公开(公告)号：US20120203265A1

公开(公告)日：2012-08-09

申请号：US13449165

申请日：2012-04-17

Applicant: Richard R. Heuser

Inventor： Richard R. Heuser

IPC: A61F2/01

CPC classification number: A61B17/12109 ,  A61F2/01 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/008

Abstract: Disclosed herein are systems and methods for protecting a subject from embolisms during TAVI and other percutaneous valve procedures. Some embodiments include two flexible catheters designed to pass over a guidewire into two separate arteries, such as carotid or innominate arteries, each flexible catheter including a vessel blocking mechanism and a bypass feature that prevents ischemia while the vessel blocking mechanism is in use. Other embodiments include a single, bifurcated flexible catheter having two arms, each of which is configured to protect a different artery. In some embodiments, each arm includes a vessel blocking mechanism and a bypass feature that prevents ischemia while the vessel blocking mechanism is in use. In some embodiments, the systems also may include one or more concentric guidewires.

Abstract translation: 本文公开了在TAVI和其它经皮瓣膜手术期间保护受试者免受栓塞的系统和方法。 一些实施例包括设计成将导线穿过两个分开的动脉（例如颈动脉或无名动脉）的两个柔性导管，每个柔性导管包括血管阻断机构和旁路特征，其在血管阻塞机制使用时防止局部缺血。 其他实施例包括具有两个臂的单个分叉的柔性导管，每个臂构造成保护不同的动脉。 在一些实施方案中，每个臂包括血管阻断机制和旁路特征，其在血管阻断机制使用时防止局部缺血。 在一些实施例中，系统还可以包括一个或多个同心导丝。

公开(公告)号：US20110197900A1

公开(公告)日：2011-08-18

申请号：US13092041

申请日：2011-04-21

Applicant: Richard R. Heuser

Inventor： Richard R. Heuser

IPC: A61B17/00

CPC classification number: A61B17/0057 ,  A61B17/0644 ,  A61B18/1492 ,  A61B2017/00247 ,  A61B2017/00637 ,  A61B2017/00659 ,  A61B2018/00369 ,  A61B2018/00392

Abstract: A system is provided for treating valvular disease percutaneously though a ventricular apex of the heart. The system includes a needle for piercing through the ventricular apex of the heart and creating a hole whereby a catheter can be passed through the skin and the wall of the heart to gain access to the interior of the heart. Once percutaneous access to the heart is obtained, any of a variety of techniques can be utilized for annular and/or valvular therapy and/or repair through, the catheter. A closure device is necessary for closing the puncture of the heart. Any of a variety of vascular closure devices can be modified to be utilized with the system to close the puncture of the ventricular apex of the heart.

Abstract translation: 提供一种用于通过心脏的心室顶点经皮治疗瓣膜疾病的系统。 该系统包括用于刺穿心脏的心室顶点的针，并且产生一个孔，由此导管可以穿过皮肤和心脏的壁以进入心脏的内部。 一旦获得对心脏的经皮进入，可以使用各种技术中的任何一种来进行环形和/或瓣膜治疗和/或通过导管进行修复。 闭合装置是闭合心脏穿刺所必需的。 可以修改各种血管闭合装置中的任何一种以与系统一起使用以闭合心脏的心室顶点的穿刺。

公开(公告)号：US20110077680A1

公开(公告)日：2011-03-31

申请号：US12964672

申请日：2010-12-09

Applicant: Richard R. Heuser

Inventor： Richard R. Heuser

IPC: A61M29/00

CPC classification number: A61B17/221 ,  A61B17/3439 ,  A61B2017/00336 ,  A61B2017/00876 ,  A61B2017/2215

Abstract: An apparatus and method for removing an object from a vessel are disclosed. The apparatus includes an expandable catheter, an expandable funnel, and a snare device configured to snare an object within the vessel. A distal end of the expandable catheter may be manipulable such that retraction of the expandable catheter allows the expandable funnel device to expand. Once the snare device has been manipulated to capture the object, the snare device and object may then be retracted into the funnel device, which may then protect the surrounding structures from being damaged by the object. In some embodiments, the expended funnel device, snare device, and object may be retracted into the expandable catheter in order to further protect the surrounding structures from damage.

Abstract translation: 公开了一种用于从容器中取出物体的装置和方法。 该装置包括可扩张的导管，可扩展的漏斗以及被配置成围绕血管内的物体进行圈套的圈套装置。 可扩张导管的远端可以是可操纵的，使得可扩张导管的缩回允许扩张漏斗装置膨胀。 一旦圈套装置被操纵以捕获物体，则圈套装置和物体然后可以缩回到漏斗装置中，然后这可以保护周围结构免受物体损坏。 在一些实施例中，消耗漏斗装置，圈套装置和物体可以缩回到可扩张导管中，以便进一步保护周围结构免受损坏。

公开(公告)号：US20100131000A1

公开(公告)日：2010-05-27

申请号：US12275822

申请日：2008-11-21

Applicant: Richard M. DeMello ,  Jonathan R. DeMello ,  Richard R. Heuser ,  Maureen A. Finlayson

Inventor： Richard M. DeMello ,  Jonathan R. DeMello ,  Richard R. Heuser ,  Maureen A. Finlayson

IPC: A61B17/221

CPC classification number: A61B17/221 ,  A61B2017/00367 ,  A61B2017/2215 ,  Y10T29/49826

Abstract: This invention provides a device and controllably expansive tool tip for thrombus removal. According to one embodiment, the controllably expansive thrombus removal tool tip (e.g., a screen and/or mesh) may be collapsed by pushing on an actuating handle, and then advanced into a balloon or guiding catheter until a distal end of device has reached the thrombus. The tool tip is then expanded by pulling the actuating handle backward; and the radially extended (expanded) tool tip is moved to receive and substantially surround (e.g., encompass) the thrombus. The tool tip may then be collapsed again by pushing on the actuating handle to engage (tighten around) the thrombus, and the device may be withdrawn from a patient's body through the vascular system with the thrombus engaged by the tool tip.

Abstract translation: 本发明提供了用于血栓去除的装置和可控制的膨胀工具尖端。 根据一个实施例，可控膨胀的血栓去除工具尖端（例如，筛网和/或网孔）可以通过推动致动手柄而折叠，然后前进到气囊或引导导管中，直到装置的远端到达 血栓。 然后通过向后拉动致动手柄来扩大工具尖端; 并且径向延伸（扩大）的工具尖端被移动以接收和基本上围绕（例如，包围）血栓。 然后可以通过推动致动手柄使工具尖端折叠以接合（紧固）血栓，并且可以通过血管系统将装置从患者的身体抽出，其中血栓由工具尖端接合。

公开(公告)号：US20080234813A1

公开(公告)日：2008-09-25

申请号：US11688785

申请日：2007-03-20

Applicant: Richard R. Heuser

Inventor： Richard R. Heuser

IPC: A61F2/24

CPC classification number: A61B17/0057 ,  A61B17/0644 ,  A61B18/1492 ,  A61B2017/00247 ,  A61B2017/00637 ,  A61B2017/00659 ,  A61B2018/00369 ,  A61B2018/00392

Abstract: A system is provided for treating valvular disease percutaneously though a ventricular apex of the heart. The system includes a needle for piercing through the ventricular apex of the heart and creating a hole whereby a catheter can be passed through the skin and the wall of the heart to gain access to the interior of the heart. Once percutaneous access to the heart is obtained, any of a variety of techniques can be utilized for annular and/or valvular therapy and/or repair through the catheter. A closure device is necessary for closing the puncture of the heart. Any of a variety of vascular closure devices can be modified to be utilized with the system to close the puncture of the ventricular apex of the heart.

Abstract translation: 提供一种用于通过心脏的心室顶点经皮治疗瓣膜疾病的系统。 该系统包括用于刺穿心脏的心室顶点的针，并且产生一个孔，由此导管可以穿过皮肤和心脏的壁以进入心脏的内部。 一旦获得对心脏的经皮进入，可以使用各种技术中的任何一种来进行环形和/或瓣膜治疗和/或通过导管进行修复。 闭合装置是闭合心脏穿刺所必需的。 可以修改各种血管闭合装置中的任何一种以与系统一起使用以闭合心脏的心室顶点的穿刺。

公开(公告)号：US07300459B2

公开(公告)日：2007-11-27

申请号：US10687783

申请日：2003-10-17

Applicant: Richard R. Heuser

Inventor： Richard R. Heuser

IPC: A61F2/06

CPC classification number: A61F2/91 ,  A61F2/07 ,  A61F2/90 ,  A61F2/915 ,  A61F2/958 ,  A61F2002/072 ,  A61F2002/91533 ,  A61F2002/91558 ,  A61F2210/0076 ,  A61F2230/0013 ,  A61F2230/0054 ,  A61F2230/0078 ,  A61F2250/0019 ,  A61F2250/0039

Abstract: A stent is provided with a multi-layer structure, combining one or more mesh layers with one or more film layers. The film layer(s) are configured to substantially prevent growth of an inner lining of a blood vessel, where the stent is placed, through the mesh layer(s). The end-to-end length of the film layer(s) may be greater than the lengths of the mesh layer(s) by at least about 0.5 mm. The mesh and film layers include a radiopaque portion adjacent their ends to provide an X-ray indication of whether the mesh layer(s) have expanded beyond the ends of the film layer(s). If the stent includes inner and outer film layers and a middle mesh layer, the film layers may be sealed together adjacent the ends, encasing and fixing in place the middle layer. The mesh layer may be constructed to be more compliant adjacent its distal end and to expand more rapidly in response to expansion of a balloon catheter as compared to a middle portion of the mesh layer.

Abstract translation: 支架设置有多层结构，将一个或多个网格层与一个或多个膜层组合。 薄膜层构造成基本上防止通过网格层放置支架的血管内衬的生长。 膜层的端到端长度可以大于网层的长度至少约0.5mm。 网格和薄膜层包括与其端部相邻的不透射线部分，以提供网格层是否已经超出薄膜层的端部的X射线指示。 如果支架包括内膜层和外膜层和中间网层，则膜层可以邻近端部密封在一起，将中间层包裹并固定到位。 与网状层的中间部分相比，网状层可以被构造为更靠近其远端附近并且响应于球囊导管的膨胀而更快地扩张。

公开(公告)号：US20160175569A1

公开(公告)日：2016-06-23

申请号：US14579907

申请日：2014-12-22

Applicant: Richard R. Heuser

Inventor： Richard R. Heuser

IPC: A61M25/10

CPC classification number: A61M25/0054 ,  A61M25/0068 ,  A61M25/0102 ,  A61M25/04 ,  A61M25/0662 ,  A61M25/10 ,  A61M2025/1047 ,  A61M2025/1061

Abstract: Disclosed herein are extension members for use with a standard guide catheter, which extension members provide backup support against forces that would otherwise tend to dislodge the guide catheter from the branch artery during interventional cardiology devices. During use, the extension member may be deeply seated in a branch artery that branches off from a main artery when extended through the lumen of the guide catheter and beyond the distal end of the guide catheter. An expandable balloon disposed adjacent the distal tip of the extension member provides additional stabilization and backup support. Also disclosed are methods of using the extension members.

Abstract translation: 这里公开的是用于与标准导向导管一起使用的延伸构件，该延伸构件提供抵抗在介入心脏病学装置期间倾向于将引导导管从分支动脉移开的力的支撑支撑。 在使用期间，当延伸穿过导管的内腔并且超过引导导管的远端时，延伸构件可以深深地位于从主动脉分支的分支动脉中。 与扩展构件的远端相邻设置的可膨胀气囊提供额外的稳定和备用支撑。 还公开了使用延伸构件的方法。

公开(公告)号：US09259340B2

公开(公告)日：2016-02-16

申请号：US13868804

申请日：2013-04-23

Applicant: Richard R. Heuser ,  James D. Joye ,  Kumar Ganesan Jambunathan ,  Eugene E. Reis ,  Richard A. Lotti

Inventor： Richard R. Heuser ,  James D. Joye ,  Kumar Ganesan Jambunathan ,  Eugene E. Reis ,  Richard A. Lotti

IPC: A61F2/95 ,  A61B17/12 ,  A61M25/04 ,  A61M25/00 ,  A61M25/01 ,  A61M25/10 ,  A61B17/00 ,  A61B17/11 ,  A61B19/00 ,  A61B17/22

CPC classification number: A61F2/95 ,  A61B17/12045 ,  A61B17/12136 ,  A61B17/22 ,  A61B2017/00252 ,  A61B2017/00986 ,  A61B2017/1107 ,  A61B2017/1139 ,  A61B2017/22044 ,  A61B2017/22095 ,  A61B2090/3966 ,  A61M25/0032 ,  A61M25/0108 ,  A61M25/0194 ,  A61M25/04 ,  A61M25/1011 ,  A61M2025/0096 ,  A61M2025/0197

Abstract: A system for deploying a stent-graft from the femoral artery into the femoral vein and back into the femoral artery in order to bypass a femoral occlusion comprises a penetration catheter and a guidewire capture and stabilization catheter. The penetration catheter may be advanced contralaterally to a location above the occlusion and the capture and stabilization catheter may be introduced upwardly through the femoral vein. The penetration tool on the penetration catheter is used in multiple steps to deploy guidewires which are then used to deploy the stent-graft in the desired location.

Abstract translation: 用于将支架移植物从股动脉部署到股静脉并且回到股动脉以绕过股骨闭塞的系统包括穿透导管和导丝捕获和稳定导管。 穿透导管可以在对侧前进到阻塞上方的位置，并且捕获和稳定导管可以向上通过股静脉引入。 穿透导管上的穿透工具用于多个步骤以部署导丝，然后将导线用于将支架移植物部署到期望的位置。

公开(公告)号：US20140052170A1

公开(公告)日：2014-02-20

申请号：US13670042

申请日：2012-11-06

Applicant: Richard R. Heuser ,  Furqan Tejani

Inventor： Richard R. Heuser ,  Furqan Tejani

IPC: A61F2/01

CPC classification number: A61F2/013 ,  A61F2/01 ,  A61F2002/018

Abstract: Disclosed herein are systems and methods for protecting a subject from embolisms during TAVI percutaneous valve procedures, coronary bypass surgery and heart valve surgery. Various embodiments include an intravascular embolism protection device that includes an elongated, compliant frame made from a material having a shape-memory function, and a mesh material coupled to the elongated, compliant frame, the mesh material having a pore size selected to allow blood to pass therethrough while retaining potential emboli. In some embodiments, the embolism protection device has a collapsed state wherein device is configured to fit within the lumen of a support catheter and an expanded state wherein the embolism protection device is configured to cover a plurality of arterial branch ostias.

Abstract translation: 本文公开了用于在TAVI经皮瓣膜手术，冠状动脉旁路手术和心脏瓣膜手术期间保护受试者免受栓塞的系统和方法。 各种实施方案包括血管内栓塞保护装置，其包括由具有形状记忆功能的材料制成的细长的柔性框架和联接到细长的柔性框架的网状材料，所述网状材料具有选择的孔径，以允许血液 通过，同时保留潜在的栓子。 在一些实施例中，栓塞保护装置具有折叠状态，其中装置被配置成装配在支撑导管的内腔中并且膨胀状态，其中栓塞保护装置构造成覆盖多个动脉分支口。

公开(公告)号：US20120095500A1

公开(公告)日：2012-04-19

申请号：US12905056

申请日：2010-10-14

Applicant: Richard R. Heuser

Inventor： Richard R. Heuser

IPC: A61F2/01

CPC classification number: A61F2/01 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/008

Abstract: An embolism protection system is disclosed that provides a first wire having a proximal end, a distal end, and an outer diameter; a second wire having a proximal end, a distal end, an inner lumen, and an outer diameter, the inner lumen sized to accommodate the outer diameter of the first wire; a third having a proximal end, a distal end, and an inner lumen, the inner lumen sized to accommodate the outer diameter of the second wire; and a substantially conical filter device formed substantially from porous metal mesh and having a central apex, a collapsed state, and an expanded state, wherein the substantially conical filter device is adapted to couple to the second wire at or near the distal end of the second wire, the second wire passing through the central apex, and wherein the substantially conical filter device is adapted to assume the expanded state when the third wire is retracted from the distal end of the second wire, and is adapted to assume the collapsed state when the third wire is advanced over the substantially conical filter device and towards the distal end of the second wire.

Abstract translation: 公开了一种提供具有近端，远端和外径的第一线的栓塞保护系统; 具有近端，远端，内腔和外径的第二线，所述内腔的尺寸适于容纳所述第一线的外径; 具有近端，远端和内腔的第三部分，所述内腔的尺寸适于容纳所述第二线的外径; 以及基本上由多孔金属网形成并且具有中心顶点，折叠状态和膨胀状态的基本上圆锥形的过滤器装置，其中所述基本上圆锥形的过滤装置适于在所述第二管的远端处或其附近 所述第二线穿过所述中心顶点，并且其中当所述第三线从所述第二线的远端缩回时，所述基本上圆锥形的过滤器装置适于呈现膨胀状态，并且适于在 第三线在基本上圆锥形的过滤器装置上并且朝向第二线的远端前进。