公开(公告)号：US20180020663A1

公开(公告)日：2018-01-25

申请号：US15668390

申请日：2017-08-03

Applicant: University of Florida Research Foundation, Inc. ,  STC.UNM

Inventor： David G. Whitten ,  Harry Craig Pappas ,  Eric H. Hill ,  Kirk S. Schanze ,  Anand Parthasarathy ,  Yun Huang ,  Thomas S. Corbitt

IPC: A01N43/50 ,  A01N33/12 ,  A61L15/46 ,  A01N43/90 ,  A61L15/24 ,  A01N33/08

CPC classification number: A01N43/50 ,  A01N33/08 ,  A01N33/12 ,  A01N43/90 ,  A61L15/24 ,  A61L15/46 ,  A61L2300/404 ,  A61L2420/02 ,  C07D233/64 ,  C07D409/06

Abstract: Various embodiments disclosed relate to conjugated polyelectrolytes and methods of using the same. Various embodiments provide a conjugated polyelectrolyte including a subunit having the structure —R1—Y—R2—Z—. At each occurrence, R1 is independently chosen from 1,4-bonded phenylene substituted by —X—R3—R4 j times and 2,5-bonded thiophene substituted by —X—R3—R4 j times. At each occurrence, Y is independently chosen from a bond and —C≡C—. At each occurrence, R2 is independently chosen from a bond, a substituted or unsubstituted phenylene, thiophenylene, azulenylene, heptalenylene, biphenylene, indacenylene, fluorenylene, phenanthrenylene, triphenylenylene, pyrenylene, naphthacenylene, chrysenylene, biphenylenylene, anthracenylene, and naphthylene. At each occurrence, Z is independently chosen from a bond and —C≡C—. The variables j, R3, and R4 are as defined herein.

公开(公告)号：US20170164614A1

公开(公告)日：2017-06-15

申请号：US15368148

申请日：2016-12-02

Applicant: University of Florida Research Foundation, Inc. ,  STC.UNM

Inventor： David G. Whitten ,  Kirk S. Schanze ,  Eunkyung Ji ,  Dimitri Dascier ,  Anand Parthasarathy ,  Thomas S. Corbitt ,  Kirsten Cicotte ,  Elizabeth LeBleu Dirk ,  Xuzhi Zhu

IPC: A01N43/90 ,  A01N25/34 ,  D01H7/00 ,  A01N33/12 ,  A01N43/10 ,  A61L15/46 ,  A61L15/20

CPC classification number: A01N43/90 ,  A01N25/34 ,  A01N33/12 ,  A01N37/10 ,  A01N43/10 ,  A61L15/20 ,  A61L15/46 ,  A61L2300/208 ,  A61L2300/404 ,  D01H7/00 ,  A01N59/00 ,  A01N2300/00

Abstract: The invention provides methods and materials for decontamination of surfaces and fabrics, such as non-woven fabrics, that are contaminated with infestations of microorganisms such as bacteria. Biocidal oligomers having conjugated oligo-(aryl/heteroaryl ethynyl) structures and comprising at least one cationic group can be used to decontaminate infested surfaces in the presence of oxygen and, optionally, illumination. Fibers incorporating biocidal oligomers having conjugated oligo-(aryl/heteroaryl ethynyl) structures and comprising at least one cationic group, wherein the oligomer is physically associated with or covalently bonded to, or both, the fiber-forming polymer can be used to form non-woven mats. Biocidal non-woven mats prepared by methods of the invention, incorporating the biocidal oligomers, can be used to suppress bacterial growth in wound and surgical dressings and personal hygiene products.