利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

99 条记录 (耗时 0.025 秒)

    Patched genes and uses related thereto
    15.
    发明授权
    Patched genes and uses related thereto 失效

    公开(公告)号：US07465552B2

    公开(公告)日：2008-12-16

    申请号：US10421446

    申请日：2003-04-22

    申请人： Matthew P. Scott ,  Lisa V. Goodrich ,  Ronald L. Johnson ,  Ervin Epstein, Jr.

    发明人： Matthew P. Scott ,  Lisa V. Goodrich ,  Ronald L. Johnson ,  Ervin Epstein, Jr.

    IPC分类号： G01N33/567 ,  C12N5/02 ,  C12Q1/68 ,  C12P21/06

    CPC分类号： C07K14/43563 ,  A01K2217/05 ,  A01K2227/40 ,  C07K14/705

    摘要： Methods for isolating patched genes, including the mouse and human patched genes, as well as invertebrate patched genes and sequences, are provided. Decreased expression of patched is associated with the occurrence of human cancers, particularly basal cell carcinomas of the skin. The patched and hedgehog genes are useful in creating transgenic animal models for these human cancers. The patched nucleic acid compositions find use in identifying homologous or related proteins and the DNA sequences encoding such proteins; in producing compositions that modulate the expression or function of the protein; and in studying associated physiological pathways. In addition, modulation of the gene activity in vivo is used for prophylactic and therapeutic purposes, such as treatment of cancer, identification of cell type based on expression, and the like. The DNA is further used as a diagnostic for a genetic predisposition to cancer, and to identify specific cancers having mutations in this gene.

    Swimmer training paddle simulating shape of human hand
    16.
    发明授权
    Swimmer training paddle simulating shape of human hand 有权
    模拟人手形状的游泳训练板

    公开(公告)号：US07179146B2

    公开(公告)日：2007-02-20

    申请号：US10410084

    申请日：2003-04-09

    申请人： Ronald L. Johnson

    发明人： Ronald L. Johnson

    IPC分类号： A63B31/10 ,  A63B31/12

    CPC分类号： A63B31/10

    摘要： A swimmer's hand paddle simulating a human hand is formed from a generally planar member of PVC foam and has a central dome-shaped palm area for receiving the palm of the swimmer's hand. The paddle includes areas for receiving the thumb and fingers of the swimmer's hand. A wrist strap and one or more finger straps secures the user's hand to the paddle. The palm area, and also the areas which receive the swimmer's thumb and fingers, are provided with a series of apertures to allow the swimmer to feel passing water. The paddle is shaped to include an inwardly directed groove such that the peripheral portion of the paddle nearest the swimmer's second finger lies closer to the central palm area than do the peripheral portions nearest the index finger and ring finger. Also, an indented peripheral portion is formed between the swimmer's thumb and index finger.

    摘要翻译： 模拟人的手的游泳者手掌由PVC泡沫的大致平面的构件形成，并且具有用于接收游泳者手掌的中心圆顶形的手掌区域。 桨片包括用于接收游泳者手的拇指和手指的区域。 腕带和一个或多个手指带将使用者的手固定在桨上。 手掌区域以及接受游泳者拇指和手指的区域设置有一系列孔，以允许游泳者感觉到通过的水。 桨形成为包括向内指向的凹槽，使得最靠近游泳者的第二手指的桨叶的周边部分比最靠近食指和无名指的周边部分更靠近中央手掌区域。 此外，在游泳者的拇指和食指之间形成缩进的周边部分。

    Patched genes and uses related thereto
    17.
    发明授权
    Patched genes and uses related thereto 失效
    修补的基因和与之相关的用途

    公开(公告)号：US06429354B1

    公开(公告)日：2002-08-06

    申请号：US08918658

    申请日：1997-08-22

    申请人： Matthew P. Scott ,  Lisa V. Goodrich ,  Ronald L. Johnson ,  Ervin Epstein, Jr.

    发明人： Matthew P. Scott ,  Lisa V. Goodrich ,  Ronald L. Johnson ,  Ervin Epstein, Jr.

    IPC分类号： A01K67027

    CPC分类号： C07K14/43563 ,  A01K2217/05 ,  A01K2227/40 ,  C07K14/705

    摘要： Methods for isolating patched genes, particularly mammalian patched genes, including the mouse and human patched genes, as well as invertebrate patched genes and sequences, are provided. Decreased expression of patched is associated with the occurrence of human cancers, particularly basal cell carcinomas of the skin. The cancers may be familial, having as a component of risk an inherited genetic predisposition, or may be sporadic. The patched and hedgehog genes are useful: in creating transgenic animal models for these human cancers. The patched nucleic acid compositions find use in identifying homologous or related proteins and the DNA sequences encoding such proteins; in producing compositions that modulate the expression or function of the protein; and in studying associated 15 physiological pathways. In addition, modulation of the gene activity in vivo is used for prophylactic and therapeutic purposes, such as treatment of cancer, identification of cell type based on expression, and the like. The DNA is further used as a diagnostic for a genetic predisposition to cancer, and to identify specific cancers having mutations in this gene.

    摘要翻译： 提供了分离修补基因，特别是哺乳动物修补基因（包括小鼠和人修补基因）以及无脊椎动物修补基因和序列的方法。 修补后的表达减少与人类癌症，特别是皮肤基底细胞癌的发生有关。 癌症可能是家族性的，作为风险的组成部分是遗传性遗传倾向，或可能是零星的。 修补和刺猬基因是有用的：为这些人类癌症创造转基因动物模型。 修补的核酸组合物用于鉴定同源或相关蛋白质和编码这种蛋白质的DNA序列; 在制备调节蛋白质的表达或功能的组合物中; 并研究相关的15个生理学途径。 此外，体内基因活性的调节用于预防和治疗目的，例如癌症的治疗，基于表达的细胞类型的鉴别等。 该DNA进一步用于诊断癌症的遗传易感性，并鉴定具有该基因突变的特异性癌症。

    Swimmer training paddle
    19.
    发明授权
    Swimmer training paddle 失效
    游泳训练桨

    公开(公告)号：US5511998A

    公开(公告)日：1996-04-30

    申请号：US502630

    申请日：1995-07-14

    申请人： Ronald L. Johnson

    发明人： Ronald L. Johnson

    IPC分类号： A63B31/10

    CPC分类号： A63B31/10

    摘要： A swimmer's hand paddle in the form of a rigid planar member has a mitten-shaped surface area, larger than the human hand and wider in the palm area than in the area of the middle finger, and has an irregularly-shaped aperture of a width approaching the width of the hand positioned at a location on the paddle so as to be covered by the most sensitive area of the palm when the hand is properly positioned on the paddle. From one end of a proximal curved wrist edge to a point beyond the end of the thumb, the thumb side edge closely approaches the outer edge of the thumb and then curves inwardly and merges with a sharply curved distal end, whereas the little finger side edge extends with flared curvature from the distal end to the other end of the curved wrist edge. The area of the little finger side of the paddle is larger than the thumb side area, and has a curved row of perforations which closely approaches the little finger side edge for reducing the resistance to water of the little finger side during the routine of a swimming stroke. The user's hand is attached to and positioned on the paddle by sections of rubber tubing pulled through sets of perforations, one set positioned near the wrist edge and another set positioned at the approximate location of the base of the user's fingers.

    摘要翻译： 游泳者的手桨形式的刚性平面构件具有手指形状的表面积，比人的手大，手掌区域比中指区域宽，并且具有不规则形状的宽度的孔 接近位于桨上位置的手的宽度，以便当手适当地定位在桨上时被手掌的最敏感区域覆盖。 从近端弯曲的手腕边缘的一端到超过拇指端的点，拇指侧边缘紧密地靠近拇指的外边缘，然后向内弯曲并与尖锐弯曲的远端合并，而小指侧边缘 从弯曲的腕部边缘的远端延伸到另一端的扩张曲率。 桨的小指侧的区域大​​于拇指侧区域，并且具有弯曲的穿孔排，其紧密接近小指侧边缘，用于在游泳过程中减少小指侧的水的阻力 行程。 使用者的手通过穿过穿孔组的橡胶管的一部分附接到桨上并定位在桨上，一组位于腕部边缘附近，另一组位于使用者手指的基部的大致位置。