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    Biological component comprising artificial membrane
    2.
    发明授权
    Biological component comprising artificial membrane 有权
    包含人造膜的生物成分

    公开(公告)号：US07713544B2

    公开(公告)日：2010-05-11

    申请号：US10343408

    申请日：2001-07-30

    申请人： Elliot L. Chaikof ,  June Feng ,  Janine M. Orban ,  Hongbo Liu ,  Xue Long Sun ,  Keith M. Faucher

    发明人： Elliot L. Chaikof ,  June Feng ,  Janine M. Orban ,  Hongbo Liu ,  Xue Long Sun ,  Keith M. Faucher

    IPC分类号： A61L27/00 ,  A61F13/00 ,  A61K9/127

    CPC分类号： C07F9/6552 ,  A61K9/1273 ,  A61K9/5031 ,  A61K9/5073 ,  A61L15/32 ,  A61L27/222 ,  A61L27/227 ,  A61L27/24 ,  A61L27/507 ,  A61L33/0082 ,  B82Y5/00 ,  B82Y30/00 ,  C08F220/28 ,  C08F220/36 ,  C12N1/00

    摘要： A biocompatible biological component is provided comprising a membrane-mimetic surface film covering a substrate. Suitable substrates include hydrated substrates, e.g. hydrogels which may contain drugs for delivery to a patient through the membrane-mimetic film, or may be made up of cells, such as islet cells, for transplantation. The surface may present exposed bioactive molecules or moieties for binding to target molecules in vivo, for modulating host response when implanted into a patient (e.g. the surface may be antithrombogenic or antiinflammatory) and the surface may have pores of selected sizes to facilitate transport of substances therethrough. An optional hydrophilic cushion or spacer between the substrate and the membrane-mimetic surface allows transmembrane proteins to extend from the surface through the hydrophilic cushion, mimicking the structure of naturally-occurring cells. An alkylated layer directly beneath the membrane-mimetic surface facilates bonding of the surface to the remainder of the biological component. Alkyl chains may extend entirely through the hydrophilic cushion when present. To facilitate binding, the substrate may optionally be treated with a polyelectrolyte or alternating layers of oppositely-charged polyelectrolytes to facilitate charged binding of the membrane-mimetic film or alkylated layer beneath the membrane-mimetic film to the substrate. The membrane-mimetic film is preferably made by in situ polymerization of phospholipid vesicles.

    摘要翻译： 提供生物相容的生物组分，其包含覆盖基质的膜模拟表面膜。 合适的底物包括水合底物，例如 水凝胶，其可以含有通过膜模拟膜递送到患者的药物，或者可以由用于移植的细胞如胰岛细胞组成。 表面可以在体内呈现暴露的生物活性分子或结合靶向分子的部分，用于当植入患者时调节宿主反应（例如表面可能是抗血栓形成或抗炎性的），并且该表面可以具有选定尺寸的孔以促进物质的运输 通过。 衬底和膜模拟表面之间的可选的亲水垫或间隔物允许跨膜蛋白从表面延伸穿过亲水垫，模仿天然存在的细胞的结构。 直接在膜 - 模拟表面下面的烷基化层促进了表面与生物组分的其余部分的结合。 当存在时，烷基链可以完全延伸穿过亲水性垫。 为了便于结合，底物可以任选地用聚电解质或交替的相反电荷的聚电解质层处理，以促进膜 - 模拟膜下面的膜模拟膜或烷基化层与底物的带电结合。 膜模拟膜优选通过磷脂囊泡的原位聚合来制备。