公开(公告)号：US10591400B2

公开(公告)日：2020-03-17

申请号：US16242491

申请日：2019-01-08

申请人： Sony Corporation

发明人： Yuya Suzuki ,  Fumitaka Otsuka ,  Masashi Kimoto ,  Shingo Imanishi ,  Yoshitsugu Sakai

IPC分类号： G01N21/00 ,  G01N15/14 ,  G01N15/10

摘要： The present technology provides a technology for stabilizing break-off timings. Therefore, according to the present technology, there is provided a microparticle analysis device or the like including at least: a flow path in which a fluid including a sample flow containing microparticles and a sheath flow flowing to contain the sample flow; a droplet formation unit configured to form a droplet in the fluid by imparting vibration to the fluid using a vibration element; an electric charge application unit configured to apply electric charge to a droplet containing the microparticles; an imaging unit configured to obtain a photo of a phase of a certain time; and a control unit configured to control a timing at which the droplet breaks off on a basis of the photo.

公开(公告)号：US20190301994A1

公开(公告)日：2019-10-03

申请号：US16242491

申请日：2019-01-08

申请人： Sony Corporation

发明人： Yuya Suzuki ,  Fumitaka Otsuka ,  Masashi Kimoto ,  Shingo Imanishi ,  Yoshitsugu Sakai

IPC分类号： G01N15/14

摘要： The present technology provides a technology for stabilizing break-off timings. Therefore, according to the present technology, there is provided a microparticle analysis device or the like including at least: a flow path in which a fluid including a sample flow containing microparticles and a sheath flow flowing to contain the sample flow; a droplet formation unit configured to form a droplet in the fluid by imparting vibration to the fluid using a vibration element; an electric charge application unit configured to apply electric charge to a droplet containing the microparticles; an imaging unit configured to obtain a photo of a phase of a certain time; and a control unit configured to control a timing at which the droplet breaks off on a basis of the photo.

公开(公告)号：US10295466B2

公开(公告)日：2019-05-21

申请号：US14452085

申请日：2014-08-05

申请人： Sony Corporation

发明人： Yasunobu Kato ,  Yoshitsugu Sakai

IPC分类号： G01N21/64

摘要： A fluorescence intensity calculating apparatus, includes a measuring section configured to receive fluorescences generated from plural fluorescent dyes excited by radiating a light to a microparticle multiply-labeled with the plural fluorescent dyes having fluorescence wavelength bands overlapping one another by photodetectors which correspond to different received light wavelength bands, respectively, and whose number is larger than the number of fluorescent dyes, and obtain measured spectra by collecting detected values from the photodetectors, and a calculating section configured to approximate the measured spectra based on a linear sum of single-dyeing spectra obtained from the microparticle individually labeled with the fluorescent dyes, thereby calculating intensities of the fluorescences generated from the fluorescent dyes, respectively.

公开(公告)号：US20190080492A1

公开(公告)日：2019-03-14

申请号：US16184616

申请日：2018-11-08

申请人： Sony Corporation

发明人： Yoshitsugu Sakai

IPC分类号： G06T11/20 ,  G06T11/00 ,  G01N21/64 ,  G01N15/14

摘要： Disclosed herein is a microparticle analyzing apparatus including a detecting portion configured to simultaneously detect a fluorescence generated from a microparticle in plural wavelength regions and a displaying portion configured to display thereon detection results in the plural wavelength regions in a form of a spectrum.

公开(公告)号：US10147209B2

公开(公告)日：2018-12-04

申请号：US15460493

申请日：2017-03-16

申请人： Sony Corporation

发明人： Yoshitsugu Sakai

IPC分类号： G06T11/00 ,  G06T11/20 ,  G01N21/64 ,  G01N15/14

摘要： Disclosed herein is a microparticle analyzing apparatus including a detecting portion configured to simultaneously detect a fluorescence generated from a microparticle in plural wavelength regions and a displaying portion configured to display thereon detection results in the plural wavelength regions in a form of a spectrum.

公开(公告)号：USD827588S1

公开(公告)日：2018-09-04

申请号：US29589012

申请日：2016-12-27

申请人： Sony Corporation

设计人： Yoshitsugu Sakai ,  Masaaki Abe ,  Ichiro Fujii

公开(公告)号：US11994468B2

公开(公告)日：2024-05-28

申请号：US17732681

申请日：2022-04-29

申请人： Sony Corporation

发明人： Yasunobu Kato ,  Yoshitsugu Sakai

IPC分类号： G01N21/64

CPC分类号： G01N21/6428 ,  G01N2021/6421 ,  G01N2021/6439

摘要： A fluorescence intensity calculating apparatus, includes a measuring section configured to receive fluorescences generated from plural fluorescent dyes excited by radiating a light to a microparticle multiply-labeled with the plural fluorescent dyes having fluorescence wavelength bands overlapping one another by photodetectors which correspond to different received light wavelength bands, respectively, and whose number is larger than the number of fluorescent dyes, and obtain measured spectra by collecting detected values from the photodetectors, and a calculating section configured to approximate the measured spectra based on a linear sum of single-dyeing spectra obtained from the microparticle individually labeled with the fluorescent dyes, thereby calculating intensities of the fluorescences generated from the fluorescent dyes, respectively.

公开(公告)号：US11340167B2

公开(公告)日：2022-05-24

申请号：US16848115

申请日：2020-04-14

申请人： Sony Corporation

发明人： Yasunobu Kato ,  Yoshitsugu Sakai

IPC分类号： G01N21/64

摘要： A fluorescence intensity calculating apparatus, includes a measuring section configured to receive fluorescences generated from plural fluorescent dyes excited by radiating a light to a microparticle multiply-labeled with the plural fluorescent dyes having fluorescence wavelength bands overlapping one another by photodetectors which correspond to different received light wavelength bands, respectively, and whose number is larger than the number of fluorescent dyes, and obtain measured spectra by collecting detected values from the photodetectors, and a calculating section configured to approximate the measured spectra based on a linear sum of single-dyeing spectra obtained from the microparticle individually labeled with the fluorescent dyes, thereby calculating intensities of the fluorescences generated from the fluorescent dyes, respectively.

公开(公告)号：US11112345B2

公开(公告)日：2021-09-07

申请号：US16305885

申请日：2017-03-07

申请人： SONY CORPORATION

发明人： Yoshitsugu Sakai ,  Masaaki Abe ,  Koichi Tsukihara ,  Shoji Akiyama ,  Shinichi Hasegawa

IPC分类号： G01N15/14

摘要： Provided is a microparticle measurement device including a light emission unit that emits light to a microparticle to be analyzed and a light detection unit that detects light generated from the microparticle at a predetermined detection position. The microparticle measurement device further includes an analysis unit that is connected to the light detection unit and analyzes a detection value of the light detected by the light detection unit. The light detection unit is movable from the detection position.

公开(公告)号：US11074727B2

公开(公告)日：2021-07-27

申请号：US16184616

申请日：2018-11-08

申请人： Sony Corporation

发明人： Yoshitsugu Sakai

IPC分类号： G01N15/14 ,  G01N21/64 ,  G06T11/00 ,  G06T11/20

摘要： Disclosed herein is a microparticle analyzing apparatus including a detecting portion configured to simultaneously detect a fluorescence generated from a microparticle in plural wavelength regions and a displaying portion configured to display thereon detection results in the plural wavelength regions in a form of a spectrum.