利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

26 条记录 (耗时 0.033 秒)

    Biological products
    12.
    发明授权
    Biological products 有权

    公开(公告)号：US10407513B2

    公开(公告)日：2019-09-10

    申请号：US13121055

    申请日：2009-09-25

    申请人： Ralph Adams ,  Laura Hancock ,  Sam Philip Heywood

    发明人： Ralph Adams ,  Laura Hancock ,  Sam Philip Heywood

    IPC分类号： A61K39/00 ,  C07K16/46 ,  C07K16/18 ,  C07K16/24 ,  C07K16/28

    摘要： A multivalent antibody fusion protein which comprises an immunoglobulin moiety, for example a Fab or Fab′ fragment, with a first specificity for an antigen of interest, and further comprises two single domain antibodies (dAb) with specificity for a second antigen of interest, wherein the two single domain antibodies are linked by a disulfide bond. There is also provided particular dual specificity antibody fusion proteins comprising a Fab or Fab′ fragment and one or more single domain antibodies which may be stabilized by a disulfide bond therebetween.

    Multivalent Antibodies
    13.
    发明申请
    Multivalent Antibodies 审中-公开
    多价抗体

    公开(公告)号：US20120283415A1

    公开(公告)日：2012-11-08

    申请号：US13395235

    申请日：2010-09-10

    申请人： David Paul Humphreys ,  Emma Dave ,  Ralph Adams

    发明人： David Paul Humphreys ,  Emma Dave ,  Ralph Adams

    IPC分类号： C07K16/00

    摘要： The present invention provides a multivalent antibody or a heavy/light chain component thereof comprising: a heavy chain comprising a constant region fragment, said constant region fragment located between two variable domains which are not a cognate pair, the heavy chain further comprising an Fc region with at least one domain selected from CH2, CH3 and combinations thereof, with the proviso that the heavy chain contains no more than one CH1 domain and only contains two variable domains, and a light chain comprising a constant region fragment located between two variable domains which are not a cognate pair, wherein said heavy and light chains are aligned to provide a first binding site formed by a first cognate pair of variable domains and a second binding site formed by a second cognate pair of variable domains.

    摘要翻译： 本发明提供了一种多价抗体或其重/轻链组分，其包含：包含恒定区片段的重链，所述恒定区片段位于不是同源对的两个可变结构域之间，所述重链还包含Fc区 其中至少一个选自CH 2，CH 3及其组合的结构域，条件是重链含有不超过一个CH1结构域并且仅含有两个可变结构域，以及包含位于两个可变结构域之间的恒定区片段的轻链， 不是同源对，其中所述重链和轻链对齐以提供由第一同源对可变结构域形成的第一结合位点和由第二同源对可变结构域形成的第二结合位点。

    Disulfide Stabilised Multivalent Antibodies
    19.
    发明申请
    Disulfide Stabilised Multivalent Antibodies 审中-公开
    二硫键稳定多价抗体

    公开(公告)号：US20120316324A1

    公开(公告)日：2012-12-13

    申请号：US13498017

    申请日：2010-09-24

    申请人： Ralph Adams ,  Laura Hancock ,  Sam Phillip Heywood

    发明人： Ralph Adams ,  Laura Hancock ,  Sam Phillip Heywood

    IPC分类号： C07K16/46 ,  C07K16/18

    摘要： A multivalent antibody fusion protein which comprises an immunoglobulin moiety, for example a Fab or Fab′ fragment, with a first specificity for an antigen of interest, and further comprises two single domain antibodies (dAb) with specificity for a second antigen of interest which are a VH/VL pair, wherein the two single domain antibodies are linked by a disulfide bond. Also provided are particular dual specificity antibody fusion proteins and other antibody fragments which are stabilised by a disulfide bond.

    摘要翻译： 一种多价抗体融合蛋白，其包含免疫球蛋白部分，例如Fab或Fab'片段，对感兴趣的抗原具有第一特异性，并且还包含对于目标第二抗原具有特异性的两个单结构域抗体（dAb） VH / VL对，其中两个单结构域抗体通过二硫键连接。 还提供了通过二硫键稳定的特异性双特异性抗体融合蛋白和其他抗体片段。