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公开(公告)号：US20070172451A1
公开(公告)日：2007-07-26
申请号：US11548408
申请日：2006-10-11
IPC分类号： A61K38/20
CPC分类号： A61K47/60 , A61K38/20 , A61K38/21 , C07K14/54 , Y02A50/385 , Y02A50/393
摘要： IL-28A, IL-28B, IL-29, and certain mutants thereof have been shown to have antiviral activity on a spectrum of viral species. Of particular interest is the antiviral activity demonstrated on viruses that infect liver, such as hepatitis B virus and hepatitis C virus. In addition, IL-28A, IL-28B, IL-29, and mutants thereof do not exhibit some of the antiproliferative activity on hematopoietic cells that is observed with interferon treatment. Without the immunosuppressive effects accompanying interferon treatment, IL-28A, IL-28B, and IL-29 will be useful in treating immunocompromised patients for viral infections.
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公开(公告)号：US20070128160A1
公开(公告)日：2007-06-07
申请号：US11548417
申请日：2006-10-11
IPC分类号： A61K38/20
CPC分类号： A61K47/60 , A61K38/20 , A61K38/21 , C07K14/54 , Y02A50/385 , Y02A50/393
摘要： IL-28A, IL-28B, IL-29, and certain mutants thereof have been shown to have antiviral activity on a spectrum of viral species. Of particular interest is the antiviral activity demonstrated on viruses that infect liver, such as hepatitis B virus and hepatitis C virus. In addition, IL-28A, IL-28B, IL-29, and mutants thereof do not exhibit some of the antiproliferative activity on hematopoietic cells that is observed with interferon treatment. Without the immunosuppressive effects accompanying interferon treatment, IL-28A, IL-28B, and IL-29 will be useful in treating immunocompromised patients for viral infections.
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公开(公告)号：US20070065402A1
公开(公告)日：2007-03-22
申请号：US11548433
申请日：2006-10-11
IPC分类号： A61K38/20
CPC分类号： A61K47/60 , A61K38/20 , A61K38/21 , C07K14/54 , Y02A50/385 , Y02A50/393
摘要： IL-28A, IL-28B, IL-29, and certain mutants thereof have been shown to have antiviral activity on a spectrum of viral species. Of particular interest is the antiviral activity demonstrated on viruses that infect liver, such as hepatitis B virus and hepatitis C virus. In addition, IL-28A, IL-28B, IL-29, and mutants thereof do not exhibit some of the antiproliferative activity on hematopoietic cells that is observed with interferon treatment. Without the immunosuppressive effects accompanying interferon treatment, IL-28A, IL-28B, and IL-29 will be useful in treating immunocompromised patients for viral infections.
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公开(公告)号：US20070128158A1
公开(公告)日：2007-06-07
申请号：US11539068
申请日：2006-10-05
申请人： Paul Sheppard , Brian Fox , Kevin Klucher , David Taft , Wayne Kindsvogel
发明人： Paul Sheppard , Brian Fox , Kevin Klucher , David Taft , Wayne Kindsvogel
IPC分类号： A61K38/19
CPC分类号： C07K14/715 , A61K38/20 , A61K38/21 , C07K14/56 , C07K16/24 , C07K16/2866 , C07K2317/76 , C12Q2600/158 , Y02A50/473
摘要： The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-α at the amino acid sequence level. The receptor for this protein family is a class II cytokine receptor. The present invention includes methods of reducing viral infections and increasing monocyte counts. The present invention also includes antibodies to the zcyto20 polypeptides, and methods of producing the polynucleotides and polypeptides.
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公开(公告)号：US20070048847A1
公开(公告)日：2007-03-01
申请号：US11539841
申请日：2006-10-09
申请人： SCOTT PRESNELL , Wenfeng Xu , Julia Novak , Theodore Whitmore , Francis Grant , Wayne Kindsvogel , Kevin Klucher
发明人： SCOTT PRESNELL , Wenfeng Xu , Julia Novak , Theodore Whitmore , Francis Grant , Wayne Kindsvogel , Kevin Klucher
IPC分类号： C12P21/04
CPC分类号： C07K14/7155
摘要： Novel methods are disclosed for forming a heterodimeric receptor complex with IL-28R and CRF2-4. The methods may be used for detecting and treating viral infections in in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies, and methods of making antibodies, thereto.
摘要翻译： 公开了与IL-28R和CRF2-4形成异二聚体受体复合物的新方法。 该方法可用于体外和体内检测和治疗病毒感染。 配体结合受体多肽也可用于在体外和体内阻断配体活性。 本发明还包括生产蛋白质的方法，其用途和抗体，以及制备抗体的方法。
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公开(公告)号：US20060063233A1
公开(公告)日：2006-03-23
申请号：US11266626
申请日：2005-11-03
申请人： Paul Sheppard , Brian Fox , Kevin Klucher , David Taft , Wayne Kindsvogel
发明人： Paul Sheppard , Brian Fox , Kevin Klucher , David Taft , Wayne Kindsvogel
IPC分类号： C07K14/705 , C12P21/06
CPC分类号： C07K14/715 , A61K38/20 , A61K38/21 , C07K14/56 , C07K16/24 , C07K16/2866 , C07K2317/76 , C12Q2600/158 , Y02A50/473
摘要： The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-α at the amino acid sequence level. The receptor for this protein family is a class II cytokine receptor. The present invention includes methods of reducing viral infections and increasing monocyte counts. The present invention also includes antibodies to the zcyto20 polypeptides, and methods of producing the polynucleotides and polypeptides.
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公开(公告)号：US20070264685A1
公开(公告)日：2007-11-15
申请号：US11539789
申请日：2006-10-09
申请人： SCOTT PRESNELL , Wenfeng Xu , Julia Novak , Theodore Whitmore , Francis Grant , Wayne Kindsvogel , Kevin Klucher
发明人： SCOTT PRESNELL , Wenfeng Xu , Julia Novak , Theodore Whitmore , Francis Grant , Wayne Kindsvogel , Kevin Klucher
IPC分类号： C07K14/705 , C07H21/04 , C12P21/06
CPC分类号： C07K14/7155
摘要： Novel methods are disclosed for forming a heterodimeric receptor complex with IL-28R and CRF2-4. The methods may be used for detecting and treating viral infections in in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
摘要翻译： 公开了用于与IL-28R和CRF2-4形成异二聚体受体复合物的新方法。 该方法可用于体外和体内检测和治疗病毒感染。 配体结合受体多肽也可用于在体外和体内阻断配体活性。 本发明还包括生产蛋白质的方法，用途及其抗体。
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公开(公告)号：US20070254340A1
公开(公告)日：2007-11-01
申请号：US11539093
申请日：2006-10-05
申请人： Paul Sheppard , Brian Fox , Kevin Klucher , David Taft , Wayne Kindsvogel
发明人： Paul Sheppard , Brian Fox , Kevin Klucher , David Taft , Wayne Kindsvogel
IPC分类号： C12P21/00
CPC分类号： C07K14/715 , A61K38/20 , A61K38/21 , C07K14/56 , C07K16/24 , C07K16/2866 , C07K2317/76 , C12Q2600/158 , Y02A50/473
摘要： The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-α at the amino acid sequence level. The receptor for this protein family is a class II cytokine receptor. The present invention includes methods of reducing viral infections and increasing monocyte counts. The present invention also includes antibodies to the zcyto20 polypeptides, and methods of producing the polynucleotides and polypeptides.
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公开(公告)号：US20070141676A1
公开(公告)日：2007-06-21
申请号：US11539033
申请日：2006-10-05
申请人： Paul Sheppard , Brian Fox , Kevin Klucher , David Taft , Wayne Kindsvogel
发明人： Paul Sheppard , Brian Fox , Kevin Klucher , David Taft , Wayne Kindsvogel
CPC分类号： C07K14/715 , A61K38/20 , A61K38/21 , C07K14/56 , C07K16/24 , C07K16/2866 , C07K2317/76 , C12Q2600/158 , Y02A50/473
摘要： The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-α at the amino acid sequence level. The receptor for this protein family is a class II cytokine receptor. The present invention includes methods of reducing viral infections and increasing monocyte counts. The present invention also includes antibodies to the zcyto20 polypeptides, and methods of producing the polynucleotides and polypeptides.
摘要翻译： 本发明涉及与氨基酸序列水平上与干扰素-α最密切相关的zcyto20，zcyto21，zcyto22，zycto24和zcyto25蛋白的多核苷酸和多肽分子。 该蛋白家族的受体是II类细胞因子受体。 本发明包括减少病毒感染和增加单核细胞计数的方法。 本发明还包括针对zcyto20多肽的抗体，以及产生多核苷酸和多肽的方法。
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公开(公告)号：US20070065401A1
公开(公告)日：2007-03-22
申请号：US11548422
申请日：2006-10-11
IPC分类号： A61K38/20
CPC分类号： A61K47/60 , A61K38/20 , A61K38/21 , C07K14/54 , Y02A50/385 , Y02A50/393
摘要： IL-28A, IL-28B, IL-29, and certain mutants thereof have been shown to have antiviral activity on a spectrum of viral species. Of particular interest is the antiviral activity demonstrated on viruses that infect liver, such as hepatitis B virus and hepatitis C virus. In addition, IL-28A, IL-28B, IL-29, and mutants thereof do not exhibit some of the antiproliferative activity on hematopoietic cells that is observed with interferon treatment. Without the immunosuppressive effects accompanying interferon treatment, IL-28A, IL-28B, and IL-29 will be useful in treating immunocompromised patients for viral infections.
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