Injectable therapeutic formulations
    14.
    发明申请
    Injectable therapeutic formulations 审中-公开
    可注射的治疗剂型

    公开(公告)号:US20050064045A1

    公开(公告)日:2005-03-24

    申请号:US10667151

    申请日:2003-09-18

    摘要: Sterile injectable formulations, which comprise the following: (a) a ablation agent in an amount effective to cause necrosis of tissue, and (b) a biodisintegrable viscosity adjusting agent in an amount effective to render the formulation highly viscous, (c) an optional imaging contrast agent, (d) an optional therapeutic agent, and (e) an optional liquid selected from water and an organic solvent. Also described are novel prostatic ablation formulations, which comprise a prostatic ablation agent selected from free-radical generating ablation agents, oxidizing ablation agents and tissue fixing ablation agents. Further aspects of the invention relate to methods of treating a variety of diseases and conditions, including benign prostatic hypertrophy, in which above injectable formulations are injected into the tissue of a subject, optionally with the assistance of a non-invasive imaging technique.

    摘要翻译: 无菌可注射制剂,其包含以下物质:(a)有效引起组织坏死的量的消融剂,和(b)有效使制剂高度粘稠的量的生物可分解粘度调节剂,(c)任选的 成像造影剂,(d)任选的治疗剂,和(e)选自水和有机溶剂的任选液体。 还描述了新型前列腺消融制剂,其包含选自自由基产生消融剂,氧化消融剂和组织固定消融剂的前列腺消融剂。 本发明的其它方面涉及治疗各种疾病和病症(包括良性前列腺肥大)的方法,其中任选地在非侵入性成像技术的帮助下,上述可注射制剂注射到受试者的组织中。