公开(公告)号：US06878830B2

公开(公告)日：2005-04-12

申请号：US10194809

申请日：2002-07-12

申请人： Milton R. Smith, III

发明人： Milton R. Smith, III

IPC分类号： B01J31/12 ,  B01J31/14 ,  B01J31/18 ,  B01J31/22 ,  B01J31/24 ,  B01J31/28 ,  C07C1/32 ,  C07C17/269 ,  C07F15/00 ,  C07F17/02 ,  C08G61/10 ,  C07D207/00

CPC分类号： C08G61/10 ,  B01J31/1805 ,  B01J31/181 ,  B01J31/22 ,  B01J31/2295 ,  B01J31/24 ,  B01J31/2404 ,  B01J31/2409 ,  B01J2231/4211 ,  B01J2531/822 ,  B01J2531/824 ,  B01J2531/827 ,  C07C1/321 ,  C07C17/269 ,  C07C2531/22 ,  C07F15/0033 ,  C07F15/004 ,  C07F15/0073 ,  C07F15/008 ,  C07F17/02 ,  C07C15/00 ,  C07C22/08 ,  C07C25/18

摘要： A process for producing a ring-substituted arene borane which comprises reacting a ring-substituted arene with an HB organic compound in the presence of a catalytically effective amount of an iridium or rhodium complex with three or more substituents, excluding hydrogen, bonded to the iridium or rhodium and a phosphorus organic ligand, which is at least in part bonded to the iridium or rhodium, to form the ring-substituted arene borane. Also provided are catalytic compounds for catalyzing the process comprising an iridium or rhodium complex with three or substituents, excluding hydrogen, bonded to the iridium or rhodium and optionally, a phosphorus organic ligand, which is at least in part bonded to the iridium or rhodium.

公开(公告)号：US06469133B2

公开(公告)日：2002-10-22

申请号：US09736991

申请日：2000-12-13

申请人： Gregory L. Baker ,  Milton R. Smith, III

发明人： Gregory L. Baker ,  Milton R. Smith, III

IPC分类号： C08G6308

CPC分类号： C08G63/08 ,  C08G63/823

摘要： The present invention provides a process for the direct synthesis of high melting polymers made from dimeric cyclic esters. In particular, the present invention provides a process for synthesis of polylactic acid (PLA) from racemic materials such as racemic lactide and polymandelide from mandelide. The process further provides racemic metal organic ligand catalysts such as racemic salbinap that catalyzes the polymerization of racemic dimeric cyclic ester monomers to a polylactide stereocomplex. Polymandelide and mixed dimeric cyclic esters are also prepared in the presence of low amounts of water.

摘要翻译： 本发明提供直接合成由二聚环酯制成的高熔点聚合物的方法。 特别地，本发明提供从外消旋材料如外消旋丙交酯和来自扁桃体的聚扁桃酸酯合成聚乳酸（PLA）的方法。 该方法进一步提供外消旋金属有机配位体催化剂，例如外消旋萨拉宾酸，其催化外消旋二聚环状酯单体聚合成聚丙交酯立体络合物。 聚山梨糖苷和混合的二聚环状酯也是在少量水存在下制备的。

公开(公告)号：US07709596B2

公开(公告)日：2010-05-04

申请号：US12583635

申请日：2009-08-24

申请人： Gregory L. Baker ,  Feng Jing ,  Milton R. Smith, III

发明人： Gregory L. Baker ,  Feng Jing ,  Milton R. Smith, III

IPC分类号： C08G69/08

CPC分类号： C07D319/12 ,  C08G63/06 ,  C08G63/823 ,  C08L2203/02

摘要： Cyclic alkyl, particularly cyclohexyl, substituted glycolides and polylactides are described. The polylactides have a high glass transition temperature and improved clarity.

公开(公告)号：US07579429B2

公开(公告)日：2009-08-25

申请号：US11639760

申请日：2006-12-15

申请人： Gregory L. Baker ,  Feng Jing ,  Milton R. Smith, III

发明人： Gregory L. Baker ,  Feng Jing ,  Milton R. Smith, III

IPC分类号： C08G69/08

CPC分类号： C07D319/12 ,  C08G63/06 ,  C08G63/823 ,  C08L2203/02

摘要： Cyclic alkyl, particularly cyclohexyl, substituted glycolides and polylactides are described. The polylactides have a high glass transition temperature and improved clarity.

摘要翻译： 描述了环状烷基，特别是环己基取代的乙交酯和聚交酯。 聚丙交酯具有高玻璃化转变温度和改善的透明度。

公开(公告)号：US20090054619A1

公开(公告)日：2009-02-26

申请号：US12229544

申请日：2008-08-25

申请人： Gregory L. Baker ,  Milton R. Smith, III ,  Xuwei Jiang ,  Erin B. Vogel

发明人： Gregory L. Baker ,  Milton R. Smith, III ,  Xuwei Jiang ,  Erin B. Vogel

IPC分类号： C08G63/08

CPC分类号： C08G63/08 ,  C08G63/823

摘要： Poly(glycolide) polymers are disclosed. The polymers generally include a polymerized alkynyl-substituted glycolide having a polymer backbone with one or more alkynyl groups appended thereto. The alkynyl groups provide reactive sites for further functionalization of the polymer, for example by reaction with azide derivatives (e.g., azide-substituted organic compounds). Alkynyl and azide groups react via the “click” chemistry mechanism to form functional groups covalently bonded to the polymer via a triazole link. The polymers are biodegradable and can be used to deliver drugs or other therapeutic substances (e.g., large biomolecules such as single strand RNA) at targeted locations in a patient's body and/or at controlled release rates.

摘要翻译： 公开了聚（乙交酯）聚合物。 聚合物通常包括聚合的炔基取代的乙交酯，其具有带有一个或多个炔基的聚合物主链。 炔基提供用于聚合物进一步官能化的反应位点，例如通过与叠氮化物衍生物（例如叠氮取代的有机化合物）反应。 炔基和叠氮基通过“点击”化学机理反应以形成通过三唑连接共价键合到聚合物上的官能团。 聚合物是可生物降解的，并且可以用于在患者身体的目标位置和/或以控制释放速率递送药物或其它治疗物质（例如大的生物分子，例如单链RNA）。

公开(公告)号：US07329769B2

公开(公告)日：2008-02-12

申请号：US11092076

申请日：2005-03-29

申请人： Milton R. Smith, III

发明人： Milton R. Smith, III

IPC分类号： C07F17/02 ,  C07F5/04 ,  B01J31/00

CPC分类号： C08G61/10 ,  B01J31/1805 ,  B01J31/181 ,  B01J31/22 ,  B01J31/2295 ,  B01J31/24 ,  B01J31/2404 ,  B01J31/2409 ,  B01J2231/4211 ,  B01J2531/822 ,  B01J2531/824 ,  B01J2531/827 ,  C07C1/321 ,  C07C17/269 ,  C07C2531/22 ,  C07F15/0033 ,  C07F15/004 ,  C07F15/0073 ,  C07F15/008 ,  C07F17/02 ,  C07C15/00 ,  C07C22/08 ,  C07C25/18

摘要： A process for producing a ring-substituted arene borane which comprises reacting a ring-substituted arene with an HB organic compound in the presence of a catalytically effective amount of an iridium or rhodium complex with three or more substituents, excluding hydrogen, bonded to the iridium or rhodium and a phosphorus organic ligand, which is at least in part bonded to the iridium or rhodium, to form the ring-substituted arene borane. Also provided are catalytic compounds for catalyzing the process comprising an iridium or rhodium complex with three or substituents, excluding hydrogen, bonded to the iridium or rhodium and optionally, a phosphorus organic ligand, which is at least in part bonded to the iridium or rhodium.

摘要翻译： 一种制备环取代的芳烃硼烷的方法，其包括使环取代的芳烃与HB有机化合物在催化有效量的铱或铑络合物的存在下反应，所述铱或铑络合物与三个或更多个取代基（不包括氢）连接在铱上 或至少部分地与铱或铑结合的铑和磷有机配体，以形成环取代的芳烃硼烷。 还提供了用于催化该方法的催化化合物，该方法包括与铱或铑键合的三个或不包括氢的取代基的铱或铑络合物和任选的至少部分与铱或铑结合的磷有机配体。

公开(公告)号：US07148356B2

公开(公告)日：2006-12-12

申请号：US11079672

申请日：2005-03-14

申请人： Milton R. Smith, III ,  Robert E. Maleczka

发明人： Milton R. Smith, III ,  Robert E. Maleczka

IPC分类号： C07D213/14 ,  C07D213/08

CPC分类号： C08G61/10 ,  B01J31/1805 ,  B01J31/22 ,  B01J31/2295 ,  B01J31/24 ,  B01J31/2404 ,  B01J31/2409 ,  B01J2231/4211 ,  B01J2531/822 ,  B01J2531/824 ,  B01J2531/827 ,  B01J2531/842 ,  C07C1/321 ,  C07C17/269 ,  C07C2531/22 ,  C07F5/025 ,  C07F15/0033 ,  C07F15/004 ,  C07F15/0073 ,  C07F15/008 ,  C07F17/02 ,  C08G2261/312 ,  C07C15/00 ,  C07C22/08 ,  C07C25/18

摘要： A process for producing organic substituted aromatic or heteroaromatic compounds including biaryl and biheteroaryl compounds in a two-step reaction. In the first step, the aromatic or heteroaromatic compound is borylated in a reaction comprising a borane or diborane reagent (any boron reagent where the boron reagent contains a B—H, B—B or B—Si bond) and an iridium or rhodium catalytic complex. In the second step, a metal catalyst catalyzes the formation of the organic substituted aromatic or heteroaromatic compound from the borylated compound and an electrophile such as an aryl or organic halide, triflate (OSO2CF3), or nonaflate (OSO2C4F9). The steps in the process can be performed in a single reaction vessel or in separate reaction vessels. The present invention also provides a process for synthesis of complex polyphenylenes starting from halogenated aromatic compounds.

摘要翻译： 一种在两步反应中制备包括联芳基和双杂芳基化合物的有机取代的芳族或杂芳族化合物的方法。 在第一步中，在包含硼烷或乙硼烷试剂（硼试剂含有B-H，B-B或B-Si键的任何硼试剂）和铱或铑催化络合物的反应中，芳族或杂芳族化合物被硼酸化。 在第二步中，金属催化剂催化从硼化化合物和亲电子试剂如芳基或有机卤化物，三氟甲磺酸酯（OSO 2 CF 3）中形成有机取代的芳族或杂芳族化合物 或非氢化物（OSO 2）4或5 F 9）。 该方法中的步骤可以在单个反应容器中或在单独的反应容器中进行。 本发明还提供从卤代芳族化合物开始合成络合聚苯的方法。