公开(公告)号：US10654882B2

公开(公告)日：2020-05-19

申请号：US15777756

申请日：2016-11-16

Applicant: SHOWA DENKO K.K.

Inventor： Daisuke Yagyu

IPC: C07H19/048 ,  A61K31/706 ,  A23L29/00 ,  A61Q19/08 ,  A61K8/60 ,  A23L33/13 ,  A61Q19/00

Abstract: The present invention provides a nicotinamide mononucleotide derivative, or salt thereof, which is a compound represented by general formula (1), wherein R1 and R2 respectively and independently represent a hydrogen atom or acyl group having 3 to 30 carbon atoms, the hydrocarbon group bound to the carbonyl carbon of the acyl group is a linear or branched, saturated or unsaturated hydrocarbon group, and at least one of R1 and R2 is the acyl group.

公开(公告)号：US10112890B2

公开(公告)日：2018-10-30

申请号：US15543261

申请日：2016-01-15

Applicant: SHOWA DENKO K.K.

Inventor： Toru Tachibana ,  Ryota Niibayashi ,  Daisuke Yagyu

IPC: C07C235/12 ,  A23L33/15 ,  A61K8/67 ,  A61Q19/00

Abstract: Provided is a compound represented by Formula (1) or a salt thereof (in the formula, R1 and R2 each independently represent a hydrogen atom or a linear or branched acyl group having 11 to 30 carbon atoms, a hydrocarbon group bonded to a carbonyl carbon of the acyl group is a saturated or unsaturated hydrocarbon group, and at least one of R1 and R2 represents the acyl group).

公开(公告)号：US11639330B2

公开(公告)日：2023-05-02

申请号：US16640132

申请日：2018-07-30

Applicant: SHOWA DENKO K.K.

Inventor： Masaki Nanko ,  Naoya Fukumoto ,  Daisuke Yagyu ,  Yuta Yamaguchi ,  Tsuyoshi Kato ,  Hiroyuki Tomita ,  Katsumi Murofushi ,  Shohei Nishizawa

IPC: C07C255/13 ,  G11B5/725 ,  C07C43/205 ,  C07C255/17 ,  C07C255/19 ,  C07C255/50 ,  C07D333/16 ,  C08G65/08 ,  C10M107/38 ,  C10N40/18

Abstract: Provided is a fluorine-containing ether compound that can be suitably used as a material for a lubricant for a magnetic recording medium, capable of forming a lubricant layer having excellent chemical substance resistance and wear resistance even when the thickness is small. A fluorine-containing ether compound represented by the following formula (1): R1—R2—CH2—R3—CH2—R4—R5  (1) In the formula (1), R3 is a perfluoropolyether chain. R2 and R4 are divalent linkage groups having a polar group, and may be the same or different. R1 and R5 are terminal groups bonded to R2 or R4, which may be the same or different, and at least one of R1 and R5 is an organic group having 1 to 8 carbon atoms wherein one or more hydrogen atoms of the organic group is substituted with a cyano group.

公开(公告)号：US11261394B2

公开(公告)日：2022-03-01

申请号：US16644586

申请日：2018-08-23

Applicant: SHOWA DENKO K.K.

Inventor： Tsuyoshi Kato ,  Daisuke Yagyu ,  Naoya Fukumoto ,  Masaki Nanko ,  Masumi Kuritani ,  Katsumi Murofushi

IPC: C10M105/54 ,  G11B5/73 ,  C07C43/23 ,  C07D333/16 ,  C10N40/18

Abstract: A fluorine-containing ether compound represented by R1—R2—CH2—R3—CH2—R4—R5 is provided. (R3 is a perfluoropolyether chain; R1 and R5 are each independently any one of an alkyl group that may have a substituent, an organic group having at least one double bond or at least one triple bond, and a hydrogen atom; and —R2—CH2—R3 is represented by Formula (2), and R3—CH2—R4— is represented by Formula (3)) -[A]-[B]—O—CH2—R3  (2) R3—CH2—O—[C]-[D]-  (3) ([A] is represented by Formula (4), [B] is represented by Formula (5), [C] is represented by Formula (6), [D] is represented by Formula (7), and in the formula, a and b are integers of 0 to 2, c is an integer of 2 to 5, d and f are integers of 0 to 2, and e is an integer of 2 to 5, and at least one of b and d in the formula is 1 or more)

公开(公告)号：US10646487B2

公开(公告)日：2020-05-12

申请号：US16314960

申请日：2017-06-08

Applicant: SHOWA DENKO K.K.

Inventor： Daisuke Yagyu ,  Yuko Nakagami ,  Ryota Niibayashi ,  Eiko Kato

IPC: A61K31/513 ,  A61Q19/02 ,  A61Q19/08 ,  A61P17/16 ,  A61K8/49

Abstract: The present invention provides an agent containing an orotic acid derivative that has high solubility in solvent and has superior physiological activity. The agent of the present invention is a melanin production inhibitor, whitening agent, fibroblast activator, collagen and/or elastin production promoter or wrinkle ameliorant containing as an active ingredient thereof an orotic acid derivative represented by the following general formula (1) or a salt thereof. In formula (1), R preferably represents a side chain of glutamic acid, glycine, histidine or aspartic acid. [In formula (1), R represents a side chain of a naturally-occurring amino acid and R may form, together with a nitrogen atom adjacent thereto through a single carbon atom, a hetero ring].