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公开(公告)号：US09278161B2
公开(公告)日：2016-03-08
申请号：US12581582
申请日：2009-10-19
申请人： Thomas M. Swanick , Joe Bienkiewicz , Joseph Ferraro , Paul Martakos , Keith M. Faucher , Alicia Dale
发明人： Thomas M. Swanick , Joe Bienkiewicz , Joseph Ferraro , Paul Martakos , Keith M. Faucher , Alicia Dale
CPC分类号： A61L31/148 , A61F2/06 , A61F2250/0067 , A61L31/00 , A61L31/10 , A61L31/145 , A61L2420/02
摘要： Exemplary embodiments of the present invention provide adhesion barriers having anti-adhesion and tissue fixating properties. The adhesion barriers are formed of fatty acid based films. The fatty acid-based films may be formed from fatty acid-derived biomaterials. The films may be coated with, or may include, tissue fixating materials to create the adhesion barrier. The adhesion barriers are well tolerated by the body, have anti-inflammation properties, fixate, well to tissue, and have a residence time sufficient to prevent post-surgical adhesions.
摘要翻译： 本发明的示例性实施方案提供了具有抗粘连和组织固定性质的粘合屏障。 粘合屏障由脂肪酸基膜形成。 脂肪酸基膜可以由脂肪酸衍生的生物材料形成。 膜可以涂覆或可以包括组织固定材料以产生粘合屏障。 粘附屏障由身体良好耐受，具有抗炎特性，固定到组织上，并具有足以防止手术后粘连的停留时间。
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12.发明授权公开(公告)号：US10322213B2
公开(公告)日：2019-06-18
申请号：US13184512
申请日：2011-07-16
IPC分类号： A61L29/08 , A61L29/14 , A61L31/08 , C08L91/00 , C09D191/00
摘要： Disclosed herein is the correlation of chemical properties of oils with the physical properties of a resulting cured oil composition. Also disclosed are biocompatible materials and coatings for medical devices prepared using enriched oils and methods for enhancing or modifying the physical and chemical characteristics of cured oils by enriching such oils with fatty acid alkyl esters. Methods of tailoring the properties of biocompatible materials and coatings to deliver one or more therapeutic agents are also provided.
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13.发明申请COMPOSITIONS AND METHODS FOR ALTERING THE RATE OF HYDROLYSIS OF CURED OIL-BASED MATERIALS 审中-公开改善固化油基材料水解速率的组合物和方法公开(公告)号：US20120016038A1
公开(公告)日：2012-01-19
申请号：US13184512
申请日：2011-07-16
IPC分类号： A61K47/44 , A61P31/00 , A61P29/00 , C09D191/02 , A61P35/00
CPC分类号： A61L31/08 , A61L29/08 , A61L29/148 , A61L2300/22 , A61L2300/604 , C09D191/00 , C08L91/00
摘要： Disclosed herein is the correlation of chemical properties of oils with the physical properties of a resulting cured oil composition. Also disclosed are biocompatible materials and coatings for medical devices prepared using enriched oils and methods for enhancing or modifying the physical and chemical characteristics of cured oils by enriching such oils with fatty acid alkyl esters. Methods of tailoring the properties of biocompatible materials and coatings to deliver one or more therapeutic agents are also provided.
摘要翻译： 本文公开了油的化学性质与所得固化油组合物的物理性质的相关性。 还公开了使用富油制备的医疗器械的生物相容性材料和涂层以及通过用脂肪酸烷基酯富集这种油来增强或改变固化油的物理和化学特性的方法。 还提供了调整生物相容性材料和涂层以递送一种或多种治疗剂的性质的方法。
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公开(公告)号：US20110045050A1
公开(公告)日：2011-02-24
申请号：US12546312
申请日：2009-08-24
IPC分类号： A61K38/12 , A61K31/7048 , A61K31/436 , A61F2/00 , A61P43/00
CPC分类号： A61K31/436 , A61K9/1075 , A61K31/7048 , A61K47/10 , A61K47/26 , A61K47/44
摘要： A nanoemulsion and corresponding methods of making and using systems of single or blended high HLB value surfactant(s) for the emulsification of single or blended oils and vitamin E components in an aqueous phase are provided. The resulting nanoemulsions and methods of administering the nanoemulsions, including a corresponding kit, provide delivery of the nanoemulsions to a patient.
摘要翻译： 提供了一种纳米乳液和相应的制备和使用单一或共混的高HLB值表面活性剂体系用于水相中单一或共混油和维生素E组分的乳化的相应方法。 得到的纳米乳剂和施用纳米乳剂的方法，包括相应的试剂盒，提供纳米乳剂向患者的递送。
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公开(公告)号：US07713544B2
公开(公告)日：2010-05-11
申请号：US10343408
申请日：2001-07-30
申请人： Elliot L. Chaikof , June Feng , Janine M. Orban , Hongbo Liu , Xue Long Sun , Keith M. Faucher
发明人： Elliot L. Chaikof , June Feng , Janine M. Orban , Hongbo Liu , Xue Long Sun , Keith M. Faucher
CPC分类号： C07F9/6552 , A61K9/1273 , A61K9/5031 , A61K9/5073 , A61L15/32 , A61L27/222 , A61L27/227 , A61L27/24 , A61L27/507 , A61L33/0082 , B82Y5/00 , B82Y30/00 , C08F220/28 , C08F220/36 , C12N1/00
摘要： A biocompatible biological component is provided comprising a membrane-mimetic surface film covering a substrate. Suitable substrates include hydrated substrates, e.g. hydrogels which may contain drugs for delivery to a patient through the membrane-mimetic film, or may be made up of cells, such as islet cells, for transplantation. The surface may present exposed bioactive molecules or moieties for binding to target molecules in vivo, for modulating host response when implanted into a patient (e.g. the surface may be antithrombogenic or antiinflammatory) and the surface may have pores of selected sizes to facilitate transport of substances therethrough. An optional hydrophilic cushion or spacer between the substrate and the membrane-mimetic surface allows transmembrane proteins to extend from the surface through the hydrophilic cushion, mimicking the structure of naturally-occurring cells. An alkylated layer directly beneath the membrane-mimetic surface facilates bonding of the surface to the remainder of the biological component. Alkyl chains may extend entirely through the hydrophilic cushion when present. To facilitate binding, the substrate may optionally be treated with a polyelectrolyte or alternating layers of oppositely-charged polyelectrolytes to facilitate charged binding of the membrane-mimetic film or alkylated layer beneath the membrane-mimetic film to the substrate. The membrane-mimetic film is preferably made by in situ polymerization of phospholipid vesicles.
摘要翻译： 提供生物相容的生物组分，其包含覆盖基质的膜模拟表面膜。 合适的底物包括水合底物，例如 水凝胶，其可以含有通过膜模拟膜递送到患者的药物，或者可以由用于移植的细胞如胰岛细胞组成。 表面可以在体内呈现暴露的生物活性分子或结合靶向分子的部分，用于当植入患者时调节宿主反应（例如表面可能是抗血栓形成或抗炎性的），并且该表面可以具有选定尺寸的孔以促进物质的运输 通过。 衬底和膜模拟表面之间的可选的亲水垫或间隔物允许跨膜蛋白从表面延伸穿过亲水垫，模仿天然存在的细胞的结构。 直接在膜 - 模拟表面下面的烷基化层促进了表面与生物组分的其余部分的结合。 当存在时，烷基链可以完全延伸穿过亲水性垫。 为了便于结合，底物可以任选地用聚电解质或交替的相反电荷的聚电解质层处理，以促进膜 - 模拟膜下面的膜模拟膜或烷基化层与底物的带电结合。 膜模拟膜优选通过磷脂囊泡的原位聚合来制备。
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