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1.发明授权Binding proteins, including antibodies, antibody derivatives and antibody fragments, that specifically bind CD154 and uses thereof 有权结合蛋白质，包括特异性结合CD154的抗体，抗体衍生物和抗体片段及其用途公开(公告)号：US08293237B2
公开(公告)日：2012-10-23
申请号：US12532517
申请日：2008-03-21
申请人： Linda C. Burkly , Janine L. Ferrant-Orgettas , Ellen A. Garber , Yen-Ming Hsu , Lihe Su , Frederick R. Taylor , Ralph Adams , Derek Thomas Brown , Andrew George Popplewell , Martyn Kim Robinson , Anthony Shock , Kerry Louise Tyson
发明人： Linda C. Burkly , Janine L. Ferrant-Orgettas , Ellen A. Garber , Yen-Ming Hsu , Lihe Su , Frederick R. Taylor , Ralph Adams , Derek Thomas Brown , Andrew George Popplewell , Martyn Kim Robinson , Anthony Shock , Kerry Louise Tyson
IPC分类号： A61K39/395 , C07K16/00 , C12N15/63 , C12N5/10 , C12P21/02
CPC分类号： C07K16/2875 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/40 , C07K2317/52 , C07K2317/55 , C07K2317/71 , C07K2317/734 , C07K2317/76 , C07K2317/92
摘要： This invention provides binding proteins, including antibodies, antibody derivatives and antibody fragments, that specifically bind a CD154 (CD40L) protein. This invention also provides a chimeric, humanized or fully human antibody, antibody derivative or antibody fragment that specifically binds to an epitope to which a humanized Fab fragment comprising a variable heavy chain sequence according to SEQ ID NO: 1 and comprising a variable light chain sequence according to SEQ ID NO: 2 specifically binds. CD154 binding proteins of this invention may elicit reduced effector function relative to a second anti-CD154 antibody. CD154 binding proteins of this invention are useful in diagnostic and therapeutic methods, such as in the treatment and prevention of diseases including those that involve undesirable immune responses that are mediated by CD154-CD40 interactions.
摘要翻译： 本发明提供特异性结合CD154（CD40L）蛋白的结合蛋白，包括抗体，抗体衍生物和抗体片段。 本发明还提供了嵌合，人源化或完全人抗体，抗体衍生物或抗体片段，其特异性结合包含根据SEQ ID NO：1的可变重链序列的人源化Fab片段的表位，并包含可变轻链序列 根据SEQ ID NO：2特异性结合。 本发明的CD154结合蛋白可以引起相对于第二抗-CD154抗体降低的效应子功能。 本发明的CD154结合蛋白可用于诊断和治疗方法，例如治疗和预防包括由CD154-CD40相互作用介导的不期望的免疫应答的疾病。
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2.发明申请BINDING PROTEINS, INCLUDING ANTIBODIES, ANTIBODY DERIVATIVES AND ANTIBODY FRAGMENTS, THAT SPECIFICALLY BIND CD154 AND USES THEREOF 有权结合蛋白质，包括抗体，抗体衍生物和抗体片段，特别是CD154及其用途公开(公告)号：US20100104573A1
公开(公告)日：2010-04-29
申请号：US12532517
申请日：2008-03-21
申请人： Linda C. Burkly , Janine L. Ferrant-Orgettas , Ellen A. Garber , Yen-Ming Hsu , Lihe Su , Frederick R. Taylor , Ralph Adams , Derek Thomas Brown , Andrew George Popplewell , Martyn Kim Robinson , Anthony Shock , Kerry Louise Tyson
发明人： Linda C. Burkly , Janine L. Ferrant-Orgettas , Ellen A. Garber , Yen-Ming Hsu , Lihe Su , Frederick R. Taylor , Ralph Adams , Derek Thomas Brown , Andrew George Popplewell , Martyn Kim Robinson , Anthony Shock , Kerry Louise Tyson
IPC分类号： A61K39/395 , C07K16/00 , C07H21/04 , C12N15/63 , C12N5/10 , C12P21/02 , A61P29/00 , A61P37/00
CPC分类号： C07K16/2875 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/40 , C07K2317/52 , C07K2317/55 , C07K2317/71 , C07K2317/734 , C07K2317/76 , C07K2317/92
摘要： This invention provides binding proteins, including antibodies, antibody derivatives and antibody fragments, that specifically bind a CD154 (CD40L) protein. This invention also provides a chimeric, humanized or fully human antibody, antibody derivative or antibody fragment that specifically binds to an epitope to which a humanized Fab fragment comprising a variable heavy chain sequence according to SEQ ID NO: 1 and comprising a variable light chain sequence according to SEQ ID NO: 2 specifically binds. CD154 binding proteins of this invention may elicit reduced effector function relative to a second anti-CD154 antibody. CD154 binding proteins of this invention are useful in diagnostic and therapeutic methods, such as in the treatment and prevention of diseases including those that involve undesirable immune responses that are mediated by CD154-CD40 interactions.
摘要翻译： 本发明提供特异性结合CD154（CD40L）蛋白的结合蛋白，包括抗体，抗体衍生物和抗体片段。 本发明还提供了嵌合，人源化或完全人抗体，抗体衍生物或抗体片段，其特异性结合包含根据SEQ ID NO：1的可变重链序列的人源化Fab片段的表位，并包含可变轻链序列 根据SEQ ID NO：2特异性结合。 本发明的CD154结合蛋白可以引起相对于第二抗-CD154抗体降低的效应子功能。 本发明的CD154结合蛋白可用于诊断和治疗方法，例如治疗和预防包括由CD154-CD40相互作用介导的不期望的免疫应答的疾病。
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公开(公告)号：US20090326203A1
公开(公告)日：2009-12-31
申请号：US12307051
申请日：2007-06-26
CPC分类号： C07K16/464 , C07K16/465 , C07K2317/24 , C07K2317/92
摘要： The present invention relates to improved methods for the selection of appropriate human acceptor framework regions for non-human (donor) antibodies and methods for obtaining humanized antibodies of high affinity using such acceptor frameworks.
摘要翻译： 本发明涉及用于选择非人（供体）抗体的合适的人受体框架区的改进方法和使用这种受体框架获得高亲和力的人源化抗体的方法。
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公开(公告)号：US09249232B2
公开(公告)日：2016-02-02
申请号：US12307051
申请日：2007-06-26
CPC分类号： C07K16/464 , C07K16/465 , C07K2317/24 , C07K2317/92
摘要： The present invention relates to improved methods for the selection of appropriate human acceptor framework regions for non-human (donor) antibodies and methods for obtaining humanized antibodies of high affinity using such acceptor frameworks.
摘要翻译： 本发明涉及用于选择非人（供体）抗体的合适的人受体框架区的改进方法和使用这种受体框架获得高亲和力的人源化抗体的方法。
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公开(公告)号：US20110229461A1
公开(公告)日：2011-09-22
申请号：US13045718
申请日：2011-03-11
申请人： Kerry Louise Tyson
发明人： Kerry Louise Tyson
IPC分类号： A61K39/395 , C07K16/28 , C07H21/04 , A61P37/00 , A61P19/02 , A61P25/00 , A61P1/00 , A61P3/10 , A61P35/00 , A61P31/00 , C12N15/63 , C12P21/02 , C12N1/00 , C12N5/10
CPC分类号： C07K14/70503 , C07K16/2818 , C07K2317/24 , C07K2317/33 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/75 , C07K2317/92
摘要： A humanised agonistic antibody which binds human PD-1 comprising a heavy chain and a light chain wherein the variable domain of the heavy chain comprises the sequence given in SEQ ID NO:1 for CDR-H1, the sequence given in SEQ ID NO:2 for CDR-H2 and the sequence given in SEQ ID NO:3 for CDR-H3 and the variable domain of the light chain comprises the sequence given in SEQ ID NO:4 for CDR-L1, the sequence given in SEQ ID NO:5 for CDR-L2 and the sequence given in SEQ ID NO:7 for CDR-L3. The invention also extends to therapeutic uses of the antibody molecules, compositions and methods for producing said antibody molecules.
摘要翻译： 结合包含重链和轻链的人PD-1的人源化激动抗体，其中重链的可变结构域包含SEQ ID NO：1中针对CDR-H1给出的序列，SEQ ID NO：2中给出的序列 对于CDR-H2和CDR-H3的SEQ ID NO：3中给出的序列，轻链的可变结构域包含SEQ ID NO：4中针对CDR-L1给出的序列，SEQ ID NO：5中给出的序列 对于CDR-L2和针对CDR-L3的SEQ ID NO：7中给出的序列。 本发明还延伸到抗体分子的治疗用途，用于产生所述抗体分子的组合物和方法。
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公开(公告)号：US20100260773A1
公开(公告)日：2010-10-14
申请号：US12720804
申请日：2010-03-10
申请人： Neil Gozzard , Alastair David Griffiths Lawson , Daniel John Lightwood , Roger Thomas Palframan , Bryan John Smith , Kerry Louise Tyson
发明人： Neil Gozzard , Alastair David Griffiths Lawson , Daniel John Lightwood , Roger Thomas Palframan , Bryan John Smith , Kerry Louise Tyson
IPC分类号： A61K39/395 , C07K16/00 , C07H21/04 , C12N15/63 , A61P11/06 , A61P35/00 , A61P37/00 , A61P31/12 , A61P9/00 , C12P21/00 , C12N1/21 , C12N5/07
CPC分类号： C07K16/244 , A61K9/0078 , A61K39/395 , A61K39/3955 , A61K2039/505 , A61K2039/544 , C07K2317/24 , C07K2317/33 , C07K2317/51 , C07K2317/515 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The invention relates to antibody molecules having specificity for antigenic determinants of human IL-13, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.
摘要翻译： 本发明涉及对人IL-13的抗原决定簇具有特异性的抗体分子，抗体分子的治疗用途以及产生所述抗体分子的方法。
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公开(公告)号：US07273744B2
公开(公告)日：2007-09-25
申请号：US10177245
申请日：2002-06-21
申请人： Edward Alexander McKenzie , Alasdair Craig Stamps , Jonathan Alexander Terrett , Kerry Louise Tyson
发明人： Edward Alexander McKenzie , Alasdair Craig Stamps , Jonathan Alexander Terrett , Kerry Louise Tyson
CPC分类号： C12Y302/01166 , C12N9/2402
摘要： The present invention provides a homologue to heparanase which is present in three splice variants.
摘要翻译： 本发明提供了存在于三个剪接变体中的乙酰肝素酶的同源物。
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公开(公告)号：US10752676B2
公开(公告)日：2020-08-25
申请号：US14344637
申请日：2012-09-10
申请人： David Paul Humphreys , Daniel John Lightwood , Kerry Louise Tyson , David Edward Ormonde Knight , Karine Jeannine Madeleine Hervé , Joanne Elizabeth Compson , Matthew Jon Timothy Page , Andrew Charles Payne , Nicola Louise Fisher , Brendon Mackenzie , Matthew Cox
发明人： David Paul Humphreys , Daniel John Lightwood , Kerry Louise Tyson , David Edward Ormonde Knight , Karine Jeannine Madeleine Hervé , Joanne Elizabeth Compson , Matthew Jon Timothy Page , Andrew Charles Payne , Nicola Louise Fisher , Brendon Mackenzie , Matthew Cox
IPC分类号： C07K16/12 , A61K39/40 , A61K45/06 , A61K39/00 , G01N33/569 , G01N33/573 , G01N33/68
摘要： This present invention describes the derivation and selection of antibodies capable of neutralising the major exotoxins; TcdA and TcdB of Clostridium difficile. The invention also describes novel neutralisation and antigen binding properties of individual Mabs and mixtures thereof.
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公开(公告)号：US20090246201A1
公开(公告)日：2009-10-01
申请号：US11893095
申请日：2007-08-14
申请人： Edward Alexander McKenzie , Alasdair Craig Stamps , Jonathan Alexander Terrett , Kerry Louise Tyson
发明人： Edward Alexander McKenzie , Alasdair Craig Stamps , Jonathan Alexander Terrett , Kerry Louise Tyson
IPC分类号： A61K39/395 , C12N9/10 , C07K16/18 , C12N15/11 , C12N15/00 , C12N5/06 , C12P21/02 , A61K38/45 , C12Q1/48
CPC分类号： C12Y302/01166 , C12N9/2402
摘要： The present invention provides a homologue to heparanase which is present in three splice variants.
摘要翻译： 本发明提供了存在于三个剪接变体中的乙酰肝素酶的同源物。
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公开(公告)号：US09102728B2
公开(公告)日：2015-08-11
申请号：US13045718
申请日：2011-03-11
申请人： Kerry Louise Tyson
发明人： Kerry Louise Tyson
IPC分类号： C07K16/28
CPC分类号： C07K14/70503 , C07K16/2818 , C07K2317/24 , C07K2317/33 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/75 , C07K2317/92
摘要： A humanised agonistic antibody which binds human PD-1 comprising a heavy chain and a light chain wherein the variable domain of the heavy chain comprises the sequence given in SEQ ID NO:1 for CDR-H1, the sequence given in SEQ ID NO:2 for CDR-H2 and the sequence given in SEQ ID NO:3 for CDR-H3 and the variable domain of the light chain comprises the sequence given in SEQ ID NO:4 for CDR-L1, the sequence given in SEQ ID NO:5 for CDR-L2 and the sequence given in SEQ ID NO:7 for CDR-L3. The invention also extends to therapeutic uses of the antibody molecules, compositions and methods for producing said antibody molecules.
摘要翻译： 结合包含重链和轻链的人PD-1的人源化激动抗体，其中重链的可变结构域包含SEQ ID NO：1中针对CDR-H1给出的序列，SEQ ID NO：2中给出的序列 对于CDR-H2和CDR-H3的SEQ ID NO：3中给出的序列，轻链的可变结构域包含SEQ ID NO：4中针对CDR-L1给出的序列，SEQ ID NO：5中给出的序列 对于CDR-L2和针对CDR-L3的SEQ ID NO：7中给出的序列。 本发明还延伸到抗体分子的治疗用途，用于产生所述抗体分子的组合物和方法。
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