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公开(公告)号：US11156544B2
公开(公告)日：2021-10-26
申请号：US16782383
申请日：2020-02-05
Applicant: Sony Corporation
Inventor： Yuya Suzuki , Fumitaka Otsuka , Masashi Kimoto , Shingo Imanishi , Yoshitsugu Sakai
Abstract: The present technology provides a technology for stabilizing break-off timings. Therefore, according to the present technology, there is provided a microparticle analysis device or the like including at least: a flow path in which a fluid including a sample flow containing microparticles and a sheath flow flowing to contain the sample flow; a droplet formation unit configured to form a droplet in the fluid by imparting vibration to the fluid using a vibration element; an electric charge application unit configured to apply electric charge to a droplet containing the microparticles; an imaging unit configured to obtain a photo of a phase of a certain time; and a control unit configured to control a timing at which the droplet breaks off on a basis of the photo.
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公开(公告)号：US11135585B2
公开(公告)日：2021-10-05
申请号：US16305768
申请日：2017-03-07
Applicant: SONY CORPORATION
Inventor： Yoshitsugu Sakai , Ichiro Fujii , Ryoichi Kubota , Shinichi Hasegawa , Takashi Miyata , Emi Ikeda
IPC: B01L3/00
Abstract: The present technology is mainly directed to providing a technology that enables smooth setting of sheath liquid. Provided is a fluid control device including at least a support portion that supports a sheath liquid storage unit and a sealed portion that houses the support portion. The support portion is detachable from the sealed portion, and the sealed portion is controlled by pressurization in order to feed sheath liquid stored in the sheath liquid storage unit to a microparticle measurement device.
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3.发明申请公开(公告)号：US20140365159A1
公开(公告)日：2014-12-11
申请号：US14452085
申请日：2014-08-05
Applicant: Sony Corporation
Inventor： Yasunobu Kato , Yoshitsugu Sakai
IPC: G01N21/64
CPC classification number: G01N21/6428 , G01N2021/6421 , G01N2021/6439
Abstract: A fluorescence intensity calculating apparatus, includes a measuring section configured to receive fluorescences generated from plural fluorescent dyes excited by radiating a light to a microparticle multiply-labeled with the plural fluorescent dyes having fluorescence wavelength bands overlapping one another by photodetectors which correspond to different received light wavelength bands, respectively, and whose number is larger than the number of fluorescent dyes, and obtain measured spectra by collecting detected values from the photodetectors, and a calculating section configured to approximate the measured spectra based on a linear sum of single-dyeing spectra obtained from the microparticle individually labeled with the fluorescent dyes, thereby calculating intensities of the fluorescences generated from the fluorescent dyes, respectively.
Abstract translation: 一种荧光强度计算装置，包括测量部分，其被配置为接收由多个荧光染料产生的荧光，该荧光染料被激发，所述荧光染料被多个荧光染料激发，所述微粒被多个荧光染料多个标记，所述荧光染料具有与对应于不同接收光的光电检测器彼此重叠的荧光波长带 波长带，其数量大于荧光染料的数量，并且通过从光电检测器收集检测值来获得测量的光谱，以及计算部件，被配置为基于获得的单染色光谱的线性和近似测量的光谱 从分别用荧光染料标记的微粒分别计算由荧光染料产生的荧光的强度。
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公开(公告)号：US11686662B2
公开(公告)日：2023-06-27
申请号：US17047009
申请日：2019-03-12
Applicant: SONY CORPORATION
Inventor： Yoshitsugu Sakai
IPC: G01N15/14
CPC classification number: G01N15/14 , G01N2015/149
Abstract: There is provided technology that enables a microparticle sorting device to be adjusted highly accurately without using adjustment beads. The present technology provides a microparticle sorting device including a light detection unit that optically detects a microparticle flowing through a flow path, a droplet forming unit that forms a droplet containing the microparticle, and a device adjustment unit that adjusts the device, in which, in a process of adjusting the device before actual measurement of the microparticle, the device adjustment unit performs optical axis position calibration for calibrating a relative position of the flow path relative to irradiation light and delay time calibration for calibrating a delay time from light irradiation to the microparticle to formation of the droplet on the basis of information obtained from the microparticle to be measured.
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公开(公告)号：US11454588B2
公开(公告)日：2022-09-27
申请号：US17142632
申请日：2021-01-06
Applicant: SONY CORPORATION
Inventor： Masaya Kakuta , Koji Futamura , Yoshitsugu Sakai , Yasunobu Kato
Abstract: A fluorescent spectrum correcting method includes comparing fluorescent spectrum obtained from micro-particles labeled with a plurality of fluorescent pigments with reference spectrum to separating the fluorescent spectrum into fluorescent spectrum for each pigment, and previously measured spectrum data is used as the reference spectrum.
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Patent Agency Ranking
公开(公告)号：US10656090B2
公开(公告)日：2020-05-19
申请号：US16295519
申请日：2019-03-07
Applicant: Sony Corporation
Inventor： Yasunobu Kato , Yoshitsugu Sakai
Abstract: A fluorescence intensity calculating apparatus, includes a measuring section configured to receive fluorescences generated from plural fluorescent dyes excited by radiating a light to a microparticle multiply-labeled with the plural fluorescent dyes having fluorescence wavelength bands overlapping one another by photodetectors which correspond to different received light wavelength bands, respectively, and whose number is larger than the number of fluorescent dyes, and obtain measured spectra by collecting detected values from the photodetectors, and a calculating section configured to approximate the measured spectra based on a linear sum of single-dyeing spectra obtained from the microparticle individually labeled with the fluorescent dyes, thereby calculating intensities of the fluorescences generated from the fluorescent dyes, respectively.
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公开(公告)号：US10908075B2
公开(公告)日：2021-02-02
申请号：US16100884
申请日：2018-08-10
Applicant: SONY CORPORATION
Inventor： Masaya Kakuta , Koji Futamura , Yoshitsugu Sakai , Yasunobu Kato
Abstract: A fluorescent spectrum correcting method includes comparing fluorescent spectrum obtained from micro-particles labeled with a plurality of fluorescent pigments with reference spectrum to separating the fluorescent spectrum into fluorescent spectrum for each pigment, and previously measured spectrum data is used as the reference spectrum.
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公开(公告)号：US20170186198A1
公开(公告)日：2017-06-29
申请号：US15460493
申请日：2017-03-16
Applicant: Sony Corporation
Inventor： Yoshitsugu Sakai
CPC classification number: G06T11/206 , G01N15/1463 , G01N21/6428 , G01N21/645 , G01N2021/6421 , G01N2021/6423 , G01N2021/6441 , G06T11/001
Abstract: Disclosed herein is a microparticle analyzing apparatus including a detecting portion configured to simultaneously detect a fluorescence generated from a microparticle in plural wavelength regions and a displaying portion configured to display thereon detection results in the plural wavelength regions in a form of a spectrum.
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公开(公告)号：US20200249166A1
公开(公告)日：2020-08-06
申请号：US16848115
申请日：2020-04-14
Applicant: Sony Corporation
Inventor： Yasunobu Kato , Yoshitsugu Sakai
IPC: G01N21/64
Abstract: A fluorescence intensity calculating apparatus, includes a measuring section configured to receive fluorescences generated from plural fluorescent dyes excited by radiating a light to a microparticle multiply-labeled with the plural fluorescent dyes having fluorescence wavelength bands overlapping one another by photodetectors which correspond to different received light wavelength bands, respectively, and whose number is larger than the number of fluorescent dyes, and obtain measured spectra by collecting detected values from the photodetectors, and a calculating section configured to approximate the measured spectra based on a linear sum of single-dyeing spectra obtained from the microparticle individually labeled with the fluorescent dyes, thereby calculating intensities of the fluorescences generated from the fluorescent dyes, respectively.
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公开(公告)号：US20200173905A1
公开(公告)日：2020-06-04
申请号：US16782383
申请日：2020-02-05
Applicant: Sony Corporation
Inventor： Yuya Suzuki , Fumitaka Otsuka , Masashi Kimoto , Shingo Imanishi , Yoshitsugu Sakai
IPC: G01N15/14
Abstract: The present technology provides a technology for stabilizing break-off timings. Therefore, according to the present technology, there is provided a microparticle analysis device or the like including at least: a flow path in which a fluid including a sample flow containing microparticles and a sheath flow flowing to contain the sample flow; a droplet formation unit configured to form a droplet in the fluid by imparting vibration to the fluid using a vibration element; an electric charge application unit configured to apply electric charge to a droplet containing the microparticles; an imaging unit configured to obtain a photo of a phase of a certain time; and a control unit configured to control a timing at which the droplet breaks off on a basis of the photo.
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