公开(公告)号：US12064304B2

公开(公告)日：2024-08-20

申请号：US17478455

申请日：2021-09-17

申请人： G & H Technologies, LLC

发明人： Gilbert Fregoso ,  Brad Heckerman ,  Yuval Charles Avniel

IPC分类号： A61C17/20 ,  A61B18/04 ,  A61C1/06 ,  A61C1/07 ,  A61C3/00 ,  A61C5/40 ,  A61C5/50 ,  A61C17/02 ,  A61C17/16 ,  A61C19/06 ,  A61L2/025 ,  A61L2/10 ,  A61L2/14 ,  A61L2/18 ,  A61N1/04 ,  A61N1/05 ,  A61N1/30 ,  A61N1/32 ,  A61N1/44 ,  A61N5/06 ,  A61L2/00 ,  A61L2/22

CPC分类号： A61C17/20 ,  A61B18/042 ,  A61C1/06 ,  A61C1/07 ,  A61C3/00 ,  A61C5/40 ,  A61C5/50 ,  A61C17/0202 ,  A61C17/16 ,  A61C19/063 ,  A61L2/025 ,  A61L2/10 ,  A61L2/14 ,  A61L2/18 ,  A61N1/04 ,  A61N1/0448 ,  A61N1/0548 ,  A61N1/306 ,  A61N1/325 ,  A61N1/44 ,  A61N5/0603 ,  A61B2217/007 ,  A61L2/00 ,  A61L2/0088 ,  A61L2/22 ,  A61L2202/25 ,  A61N2005/0606 ,  A61N2005/0661 ,  F04C2270/0421

摘要： An electrical discharge irrigation includes a power source to produce a first voltage, a circuit coupled to the power source to convert the first voltage to a second voltage, a discharge capacitor to receive the second voltage from the circuit, a transistor and/or a controlled rectifier coupled to the discharge capacitor to receive the second voltage, and an output tip. This tip is coupled to a transistor and/or a controlled rectifier and includes a first end, a second end, a longitudinal axis extending between them, an electrode located in an interior space of the tip to receive an electrical charge from the a transistor and/or a controlled rectifier and to release an electric discharge, and a ground return. The ground return is an outside surface of the tip. A space between the electrode and the ground return holds a conductive medium in contact with the electrode and the ground return.

公开(公告)号：US11973442B2

公开(公告)日：2024-04-30

申请号：US17622822

申请日：2019-11-25

申请人： ZHEJIANG UNIVERSITY

发明人： Jianfeng Ping ,  Chengmei Jiang ,  Yibin Ying

IPC分类号： H02N1/04 ,  A61N1/04 ,  C08J5/18

CPC分类号： H02N1/04 ,  A61N1/04 ,  C08J5/18

摘要： A plant protein-based triboelectric nanogenerator (TENG), and a fabrication method and use thereof are provided. The TENG includes a triboelectric negative layer and a protein film, where the protein film and the triboelectric negative layer are stacked surface-to-surface; and an electrode is adhered to or plated on a back surface of each of the protein film and the triboelectric negative layer, or only a back surface of either of the protein film and the triboelectric negative layer is provided with a grounded electrode. A protein powder is dissolved in water or an ethanol aqueous solution, then a plasticizing agent is added, and the protein is denatured through thermal treatment to obtain an extended structure required for film formation; and the solvent is evaporated, and a resulting product is dried to obtain the protein film with uniform texture and excellent transparency and flexibility. The TENG is used in crop growth.

公开(公告)号：US11794009B2

公开(公告)日：2023-10-24

申请号：US17318110

申请日：2021-05-12

申请人： University of Pittsburgh—Of the Commonwealth System of Higher Education

发明人： Changfeng Tai

IPC分类号： A61N1/36 ,  A61K31/137 ,  A61N1/04 ,  A61N1/372 ,  A61K31/428 ,  A61N1/18 ,  A61K31/435 ,  A61N1/24 ,  A61N1/32 ,  A61K31/381

CPC分类号： A61N1/36007 ,  A61K31/137 ,  A61K31/381 ,  A61K31/428 ,  A61K31/435 ,  A61N1/04 ,  A61N1/0456 ,  A61N1/0484 ,  A61N1/0492 ,  A61N1/18 ,  A61N1/24 ,  A61N1/32 ,  A61N1/3603 ,  A61N1/36021 ,  A61N1/372 ,  A61N1/37264 ,  A61N1/36034

摘要： Provided herein are devices, systems, and methods for treating urological and gastrointestinal disorders, including bedwetting, through stimulation of the dorsal or plantar surface of the foot, including the superficial peroneal nerve and branches thereof, such as the dorsal intermediate and medial cutaneous nerves, or the medial and/or and lateral plantar nerves. The device facilitates placement of electrodes on the foot. Also provided herein is a system including the device, a pulse generator, and a controller, and methods of manufacturing and using the same.

公开(公告)号：US20230329916A1

公开(公告)日：2023-10-19

申请号：US18026870

申请日：2021-09-21

申请人： Case Western Reserve University ,  The United States Government as Represented by The Department of Veteran Affairs

发明人： Dhruv SESHADRI ,  Christian ZORMAN ,  Katherine M. BOGIE

IPC分类号： A61F13/02 ,  A61L15/24 ,  A61F13/00 ,  A61N1/04 ,  A61L15/44

CPC分类号： A61F13/0206 ,  A61L15/24 ,  A61F13/00063 ,  A61N1/04 ,  A61L15/44 ,  A61F2013/00182

摘要： The present disclosure is directed to transparent, flexible substrates and, in particular, moisture-absorbing substrates for use in wound healing and wearable bioelectronics. Substrates of the present application can be formulated and used as wound dressings, electrodes, and electroceutical devices. Advantageously, in some aspects, substrates of the present application can absorb moisture (e.g., wound exudate, apocrine sweat, eccrine sweat), without swelling while also remaining transparent even with moisture absorption. In other aspects, substrates of the present application can be formulated to exhibit superior mechanical and electrical properties for application to a wide array of bioelectronic applications.

公开(公告)号：US11724099B1

公开(公告)日：2023-08-15

申请号：US17888614

申请日：2022-08-16

申请人： Brain Electrophysiology Laboratory Company, LLC

发明人： Don M. Tucker ,  Easwara Moorthy Essaki Arumugam

IPC分类号： A61N1/04

CPC分类号： A61N1/04 ,  A61N1/044 ,  A61B2562/0217

摘要： A semi-dry electrode for a neural sensor net. The electrode may comprise an electrolyte storage medium for storing electrolyte, a body portion including an electrolyte reservoir for receiving the bottom surface of the electrolyte storage medium, a cap connected to the body portion for at least partially covering the top surface of the electrolyte storage medium so as to prevent contact between the top surface of the electrolyte storage medium and a person's finger(s), and a vibrating device for vibrating the electrode so as to release electrolyte from the electrolyte storage medium out through the body portion.

公开(公告)号：US20230173293A1

公开(公告)日：2023-06-08

申请号：US17995229

申请日：2021-04-01

申请人： Regents of the University of Minnesota

发明人： Jian-Ping Wang ,  Renata Saha ,  Diqing Su ,  Kai Wu

IPC分类号： A61N2/02 ,  A61N2/00 ,  A61N1/04

CPC分类号： A61N2/02 ,  A61N2/006 ,  A61N2/002 ,  A61N1/04

摘要： A stimulator includes a support layer, a coil supported by the support layer, the coil extending around a central area, and a plurality of pillars supported by the support layer in the central area.

公开(公告)号：US20170361091A1

公开(公告)日：2017-12-21

申请号：US15539503

申请日：2015-12-21

申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education

发明人： Changfeng Tai

IPC分类号： A61N1/36 ,  A61N1/04 ,  A61K31/381 ,  A61K31/137

CPC分类号： A61N1/36007 ,  A61K31/137 ,  A61K31/381 ,  A61K31/428 ,  A61K31/435 ,  A61N1/04 ,  A61N1/0456 ,  A61N1/0484 ,  A61N1/0492 ,  A61N1/08 ,  A61N1/18 ,  A61N1/24 ,  A61N1/32 ,  A61N1/36014 ,  A61N1/36021 ,  A61N1/372 ,  A61N1/37264

摘要： Provided herein are devices, systems, and methods for treating urological and gastrointestinal disorders, including bedwetting, through stimulation of the dorsal or plantar surface of the foot, including the superficial peroneal nerve and branches thereof, such as the dorsal intermediate and medial cutaneous nerves, or the medial and/or and lateral plantar nerves. The device facilitates placement of electrodes on the foot. Also provided herein is a system including the device, a pulse generator, and a controller, and methods of manufacturing and using the same.

公开(公告)号：US09789329B2

公开(公告)日：2017-10-17

申请号：US15198500

申请日：2016-06-30

申请人： The Research Foundation of the City University of New York

发明人： Zaghloul Ahmed

IPC分类号： A61N2/00 ,  A61N2/02 ,  A61N1/36 ,  A61N1/04 ,  A61N1/20

CPC分类号： A61N2/002 ,  A61N1/04 ,  A61N1/0456 ,  A61N1/205 ,  A61N1/36014 ,  A61N1/36025 ,  A61N2/006 ,  A61N2/02

摘要： Effective systems and methods for improving neural communication impairment of a vertebrate being and affecting motor activity of a peripheral body part including a first signal providing component configured to provide pulsed peripheral stimulation signals at the peripheral body part, a second signal providing component configured to provide a pulsed motor cortex stimulation signal to a motor cortex area, a substantially DC signal providing component configured to provide direct current spinal stimulation signal at a neural spinal junction and a controller component configured to control timing of the pulsed peripheral stimulation signals and the pulsed motor cortex stimulation signal.

公开(公告)号：US20170252486A1

公开(公告)日：2017-09-07

申请号：US15518244

申请日：2015-10-09

申请人： Albert-Ludwigs-Universitat Freiburg

发明人： PRASAD SHASTRI ,  NILS BLUMENTHAL

IPC分类号： A61L27/50 ,  A61L27/36 ,  G01N33/68 ,  A61N1/05 ,  G01N33/50 ,  A61B5/04 ,  A61N1/04

CPC分类号： A61L27/50 ,  A61B5/04 ,  A61B5/04001 ,  A61B5/4082 ,  A61B5/4088 ,  A61L27/3675 ,  A61L2400/12 ,  A61N1/04 ,  A61N1/0531 ,  A61N1/0536 ,  A61N1/0551 ,  G01N33/502 ,  G01N33/5023 ,  G01N33/5058 ,  G01N33/68

摘要： The present invention relates to a neural implant comprising a biomaterial having an outer surface with a stochastic nanoroughness (Rq), and the application of said stochastic nanoroughness in the diagnosis and/or treatment of a neurological disorder, such as, for example, Parkinson's disease, Alzheimer's disease, glioblastoma and/or for disrupting and/or preventing glial scars in the context of mammalian mechanosensing ion channels selected from the family of PIEZO-1 and PIEZO-2 ion channels.

公开(公告)号：US20170224978A1

公开(公告)日：2017-08-10

申请号：US15500308

申请日：2015-07-06

申请人： Y-BRAIN INC.

发明人： Kiwon LEE

IPC分类号： A61N1/04 ,  A61N1/36

CPC分类号： A61N1/0484 ,  A61B5/0531 ,  A61B5/6803 ,  A61B2560/0276 ,  A61N1/04 ,  A61N1/0456 ,  A61N1/0476 ,  A61N1/0492 ,  A61N1/36 ,  A61N1/36014 ,  A61N1/36025 ,  A61N1/3603

摘要： An electrical stimulation device is provided. The electrical stimulation device according to one embodiment of the present inventive concept is worn on the head so as to apply electrical stimulation to the brain, and comprises: a frame to be worn on the head; an electrode structure including an electrode part formed of a conductive member and a cover unit formed of an insulating member covering at least a part of the electrode part, and of which one end is connected to the frame; and a patch detachable from the electrode structure and making contact with the head when attached to the electrode structure.