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公开(公告)号：US20100233232A1
公开(公告)日：2010-09-16
申请号：US12401243
申请日：2009-03-10
申请人： Thomas M. SWANICK , Joseph FERRARO , Lisa ROGERS , Paul MARTAKOS
发明人： Thomas M. SWANICK , Joseph FERRARO , Lisa ROGERS , Paul MARTAKOS
IPC分类号： A61K9/00 , C07C57/00 , A61K47/06 , A61K31/4353 , A61K31/4545 , A61K38/13 , A61K31/496 , A61K31/7028 , A61K9/14 , A61K31/20 , A61P29/00
CPC分类号： A61K31/20 , A61K9/10 , A61K9/145 , A61K9/16 , A61K9/7007 , A61K31/00 , A61K31/4353 , A61K31/436 , A61K31/445 , A61K31/4545 , A61K31/496 , A61K31/7028 , A61K31/7036 , A61K35/60 , A61K38/13 , A61L27/28 , A61L27/54 , A61L31/08 , A61L31/16 , A61L2300/606
摘要： The present invention is directed toward fatty acid-based particles, and methods of making such particles. The particles can be associated with an additional, therapeutic agent. Also provided herein is a method of forming fatty acid particles, comprising associating a cross-linked, fatty acid-derived biomaterial with a cryogenic liquid; and fragmenting the bio material/cryogenic liquid composition, such that fatty acid particles are formed. The particles can be used for a variety of therapeutic applications.
摘要翻译： 本发明涉及脂肪酸类颗粒，以及制造这种颗粒的方法。 颗粒可以与另外的治疗剂相关联。 本文还提供了形成脂肪酸颗粒的方法，其包括将交联的脂肪酸衍生的生物材料与低温液体缔合; 并使生物材料/低温液体组合物分裂，从而形成脂肪酸颗粒。 该颗粒可用于各种治疗应用。
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公开(公告)号：US09427423B2
公开(公告)日：2016-08-30
申请号：US12401243
申请日：2009-03-10
申请人： Thomas M. Swanick , Joseph Ferraro , Lisa Rogers , Paul Martakos
发明人： Thomas M. Swanick , Joseph Ferraro , Lisa Rogers , Paul Martakos
IPC分类号： A61K31/20 , A61K31/7028 , A61K38/13 , A61K9/10 , A61K31/4353 , A61K9/70 , A61K31/00 , A61K9/14 , A61K31/4545 , A61K31/496
CPC分类号： A61K31/20 , A61K9/10 , A61K9/145 , A61K9/16 , A61K9/7007 , A61K31/00 , A61K31/4353 , A61K31/436 , A61K31/445 , A61K31/4545 , A61K31/496 , A61K31/7028 , A61K31/7036 , A61K35/60 , A61K38/13 , A61L27/28 , A61L27/54 , A61L31/08 , A61L31/16 , A61L2300/606
摘要： The present invention is directed toward fatty acid-based particles, and methods of making such particles. The particles can be associated with an additional, therapeutic agent. Also provided herein is a method of forming fatty acid particles, comprising associating a cross-linked, fatty acid-derived biomaterial with a cryogenic liquid; and fragmenting the bio material/cryogenic liquid composition, such that fatty acid particles are formed. The particles can be used for a variety of therapeutic applications.
摘要翻译： 本发明涉及脂肪酸类颗粒，以及制造这种颗粒的方法。 颗粒可以与另外的治疗剂相关联。 本文还提供了形成脂肪酸颗粒的方法，其包括将交联的脂肪酸衍生的生物材料与低温液体缔合; 并使生物材料/低温液体组合物分裂，从而形成脂肪酸颗粒。 该颗粒可用于各种治疗应用。
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公开(公告)号：US08858978B2
公开(公告)日：2014-10-14
申请号：US11237263
申请日：2005-09-28
申请人： Roger Labrecque , Philip McNamara , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck , Keith M. Faucher , Thomas M. Swanick
发明人： Roger Labrecque , Philip McNamara , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck , Keith M. Faucher , Thomas M. Swanick
CPC分类号： A61K35/60 , A61F2/06 , A61F13/02 , A61F13/023 , A61F2250/0067 , A61K9/0024 , A61K9/06 , A61K31/225 , A61K31/355 , A61K38/13 , A61K47/12 , A61K47/14 , A61L2/07 , A61L2/081 , A61L2/087 , A61L2/206 , A61L2/208 , A61L27/36 , A61L27/3604 , A61L27/52 , A61L27/54 , A61L31/005 , A61L31/10 , A61L31/145 , A61L2202/24 , A61L2300/22 , A61L2300/252 , A61L2300/404 , A61L2300/41 , A61L2300/414 , A61L2300/42 , A61L2300/602 , B05D3/067
摘要： A method of curing and corresponding resulting non-polymeric cross-linked gel are provided. The cross-linked gel can be combined with a medical device structure. The cross-linked gel can provide anti-adhesion characteristics, in addition to improved healing and anti-inflammatory response. The cross-linked gel is generally formed of a naturally occurring oil, or an oil composition formed in part of a naturally occurring oil, that is at least partially cured forming a cross-linked gel derived from at least one fatty acid compound. In addition, the oil composition can include a therapeutic agent component, such as a drug or other bioactive agent. The curing method can vary the application of heat in both temperature and duration to achieve a desired amount of cross-linking forming the gel.
摘要翻译： 提供固化方法和相应的所得非聚合交联凝胶。 交联凝胶可以与医疗装置结构组合。 除了改善愈合和抗炎反应之外，交联凝胶还可提供抗粘附特性。 交联凝胶通常由天然存在的油或部分天然存在的油形成的油组合物形成，其至少部分固化形成由至少一种脂肪酸化合物衍生的交联凝胶。 此外，油组合物可以包括治疗剂组分，例如药物或其它生物活性剂。 固化方法可以在温度和持续时间内改变热量的应用以实现形成凝胶的所需量的交联。
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公开(公告)号：US09278161B2
公开(公告)日：2016-03-08
申请号：US12581582
申请日：2009-10-19
申请人： Thomas M. Swanick , Joe Bienkiewicz , Joseph Ferraro , Paul Martakos , Keith M. Faucher , Alicia Dale
发明人： Thomas M. Swanick , Joe Bienkiewicz , Joseph Ferraro , Paul Martakos , Keith M. Faucher , Alicia Dale
CPC分类号： A61L31/148 , A61F2/06 , A61F2250/0067 , A61L31/00 , A61L31/10 , A61L31/145 , A61L2420/02
摘要： Exemplary embodiments of the present invention provide adhesion barriers having anti-adhesion and tissue fixating properties. The adhesion barriers are formed of fatty acid based films. The fatty acid-based films may be formed from fatty acid-derived biomaterials. The films may be coated with, or may include, tissue fixating materials to create the adhesion barrier. The adhesion barriers are well tolerated by the body, have anti-inflammation properties, fixate, well to tissue, and have a residence time sufficient to prevent post-surgical adhesions.
摘要翻译： 本发明的示例性实施方案提供了具有抗粘连和组织固定性质的粘合屏障。 粘合屏障由脂肪酸基膜形成。 脂肪酸基膜可以由脂肪酸衍生的生物材料形成。 膜可以涂覆或可以包括组织固定材料以产生粘合屏障。 粘附屏障由身体良好耐受，具有抗炎特性，固定到组织上，并具有足以防止手术后粘连的停留时间。
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公开(公告)号：US08388685B2
公开(公告)日：2013-03-05
申请号：US11534313
申请日：2006-09-22
申请人： Alan Lombardo , Mark Semler , Joseph F. Ferraro , Theodore Karwoski , Thomas M. Swanick , Brian C. Sunter
发明人： Alan Lombardo , Mark Semler , Joseph F. Ferraro , Theodore Karwoski , Thomas M. Swanick , Brian C. Sunter
IPC分类号： A61F2/44
CPC分类号： A61F2/442 , A61B17/025 , A61B2017/0256 , A61F2/30742 , A61F2/30767 , A61F2/4425 , A61F2/4611 , A61F2002/302 , A61F2002/30291 , A61F2002/30331 , A61F2002/30433 , A61F2002/30434 , A61F2002/30448 , A61F2002/30462 , A61F2002/30495 , A61F2002/30563 , A61F2002/30616 , A61F2002/30649 , A61F2002/30769 , A61F2002/30818 , A61F2002/30841 , A61F2002/30843 , A61F2002/30919 , A61F2002/3093 , A61F2002/30932 , A61F2002/3097 , A61F2002/443 , A61F2002/4495 , A61F2002/4627 , A61F2002/4628 , A61F2220/0025 , A61F2220/0033 , A61F2220/0041 , A61F2220/005 , A61F2220/0075 , A61F2230/0065 , A61F2230/0091 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00796 , Y10T29/49826
摘要： The present invention is directed to the field of prosthetic devices. More particularly, one embodiment of the present invention is directed to an artificial disc that can be used as a replacement for an intervertebral disc (e.g., a human intervertebral lumbar disc, a human intervertebral cervical disc and/or a human intervertebral thoracic disc).
摘要翻译： 本发明涉及假体装置领域。 更具体地，本发明的一个实施例涉及可用作椎间盘（例如人椎间盘腰椎，人椎间盘和/或人椎间胸椎间盘）的替代物的人造椎间盘。
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公开(公告)号：US08367099B2
公开(公告)日：2013-02-05
申请号：US11525390
申请日：2006-09-22
申请人： Steve A. Herweck , Thomas M. Swanick , Joseph Ferraro , Paul Martakos , Lisa Rogers , Theodore Karwoski , Keith M. Faucher , Philip McNamara , Roger Labrecque , Suzanne Conroy , Trevor Carlton
发明人： Steve A. Herweck , Thomas M. Swanick , Joseph Ferraro , Paul Martakos , Lisa Rogers , Theodore Karwoski , Keith M. Faucher , Philip McNamara , Roger Labrecque , Suzanne Conroy , Trevor Carlton
IPC分类号： A61L15/16
CPC分类号： B65B55/18 , A61B2017/00004 , A61B2017/320044 , A61B2090/0816 , A61F2/0059 , A61F2/0095 , A61L2/07 , A61L2/081 , A61L2/087 , A61L2/14 , A61L2/186 , A61L2/206 , A61L2/208 , A61L31/00 , A61L31/145 , A61L31/148 , A61L2202/24 , B26F1/18 , B29C39/02 , B65B31/04 , Y10T83/0481
摘要： A bio-absorbable stand-alone film is derived at least in part from fatty acids. The bio-absorbable stand-alone film can have anti-adhesive, anti-inflammatory, non-inflammatory, and wound healing properties, and can additionally include one or more therapeutic agents incorporated therein. The stand-alone film has one or more perforations or depressions formed therein. Corresponding methods of making the bio-absorbable stand-alone film with one or more perforations or depressions include molding, cutting, carving, puncturing or otherwise suitable methods to create the perforations or depressions in the bio-absorbable stand-alone film. The resulting stand-alone film is bioabsorbable.
摘要翻译： 生物可吸收的独立膜至少部分地由脂肪酸衍生。 生物吸收性独立膜可以具有抗粘连性，抗炎性，非炎性和伤口愈合性，并且还可以包括一种或多种掺入其中的治疗剂。 独立膜具有形成在其中的一个或多个穿孔或凹陷。 使具有一个或多个穿孔或凹陷的生物吸收性独立薄膜的相应方法包括成型，切割，雕刻，穿刺或以其它方式适当地在生物吸收性独立薄膜中产生穿孔或凹陷的方法。 所得到的独立膜是生物可吸收的。
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公开(公告)号：US08518116B2
公开(公告)日：2013-08-27
申请号：US13559131
申请日：2012-07-26
申请人： Alan Lombardo , Mark Semler , Joseph F. Ferraro , Theodore Karwoski , Thomas M. Swanick , Brian C. Sunter
发明人： Alan Lombardo , Mark Semler , Joseph F. Ferraro , Theodore Karwoski , Thomas M. Swanick , Brian C. Sunter
IPC分类号： A61F2/44
CPC分类号： A61F2/442 , A61B17/025 , A61B2017/0256 , A61F2/30742 , A61F2/30767 , A61F2/4425 , A61F2/4611 , A61F2002/302 , A61F2002/30291 , A61F2002/30331 , A61F2002/30433 , A61F2002/30434 , A61F2002/30448 , A61F2002/30462 , A61F2002/30495 , A61F2002/30563 , A61F2002/30616 , A61F2002/30649 , A61F2002/30769 , A61F2002/30818 , A61F2002/30841 , A61F2002/30843 , A61F2002/30919 , A61F2002/3093 , A61F2002/30932 , A61F2002/3097 , A61F2002/443 , A61F2002/4495 , A61F2002/4627 , A61F2002/4628 , A61F2220/0025 , A61F2220/0033 , A61F2220/0041 , A61F2220/005 , A61F2220/0075 , A61F2230/0065 , A61F2230/0091 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00796 , Y10T29/49826
摘要： The present invention is directed to the field of prosthetic devices. More particularly, one embodiment of the present invention is directed to an artificial disc that can be used as a replacement for an intervertebral disc (e.g., a human intervertebral lumbar disc, a human intervertebral cervical disc and/or a human intervertebral thoracic disc).
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公开(公告)号：US20100183697A1
公开(公告)日：2010-07-22
申请号：US12581582
申请日：2009-10-19
申请人： Thomas M. SWANICK , Joe BIENKIEWICZ , Joseph FERRARO , Paul MARTAKOS , Keith M. FAUCHER , Alicia DALE
发明人： Thomas M. SWANICK , Joe BIENKIEWICZ , Joseph FERRARO , Paul MARTAKOS , Keith M. FAUCHER , Alicia DALE
CPC分类号： A61L31/148 , A61F2/06 , A61F2250/0067 , A61L31/00 , A61L31/10 , A61L31/145 , A61L2420/02
摘要： Exemplary embodiments of the present invention provide adhesion barriers having anti-adhesion and tissue fixating properties. The adhesion barriers are formed of fatty acid based films. The fatty acid-based films may be formed from fatty acid-derived biomaterials. The films may be coated with, or may include, tissue fixating materials to create the adhesion barrier. The adhesion barriers are well tolerated by the body, have anti-inflammation properties, fixate, well to tissue, and have a residence time sufficient to prevent post-surgical adhesions.
摘要翻译： 本发明的示例性实施方案提供了具有抗粘连和组织固定性质的粘合屏障。 粘合屏障由脂肪酸基膜形成。 脂肪酸基膜可以由脂肪酸衍生的生物材料形成。 膜可以涂覆或可以包括组织固定材料以产生粘合屏障。 粘附屏障由身体良好耐受，具有抗炎特性，固定到组织上，并具有足以防止手术后粘连的停留时间。
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公开(公告)号：US08962023B2
公开(公告)日：2015-02-24
申请号：US11236943
申请日：2005-09-28
申请人： Roger Labrecque , Philip McNamara , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck , Keith Faucher , Thomas M. Swanick
发明人： Roger Labrecque , Philip McNamara , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck , Keith Faucher , Thomas M. Swanick
IPC分类号： A61K9/00 , A61L27/54 , A61F13/02 , A61K9/06 , A61K31/225 , A61K31/355 , A61K47/12 , A61K47/14 , A61L2/07 , A61L2/08 , A61L2/20 , A61L27/36 , A61L27/52 , A61L31/00 , A61L31/10 , A61L31/14 , A61F2/06 , B05D3/06
CPC分类号： A61K35/60 , A61F2/06 , A61F13/02 , A61F13/023 , A61F2250/0067 , A61K9/0024 , A61K9/06 , A61K31/225 , A61K31/355 , A61K38/13 , A61K47/12 , A61K47/14 , A61L2/07 , A61L2/081 , A61L2/087 , A61L2/206 , A61L2/208 , A61L27/36 , A61L27/3604 , A61L27/52 , A61L27/54 , A61L31/005 , A61L31/10 , A61L31/145 , A61L2202/24 , A61L2300/22 , A61L2300/252 , A61L2300/404 , A61L2300/41 , A61L2300/414 , A61L2300/42 , A61L2300/602 , B05D3/067
摘要： A method of UV curing and corresponding resulting non-polymeric cross-linked gel are provided. The cross-linked gel can be combined with a medical device structure. The cross-linked gel can provide anti-adhesion characteristics, in addition to improved healing and anti-inflammatory response. The cross-linked gel is generally formed of a naturally occurring oil, or an oil composition formed in part of a naturally occurring oil, that is at least partially cured forming a cross-linked gel derived from at least one fatty acid compound. In addition, the oil composition can include a therapeutic agent component, such as a drug or other bioactive agent. The curing method can vary the application of UV light in both intensity and duration to achieve a desired amount of cross-linking forming the gel.
摘要翻译： 提供UV固化方法和相应的所得非聚合交联凝胶。 交联凝胶可以与医疗装置结构组合。 除了改善愈合和抗炎反应之外，交联凝胶还可提供抗粘附特性。 交联凝胶通常由天然存在的油或部分天然存在的油形成的油组合物形成，其至少部分固化形成由至少一种脂肪酸化合物衍生的交联凝胶。 此外，油组合物可以包括治疗剂组分，例如药物或其它生物活性剂。 固化方法可以改变UV光在强度和持续时间上的应用，以实现形成凝胶的所需量的交联。
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公开(公告)号：US08795703B2
公开(公告)日：2014-08-05
申请号：US11237264
申请日：2005-09-28
申请人： Thomas M. Swanick , Joseph Ferraro , Paul Martakos , Lisa Rogers , Theodore Karwoski , Steve A. Herweck , Keith Faucher , Philip McNamara
发明人： Thomas M. Swanick , Joseph Ferraro , Paul Martakos , Lisa Rogers , Theodore Karwoski , Steve A. Herweck , Keith Faucher , Philip McNamara
CPC分类号： A61K35/60 , A61F2/06 , A61F13/02 , A61F13/023 , A61F2250/0067 , A61K9/0024 , A61K9/06 , A61K31/225 , A61K31/355 , A61K38/13 , A61K47/12 , A61K47/14 , A61L2/07 , A61L2/081 , A61L2/087 , A61L2/206 , A61L2/208 , A61L27/36 , A61L27/3604 , A61L27/52 , A61L27/54 , A61L31/005 , A61L31/10 , A61L31/145 , A61L2202/24 , A61L2300/22 , A61L2300/252 , A61L2300/404 , A61L2300/41 , A61L2300/414 , A61L2300/42 , A61L2300/602 , B05D3/067
摘要： A stand-alone film is derived at least in part from fatty acids. The stand-alone film can have anti-adhesive, anti-inflammatory, non-inflammatory, and wound healing properties, and can additionally include one or more therapeutic agents incorporated therein. Corresponding methods of making the stand-alone film include molding, casting, or otherwise applying a liquid or gel to a substrate, and curing or otherwise treating to form the stand-alone film. The resulting stand-alone film is bioabsorbable.
摘要翻译： 至少部分地从脂肪酸衍生独立的膜。 独立膜可以具有抗粘连，抗炎，非炎性和伤口愈合性质，并且还可以包括一种或多种掺入其中的治疗剂。 制造独立膜的相应方法包括将液体或凝胶成型，铸造或以其它方式施加到基底，以及固化或以其他方式处理以形成独立的膜。 所得到的独立膜是生物可吸收的。
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