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1.发明授权公开(公告)号：US09738707B2
公开(公告)日：2017-08-22
申请号：US14232868
申请日：2012-07-13
申请人： Frederick R. Taylor , Justin A. Caravella , Alexey A. Lugovskoy , Amna Saeed-Kothe , Ellen A. Garber
发明人： Frederick R. Taylor , Justin A. Caravella , Alexey A. Lugovskoy , Amna Saeed-Kothe , Ellen A. Garber
CPC分类号： C07K16/18 , C07K16/00 , C07K2317/31 , C07K2317/522 , C07K2317/524 , C07K2317/53 , C07K2317/60 , C07K2317/66
摘要： The present invention features inter alia polypeptides comprising heterodimeric Fc regions. In addition, the instant invention provides methods for treating or preventing a disease or disorder in subject by administering the polypeptides of the invention to said subject.
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公开(公告)号：US20090252748A1
公开(公告)日：2009-10-08
申请号：US12410181
申请日：2009-03-24
申请人： Sha MI , R. Blake Pepinsky , Zhaohui Shao , Ellen A. Garber , Steven D. Miklasz
发明人： Sha MI , R. Blake Pepinsky , Zhaohui Shao , Ellen A. Garber , Steven D. Miklasz
CPC分类号： C07K16/2803 , A61K2039/505 , C07K16/28 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/41 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： Endogenous Sp35 is a negative regulator for neuronal survival, axon regeneration, oligodendrocyte differentiation and myelination. Molecules that block endogenous Sp35 function, such anti-Sp35 antibodies can be used as therapeutics for the treatment of neuron and oligodendrocyte dysfunction. The present invention provides antibodies specific for Sp35, and methods of using such antibodies as antagonists of endogenous Sp35 function. The invention further provides specific hybridoma and phage library-derived monoclonal antibodies, nucleic acids encoding these antibodies, and vectors and host cells comprising these antibodies. The invention further provides methods of promoting oligodendrocyte survival and myelination in a vertebrate, comprising administering to a vertebrate in need of such treatment an effective amount of an anti-Sp35 antibody.
摘要翻译： 内源性Sp35是神经元存活，轴突再生，少突胶质细胞分化和髓鞘形成的负调节因子。 阻断内源性Sp35功能的分子，这种抗Sp35抗体可以用作治疗神经元和少突胶质细胞功能障碍的治疗剂。 本发明提供对Sp35特异性的抗体，以及使用抗体作为内源性Sp35功能拮抗剂的方法。 本发明还提供特异性杂交瘤和源自噬菌体文库的单克隆抗体，编码这些抗体的核酸，以及包含这些抗体的载体和宿主细胞。 本发明还提供了在脊椎动物中促进少突胶质细胞存活和髓鞘形成的方法，其包括对需要这种治疗的脊椎动物施用有效量的抗Sp35抗体。
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公开(公告)号：US20090010930A1
公开(公告)日：2009-01-08
申请号：US12015213
申请日：2008-01-16
IPC分类号： A61K39/395 , C07K16/18 , A61P37/00 , C07H21/00
CPC分类号： C07K16/2842 , A61K2039/505 , C07K2299/00 , C07K2317/24 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , Y02A90/26
摘要： Antibodies that specifically bind to VLA-1 integrin and methods of using these antibodies to treat immunological disorders in a subject. Also included are crystal structures of complexes formed by VLA-1 antibodies and their ligands, and VLA-1 antagonists and agonists identified by using the structure coordinates of these structures.
摘要翻译： 特异性结合VLA-1整联蛋白的抗体以及使用这些抗体治疗受试者的免疫学障碍的方法。 还包括由VLA-1抗体及其配体形成的复合物的晶体结构，以及通过使用这些结构的结构坐标鉴定的VLA-1拮抗剂和激动剂。
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公开(公告)号：US08609407B2
公开(公告)日：2013-12-17
申请号：US13356413
申请日：2012-01-23
申请人： Sha Mi , R. Blake Pepinsky , Zhaohui Shao , Ellen A. Garber , Steven D. Miklasz , Christilyn Graff
发明人： Sha Mi , R. Blake Pepinsky , Zhaohui Shao , Ellen A. Garber , Steven D. Miklasz , Christilyn Graff
CPC分类号： C07K16/2803 , A61K2039/505 , C07K16/28 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/41 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： Endogenous Sp35 is a negative regulator for neuronal survival, axon regeneration, oligodendrocyte differentiation and myelination. Molecules that block endogenous Sp35 function, such anti-Sp35 antibodies can be used as therapeutics for the treatment of neuron and oligodendrocyte dysfunction. The present invention provides antibodies specific for Sp35, and methods of using such antibodies as antagonists of endogenous Sp35 function. The invention further provides specific hybridoma and phage library-derived monoclonal antibodies, nucleic acids encoding these antibodies, and vectors and host cells comprising these antibodies. The invention further provides methods of promoting oligodendrocyte survival and myelination in a vertebrate, comprising administering to a vertebrate in need of such treatment an effective amount of an anti-Sp35 antibody.
摘要翻译： 内源性Sp35是神经元存活，轴突再生，少突胶质细胞分化和髓鞘形成的负调节因子。 阻断内源性Sp35功能的分子，这种抗Sp35抗体可以用作治疗神经元和少突胶质细胞功能障碍的治疗剂。 本发明提供对Sp35特异性的抗体，以及使用抗体作为内源性Sp35功能拮抗剂的方法。 本发明还提供特异性杂交瘤和源自噬菌体文库的单克隆抗体，编码这些抗体的核酸，以及包含这些抗体的载体和宿主细胞。 本发明还提供了在脊椎动物中促进少突胶质细胞存活和髓鞘形成的方法，其包括对需要这种治疗的脊椎动物施用有效量的抗Sp35抗体。
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公开(公告)号：US20100272716A1
公开(公告)日：2010-10-28
申请号：US12727965
申请日：2010-03-19
IPC分类号： A61K39/395 , A61P1/00 , A61P17/06 , A61P25/00 , A61P19/02
CPC分类号： C07K16/2842 , A61K2039/505 , C07K2299/00 , C07K2317/24 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , Y02A90/26
摘要： Antibodies that specifically bind to VLA-1 integrin and methods of using these antibodies to treat immunological disorders in a subject. Also included are crystal structures of complexes formed by VLA-1 antibodies and their ligands, and VLA-1 antagonists and agonists identified by using the structure coordinates of these structures.
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公开(公告)号：US07358054B2
公开(公告)日：2008-04-15
申请号：US10474832
申请日：2002-04-12
申请人： Paul D Lyne , Ellen A Garber , Jose W Saldanha , Michael Karpusas
发明人： Paul D Lyne , Ellen A Garber , Jose W Saldanha , Michael Karpusas
CPC分类号： C07K16/2842 , A61K2039/505 , C07K2299/00 , C07K2317/24 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , Y02A90/26
摘要： Antibodies that specifically bind to VLA-1 integrin and methods of using these antibodies to treat immunological disorders in a subject. Also included are crystal structures of complexes formed by VLA-1 antibodies and their ligands, and VLA-1 antagonists and agonists identified by using the structure coordinates of these structures.
摘要翻译： 特异性结合VLA-1整联蛋白的抗体以及使用这些抗体治疗受试者的免疫学障碍的方法。 还包括由VLA-1抗体及其配体形成的复合物的晶体结构，以及通过使用这些结构的结构坐标鉴定的VLA-1拮抗剂和激动剂。
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公开(公告)号：US20120177638A1
公开(公告)日：2012-07-12
申请号：US13297124
申请日：2011-11-15
IPC分类号： A61K39/395 , A61P17/06 , A61P17/00
CPC分类号： C07K16/2842 , A61K2039/505 , C07K2299/00 , C07K2317/24 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , Y02A90/26
摘要： Antibodies that specifically bind to VLA-1 integrin and methods of using these antibodies to treat immunological disorders in a subject. Also included are crystal structures of complexes formed by VLA-1 antibodies and their ligands, and VLA-1 antagonists and agonists identified by using the structure coordinates of these structures.
摘要翻译： 特异性结合VLA-1整联蛋白的抗体以及使用这些抗体治疗受试者的免疫学障碍的方法。 还包括由VLA-1抗体及其配体形成的复合物的晶体结构，以及通过使用这些结构的结构坐标鉴定的VLA-1拮抗剂和激动剂。
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公开(公告)号：US07910099B2
公开(公告)日：2011-03-22
申请号：US12727965
申请日：2010-03-19
IPC分类号： A61K39/395
CPC分类号： C07K16/2842 , A61K2039/505 , C07K2299/00 , C07K2317/24 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , Y02A90/26
摘要： Antibodies that specifically bind to VLA-1 integrin and methods of using these antibodies to treat immunological disorders in a subject. Also included are crystal structures of complexes formed by VLA-1 antibodies and their ligands, and VLA-1 antagonists and agonists identified by using the structure coordinates of these structures.
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公开(公告)号：US07723073B2
公开(公告)日：2010-05-25
申请号：US12015213
申请日：2008-01-16
CPC分类号： C07K16/2842 , A61K2039/505 , C07K2299/00 , C07K2317/24 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , Y02A90/26
摘要： Antibodies that specifically bind to VLA-1 integrin and methods of using these antibodies to treat immunological disorders in a subject. Also included are crystal structures of complexes formed by VLA-1 antibodies and their ligands, and VLA-1 antagonists and agonists identified by using the structure coordinates of these structures.
摘要翻译： 特异性结合VLA-1整联蛋白的抗体以及使用这些抗体治疗受试者的免疫学障碍的方法。 还包括由VLA-1抗体及其配体形成的复合物的晶体结构，以及通过使用这些结构的结构坐标鉴定的VLA-1拮抗剂和激动剂。
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公开(公告)号：US20090054632A1
公开(公告)日：2009-02-26
申请号：US11894745
申请日：2007-08-20
申请人： R. Blake Pepinsky , Alphonse Galdes , Ellen A. Garber , Darren P. Baker , Jeffery A. Porter , Frederick R. Taylor , Kevin P. Williams , Russell C. Petter , Kathryn Strauch , Paul H. Weinreb , Dingyi Wen , Chenhui Zeng
发明人： R. Blake Pepinsky , Alphonse Galdes , Ellen A. Garber , Darren P. Baker , Jeffery A. Porter , Frederick R. Taylor , Kevin P. Williams , Russell C. Petter , Kathryn Strauch , Paul H. Weinreb , Dingyi Wen , Chenhui Zeng
CPC分类号： C07K14/46 , A61K38/1709 , C07K2319/00
摘要： Hydrophobically-modified proteins and methods of making them are described. A hydrophobic moiety is attached to a surface amino acid residue of the protein. The hydrophobic moiety can be a lipid or a peptide. Alternatively, the protein can be derivatized by a wide variety of chemical reactions that append a hydrophobic structure to the protein. The preferred protein is of mammalian origin and is selected from the group consisting of Sonic, Indian, and Desert hedgehog. The hydrophobic moiety is used as a convenient tether to which may be attached a vesicle such as a cell membrane, liposome, or micelle.
摘要翻译： 描述了疏水性修饰的蛋白质及其制备方法。 疏水部分连接到蛋白质的表面氨基酸残基。 疏水部分可以是脂质或肽。 或者，蛋白质可以通过向蛋白质附加疏水结构的各种化学反应衍生化。 优选的蛋白质是哺乳动物来源的，并且选自Sonic，Indian和Desert hedgehog。 疏水部分用作方便的系链，其可以连接囊泡，例如细胞膜，脂质体或胶束。
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