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公开(公告)号：US20150374999A1
公开(公告)日：2015-12-31
申请号：US14844929
申请日：2015-09-03
CPC分类号： A61N1/36139 , A61N1/0551 , A61N1/36071 , A61N1/36167
摘要： A method of applying a neural stimulus with an implanted electrode array involves applying a sequence of stimuli configured to yield a therapeutic effect while suppressing psychophysical side effects. The stimuli sequence is configured such that a first stimulus recruits a portion of the fibre population, and a second stimulus is delivered within the refractory period following the first stimulus and the second stimulus being configured to recruit a further portion of the fibre population. Using an electrode array and suitable relative timing of the stimuli, ascending or descending volleys of evoked responses can be selectively synchronised or desynchronised to give directional control over responses evoked.
摘要翻译： 施加具有植入电极阵列的神经刺激的方法包括施加构造成产生治疗效果同时抑制心理物理副作用的刺激序列。 刺激序列被配置为使得第一刺激物招募纤维群体的一部分，并且第二刺激在第一刺激之后的不应期内递送，并且第二刺激被配置为招募纤维群体的另外部分。 使用电极阵列和刺激的合适的相对定时，诱发反应的上升或下降的波浪可以被选择性地同步或去同步，以对诱发的响应进行方向控制。
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公开(公告)号：US11872387B2
公开(公告)日：2024-01-16
申请号：US17387831
申请日：2021-07-28
发明人： Phil Stallard , John Louis Parker
IPC分类号： A61N1/04
CPC分类号： A61N1/04
摘要： A system adapted for neurostimulation of a patient, using a trial stimulator unit for generating stimulation pulses to targeted tissue in a patient through at least one neurostimulation lead. The trial stimulator unit has at least one receiving connection port adapted to receive at least one lead adapter. The lead adapter has a receiving portion, a sliding portion and a connection port. The receiving portion receives a proximal end of a stimulation lead. The sliding portion couples to the receiving portion. The connection port is adapted to connect to at least one receiving connection port. A case for enclosing the trial stimulator unit and the at least one lead adapter is provided.
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公开(公告)号：US11491334B2
公开(公告)日：2022-11-08
申请号：US17031749
申请日：2020-09-24
发明人： John Louis Parker , James Hamilton Wah , Dean Michael Karantonis , Milan Obradovic , Robert Bruce Gorman
摘要： A method of applying a neural stimulus with an implanted electrode array involves applying a sequence of stimuli configured to yield a therapeutic effect while suppressing psychophysical side effects. The stimuli sequence is configured such that a first stimulus recruits a portion of the fibre population, and a second stimulus is delivered within the refractory period following the first stimulus and the second stimulus being configured to recruit a further portion of the fibre population. Using an electrode array and suitable relative timing of the stimuli, ascending or descending volleys of evoked responses can be selectively synchronised or desynchronised to give directional control over responses evoked.
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公开(公告)号：US20220080211A1
公开(公告)日：2022-03-17
申请号：US17412001
申请日：2021-08-25
IPC分类号： A61N1/375
摘要： A lead anchor (1) to secure a stimulation lead (3) with an internal lead lumen (5), the lead anchor (1) comprising: a first clamp surface (7); a second clamp surface (9) opposed to the first clamp surface (7); and an adjustable fastener (11) to selectively draw the first clamp surface (7) towards the second clamp surface (9) to secure the stimulation lead (3) located between the first clamp surface (7) and the second clamp surface (9), wherein the first clamp surface (7) and the second clamp surface (9) are profiled to apply clamping force (13) to secure the stimulation lead (3) while maintaining an open internal lead lumen (5).
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公开(公告)号：US11129980B2
公开(公告)日：2021-09-28
申请号：US16489908
申请日：2018-03-02
摘要： An electrode assembly (1) for an active implantable medical device comprising: an elongated, biocompatible, electrically non-conductive body (3) having a first portion (7) and a second portion (9); one or more biocompatible, electrically conductive filaments (5) inside the elongated non-conductive body (3) between the first portion (7) and the second portion (9); and one or more fluid passages (11) along the elongated electrically non-conductive body (3) between the first portion (7) and second portion (9), wherein the one or more fluid passages (11) allow a surrounding fluid (13) of a patient to be in electrical contact with the one or more conductive filaments (5). There is also disclosed a method of manufacturing an electrode assembly.
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公开(公告)号：US20210016091A1
公开(公告)日：2021-01-21
申请号：US17031749
申请日：2020-09-24
摘要： A method of applying a neural stimulus with an implanted electrode array involves applying a sequence of stimuli configured to yield a therapeutic effect while suppressing psychophysical side effects. The stimuli sequence is configured such that a first stimulus recruits a portion of the fibre population, and a second stimulus is delivered within the refractory period following the first stimulus and the second stimulus being configured to recruit a further portion of the fibre population. Using an electrode array and suitable relative timing of the stimuli, ascending or descending volleys of evoked responses can be selectively synchronised or desynchronised to give directional control over responses evoked.
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公开(公告)号：US20160166164A1
公开(公告)日：2016-06-16
申请号：US14954529
申请日：2015-11-30
发明人： Milan Obradovic , Tracy Cameron , Robert Bruce Gorman , Nastaran Hesam Shariati , John Louis Parker
CPC分类号： A61B5/04001 , A61B5/407 , A61B5/4836 , A61B5/686 , A61B5/7282 , A61N1/0551 , A61N1/3605
摘要： An implantable device for monitoring for neural injury has a plurality of electrodes including stimulus electrodes and sense electrodes. A stimulus source provides a stimulus to be delivered to a nerve in order to give rise to an evoked action potential. Measurement circuitry records a neural compound action potential signal sensed at the sense electrodes. A stream of control stimuli are applied to the nerve over time and the evoked neural responses are measured. A diagnostic parameter of the measured neural responses is monitored over time, in order to detect a change in the diagnostic parameter. If a change in the diagnostic parameter occurs over time, an indication is output that neural injury has occurred.
摘要翻译： 用于监测神经损伤的可植入装置具有包括刺激电极和感测电极的多个电极。 刺激源提供刺激以递送到神经以引起诱发动作电位。 测量电路记录在感测电极处感测的神经复合动作电位信号。 随着时间的推移，对神经施加控制刺激流，并测量诱发的神经反应。 随着时间的推移监测测量的神经反应的诊断参数，以便检测诊断参数的变化。 如果诊断参数随时间发生变化，则输出发生神经损伤的指示。
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