公开(公告)号：US10918585B2

公开(公告)日：2021-02-16

申请号：US16061008

申请日：2016-10-28

Applicant: SHOWA DENKO K.K.

Inventor： Yuko Nakagami ,  Shinji Yamaki ,  Ichiro Fujita ,  Tadashi Yoneda

IPC: A61K8/60 ,  A61Q19/08 ,  A61P43/00 ,  A61K31/7034 ,  A61K8/73 ,  A61K31/7016 ,  A61K31/702

Abstract: Provided is an anti-aging agent for skin which contains, as an active component, an inositol derivative in which a monosaccharide or an oligosaccharide is bonded to inositol, in which a total amount of the monosaccharide or the oligosaccharide bonded to one inositol molecule is 2 or greater in terms of monosaccharide unit.

公开(公告)号：US10646487B2

公开(公告)日：2020-05-12

申请号：US16314960

申请日：2017-06-08

Applicant: SHOWA DENKO K.K.

Inventor： Daisuke Yagyu ,  Yuko Nakagami ,  Ryota Niibayashi ,  Eiko Kato

IPC: A61K31/513 ,  A61Q19/02 ,  A61Q19/08 ,  A61P17/16 ,  A61K8/49

Abstract: The present invention provides an agent containing an orotic acid derivative that has high solubility in solvent and has superior physiological activity. The agent of the present invention is a melanin production inhibitor, whitening agent, fibroblast activator, collagen and/or elastin production promoter or wrinkle ameliorant containing as an active ingredient thereof an orotic acid derivative represented by the following general formula (1) or a salt thereof. In formula (1), R preferably represents a side chain of glutamic acid, glycine, histidine or aspartic acid. [In formula (1), R represents a side chain of a naturally-occurring amino acid and R may form, together with a nitrogen atom adjacent thereto through a single carbon atom, a hetero ring].

公开(公告)号：US11045471B2

公开(公告)日：2021-06-29

申请号：US16820773

申请日：2020-03-17

Applicant: SHOWA DENKO K.K.

Inventor： Daisuke Yagyu ,  Yuko Nakagami ,  Ryota Niibayashi ,  Eiko Kato

IPC: A61K31/513 ,  A61Q19/02 ,  A61Q19/08 ,  A61P17/16 ,  A61K8/49

Abstract: The present invention provides an agent containing an orotic acid derivative that has high solubility in solvent and has superior physiological activity. The agent of the present invention is a melanin production inhibitor, whitening agent, fibroblast activator, collagen and/or elastin production promoter or wrinkle ameliorant containing as an active ingredient thereof an orotic acid derivative represented by the following general formula (1) or a salt thereof. In formula (1), R preferably represents a side chain of glutamic acid, glycine, histidine or aspartic acid. [In formula (1), R represents a side chain of a naturally-occurring amino acid and R may form, together with a nitrogen atom adjacent thereto through a single carbon atom, a hetero ring.]