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21 条记录 (耗时 0.052 秒)

    Bicyclic derivatives as ppar modulators
    11.
    发明申请
    Bicyclic derivatives as ppar modulators 失效
    双环衍生物作为ppar调节剂

    公开(公告)号：US20070106081A1

    公开(公告)日：2007-05-10

    申请号：US10596322

    申请日：2004-12-16

    申请人： Scott Conner ,  Nathan Mantlo ,  Guoxin Zhu ,  Robert Herr

    发明人： Scott Conner ,  Nathan Mantlo ,  Guoxin Zhu ,  Robert Herr

    IPC分类号： C07D231/56

    CPC分类号： C07D409/12 ,  C07D231/56

    摘要： The present invention is directed to compounds represented by the following structural formula, Formula (I), and stereoisomers, pharmaceutically acceptable salts, solvates and hydrates thereof, wherein: (a) R2 is selected from the group consisting of C0-C8 alkyl and C1-4-heteroalkyl; (b) X is selected from the group consisting of a single bond, O, S, S(O)2 and N; (c) U is an aliphatic linker wherein one carbon atom of the aliphatic linker is optionally replaced with O, NH or S, and wherein such aliphatic linker is optionally substituted with from one to four substituents each independently selected from R30; (d) Y is selected from the group consisting of C, O, S, NH and a single bond; and (e) E is C(R3)(R4)A or A.

    摘要翻译： 本发明涉及由下列结构式（I）表示的化合物及其立体异构体，药学上可接受的盐，溶剂合物和水合物，其中：（a）R2选自C 0〜 C 1 -C 8烷基和C 1-4 - 杂烷基; （b）X选自单键O，S，S（O）2 N和N; （c）U是脂族连接体，其中脂族连接体的一个碳原子任选被O，NH或S取代，并且其中这种脂族连接体任选地被1至4个独立地选自R 30的取代基取代; （d）Y选自C，O，S，NH和单键; 和（e）E是C（R3）（R4）A或A。

    Peroxisome proliferator activated receptor modulators
    12.
    发明申请
    Peroxisome proliferator activated receptor modulators 失效
    过氧化物酶体增殖物激活受体调节剂

    公开(公告)号：US20060084663A1

    公开(公告)日：2006-04-20

    申请号：US10505103

    申请日：2003-02-13

    申请人： Scott Conner ,  Nathan Mantlo ,  Guoxin Zhu

    发明人： Scott Conner ,  Nathan Mantlo ,  Guoxin Zhu

    IPC分类号： A61K31/506 ,  A61K31/501 ,  A61K31/497 ,  A61K31/4439 ,  C07D417/02

    CPC分类号： C07D413/04 ,  C07D263/32 ,  C07D277/24 ,  C07D277/26 ,  C07D413/10 ,  C07D417/04 ,  C07D417/10

    摘要： The present invention is directed to compounds represented by the following structural formula, and pharmaceutically acceptable salts thereof, Formula I: wherein: (a) R5 is selected from the group consisting of (C1-C6) alkyl, (C1-C6) alkenyl, substituted aryl(C0-C4)alkyl, substituted aryloxy(C0-C4)alkyl, substituted arylthio(C0-C4)alkyl, unsubstituted aryl(C0-C4)alkyl, unsubstituted aryloxy(C0-C4)alkyl, and unsubstituted arylthio(C0-C4)alkyl; (b) T1 is C or N; (c) Q is selected from the group consisting of O, a single bond, O(CH2)q and C; (d) q is 1 or 2; (e) W is selected from the group consisting of O, S, (CH2)rN(R20)(CH2)k, NHSO2, C(O)N(R20)(CH2)r, (CH2)rN(R20)C(O), and SO2; (f) X is CmH2m; (g) m is 0, 1 or 2; (h) A is an functional group selected from the group consisting of carboxyl, C1-C3 alkylnitrile, carboxamide, and (CH2)nCOOR19; and (i) R19 is selected from the group consisting of hydrogen, optionally substituted C1-C4alkyl and optionally substituted arylmethyl.

    摘要翻译： 本发明涉及由以下结构式表示的化合物及其药学上可接受的盐，式I：其中：（a）R 5选自（C 1 -C 3） （C 1 -C 6）烷基，（C 1 -C 6 -C 6）链烯基，取代的芳基（C 0 -C 6 - 取代的芳氧基（C 0 -C 4 -C 4烷基）烷基，取代的芳硫基（C 0 -C 4 - 烷基，未取代的芳基（C 0 -C 4 -C 4）烷基，未取代的芳氧基（C 0 -C 4 - 烷基和未取代的芳硫基（C 0 -C 4 -C 4）烷基; （b）T1为C或N; （c）Q选自O，单键，O（CH 2 CH 2）q C和C; （d）q为1或2; （e）W选自O，S，（CH 2）n N（R 20）（CH 2 CH 2） C（O）N（R 20）（CH 2）n），（CH

    Thiophene derivative ppar modulators
    13.
    发明申请
    Thiophene derivative ppar modulators 失效
    噻吩衍生物ppar调节剂

    公开(公告)号：US20060094768A1

    公开(公告)日：2006-05-04

    申请号：US10540330

    申请日：2003-12-31

    申请人： Nathan Mantlo ,  Xiaodong Wang ,  Guoxin Zhu

    发明人： Nathan Mantlo ,  Xiaodong Wang ,  Guoxin Zhu

    IPC分类号： A61K31/381 ,  C07D333/22 ,  A61K31/41 ,  C07D409/02 ,  A01N43/06 ,  A01N43/64 ,  A61K31/38 ,  C07D257/00

    CPC分类号： C07D333/18 ,  C07D333/16

    摘要： The present invention is directed to compounds represented by the following structural formula, Formula I: and stereoisomers, pharmaceutically acceptable salts, solvates and hydrates thereof, wherein: (a) X is selected from the group consisting of O, S, S(O)2, N, and a bond; (b) U is an aliphatic linker wherein one carbon atom of the aliphatic linker may be replaced with O, NH or S, and wherein such aliphatic linker is optionally substituted with R30; (c) Y is selected from the group consisting of C, O, S, NH and a single bond; and (d) E is C(R3)(R4)A or A.

    摘要翻译： 本发明涉及由以下结构式式I表示的化合物及其立体异构体，药学上可接受的盐，溶剂合物和水合物，其中：（a）X选自O，S，S（O） 2，N和键; （b）U是脂族连接体，其中脂族连接体的一个碳原子可被O，NH或S取代，并且其中这种脂族连接基任选被R 30取代; （c）Y选自C，O，S，NH和单键; 和（d）E是C（R3）（R4）A或A。

    Triazole ppar modulators
    18.
    发明申请
    Triazole ppar modulators 失效
    三唑ppar调节剂

    公开(公告)号：US20070112045A1

    公开(公告)日：2007-05-17

    申请号：US10580202

    申请日：2004-12-21

    申请人： Nathan Mantlo ,  Antonio Navarro ,  Ashraf Saeed ,  Douglas Gernert ,  Tianwei Ma ,  Lance Pfeifer

    发明人： Nathan Mantlo ,  Antonio Navarro ,  Ashraf Saeed ,  Douglas Gernert ,  Tianwei Ma ,  Lance Pfeifer

    IPC分类号： A61K31/433 ,  A61K31/4245 ,  A61K31/4196 ,  C07D285/12 ,  C07D271/10 ,  C07D249/08

    CPC分类号： A61K31/4196 ,  A61K31/4245 ,  A61K31/433 ,  C07D249/08 ,  C07D271/107 ,  C07D285/12

    摘要： The present invention is directed to compounds represented by the following structural formula, Formula (I): wherein: (a) X is selected from the group consisting of a single bond, O, S, S(O)2 and N; (b) U is an aliphatic linker; (c) Y is selected from the group consisting of O, C, S, NH and a single bond; (d) W is N, O or S; (e) E is C(R3)(R4)A or A and wherein; (f) A is selected from the group consisting of carboxyl, tetrazole, C1-C6 alkylnitrile, carboxamide, sulfonamide and acylsufonamide. The other substituents are defined in the claims; the compounds are modulators of peroxisome proleferator activated receptors (PPARs) and are useful for the treatment of diabetes and other metabolic disorders.

    摘要翻译： 本发明涉及由下列结构式（I）表示的化合物：其中：（a）X选自单键，O，S，S（O）2， SUB>和N; （b）U是脂族连接体; （c）Y选自O，C，S，NH和单键; （d）W是N，O或S; （e）E是C（R3）（R4）A或A，其中; （f）A选自羧基，四唑，C 1 -C 6烷基腈，甲酰胺，磺酰胺和酰基磺酰胺。 其它取代基在权利要求书中定义; 该化合物是过氧化物酶体促进剂激活受体（PPAR）的调节剂，可用于治疗糖尿病和其他代谢紊乱。