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公开(公告)号：US12121715B2
公开(公告)日：2024-10-22
申请号：US16489642
申请日：2018-03-01
IPC分类号： A61N1/04 , A61N1/05 , A61N1/375 , B29C64/118 , B29C64/245 , B29C64/295 , B32B3/30 , B32B7/12 , B32B37/12 , B33Y10/00 , B33Y30/00 , B33Y50/02 , B33Y80/00 , H01B1/00 , H05K3/12
CPC分类号： A61N1/0488 , A61N1/05 , B29C64/118 , B29C64/245 , B29C64/295 , B32B3/30 , B32B7/12 , H01B1/00 , H05K3/1241 , A61N1/3752 , B32B2037/1253 , B33Y10/00 , B33Y30/00 , B33Y50/02 , B33Y80/00
摘要： A method (100) of manufacturing a lead for an implantable medical device. The method includes: depositing (110) a base layer (3) of biocompatible, electrically non-conductive material; depositing (120) one or more complementary layers (5) of biocompatible, electrically non-conductive material to the base layer (3), wherein the base layer (3) and complementary layer (5) form at least one slot (7); and depositing (130) biocompatible, electrically conductive material (9) into the slot (7). There is also disclosed a lead for an implantable medical device and an apparatus (41) to manufacture the lead.
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公开(公告)号：US20180117335A1
公开(公告)日：2018-05-03
申请号：US15846069
申请日：2017-12-18
CPC分类号： A61N1/36139 , A61N1/0551 , A61N1/36071 , A61N1/36167
摘要： A method of applying a neural stimulus with an implanted electrode array involves applying a sequence of stimuli configured to yield a therapeutic effect while suppressing psychophysical side effects. The stimuli sequence is configured such that a first stimulus recruits a portion of the fibre population, and a second stimulus is delivered within the refractory period following the first stimulus and the second stimulus being configured to recruit a further portion of the fibre population. Using an electrode array and suitable relative timing of the stimuli, ascending or descending volleys of evoked responses can be selectively synchronised or desynchronised to give directional control over responses evoked.
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公开(公告)号：US20220032039A1
公开(公告)日：2022-02-03
申请号：US17387831
申请日：2021-07-28
发明人： Phil Stallard , John Louis Parker
IPC分类号： A61N1/04
摘要： A system adapted for neurostimulation of a patient, using a trial stimulator unit for generating stimulation pulses to targeted tissue in a patient through at least one neurostimulation lead. The trial stimulator unit has at least one receiving connection port adapted to receive at least one lead adapter. The lead adapter has a receiving portion, a sliding portion and a connection port. The receiving portion receives a proximal end of a stimulation lead. The sliding portion couples to the receiving portion. The connection port is adapted to connect to at least one receiving connection port. A case for enclosing the trial stimulator unit and the at least one lead adapter is provided.
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公开(公告)号：US11420064B2
公开(公告)日：2022-08-23
申请号：US17478793
申请日：2021-09-17
发明人： John Louis Parker , James Hamilton Wah , Dean Michael Karantonis , Milan Obradovic , Robert Bruce Gorman
摘要： A method of applying a neural stimulus with an implanted electrode array involves applying a sequence of stimuli configured to yield a therapeutic effect while suppressing psychophysical side effects. The stimuli sequence is configured such that a first stimulus recruits a portion of the fibre population, and a second stimulus is delivered within the refractory period following the first stimulus and the second stimulus being configured to recruit a further portion of the fibre population. Using an electrode array and suitable relative timing of the stimuli, ascending or descending volleys of evoked responses can be selectively synchronised or desynchronised to give directional control over responses evoked.
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公开(公告)号：US20200001075A1
公开(公告)日：2020-01-02
申请号：US16489908
申请日：2018-03-02
摘要： An electrode assembly (1) for an active implantable medical device comprising: an elongated, biocompatible, electrically non-conductive body (3) having a first portion (7) and a second portion (9); one or more biocompatible, electrically conductive filaments (5) inside the elongated non-conductive body (3) between the first portion (7) and the second portion (9); and one or more fluid passages (11) along the elongated electrically non-conductive body (3) between the first portion (7) and second portion (9), wherein the one or more fluid passages (11) allow a surrounding fluid (13) of a patient to be in electrical contact with the one or more conductive filaments (5). There is also disclosed a method of manufacturing an electrode assembly.
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公开(公告)号：US09872990B2
公开(公告)日：2018-01-23
申请号：US14844929
申请日：2015-09-03
CPC分类号： A61N1/36139 , A61N1/0551 , A61N1/36071 , A61N1/36167
摘要： A method of applying a neural stimulus with an implanted electrode array involves applying a sequence of stimuli configured to yield a therapeutic effect while suppressing psychophysical side effects. The stimuli sequence is configured such that a first stimulus recruits a portion of the fibre population, and a second stimulus is delivered within the refractory period following the first stimulus and the second stimulus being configured to recruit a further portion of the fibre population. Using an electrode array and suitable relative timing of the stimuli, ascending or descending volleys of evoked responses can be selectively synchronised or desynchronised to give directional control over responses evoked.
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公开(公告)号：US20140296737A1
公开(公告)日：2014-10-02
申请号：US14117140
申请日：2012-05-11
CPC分类号： A61B5/40 , A61B5/04001 , A61B5/4029 , A61B5/4836 , A61B5/4893 , A61B5/686 , A61B18/14 , A61N1/0551 , A61N1/3605 , A61N1/36071 , A61N1/36139 , A61N1/36185
摘要： A method for determining a desired location at which to apply a neural therapy. An array of electrodes is positioned proximal to neural tissue. A stimulus is applied from the array which evokes a neural compound action potential response in the neural tissue proximal to the array. A plurality of electrodes of the array simultaneously obtain respective measurements of the neural compound action potential response. From the measurements of the neural compound action potential response a desired location for a neural therapy is determined.
摘要翻译： 一种用于确定应用神经疗法的期望位置的方法。 电极阵列位于神经组织附近。 从阵列中施加刺激，其在靠近阵列的神经组织中引起神经化合物动作电位响应。 阵列的多个电极同时获得神经化合物动作电位响应的各自的测量值。 根据神经化合物动作电位响应的测量，确定神经治疗的期望位置。
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公开(公告)号：US20140288577A1
公开(公告)日：2014-09-25
申请号：US14359777
申请日：2012-11-23
发明人： David Robinson , Mark Fretz , David Thomas , John Louis Parker
IPC分类号： A61N1/05
CPC分类号： A61N1/0553 , Y10T29/49208
摘要： An electrode assembly for an active implantable medical device can be delivered by catheter but expands to become a paddle electrode once implanted. The electrode assembly comprises a support member carrying wires for electrically connecting a control unit to electrodes of the electrode assembly. At least one, and usually two resilient deformable paddle wings are mounted to the support member. The paddle wings can be furled close to the support member under a deformation force to permit implantation via an introducer. The paddle wings resiliently unfurl away from the support member upon release of the deformation force. The paddle wings bear rows and columns of electrodes, and the electrode assembly as a whole has sufficient longitudinal rigidity for implantation via an introducer.
摘要翻译： 用于有源可植入医疗装置的电极组件可以通过导管输送，但一旦植入就膨胀成桨电极。 电极组件包括承载用于将控制单元电连接到电极组件的电极的导线的支撑构件。 至少一个并且通常两个弹性变形的桨翼安装到支撑构件上。 桨翼可以在变形力下靠近支撑构件进行折叠，以允许通过导引器进行植入。 在释放变形力时，桨翼在支撑构件上弹性地展开。 桨翼承载行和列的电极，并且电极组件作为整体具有足够的纵向刚度用于通过导引器进行植入。
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公开(公告)号：US20220023634A1
公开(公告)日：2022-01-27
申请号：US17478793
申请日：2021-09-17
摘要： A method of applying a neural stimulus with an implanted electrode array involves applying a sequence of stimuli configured to yield a therapeutic effect while suppressing psychophysical side effects. The stimuli sequence is configured such that a first stimulus recruits a portion of the fibre population, and a second stimulus is delivered within the refractory period following the first stimulus and the second stimulus being configured to recruit a further portion of the fibre population. Using an electrode array and suitable relative timing of the stimuli, ascending or descending volleys of evoked responses can be selectively synchronised or desynchronised to give directional control over responses evoked.
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公开(公告)号：US20170001017A9
公开(公告)日：2017-01-05
申请号：US14844929
申请日：2015-09-03
CPC分类号： A61N1/36139 , A61N1/0551 , A61N1/36071 , A61N1/36167
摘要： A method of applying a neural stimulus with an implanted electrode array involves applying a sequence of stimuli configured to yield a therapeutic effect while suppressing psychophysical side effects. The stimuli sequence is configured such that a first stimulus recruits a portion of the fibre population, and a second stimulus is delivered within the refractory period following the first stimulus and the second stimulus being configured to recruit a further portion of the fibre population. Using an electrode array and suitable relative timing of the stimuli, ascending or descending volleys of evoked responses can be selectively synchronised or desynchronised to give directional control over responses evoked.
摘要翻译： 施加具有植入电极阵列的神经刺激的方法包括施加构造成产生治疗效果同时抑制心理物理副作用的刺激序列。 刺激序列被配置为使得第一刺激物招募纤维群体的一部分，并且第二刺激在第一刺激之后的不应期内递送，并且第二刺激被配置为招募纤维群体的另外部分。 使用电极阵列和刺激的合适的相对定时，诱发反应的上升或下降的波浪可以被选择性地同步或去同步，以对诱发的响应进行方向控制。
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