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公开(公告)号：US09958351B2
公开(公告)日：2018-05-01
申请号：US13428108
申请日：2012-03-23
申请人： Jonathan L. Kuhn , Richard J. O'Brien , Jonathan P. Roberts , James D. Reinke , Michael B. Terry , Kamal Deep Mothilal
发明人： Jonathan L. Kuhn , Richard J. O'Brien , Jonathan P. Roberts , James D. Reinke , Michael B. Terry , Kamal Deep Mothilal
CPC分类号： G01L9/125 , A61B5/00 , A61B5/0215 , A61B5/031 , A61B5/036 , A61B5/205 , A61B5/42 , G01L15/00 , G01L19/02 , G01L19/149
摘要： A pressure sensing system provides signals representative of a magnitude of pressure at a selected site. A sensor module includes a first transducer producing a first signal having an associated first response to pressure and strain applied to the sensor module and a second transducer producing a second signal having an associated second response to pressure and strain applied to the sensor module. A calculated pressure, a bending pressure error and a bend-compensated pressure are computed in response to the first signal and the second signal.
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公开(公告)号：US08720276B2
公开(公告)日：2014-05-13
申请号：US13176018
申请日：2011-07-05
申请人： Jonathan L. Kuhn , Jonathan P. Roberts , James D. Reinke , Richard J. O'Brien , Michael B. Terry , Kamal Deep Mothilal
发明人： Jonathan L. Kuhn , Jonathan P. Roberts , James D. Reinke , Richard J. O'Brien , Michael B. Terry , Kamal Deep Mothilal
IPC分类号： G01L7/00
CPC分类号： G01L9/125 , A61B5/00 , A61B5/0215 , A61B5/031 , A61B5/036 , A61B5/205 , A61B5/42 , G01L15/00 , G01L19/02 , G01L19/149
摘要： An implantable medical sensor system provides signals representative of a magnitude of moment fraction applied to a sensor module at a selected site. A sensor module includes a first transducer producing a first signal having an associated first response to pressure and strain applied to the sensor module and a second transducer producing a second signal having an associated second response to pressure and strain applied to the sensor module. A moment fraction is computed in response to the first signal and the second signal. In various embodiments, the moment fraction is used to guide positioning of the sensor module, indicate a need for repositioning the sensor module, report loading of the sensor module during normal operation for use as sensor design information and in setting sensor calibration ranges.
摘要翻译： 可植入医疗传感器系统提供表示在所选位置处施加到传感器模块的力矩分数的大小的信号。 传感器模块包括第一传感器，其产生具有对施加到传感器模块的压力和应变的相关联的第一响应的第一信号，以及产生具有对施加到传感器模块的压力和应变的相关联的第二响应的第二信号的第二传感器。 响应于第一信号和第二信号计算力矩分数。 在各种实施例中，力矩分数用于引导传感器模块的定位，指示需要重新定位传感器模块，在正常操作期间报告传感器模块的负载，以用作传感器设计信息和设置传感器校准范围。
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公开(公告)号：US10179242B2
公开(公告)日：2019-01-15
申请号：US12797815
申请日：2010-06-10
摘要： A medical device for monitoring delivery of a therapy that includes a therapy delivery module to deliver a therapy, a controller to set a therapy delivery control parameter, an optical sensor to produce a signal corresponding to tissue light attenuation, and a processor configured to compute a tissue oxygenation measurement from the optical sensor signal, wherein the controller, the optical sensor, and the processor operate cooperatively to determine a setting of the therapy delivery control parameter corresponding to a maximum tissue oxygenation.
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公开(公告)号：US08571620B2
公开(公告)日：2013-10-29
申请号：US12797816
申请日：2010-06-10
IPC分类号： A61B5/00
CPC分类号： A61N1/36557
摘要： A medical device system and associated method are used for monitoring a heart failure patient. A medical device for monitoring delivery of a therapy includes a sensor sensing an optical sensor signal corresponding to light attenuation by a volume of body tissue of a patient, a therapy delivery module to deliver a therapy, and a processor configured to compute a first tissue oxygenation measurement from the optical sensor signal prior to initiating delivery of the therapy, compute a second tissue oxygenation measurement from the optical sensor signal subsequent to initiating delivery of the therapy, compare the first and the second tissue oxygenation measurements, and determine whether the delivered therapy was successful in response to the first tissue oxygenation measurement and the second tissue oxygenation measurement.
摘要翻译： 医疗器械系统和相关方法用于监测心力衰竭患者。 用于监测治疗递送的医疗装置包括传感器，其感测对应于患者的身体组织的体积的光衰减的光学传感器信号，用于递送治疗的治疗递送模块和被配置为计算第一组织氧合的处理器 在开始递送治疗之前从光学传感器信号进行的测量，在开始递送治疗之后从光学传感器信号计算第二组织氧合测量，比较第一和第二组织氧合测量，并确定递送的治疗是否为 成功地响应于第一次组织氧合测量和第二次组织氧合测量。
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公开(公告)号：US20100318146A1
公开(公告)日：2010-12-16
申请号：US12797815
申请日：2010-06-10
IPC分类号： A61N1/365
CPC分类号： A61N1/36557
摘要： A medical device for monitoring delivery of a therapy that includes a therapy delivery module to deliver a therapy, a controller to set a therapy delivery control parameter, an optical sensor to produce a signal corresponding to tissue light attenuation, and a processor configured to compute a tissue oxygenation measurement from the optical sensor signal, wherein the controller, the optical sensor, and the processor operate cooperatively to determine a setting of the therapy delivery control parameter corresponding to a maximum tissue oxygenation.
摘要翻译： 一种用于监测治疗递送的医疗装置，其包括用于递送疗法的治疗递送模块，用于设置治疗递送控制参数的控制器，用于产生对应于组织光衰减的信号的光学传感器，以及被配置为计算 来自光学传感器信号的组织氧合测量，其中所述控制器，所述光学传感器和所述处理器协同工作以确定对应于最大组织氧合的所述治疗传递控制参数的设置。
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公开(公告)号：US20100317942A1
公开(公告)日：2010-12-16
申请号：US12797816
申请日：2010-06-10
IPC分类号： A61B5/00
CPC分类号： A61N1/36557
摘要： A medical device system and associated method are used for monitoring a heart failure patient. A medical device for monitoring delivery of a therapy includes a sensor sensing an optical sensor signal corresponding to light attenuation by a volume of body tissue of a patient, a therapy delivery module to deliver a therapy, and a processor configured to compute a first tissue oxygenation measurement from the optical sensor signal prior to initiating delivery of the therapy, compute a second tissue oxygenation measurement from the optical sensor signal subsequent to initiating delivery of the therapy, compare the first and the second tissue oxygenation measurements, and determine whether the delivered therapy was successful in response to the first tissue oxygenation measurement and the second tissue oxygenation measurement.
摘要翻译： 医疗器械系统和相关方法用于监测心力衰竭患者。 用于监测治疗递送的医疗装置包括传感器，其感测对应于患者的身体组织的体积的光衰减的光学传感器信号，用于递送治疗的治疗递送模块和被配置为计算第一组织氧合的处理器 在开始递送治疗之前从光学传感器信号进行的测量，在开始递送治疗之后从光学传感器信号计算第二组织氧合测量，比较第一和第二组织氧合测量，并确定递送的治疗是否为 成功地响应于第一次组织氧合测量和第二次组织氧合测量。
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17.发明申请Device and Method for Monitoring of Absolute Oxygen Saturation and Tissue Hemoglobin Concentration 有权用于监测绝对氧饱和度和组织血红蛋白浓度的装置和方法公开(公告)号：US20100317939A1
公开(公告)日：2010-12-16
申请号：US12797770
申请日：2010-06-10
申请人： Jonathan L. Kuhn , Can Cinbis , James K. Carney
发明人： Jonathan L. Kuhn , Can Cinbis , James K. Carney
IPC分类号： A61B5/1455
CPC分类号： A61B5/14552 , A61B5/0084 , A61B5/14546 , A61B5/1459 , A61B5/7239 , A61N1/36557
摘要： A method and medical device for detecting signals that detects emitted light scattered by a volume of tissue delivered along a first pathway and a second pathway different from the first pathway, detects emitted light scattered by a volume of tissue delivered along a third pathway and a fourth pathway different from the third pathway, determines a first uniformity corresponding to the emitted light detected along the first pathway and the second pathway, determines a second uniformity corresponding to the emitted light detected along third pathway and the fourth pathway, determines a total uniformity in response to the determined first uniformity and the determined second uniformity, and alters sensing by the device in response to the determined total uniformity.
摘要翻译： 一种用于检测信号的方法和医疗装置，其检测由沿着第一路径传送的组织体积散射的发射光和不同于第一路径的第二路径的信号，检测由沿着第三路径传送的组织体积散射的发射光， 确定与沿着第一路径和第二路径检测到的发射光相对应的第一均匀度，确定对应于沿着第三路径和第四路径检测的发射光的第二均匀度，确定响应中的总均匀性 到所确定的第一均匀性和确定的第二均匀性，并且改变由所述装置响应于所确定的总均匀性的感测。
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18.发明授权Shock reduction using absolute calibrated tissue oxygen saturation and total hemoglobin volume fraction 有权使用绝对校准的组织氧饱和度和总血红蛋白体积分数进行减震公开(公告)号：US09126049B2
公开(公告)日：2015-09-08
申请号：US12797781
申请日：2010-06-10
IPC分类号： A61B5/00 , A61N1/362 , A61B5/02 , A61B5/145 , A61B5/1459 , A61N1/365 , A61N1/39 , A61B5/0215 , A61B5/042 , A61B5/11
CPC分类号： A61N1/3622 , A61B5/02028 , A61B5/0215 , A61B5/042 , A61B5/1116 , A61B5/14542 , A61B5/1459 , A61N1/36557 , A61N1/3956
摘要： An implantable medical device for detecting and treating an arrhythmia includes an optical sensor adapted for positioning adjacent to a blood-perfused tissue volume. In one embodiment for controlling arrhythmia therapies delivered by the device, the optical sensor is controlled to emit light in response to detecting an arrhythmia, detect light scattered by the volume of blood perfused tissue including measuring an optical sensor output signal corresponding to the intensity of scattered light for at least four spaced-apart wavelengths, and compute a volume-independent measure of tissue oxygen saturation from the detected light. The hemodynamic status of the arrhythmia is detected in response to the measure of tissue oxygen saturation.
摘要翻译： 用于检测和治疗心律失常的可植入医疗装置包括适于邻近于血液灌注的组织体积定位的光学传感器。 在用于控制由装置传送的心律失常治疗的一个实施例中，响应于检测到心律失常，控制光学传感器发光，检测由血液灌注组织的体积散射的光，包括测量对应于散射强度的光学传感器输出信号 用于至少四个间隔波长的光，并且从检测到的光计算组织氧饱和度的体积独立测量。 响应于组织氧饱和度的测量，检测心律失常的血液动力学状态。
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19.发明申请METHOD AND APPARATUS FOR POST-SHOCK EVALUATION USING TISSUE OXYGENATION MEASUREMENTS 有权使用组织氧化测量法进行后期评估的方法和装置公开(公告)号：US20110066206A1
公开(公告)日：2011-03-17
申请号：US12845843
申请日：2010-07-29
IPC分类号： A61N1/365
CPC分类号： A61B5/14551 , A61B5/1459 , A61B5/6846 , A61B5/7285 , A61N1/36557 , A61N1/3925 , A61N1/3956
摘要： A method and device for delivering therapy that includes an electrode to sense cardiac signals and to deliver a therapy, a monitoring module detecting a cardiac event in response to the sensed cardiac signals using first detection criteria, a sensor emitting light and detecting emitted light scattered by a tissue volume adjacent the sensor to generate a corresponding detected light intensity output signal, a control module coupled to the sensor to control light emission of the sensor in response to delivering the therapy, and a controller coupled to the monitoring module, the therapy delivery module and the sensor, the controller configured to determine tissue oxygenation measurements in response to the output signal, determine a tissue oxygenation trend in response to the tissue oxygenation measurements, determine a recovery index in response to the determined tissue oxygenation trend, and control one or both of detecting a cardiac event by the monitoring module and delivery of therapy by the therapy delivery module in response to the determined recovery index.
摘要翻译： 一种用于递送疗法的方法和装置，其包括用于感测心脏信号并递送治疗的电极，监测模块，响应于使用第一检测标准的所感测到的心脏信号检测心脏事件，发射光并检测由 与所述传感器相邻的组织体积以产生相应的检测到的光强度输出信号;控制模块，耦合到所述传感器以响应于递送所述治疗来控制所述传感器的光发射;以及控制器，耦合到所述监测模块，所述治疗递送模块 以及所述传感器，所述控制器被配置为响应于所述输出信号确定组织氧合测量，响应于组织氧合测量确定组织氧合趋势，响应于所确定的组织氧合趋势确定恢复指数，并且控制一个或两个 通过监测模块检测心脏事件并进行治疗 y由治疗递送模块响应于确定的恢复指数。
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20.发明申请METHOD AND APPARATUS FOR POST-SHOCK EVALUATION USING TISSUE OXYGENATION MEASUREMENTS 有权使用组织氧化测量法进行后期评估的方法和装置公开(公告)号：US20110066204A1
公开(公告)日：2011-03-17
申请号：US12845818
申请日：2010-07-29
IPC分类号： A61B5/1455 , A61N1/365
CPC分类号： A61B5/14551 , A61B5/1459 , A61B5/6846 , A61B5/7285 , A61N1/36557 , A61N1/3925 , A61N1/3956
摘要： A method and device for delivering therapy that includes an electrode to sense cardiac signals and to deliver a therapy, a therapy delivery module coupled to the electrode to deliver a therapy via the electrode in response to the sensed cardiac signals, a sensor emitting light and detecting emitted light scattered by a tissue volume adjacent the sensor to generate a corresponding detected light intensity output signal, a control module coupled to the sensor to control light emission of the sensor in response to delivering the therapy; and a controller coupled to the therapy delivery module and the sensor, the controller configured to determine a tissue oxygenation measurement in response to the output signal, and determine whether the delivered therapy was successful in restoring cardiac hemodynamic function in response to the tissue oxygenation measurement.
摘要翻译： 一种用于递送治疗的方法和装置，其包括用于感测心脏信号并递送治疗的电极，治疗递送模块，其耦合到所述电极，以响应于感测到的心脏信号经由所述电极递送治疗;发射光和检测的传感器 发射由邻近传感器的组织体积散射的光，以产生相应的检测到的光强度输出信号;控制模块，其耦合到所述传感器，以响应于递送所述治疗来控制所述传感器的光发射; 以及耦合到所述治疗递送模块和所述传感器的控制器，所述控制器被配置为响应于所述输出信号确定组织氧合测量，并且确定所递送的治疗是否成功响应于所述组织氧合测量来恢复心脏血液动力学功能。
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