公开(公告)号：US4275068A

公开(公告)日：1981-06-23

申请号：US48536

申请日：1979-04-23

申请人： Kurt Thiele ,  Quazi Ahmed ,  Ulrich Jahn ,  Rudolf Adrian

发明人： Kurt Thiele ,  Quazi Ahmed ,  Ulrich Jahn ,  Rudolf Adrian

IPC分类号： C07D213/80 ,  A61K31/455 ,  A61K31/60 ,  C07C69/90

CPC分类号： C07D213/80

摘要： Novel alkylene glycol derivatives of the formula (1) ##STR1## in which R.sup.1 is the hydrogen atom, an alkyl group having 1-4 C-atoms or an aryl group, R.sup.2 is the hydrogen atom or an alkyl group having 1-4 C-atoms, R.sup.3 is the hydrogen atom or a group of the formula ##STR2## in which Z is an alkyl residue, an optionally substituted aryl residue or a heterocyclic residue and R.sup.4 is a residue of the formula ##STR3## in which R.sup.5 is the hydrogen atom or chlorine atom, or the methyl group, exhibit an advantageous activity in regard of lowering the cholesterol and triglyceride level in the blood. Production of the novel derivatives by reduction of the corresponding acids, or by reacting a phenol of the formula ##STR4## and an alcohol of the formula ##STR5## optionally with subsequent esterification, is described.

摘要翻译： 式（1）的新型亚烷基二醇衍生物其中R1是氢原子，具有1-4个碳原子的烷基或芳基，R2是氢原子或具有1个碳原子的烷基 -4个C原子，R3是氢原子或其中Z是烷基残基，任选取代的芳基残基或杂环残基的式“IMAGE”的基团，R4是式“IMAGE”的残基，其中 R5是氢原子或氯原子或甲基，在降低血液中的胆固醇和甘油三酯水平方面表现出有利的活性。 描述了通过还原相应的酸或通过使式（IMAGE）的酚与式（IMAGE）的醇任选地随后的酯化反应制备新衍生物。

公开(公告)号：US4182902A

公开(公告)日：1980-01-08

申请号：US942129

申请日：1978-09-13

申请人： Kurt Thiele ,  Quazi Armed ,  Rudolf Adrian ,  Ulrich Jahn

发明人： Kurt Thiele ,  Quazi Armed ,  Rudolf Adrian ,  Ulrich Jahn

IPC分类号： C07C59/68 ,  C07C59/70 ,  C07D211/46 ,  C07D213/30 ,  C07D473/08 ,  C07C63/33

CPC分类号： C07D213/30 ,  C07C59/68 ,  C07C59/70 ,  C07D211/46 ,  C07D473/08

摘要： p-(p'-chlorobenzyl) phenoxyacetic acid.

摘要翻译： 对 - （对 - 氯苄基）苯氧基乙酸。

公开(公告)号：US4526898A

公开(公告)日：1985-07-02

申请号：US530145

申请日：1983-09-07

申请人： Istvan Molnar ,  Kurt Thiele ,  Felix Geissmann ,  Ulrich Jahn

发明人： Istvan Molnar ,  Kurt Thiele ,  Felix Geissmann ,  Ulrich Jahn

IPC分类号： C07D403/12 ,  A61K31/415

CPC分类号： C07D403/12

摘要： 4-(2-Imidazolin-2-yl-amino)-2-methyl-indazole is a highly selective and effective .alpha..sub.2 -antagonist, .alpha..sub.1 -partial agonist and .alpha..sub.1s -agonist and displays anti-hypertensive activity and antagonistic activity on adrenaline and noradrenaline. It is useful as an .alpha.-adrenoceptor influencing and as an anti-hypertensively active drug.

摘要翻译： 4-（2-咪唑啉-2-基 - 氨基）-2-甲基 - 吲唑是一种高选择性和有效的α2拮抗剂，α1-部分激动剂和α1s激动剂，并且对抗高血压活性和拮抗活性 肾上腺素和去甲肾上腺素。 作为α肾上腺素能受体影响作为抗高血压活性药物是有用的。

公开(公告)号：US4305942A

公开(公告)日：1981-12-15

申请号：US201500

申请日：1980-10-28

申请人： Kurt Thiele ,  James S. G. Cox ,  Johanna Fischer ,  Ulrich Jahn

发明人： Kurt Thiele ,  James S. G. Cox ,  Johanna Fischer ,  Ulrich Jahn

IPC分类号： A61K31/53 ,  A61K31/535 ,  A61P19/06 ,  A61P43/00 ,  C07D487/04

CPC分类号： C07D487/04 ,  A61K31/00

摘要： Therapeutic xanthine oxidase inhibitor composition containing as an active ingredient 3-dimethylamino-7-methyl-1,2-(n-propylmalonyl)-1,2-dihydro-1,2,4-benzotriazine dihydrate of the formula ##STR1## Uratic diathesis in warm-blooded animals is therapeutically treated by administering the aforementioned xanthine oxidase inhibitor to such animals, e.g., human, either orally or by means of an injection, thereby inhibiting their xanthine oxidase activity.

摘要翻译： 含有下式的作为活性成分的3-二甲基氨基-7-甲基-1,2-（正丙基丙二酰基）-1,2-二氢-1,2,4-苯并三嗪二水合物的治疗性黄嘌呤氧化酶抑制剂组合物 通过以口服或注射方式向这些动物例如人类施用上述黄嘌呤氧化酶抑制剂来治疗温血动物的素质，由此抑制其黄嘌呤氧化酶活性。

公开(公告)号：US4204998A

公开(公告)日：1980-05-27

申请号：US903128

申请日：1978-05-05

申请人： Franz Schatz ,  Christian Stammbach ,  Kurt Thiele ,  Theodor W. Wagner-Jauregg ,  Ludwig Zirngibl ,  Johanna Fischer ,  Ulrich Jahn

发明人： Franz Schatz ,  Christian Stammbach ,  Kurt Thiele ,  Theodor W. Wagner-Jauregg ,  Ludwig Zirngibl ,  Johanna Fischer ,  Ulrich Jahn

IPC分类号： C07D209/08 ,  C07D209/10 ,  C07D209/12 ,  C07D209/44 ,  C07D231/56 ,  C07D235/22 ,  C07D249/18

CPC分类号： C07D249/18 ,  C07D209/08 ,  C07D209/10 ,  C07D209/12 ,  C07D209/44 ,  C07D231/56 ,  C07D235/22

摘要： Novel hydrazines are disclosed in which one of the nitrogen atoms forms a ring member of the five membered ring of a [4.3.0] heterobicyclic compound which may be substituted elsewhere in the ring system. Characteristic ring systems described include indole and benztriazole ring systems. The compounds possess anti-depressant properties as well as anti-microbial, in particular fungistatic and bacteriostatic, properties.

摘要翻译： 公开了新的肼，其中一个氮原子形成[4.3.0]杂双环化合物的五元环的环成员，其可以在环系中的别处取代。 描述的特征环体系包括吲哚和苯并三唑环体系。 该化合物具有抗抑郁特性以及抗微生物，特别是抑菌和抑菌性质。

公开(公告)号：US06228524B1

公开(公告)日：2001-05-08

申请号：US09188794

申请日：1998-11-09

申请人： Uwe Köhler ,  Ulrich Jahn

发明人： Uwe Köhler ,  Ulrich Jahn

IPC分类号： H01M1050

CPC分类号： H01M10/613 ,  H01M2/105 ,  H01M10/615 ,  H01M10/625 ,  H01M10/643 ,  H01M10/6556 ,  H01M10/6567

摘要： The invention relates to a storage battery with several cylindrical cells, the cell walls of which are in close heat-conducting contact with a temperature-control device. The temperature-control device has at least two hollow bodies (2) through which a temperature-control medium flows, which bodies display semicircular bulges (6), the radii of which correspond approximately to that of the cells (1), and which are arranged in such a way that they fix the spatial positions of the cells (1) to each other.

摘要翻译： 本发明涉及具有几个圆柱形电池的蓄电池，其单元壁与温度控制装置紧密地导热接触。 温度控制装置具有至少两个中空体（2），温度控制介质通过该中空体（2），这些主体显示出半圆形凸起（6），其半径大致对应于电池（1）的半径， 以这样的方式布置，使得它们将单元（1）的空间位置彼此固定。

公开(公告)号：US4668786A

公开(公告)日：1987-05-26

申请号：US813439

申请日：1985-12-26

申请人： Kurt Thiele ,  Felix Geissmann ,  Ludwig Zirngibl ,  Ulrich Jahn

发明人： Kurt Thiele ,  Felix Geissmann ,  Ludwig Zirngibl ,  Ulrich Jahn

IPC分类号： A61K31/52 ,  A61K31/522 ,  A61P25/02 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07D295/22 ,  C07D307/02 ,  C07D473/08

CPC分类号： C07D473/08

摘要： New derivatives of theophylline having the formula ##STR1## wherein R is hydrogen or a hydroxy group, and n is an integer of 0.ltoreq.n.ltoreq.3 and/or the pharmaceutically acceptable, acid addition salts thereof, exhibit in addition to other properties, histamine-serotinine- bradykynine- antagonistic, anti-anaphylactic and .beta.-adrenergic stimulating effects.

公开(公告)号：US4483999A

公开(公告)日：1984-11-20

申请号：US773148

申请日：1977-03-01

申请人： Kurt Thiele ,  Quazi Ahmed ,  Rudolf Adrian ,  Ulrich Jahn

发明人： Kurt Thiele ,  Quazi Ahmed ,  Rudolf Adrian ,  Ulrich Jahn

IPC分类号： C07C59/68 ,  C07C59/70 ,  C07C69/712 ,  C07D211/46 ,  C07D473/08 ,  C07C69/76

CPC分类号： C07C321/00 ,  C07C59/68 ,  C07C59/70 ,  C07D211/46 ,  C07D473/08

摘要： Novel compounds of the formula ##STR1## wherein R.sup.1 is hydrogen, halogen, or alkyl or alkoxy containing from 1 to 4 carbon atoms,R.sup.2 is hydrogen, halogen, hydroxy or alkyl of alkoxy containing from 1 to 4 carbon atoms,n and m are integers such that the sum (n+m) lies in the range from 3 to 10 inclusive and n differs from m, andx is alkyl containing from 1 to 4 carbon atoms, hydrogen or a cation which is a metal cation of main Groups 1, 2 and 3 of the Periodic System of the Elements, an organic base cation or an ammonium ion. These compounds have pharmaceutical utility by virtue of their considerable ability to reduce the level of fatty substances in the blood.

摘要翻译： 式中，R 1为氢，卤素，含有1至4个碳原子的烷基或烷氧基，R2为氢，卤素，羟基或含有1至4个碳原子的烷氧基烷基，n和m的新型化合物 整数，使得和（n + m）在3〜10的范围内，n与m不同，x是含有1〜4个碳原子的烷基，氢或作为主体1的金属阳离子的阳离子 ，元素周期系统的2和3，有机碱性离子或铵离子。 这些化合物由于其相当的降低血液中脂肪物质含量的能力而具有药用效用。

公开(公告)号：US4153803A

公开(公告)日：1979-05-08

申请号：US773144

申请日：1977-03-01

申请人： Kurt Thiele ,  Quazi Ahmed ,  Rudolf Adrian ,  Ulrich Jahn

发明人： Kurt Thiele ,  Quazi Ahmed ,  Rudolf Adrian ,  Ulrich Jahn

IPC分类号： A61K31/22 ,  C07C59/68 ,  C07C59/70 ,  C07C69/712 ,  C07C69/736 ,  C07D211/46 ,  C07D213/30 ,  C07D473/08 ,  C07C69/76

CPC分类号： C07C321/00 ,  C07C59/68 ,  C07C59/70 ,  C07D211/46 ,  C07D473/08

摘要： Compounds possessing pharmaceutical activity as substances able to lower the level of fatty substances in the blood possess the following general formula: ##STR1## wherein R represents hydrogen, halogen, hydroxy or alkyl or alkoxy containing from 1 to 4 carbon atoms;A.sup.1 and A.sup.2 which can be the same or different are hydrogen or alkyl containing from 1 to 9 carbon atoms such that A.sup.1 and A.sup.2 contain together not more than 10 carbon atoms,Y is oxygen, in which case X is benzyl, benzyloxy or benzylthio or benzyl, benzyloxy or benzylthio substituted by R and Z is amine, azacyclohydrocarbyloxy cycloalkoxy containing from 3 to 6 ring carbon atoms or tertiary aminoalkoxy or pivaloyloxyalkoxy in which the alkoxy group contains from 1 to 3 carbon atoms, or X is hydrogen and Z is pivaloyloxyalkoxy in which the alkoxy group contains from 1 to 3 carbon atoms, orY is oxygen, X is benzyl, benzyloxy or benzylthio or benzyl, benzyloxy or benzylthio substituted by R and Z is alkoxy containing from 1 to 4 carbon atoms, hydroxy or O.sup.- M.sup.+, M being a metal cation of Main Groups I, II or III of the Periodic System of the Elements or an organic base cation or ammonium ion, A.sup.1 and A.sup.2 being the same and being as aforesaid or being different with one of A.sup.1 and A.sup.2 being hydrogen or both being hydrogen and X being a para substituent with respect to Y in the benzene ring in the same general formula,Y is oxygen, X is hydrogen and Z is amine, azacyclohydrocarbyloxy or pivaloyloxyalkoxy in which the alkoxy group contains from 1 to 3 carbon atoms,Or Y is sulphur, in which case X is hydrogen, benzyl, benzyloxy or benzylthio or benzyl, benzyloxy or benzylthio substituted by R and Z is amine, azacyclohydrocarbyloxy, alkoxy containing from 1 to 4 carbon atoms, hydroxy, O.sup.- M.sup.+ wherein M is a metal cation of Main Groups I, II or III of the Periodic System of The Elements or an organic base cation or ammonium ion, cycloalkoxy containing from 3 to 6 ring carbon atoms or tertiaryaminoalkoxy, pivaloyloxyalkoxy or pyridyl-C-alkoxy in which the alkoxy group contains from 1 to 3 carbon atoms, and pharmacologically acceptable acid addition and quaternary ammonium salts of compounds containing basic groups, and optical isomers of said compounds when A.sup.1 and A.sup.2 are different.

公开(公告)号：US3947584A

公开(公告)日：1976-03-30

申请号：US397779

申请日：1973-09-17

申请人： Ludwig Zirngibl ,  Rudolf Adrian ,  Ulrich Jahn

发明人： Ludwig Zirngibl ,  Rudolf Adrian ,  Ulrich Jahn

IPC分类号： C07D209/14 ,  C07D209/16 ,  A61K31/40

CPC分类号： C07D209/16 ,  Y10S514/91

摘要： Indolyl alkyl amines of the following formula: ##SPC1##And their salts with organic or inorganic acids. In this formula I, A and A.sup.1 denote identical or different alkyl radicals which both together have a total of 3-8 C-atoms. R.sup.1 denotes hydrogen, a lower alkyl radical having up to 4 C-atoms or a possibly substituted benzyl or benzoyl radical. R.sup.2 and R.sup.3 may be the same or different and denote hydrogen, a halogen (more particularly chlorine, bromine or fluorine) or (possibly halogenated) lower alkyl radicals or (possibly etherified) hydroxy radicals. R.sup.4 denotes hydrogen, a lower alkyl radical, an acyl group or a (possibly substituted) benzyl radical or the cyano-ethyl group. The compounds are useful as anoretics (appetite inhibitors) and can be made by various disclosed methods.

摘要翻译： 下式的吲哚基烷基胺：