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公开(公告)号:US20070254880A1
公开(公告)日:2007-11-01
申请号:US10593950
申请日:2005-03-23
申请人: Wesley Blackaby , Mark Duggan , David Hallett , George Hartman , Andrew Jennings , William Leister , Richard Lewis , Craig Lindsley , Elizabeth Naylor , Leslie Street , Yi Wang , David Wisnoski , Scott Wolkenberg , Zhijian Zhao
发明人: Wesley Blackaby , Mark Duggan , David Hallett , George Hartman , Andrew Jennings , William Leister , Richard Lewis , Craig Lindsley , Elizabeth Naylor , Leslie Street , Yi Wang , David Wisnoski , Scott Wolkenberg , Zhijian Zhao
IPC分类号: A61K31/445 , A61K31/5375 , C07D211/06 , C07D413/02
CPC分类号: C07D409/14 , C07D401/04 , C07D401/14 , C07D413/14
摘要: The present invention is directed to pyridyl, pyridazinyl, pyrimidinyl and pyrazinyl piperidine compounds that inhibit the glycine transporter GlyT1 and which are useful in the treatment of neurological and psychiatric disorders associated with glycinergic or glutamatergic neurotransmission dysfunction and diseases in which the glycine transporter GlyT1 is involved.
摘要翻译: 本发明涉及抑制甘氨酸转运蛋白GlyT1的吡啶基,哒嗪基,嘧啶基和吡嗪基哌啶化合物,其可用于治疗与甘氨酸能或谷氨酸能神经传递功能障碍相关的神经和精神疾病以及其中涉及甘氨酸转运蛋白GlyT1的疾病 。
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公开(公告)号:US20070189529A1
公开(公告)日:2007-08-16
申请号:US11342479
申请日:2006-01-30
申请人: Raymond Hauge , Richard Lewis , Rudolf Turner
发明人: Raymond Hauge , Richard Lewis , Rudolf Turner
IPC分类号: H04N7/167
CPC分类号: H04N7/1675 , H04N21/2347 , H04N21/23476 , H04N21/2362 , H04N21/26606 , H04N21/4345 , H04N21/4405 , H04N21/44055 , H04N21/835
摘要: At a transmitter, a program is encrypting according to a one program key, the program key is encrypted, and the encrypted program, the encrypted program key, and non-encrypted PSI data to a receiver are transmitted. At a receiver, the encrypted program, the encrypted program key, and the non-encrypted PSI data are received, the encrypted program key is decrypted, the encrypted program is located according to the non-encrypted PSI data, and the located encrypted program is decrypted according to decrypted program key.
摘要翻译: 在发射机上,程序根据一个程序密钥进行加密,程序密钥被加密,并且将加密的程序,加密的程序密钥和未加密的PSI数据传送到接收器。 在接收机处,接收到加密程序,加密程序密钥和未加密的PSI数据,加密的程序密钥被解密,加密的程序根据未加密的PSI数据被定位,并且所定位的加密程序是 根据解密的程序密钥解密。
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公开(公告)号:US20060270832A1
公开(公告)日:2006-11-30
申请号:US10537088
申请日:2003-12-02
申请人: Richard Lewis , Paul Alewood , Dianne Alewood , Elka Palant
发明人: Richard Lewis , Paul Alewood , Dianne Alewood , Elka Palant
CPC分类号: C07K14/43504 , A61K38/00 , C07K7/08
摘要: An isolated, synthetic or recombinant χ-conotoxin peptide having the ability to inhibit neuronal amine transporter comprising the following sequence of amino acids: Cys Cys Gly Tyr Lys Leu Cys Xaa5 Xaa6 Cys, SEQ ID NO. 3, where Xaa5 and Xaa6 are independently absent or represent any amino acid residue except Cys; or a sequence in which Gly, Tyr, Lys or Leu are subject to conservative amino acid substitution or side chain modification; with the proviso that the peptide is not χ-MrIA, χ-MrIB, Mar2, CMrVIA, Bn1.5, Mr1.3 or Au1.4; or a salt, ester, amide, prodrug or cyclised derivative thereof.
摘要翻译: 具有抑制神经元胺转运蛋白的能力的分离的,合成的或重组的咳嗽毒素肽,其包含以下氨基酸序列:Cys Cys Gly Tyr Lys Leu Cys Xaa5 Xaa6 Cys,SEQ ID NO: 3,其中Xaa5和Xaa6独立地不存在或表示除Cys之外的任何氨基酸残基; 或Gly,Tyr,Lys或Leu进行保守氨基酸取代或侧链修饰的序列; 条件是肽不是chi-MrIA,chi-MrIB,Mar2,CMrVIA,Bn1.5,Mr1.3或Au1.4; 或其盐,酯,酰胺,前药或环化衍生物。
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公开(公告)号:US20060266759A1
公开(公告)日:2006-11-30
申请号:US11420085
申请日:2006-05-24
申请人: Paul Tramontina , Richard Lewis , Guy Provenzano
发明人: Paul Tramontina , Richard Lewis , Guy Provenzano
IPC分类号: B65H1/00
CPC分类号: B65D83/0811 , A47K10/423 , A47K2010/3266 , B65D83/0894
摘要: A restrictor and dispensing system for dispensing sheet material is provided. The restrictor includes a restrictor body positioned on a top sheet of a stack of sheet materials which are positioned in a dispenser. The restrictor assists in one at a time dispensing from a dispensing assembly. The dispensing assembly includes the dispenser, which has a housing including a container and a lid, and the housing is configured to hold and dispense sheet material. The dispenser also includes a sheet mover mounted to the housing. The sheet mover is configured to move over at least a portion of a sheet material away from additional sheet materials for dispensing. The restrictor cooperates with the housing and sheet mover to dispense one sheet material at a time. The restrictor may be provided with the dispenser, or separately. Alternatively, the restrictor may be provided in a cartridge filled with a stack of sheet materials.
摘要翻译: 提供了用于分配片材的限流器和分配系统。 限流器包括定位在位于分配器中的片材堆叠的顶片上的限制器体。 限流器一次从分配组件中分配一次。 分配组件包括分配器,其具有包括容器和盖的壳体,并且壳体构造成保持和分配片材。 分配器还包括安装到壳体的薄片移动器。 片材移动器被配置为移动片材的至少一部分远离用于分配的附加片材。 限流器与壳体和薄片移动器配合,一次分配一张薄片材料。 限流器可以设置有分配器,或者单独设置。 或者,限制器可以设置在填充有堆叠的片材的盒中。
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公开(公告)号:US20060235021A1
公开(公告)日:2006-10-19
申请号:US10524173
申请日:2003-08-04
申请人: Wesley Blackaby , Peter Blurton , Frank Burkamp , Stephen Fletcher , Andrew Jennings , Richard Lewis , Angus Macleod , Leslie Street , Steve Thomas , Monique Van Niel , Kevin Wilson
发明人: Wesley Blackaby , Peter Blurton , Frank Burkamp , Stephen Fletcher , Andrew Jennings , Richard Lewis , Angus Macleod , Leslie Street , Steve Thomas , Monique Van Niel , Kevin Wilson
IPC分类号: A61K31/501 , C07D403/02 , A61K31/50
CPC分类号: C07D231/12 , C07D233/56 , C07D237/08 , C07D237/14 , C07D237/20 , C07D237/24 , C07D249/08 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D409/04 , C07D417/14
摘要: A class of 4-phenylpyridazine derivatives of Formula (I), being selective ligands for GABAA receptors, in particular having high affinity for the α2 and/or α3 and or α5 subunit thereof, are accordingly of benefit in the treatment and/or prevention of adverse conditions of the central nervous system, including anxiety, convulsions and cognitive disorders.
摘要翻译: 一类式(I)的4-苯基哒嗪衍生物,作为GABA A A受体的选择性配体,特别是对α2和/或α3和α5亚基具有高亲和力,因此具有益处 在治疗和/或预防中枢神经系统的不利条件,包括焦虑,抽搐和认知障碍。
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公开(公告)号:US20060027642A1
公开(公告)日:2006-02-09
申请号:US11205451
申请日:2005-08-15
申请人: Richard Lewis
发明人: Richard Lewis
CPC分类号: G08B21/02
摘要: The present invention provides safety confirmation or hazard warning to a technician in the field, e.g., by scanning an equipment identification label and comparing the identification to a schedule of equipment inactivation times. The systems and methods of the invention can optionally provide remote interactions to reschedule inactivations or to protect the technician by lock-out from a hazardous condition.
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公开(公告)号:US20050284887A1
公开(公告)日:2005-12-29
申请号:US10877053
申请日:2004-06-25
申请人: Richard Lewis , Victor Shoaf , Cleary Mahaffey
发明人: Richard Lewis , Victor Shoaf , Cleary Mahaffey
CPC分类号: B05B11/3087 , B05B7/0037
摘要: A self contained viscous liquid dispenser with a foaming pump mechanism includes a housing defining an internal liquid reservoir. A foaming pump mechanism is configured with the housing and includes a horizontally disposed pump chamber fitted through an opening in the housing to extend into the reservoir. A pump cylinder is slidably disposed and retained in the chamber. Actuation of the pump cylinder results in a liquid/air mixture within the pump chamber being pressurized and dispensed from the chamber as a foam.
摘要翻译: 具有发泡泵机构的自包含粘性液体分配器包括限定内部液体储存器的壳体。 发泡泵机构配置有壳体并且包括水平布置的泵室,其通过壳体中的开口配合以延伸到储存器中。 泵筒可滑动地设置并保持在腔室中。 泵筒的致动导致泵室内的液体/空气混合物被加压并作为泡沫从室中分配。
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公开(公告)号:US06506059B2
公开(公告)日:2003-01-14
申请号:US09821828
申请日:2001-03-29
申请人: Peter Bishop , Richard Lewis
发明人: Peter Bishop , Richard Lewis
IPC分类号: H01R1200
CPC分类号: G02F1/133615 , G02F1/13452 , H01C1/028 , H01C1/142 , H01R12/52 , H01R12/7076 , H01R12/714 , H01R13/24 , Y10S439/91
摘要: An electrical connector for interconnecting a display to a printed circuit board. One application of the invention provides connection between a liquid crystal display (“LCD”) and a circuit board. The connector is capable of serving a dual function as both a lightguide that disperses light for the display, and as an electrical connector for interconnection of the display with the circuit board. A leg member is mounted on the connector, and the leg member includes a row of contact feet for electrical communication. The connector may include a plurality of spaced apart U-shaped strip members mounted in parallel upon a leg member, with contact feet that extend upwardly to resiliently mate with contact pads of the display and downwardly to resiliently mate with contact pads of a printed circuit board.
摘要翻译: 一种用于将显示器与印刷电路板互连的电连接器。 本发明的一个应用提供了液晶显示器(“LCD”)和电路板之间的连接。 连接器能够作为分散用于显示器的光的光导以及用于将显示器与电路板互连的电连接器用作双重功能。 腿部件安装在连接器上,腿部件包括一排用于电连接的接触脚。 连接器可以包括平行安装在腿部件上的多个间隔开的U形条状部件,其中接触脚向上延伸以弹性地与显示器的接触垫配合,并向下弹性地与印刷电路板的接触垫配合 。
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公开(公告)号:US4176824A
公开(公告)日:1979-12-04
申请号:US893274
申请日:1978-04-05
申请人: Francis E. Linton , Richard Lewis
发明人: Francis E. Linton , Richard Lewis
摘要: Lifting apparatus in which a hydraulic cylinder-piston unit is adjustably mounted on a vehicle or other object to be lifted by replaceable pins to facilitate rapid changes in position of the unit to accommodate varying distances between the object and the surface above which it is to be supported.
摘要翻译: 提升装置,其中液压缸 - 活塞单元可调节地安装在车辆或其他物体上,以通过可更换的销来提升,以促进单元的位置的快速改变,以适应物体与表面之间的不同距离 支持的。
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公开(公告)号:US4084444A
公开(公告)日:1978-04-18
申请号:US685158
申请日:1976-05-11
申请人: Richard Lewis
发明人: Richard Lewis
摘要: Rotary ultrasonic testing apparatus comprises an annular stator; a replaceable annular ultrasonic probe assembly mounted for rotation on the stator; and first and second fixed replaceable annular guideways for the articles to be tested, said guideways having internal configurations arranged to conform to the cross-section of the article to be tested and provide a close tolerance guide therefor, and said guideways each having a side surface adjacent the probe assembly which serves at least partially as a radially inwardly extending side wall of the probe assembly.
摘要翻译: 旋转超声波检测装置包括环形定子; 可更换的环形超声波探头组件安装成在定子上旋转; 以及用于待测试物品的第一和第二固定可更换的环形导轨,所述导轨具有被布置成符合待测制品的横截面并具有紧密公差导向件的内部构造,并且所述导轨各自具有侧面 邻近探针组件,其至少部分地用作探针组件的径向向内延伸的侧壁。
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