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公开(公告)号：US20050064008A1
公开(公告)日：2005-03-24
申请号：US10664601
申请日：2003-09-18
CPC分类号： A61K9/0024 , A61K9/0034 , A61K9/0092 , A61K9/1652 , A61K9/204 , A61K9/205 , A61K9/2054 , A61K45/06
摘要： An injectable or insertable dosage form comprising a biodisintegrable binder and an ablation agent in a concentration effective to cause tissue necrosis. The injectable dosage form is a solid or semi-solid dosage form. Due to the solid or semi-solid nature of the dosage form, retention at the site of injection or insertion is improved, thereby improving delivery efficiency of the ablation agents within the dosage form and/or reducing the nonspecific tissue damage associated with the dosage form.
摘要翻译： 一种可注射或可插入的剂型，其包含生物可分解的粘合剂和消融剂，其浓度有效地引起组织坏死。 可注射剂型是固体或半固体剂型。 由于剂型的固体或半固体性质，提高注射或插入部位的保留性，从而提高剂型内消融剂的输送效率和/或减少与剂型相关的非特异性组织损伤 。
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公开(公告)号：US20050064045A1
公开(公告)日：2005-03-24
申请号：US10667151
申请日：2003-09-18
IPC分类号： A61K9/08 , A61K9/10 , A61K31/045 , A61K33/14 , A61K47/02 , A61K47/10 , A61K47/34 , A61K47/38 , A61P13/08
CPC分类号： A61K9/0019 , A61K47/32 , A61K47/36 , A61K47/38
摘要： Sterile injectable formulations, which comprise the following: (a) a ablation agent in an amount effective to cause necrosis of tissue, and (b) a biodisintegrable viscosity adjusting agent in an amount effective to render the formulation highly viscous, (c) an optional imaging contrast agent, (d) an optional therapeutic agent, and (e) an optional liquid selected from water and an organic solvent. Also described are novel prostatic ablation formulations, which comprise a prostatic ablation agent selected from free-radical generating ablation agents, oxidizing ablation agents and tissue fixing ablation agents. Further aspects of the invention relate to methods of treating a variety of diseases and conditions, including benign prostatic hypertrophy, in which above injectable formulations are injected into the tissue of a subject, optionally with the assistance of a non-invasive imaging technique.
摘要翻译： 无菌可注射制剂，其包含以下物质：（a）有效引起组织坏死的量的消融剂，和（b）有效使制剂高度粘稠的量的生物可分解粘度调节剂，（c）任选的 成像造影剂，（d）任选的治疗剂，和（e）选自水和有机溶剂的任选液体。 还描述了新型前列腺消融制剂，其包含选自自由基产生消融剂，氧化消融剂和组织固定消融剂的前列腺消融剂。 本发明的其它方面涉及治疗各种疾病和病症（包括良性前列腺肥大）的方法，其中任选地在非侵入性成像技术的帮助下，上述可注射制剂注射到受试者的组织中。
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公开(公告)号：US07906125B2
公开(公告)日：2011-03-15
申请号：US10664601
申请日：2003-09-18
CPC分类号： A61K9/0024 , A61K9/0034 , A61K9/0092 , A61K9/1652 , A61K9/204 , A61K9/205 , A61K9/2054 , A61K45/06
摘要： An injectable or insertable dosage form comprising a biodisintegrable binder and an ablation agent in a concentration effective to cause tissue necrosis. The injectable dosage form is a solid or semi-solid dosage form. Due to the solid or semi-solid nature of the dosage form, retention at the site of injection or insertion is improved, thereby improving delivery efficiency of the ablation agents within the dosage form and/or reducing the nonspecific tissue damage associated with the dosage form.
摘要翻译： 一种可注射或可插入的剂型，其包含生物可分解的粘合剂和消融剂，其浓度有效地引起组织坏死。 可注射剂型是固体或半固体剂型。 由于剂型的固体或半固体性质，提高注射或插入部位的保留性，从而提高剂型内消融剂的输送效率和/或减少与剂型相关的非特异性组织损伤 。
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公开(公告)号：US20070020307A1
公开(公告)日：2007-01-25
申请号：US11184196
申请日：2005-07-19
申请人： Sheng-Ping Zhong , Enxin Ma , Eun-Hyun Jang
发明人： Sheng-Ping Zhong , Enxin Ma , Eun-Hyun Jang
摘要： The present invention relates generally to radiation-resistant medical devices which contain polymer regions for release of therapeutic agents. The present invention also relates to radiation-resistant copolymer materials for use in connection with insertable or implantable medical devices. The radiation-sterilized medical device comprises (a) a release region and (b) at least one therapeutic agent and the release region comprises a phenoxy resin block.
摘要翻译： 本发明一般涉及含有用于释放治疗剂的聚合物区域的耐辐射医疗装置。 本发明还涉及用于与可插入或可植入的医疗装置相结合的耐辐射共聚物材料。 辐射消毒的医疗装置包括（a）释放区和（b）至少一种治疗剂，并且释放区包含苯氧树脂嵌段。
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公开(公告)号：US08722074B2
公开(公告)日：2014-05-13
申请号：US11184196
申请日：2005-07-19
申请人： Sheng-Ping Zhong , Enxin Ma , Eun-Hyun Jang
发明人： Sheng-Ping Zhong , Enxin Ma , Eun-Hyun Jang
IPC分类号： A61F2/02
摘要： The present invention relates generally to radiation-resistant medical devices which contain polymer regions for release of therapeutic agents. The present invention also relates to radiation-resistant copolymer materials for use in connection with insertable or implantable medical devices. The radiation-sterilized medical device comprises (a) a release region and (b) at least one therapeutic agent and the release region comprises a phenoxy resin block.
摘要翻译： 本发明一般涉及含有用于释放治疗剂的聚合物区域的耐辐射医疗装置。 本发明还涉及用于与可插入或可植入的医疗装置相结合的耐辐射共聚物材料。 辐射消毒的医疗装置包括（a）释放区和（b）至少一种治疗剂，并且释放区包含苯氧树脂嵌段。
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6.发明授权Implantable or insertable medical devices visible under magnetic resonance imaging 有权可植入或可插入的医疗器械在磁共振成像下可见公开(公告)号：US08163326B2
公开(公告)日：2012-04-24
申请号：US11637263
申请日：2006-12-12
申请人： Sheng-Ping Zhong , Ronald A. Sahatjian , Enxin Ma
发明人： Sheng-Ping Zhong , Ronald A. Sahatjian , Enxin Ma
CPC分类号： G01R33/286 , A61L29/145 , A61L29/18 , A61L31/145 , A61L31/18 , A61M25/0045 , A61M25/0108
摘要： Disclosed is an implantable or insertable medical device comprising (a) a substrate and (b) a hydrogel polymer coating at a least a portion of the surface of the substrate, wherein the hydrogel polymer is adapted to render the medical device visible under magnetic resonance imaging (MRI) upon insertion or implantation of the medical device into a patient. Also disclosed is the use of such a hydrogel coated implantable or insertable medical device in a medical procedure, wherein during or after insertion or implantation of the medical device in a patient, the position of the medical device is viewed under MRI. The use of a hydrogel polymer for coating a medical device wherein the hydrogel polymer is adapted to render a medical device coated with the hydrogel polymer visible under MRI and a hydrogel polymer adapted to render a medical device coated therewith visible under MRI are also disclosed.
摘要翻译： 公开了一种可植入或可插入的医疗装置，其包括（a）基底和（b）在所述基底表面的至少一部分表面上的水凝胶聚合物涂层，其中所述水凝胶聚合物适于使所述医疗装置在磁共振成像 （MRI）在将医疗装置插入或植入患者体内时。 还公开了在医疗过程中使用这种水凝胶涂覆的可植入或可插入的医疗装置，其中在将医疗装置插入或植入患者体内或之后，在MRI下观察医疗装置的位置。 还公开了使用水凝胶聚合物涂覆医疗装置，其中水凝胶聚合物适于使涂覆有水凝胶聚合物的医疗装置在MRI下可见，并且还公开了适于使其涂覆的医疗装置在MRI下可见的水凝胶聚合物。
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7.发明申请Implantable or insertable medical devices visible under magnetic resonance imaging 有权可植入或可插入的医疗器械在磁共振成像下可见公开(公告)号：US20070167735A1
公开(公告)日：2007-07-19
申请号：US11637263
申请日：2006-12-12
申请人： Sheng-Ping Zhong , Ronald Sahatjian , Enxin Ma
发明人： Sheng-Ping Zhong , Ronald Sahatjian , Enxin Ma
IPC分类号： A61B5/05
CPC分类号： G01R33/286 , A61L29/145 , A61L29/18 , A61L31/145 , A61L31/18 , A61M25/0045 , A61M25/0108
摘要： Disclosed is an implantable or insertable medical device comprising (a) a substrate and (b) a hydrogel polymer coating at a least a portion of the surface of the substrate, wherein the hydrogel polymer is adapted to render the medical device visible under magnetic resonance imaging (MRI) upon insertion or implantation of the medical device into a patient. Also disclosed is the use of such a hydrogel coated implantable or insertable medical device in a medical procedure, wherein during or after insertion or implantation of the medical device in a patient, the position of the medical device is viewed under MRI. The use of a hydrogel polymer for coating a medical device wherein the hydrogel polymer is adapted to render a medical device coated with the hydrogel polymer visible under MRI and a hydrogel polymer adapted to render a medical device coated therewith visible under MRI are also disclosed.
摘要翻译： 公开了一种可植入或可插入的医疗装置，其包括（a）基底和（b）在所述基底表面的至少一部分表面上的水凝胶聚合物涂层，其中所述水凝胶聚合物适于使所述医疗装置在磁共振成像 （MRI）在将医疗装置插入或植入患者体内时。 还公开了在医疗过程中使用这种水凝胶涂覆的可植入或可插入的医疗装置，其中在将医疗装置插入或植入患者体内或之后，在MRI下观察医疗装置的位置。 还公开了使用水凝胶聚合物涂覆医疗装置，其中水凝胶聚合物适于使涂覆有水凝胶聚合物的医疗装置在MRI下可见，并且还公开了适于使其涂覆的医疗装置在MRI下可见的水凝胶聚合物。
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公开(公告)号：US08435285B2
公开(公告)日：2013-05-07
申请号：US10962567
申请日：2004-10-13
IPC分类号： A61F2/82
CPC分类号： A61F2/82 , A61F2/07 , A61F2/86 , A61F2/90 , A61F2002/075 , A61F2210/0076 , A61F2220/0008 , A61F2220/0041 , A61F2220/005 , A61F2220/0066 , A61F2220/0075 , A61F2250/0067 , A61L31/129 , A61L31/146 , B05D1/002
摘要： An endoprosthesis comprising a stent, a cover fully covering the stent wherein the cover has variable porosity in the radial direction; and an adhesion layer connecting the stent to the cover. Another aspect of the invention is a method of implanting an endoprosthesis which includes a stent, providing a cover with variable porosity in the radial direction, connecting the stent to the cover with an adhesion layer to form a covered stent, and implanting the covered stent within a body lumen of a patient.
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公开(公告)号：US07792568B2
公开(公告)日：2010-09-07
申请号：US10390202
申请日：2003-03-17
IPC分类号： A61B5/05
CPC分类号： G01R33/286 , A61B90/39 , A61B2090/3933 , A61B2090/3954 , A61M25/00 , A61M25/0009 , A61M25/0127 , A61M2025/1079
摘要： A medical device includes a body, a member in the body, and a contrast agent in the member. The device can be visible by magnetic resonance imaging.
摘要翻译： 医疗装置包括主体，身体中的构件和构件中的造影剂。 该装置可以通过磁共振成像可见。
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10.发明授权
公开(公告)号：US5869127A
公开(公告)日：1999-02-09
申请号：US877825
申请日：1997-06-18
申请人： Sheng-Ping Zhong
发明人： Sheng-Ping Zhong
IPC分类号： A61M25/00 , A61L29/00 , A61L29/08 , A61L29/16 , A61L31/00 , A61L31/10 , A61L31/16 , C03C17/32 , C08J7/04 , C08L33/02 , C08L75/00 , C08L75/04 , C09D201/00 , B05D3/10 , A61L33/00 , B05D3/00
CPC分类号： A61L31/16 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/208 , A61L2300/21 , A61L2300/236 , A61L2300/25 , A61L2300/42 , A61L2300/608 , A61L2300/61 , Y10S623/92
摘要： Disclosed is a method of enhancing the biocompatibility of a substrate by providing the substrate with a continuous bio-active surface coating. This method includes applying to the substrate a first coating which includes an aqueous dispersion or emulsion of a polymer containing an organic acid functional group and an excess of a polyfunctional cross-linking agent which is reactive with the organic acid groups of the polymer. A continuous bio-active surface coating is then formed over the dried first coating by applying thereover a bio-active agent containing an organic acid functional group or metal salt thereof. The first and second coatings are then dried to covalently bond the organic acid functional groups of the bio-active agent to the polymer through the excess unreacted polyfunctional cross-linking agent.
摘要翻译： 公开了通过向基材提供连续的生物活性表面涂层来提高基底的生物相容性的方法。 该方法包括向基材施加第一涂层，该涂层包括含有有机酸官能团的聚合物的水性分散体或乳液，以及过量的与聚合物的有机酸基团反应的多官能交联剂。 然后通过在其上施加含有有机酸官能团或其金属盐的生物活性剂，在干燥的第一涂层上形成连续的生物活性表面涂层。 然后干燥第一和第二涂层，以通过过量的未反应的多官能交联剂将生物活性剂的有机酸官能团与聚合物共价键合。
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