公开(公告)号：US20100136126A1

公开(公告)日：2010-06-03

申请号：US12532311

申请日：2008-01-22

申请人： Hee-Yong Lee ,  Eun-Young Seol ,  Joon-Sik Kim ,  Mi-Jin Baek ,  Jung-Soo Kim ,  Ju-Han Lee ,  Yeon-Jin Chae ,  Chae-Jin Lim ,  Mi-Young Baek ,  Ho-Il Choi

发明人： Hee-Yong Lee ,  Eun-Young Seol ,  Joon-Sik Kim ,  Mi-Jin Baek ,  Jung-Soo Kim ,  Ju-Han Lee ,  Yeon-Jin Chae ,  Chae-Jin Lim ,  Mi-Young Baek ,  Ho-Il Choi

IPC分类号： A61K38/16 ,  A61K9/14 ,  A61P3/10

CPC分类号： A61K9/1647 ,  A61K9/0024 ,  A61K9/19 ,  A61K9/5015 ,  A61K9/5026 ,  A61K38/2278 ,  A61K47/26 ,  A61K47/38

摘要： A controlled-release composition and controlled-release microspheres containing an exendin as an active ingredient, and a method of preparing the same are provided. More specifically, a controlled-release composition containing an exendin as an active ingredient, a biodegradable polymer with a specific viscosity, and coating materials, having high bioavailability and showing sustained release of the active ingredient in an effective concentration for a certain period without an excessive initial burst of the active ingredient; controlled-release microspheres containing a core including an exendin as an active ingredient and a biodegradable polymer, and a coating layer coating the core; and a method of preparing controlled-release microspheres including the steps of mixing an exendin, a biodegradable polymer, and a solvent, removing the solvent from the mixture to prepare hardened microspheres, and coating the hardened microspheres to form a coating layer on the surface of each microsphere, are provided.

摘要翻译： 提供含有毒蜥外泌肽作为活性成分的控释组合物和控释微球及其制备方法。 更具体地说，含有毒蜥外泌肽作为活性成分的控释组合物，具有特定粘度的可生物降解的聚合物和具有高生物利用度的涂层材料，并显示有效浓度的有效成分在一定时间内持续释放而不会过度 初步爆发的活性成分; 含有包含毒蜥外泌肽作为活性成分的核心和可生物降解的聚合物的控释微球，以及涂覆该芯的涂层; 以及制备控释微球的方法，包括以下步骤：混合毒蜥外泌素，可生物降解的聚合物和溶剂，从混合物中除去溶剂以制备硬化的微球，并涂覆硬化的微球，以在 提供每个微球。

公开(公告)号：US20060203142A1

公开(公告)日：2006-09-14

申请号：US11369744

申请日：2006-03-08

申请人： Jung-Soo Kim

发明人： Jung-Soo Kim

IPC分类号： G02F1/1333

CPC分类号： G02F1/133308 ,  G02F2201/46

摘要： A liquid crystal display (LCD) device includes an LCD panel, a printed circuit board, and a guide panel which supports the LCD panel and to which the printed circuit board is fixed, wherein the guide panel has at least one rib to hold the printed circuit board.

公开(公告)号：US06847889B2

公开(公告)日：2005-01-25

申请号：US09931781

申请日：2001-08-17

申请人： Sang-Ho Park ,  Be-Young Chung ,  Jung-Soo Kim

发明人： Sang-Ho Park ,  Be-Young Chung ,  Jung-Soo Kim

IPC分类号： G01C21/34 ,  G08G1/0968 ,  G01C21/00

CPC分类号： G08G1/096811 ,  G01C21/36 ,  G01C21/3629 ,  G01C21/3655 ,  G08G1/096844 ,  G08G1/096861 ,  G08G1/096872 ,  G08G1/096883 ,  G08G1/096894

摘要： There is provided a navigation system using a wireless communication system and a route guidance method thereof. In the navigation system, an information center searches out an optimum route between a present vehicle position and a destination referring to map data in its map database and generates route guidance data. A navigation terminal inside the vehicle calculates the present position of the vehicle, transmits the vehicle's current position information to the information center, receives the route guidance data, and announces a notification message. A wireless communication network connects the information center to the navigation terminal wirelessly.

摘要翻译： 提供了使用无线通信系统的导航系统及其路线引导方法。 在导航系统中，信息中心根据其地图数据库中的地图数据来搜索当前车辆位置与目的地之间的最佳路线，并生成路线引导数据。 车辆内的导航终端计算车辆的当前位置，将车辆的当前位置信息发送到信息中心，接收路线引导数据，并通知通知消息。 无线通信网络将信息中心无线连接到导航终端。

公开(公告)号：US4954764A

公开(公告)日：1990-09-04

申请号：US139735

申请日：1987-12-30

申请人： Jung-Soo Kim

发明人： Jung-Soo Kim

IPC分类号： H02M5/293 ,  H02P27/08

CPC分类号： H02P27/08 ,  H02M5/293 ,  H02P27/047 ,  Y02P80/116

摘要： A circuit and method to improve power efficiency of AC induction motors is described for adopting an AC PWM chopper method in power input controls. For a period of several seconds after initially supplying power source voltage, the starting voltage is bypassed by a relay switch to prevent malfunctioning of devices.A PWM waveform is provided by a microcomputer and it is combined with a zero crossing signal of the power source voltage. The combined signal is controlled and buffered by photo couplers, by which power source voltage is controlled with transistors of a power controller unit.A current flow through the motor is detected and store into memory of the microcomputer. In a next sequence, another PWM waveform is provided to again detect other current flow through the motor and its detected value is compared with the previous value store in the memory. These sequences are repeated to search for a minimum current value according to variation of loading on the motor.

摘要翻译： 描述了一种用于提高交流感应电动机功率效率的电路和方法，用于在电力输入控制中采用交流PWM斩波方法。 在最初提供电源电压后的几秒钟内，起动电压由继电器开关旁路，以防止器件发生故障。 PWM波形由微型计算机提供，并与电源电压的过零信号组合。 组合的信号由光耦合器控制和缓冲，由功率控制器单元的晶体管控制电源电压。 检测到通过马达的电流，并存储到微型计算机的存储器中。 在下一个序列中，提供另一个PWM波形，以再次检测通过电机的其他电流，并将其检测值与存储器中的先前值存储进行比较。 重复这些序列以根据电机上的负载变化来搜索最小电流值。

公开(公告)号：US08174353B2

公开(公告)日：2012-05-08

申请号：US12235437

申请日：2008-09-22

申请人： Tae-Hoon Jeong ,  Kyo-Sung Ji ,  Jung-Soo Kim ,  Jung-Hwan Kim ,  Sung-Wook Choi

发明人： Tae-Hoon Jeong ,  Kyo-Sung Ji ,  Jung-Soo Kim ,  Jung-Hwan Kim ,  Sung-Wook Choi

IPC分类号： H01C7/10

CPC分类号： H01C1/022 ,  H01C1/144 ,  H01C7/126

摘要： A varistor comprises a main body having first and second external terminals formed on the outer surface thereof, a first withdrawn terminal plate joined to the first external terminal, and a second withdrawn terminal plate joined to the second external terminal, wherein the melting point of a second bonding material for allowing the second withdrawn terminal plate and the second external terminal to be joined to each other is lower than that of a first bonding material for allowing the first withdrawn terminal plate and the first external terminal to be joined to each other.

摘要翻译： 变阻器包括：主体，其外表面上形成有第一和第二外部端子，与第一外部端子接合的第一引出端子板和与第二外部端子连接的第二抽出端子板，其中熔点 用于使第二取出端子板和第二外部端子彼此接合的第二接合材料低于用于使第一取出端子板和第一外部端子彼此接合的第一接合材料的接合材料。

公开(公告)号：US20090269414A1

公开(公告)日：2009-10-29

申请号：US12429523

申请日：2009-04-24

申请人： Hee-Yong Lee ,  Jung-Soo Kim ,  Eun-Ho Shin ,  Seong-Kyu Kim ,  Eun-Young Seol ,  Mi-Jin Baek ,  Mi-Young Baek ,  Yeon-Jin Chae ,  Ho-Il Choi ,  Ju-Han Lee

发明人： Hee-Yong Lee ,  Jung-Soo Kim ,  Eun-Ho Shin ,  Seong-Kyu Kim ,  Eun-Young Seol ,  Mi-Jin Baek ,  Mi-Young Baek ,  Yeon-Jin Chae ,  Ho-Il Choi ,  Ju-Han Lee

IPC分类号： A61K9/52 ,  A61P43/00

CPC分类号： A61K9/1647 ,  A61K9/1635 ,  A61K9/1694 ,  A61K31/765 ,  A61K38/09 ,  A61K38/31

摘要： Disclosed is a process of preparing sustained release microspheres, containing a biodegradable polymer as a carrier and a drug, using spray drying. The process comprises preparing a solution, suspension or emulsion containing a biodegradable polymer, a drug and a solvent; spray drying the solution, suspension or emulsion; and suspending spray-dried microspheres in an aqueous solution containing polyvinyl alcohol to remove the residual solvent and increase the hydrophilicity of the microsphere surface. The process enables the preparation of microspheres having high drug encapsulation efficiency, almost not having a toxicity problem due to the residual solvent, and having good syringeability. The microspheres prepared according to the present invention release an effective concentration of a drug in a sustained manner for a predetermined period when administered to the body, and are thus useful in the treatment of diseases.

摘要翻译： 公开了一种使用喷雾干燥制备含有可生物降解的聚合物作为载体和药物的缓释微球的方法。 该方法包括制备含有可生物降解的聚合物，药物和溶剂的溶液，悬浮液或乳液; 喷雾干燥溶液，悬浮液或乳液; 并将喷雾干燥的微球悬浮在含有聚乙烯醇的水溶液中以除去残留溶剂并增加微球表面的亲水性。 该方法能够制备具有高药物包封效率的微球，由于残留溶剂几乎不具有毒性问题，并且具有良好的可注射性。 根据本发明制备的微球体在施用于身体时以持续的方式释放药物的有效浓度达预定时间，因此可用于治疗疾病。

公开(公告)号：US20070264341A1

公开(公告)日：2007-11-15

申请号：US11511951

申请日：2006-08-29

申请人： Hee-Yong Lee ,  Jung-Soo Kim ,  Eun-Ho Shin ,  Seong-Kyu Kim ,  Eun-Young Soel ,  Mi-Jin Baek ,  Mi-Young Baek ,  Yeon-Jin Chae ,  Ho-Il Choi

发明人： Hee-Yong Lee ,  Jung-Soo Kim ,  Eun-Ho Shin ,  Seong-Kyu Kim ,  Eun-Young Soel ,  Mi-Jin Baek ,  Mi-Young Baek ,  Yeon-Jin Chae ,  Ho-Il Choi

IPC分类号： A61K9/10

CPC分类号： A61K9/1647 ,  A61K9/1635 ,  A61K9/1694 ,  A61K31/765 ,  A61K38/09 ,  A61K38/31

摘要： Disclosed is a process of preparing sustained release microspheres, containing a biodegradable polymer as a carrier and a drug, using spray drying. The process comprises preparing a solution, suspension or emulsion containing a biodegradable polymer, a drug and a solvent; spray drying the solution, suspension or emulsion; and suspending spray-dried microspheres in an aqueous solution containing polyvinyl alcohol to remove the residual solvent and increase the hydrophilicity of the microsphere surface. The process enables the preparation of microspheres having high drug encapsulation efficiency, almost not having a toxicity problem due to the residual solvent, and having good syringeability. The microspheres prepared according to the present invention release an effective concentration of a drug in a sustained manner for a predetermined period when administered to the body, and are thus useful in the treatment of diseases.

摘要翻译： 公开了一种使用喷雾干燥制备含有可生物降解的聚合物作为载体和药物的缓释微球的方法。 该方法包括制备含有可生物降解的聚合物，药物和溶剂的溶液，悬浮液或乳液; 喷雾干燥溶液，悬浮液或乳液; 并将喷雾干燥的微球悬浮在含有聚乙烯醇的水溶液中以除去残留溶剂并增加微球表面的亲水性。 该方法能够制备具有高药物包封效率的微球，由于残留溶剂几乎不具有毒性问题，并且具有良好的可注射性。 根据本发明制备的微球体在施用于身体时以持续的方式释放药物的有效浓度达预定时间，因此可用于治疗疾病。

公开(公告)号：US20050175693A1

公开(公告)日：2005-08-11

申请号：US10512090

申请日：2003-05-09

申请人： Hee-Yong Lee ,  Jung-Soo Kim ,  Ji-Suk Lee ,  Jung-In Kim ,  Yun-Mi Seo ,  Chae-Jin Lim ,  Sung-Kyu Kim ,  Young-Hwan Jung ,  Seung-Gu Chang ,  Ho-Il Choi

发明人： Hee-Yong Lee ,  Jung-Soo Kim ,  Ji-Suk Lee ,  Jung-In Kim ,  Yun-Mi Seo ,  Chae-Jin Lim ,  Sung-Kyu Kim ,  Young-Hwan Jung ,  Seung-Gu Chang ,  Ho-Il Choi

IPC分类号： A61K9/00 ,  A61K9/16 ,  A61K38/17 ,  A61K9/22 ,  A61K31/737

CPC分类号： A61K9/1617 ,  A61K9/1652

摘要： The present invention relates to a sustained release formulation comprising protein as an active ingredient, and a preparation method thereof. According to the present invention, the sustained release formulation contains protein drugs that are encapsulated in biodegradable hydrophobic matrices as pharmaceutically active forms by forming complexes with sulfated polysaccharides. The sustained release formulation prepared by the present invention can be used to effectively treat a disease without frequent injections by keeping the protein concentration at a sufficiently high level for a long period when injected in vivo once.

摘要翻译： 本发明涉及包含蛋白质作为活性成分的缓释制剂及其制备方法。 根据本发明，持续释放制剂含有通过与硫酸化多糖形成复合物而包封在可生物降解的疏水基质中作为药物活性形式的蛋白质药物。 通过本发明制备的持续释放制剂可以用于通过在体内注射一次时将蛋白质浓度保持在足够高的水平长时间来有效地治疗疾病而不经常注射。

公开(公告)号：US06419125B1

公开(公告)日：2002-07-16

申请号：US09755624

申请日：2001-01-05

申请人： Jung-Soo Kim

发明人： Jung-Soo Kim

IPC分类号： G01F1142

CPC分类号： B05B11/305 ,  B05B11/3001 ,  B05B11/306 ,  B05B11/3067 ,  B05B11/3074 ,  G01F11/028

摘要： A dispenser for transferring a liquid from a container includes a dispenser body having a first end, a second end and an inner surface. The first end has an aperture through which the body is capable of receiving at least a portion of the liquid. A valve stem is slidably disposed within the dispenser body in engagement with the inner surface proximate to the first end for movement between a first position and a second position. The valve stem and the dispenser body are configured to limit the motion of the valve stem between the first and second positions to linear motion. The dispenser may include at least one thread disposed on a generally outwardly facing surface of a dispenser body capable of releasably threadably engaging the nozzle when the nozzle is in the closed position.

摘要翻译： 用于从容器传送液体的分配器包括具有第一端，第二端和内表面的分配器本体。 第一端具有孔，主体能够容纳至少一部分液体。 阀杆可滑动地设置在分配器主体内，与靠近第一端的内表面接合，用于在第一位置和第二位置之间移动。 阀杆和分配器主体被配置为将阀杆在第一和第二位置之间的运动限制为线性运动。 分配器可以包括设置在分配器主体的大致朝外的表面上的至少一个螺纹，当喷嘴处于关闭位置时，其能够可释放地螺纹地接合喷嘴。