09008 , A61M2025/09183 , A61M2205/3592 , A61B2018/2261
摘要： A catheter system for pressure wave and inertial impulse generation for intravascular lesion disruption includes a balloon coupled to an elongate shaft, and a first and second light guide disposed along the elongate shaft. The first and second light guides each include a diverting feature in optical communication with at least one light window to direct light to exit each light guide toward a side surface portion thereof and toward the balloon. A method includes expanding the balloon from a collapsed configuration to a first expanded configuration, and activating a light source in optical communication with each light guide to provide sub-millisecond pulses of light to the diverting features, thereby inducing plasma formation in a balloon fluid, causing rapid bubble formation, and imparting pressure waves upon the treatment site.
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公开(公告)号：US11747082B2
公开(公告)日：2023-09-05
申请号：US18070085
申请日：2022-11-28
发明人： Kestas P. Parakininkas , Eric T. Hansen , Kirk L. Weimer , Nathaniel T. Johnson , Dennis J. Hlavinka
IPC分类号： F26B5/06 , A61M1/02 , A01N1/02 , A61J1/10 , F26B21/14 , A61J1/14 , B65D51/24 , F26B25/06 , F26B25/18
CPC分类号： F26B5/06 , A01N1/0263 , A01N1/0284 , A01N1/0289 , A61J1/10 , A61M1/0277 , F26B21/14 , A01N1/0252 , A61J1/1468 , A61M2202/0415 , A61M2205/3389 , A61M2205/584 , B65D51/241 , F26B25/063 , F26B25/18
摘要： Provided is a multi-part lyophilization container for lyophilizing a fluid, storing the lyophilizate, reconstituting the lyophilizate, and infusing the reconstituted lyophilizate into a patient, including a method of using same. The container includes a front surface, a back surface, a non-breathable section including a port region, a breathable section including a breathable membrane, and a peelable region including a peelable seal encompassing a boundary between the non-breathable section and the breathable section. The method includes inputting a fluid into a non-breathable section of the container, freezing the fluid, applying, in a lyophilization chamber, vacuum pressure, opening the peelable seal using a pressure differential, applying heat energy, sublimating the fluid and creating a temporary occlusion in a peelable region of the container.
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