公开(公告)号：US20180273517A1

公开(公告)日：2018-09-27

申请号：US15764204

申请日：2016-09-21

Applicant: Senomyx, Inc.

Inventor： Andrew P. Patron ,  Alain Noncovich ,  Timothy Davis ,  Chad Priest ,  Joseph R. Fotsing ,  Jane Ung ,  Catherine Tachdjian

IPC: C07D409/12 ,  A23L33/10 ,  A23L2/52 ,  B65D81/18 ,  B65D65/38

CPC classification number: C07D409/12 ,  A23L2/52 ,  A23L33/10 ,  A23V2002/00 ,  A61K9/0014 ,  A61K31/4155 ,  B65D65/38 ,  B65D81/18

Abstract: The present disclosure relates to compounds which are useful as cooling sensation compounds.

公开(公告)号：US20180220689A1

公开(公告)日：2018-08-09

申请号：US15948282

申请日：2018-04-09

Applicant: SENOMYX, INC.

Inventor： Joseph R. Fotsing

IPC: A23L27/20 ,  C07D413/06 ,  C07D217/16 ,  A23L27/00 ,  C07D413/14 ,  C07D471/04 ,  C07D309/12

CPC classification number: A23L27/2054 ,  A23L27/2056 ,  A23L27/86 ,  C07D217/16 ,  C07D309/12 ,  C07D413/06 ,  C07D413/14 ,  C07D471/04

Abstract: The present invention relates to processes and intermediates for the preparation of compounds of formula (I): or a salt or oxide thereof wherein Alk, M1, M2, R1, R2, R3, R4, R5, R6, R7, and n are as described herein. The present invention also relates to compounds of formula (I) and composition comprising a compound of formula (I). Also disclosed is a method of altering or improving the taste of a composition that includes adding to the composition at least one compound of formula (I), in an amount effective to obtain a modified composition having altered or improved taste relative to an otherwise identical composition lacking said compound.

公开(公告)号：US09695162B2

公开(公告)日：2017-07-04

申请号：US15290691

申请日：2016-10-11

Applicant: SENOMYX, INC.

Inventor： Sara Adamski-Werner ,  Vincent Darmohusodo ,  Catherine Tachdjian ,  Donald Karanewsky ,  Goran Petrovic ,  Rachel Kimmich ,  Joseph R. Fotsing

IPC: C07D417/14 ,  C07D417/12 ,  C07D471/04 ,  C07D473/00 ,  C07D498/04 ,  A23L27/20 ,  A23L33/15

CPC classification number: C07D417/12 ,  A23L27/2056 ,  A23L33/15 ,  A23V2002/00 ,  C07D417/14 ,  C07D471/04 ,  C07D473/00 ,  C07D498/04

Abstract: The present invention includes compounds having structural formula (Ia): or salts or solvates thereof. These compounds are useful as sweet flavor modifiers. The present invention also includes compositions comprising the present compounds and methods of enhancing the sweet taste of compositions.

公开(公告)号：US20170096418A1

公开(公告)日：2017-04-06

申请号：US15282432

申请日：2016-09-30

Applicant: Senomyx, Inc.

Inventor： Andrew P. Patron ,  Alain Noncovich ,  Jane Ung ,  Timothy Davis ,  Joseph R. Fotsing ,  Chad Priest ,  Catherine Tachdjian

IPC: C07D409/12 ,  A61K9/00 ,  A61K31/4155

CPC classification number: C07D409/12 ,  A61K9/0014 ,  A61K31/4155

Abstract: The present disclosure relates to compounds which are useful as cooling sensation compounds.

公开(公告)号：US20170042196A1

公开(公告)日：2017-02-16

申请号：US14823920

申请日：2015-08-11

Applicant: Senomyx, Inc.

Inventor： Stacy Markison ,  Tanya Ditschun ,  Joseph R. Fotsing ,  Nicole Gonsalves ,  Guy Servant

IPC: A01N25/00

CPC classification number: A23L27/45 ,  A23L27/40

Abstract: Provided herein are umami compounds for use as salt-enhancing agents, and for use in enhancing the flavor of reduced sodium products or sodium-free products and increasing the palatability of products that may have reduced sodium content. Also provided herein are methods for modulating the perceived saltiness of a product by adding salt-enhancing compounds to the product.

Abstract translation: 本文提供用作盐增强剂的鲜味化合物，并用于增强还原钠产品或无钠产品的风味，并增加可能具有降低的钠含量的产品的适口性。 本文还提供了通过向产品中加入盐增强化合物来调节产品感觉到的咸味的方法。

公开(公告)号：US09247759B2

公开(公告)日：2016-02-02

申请号：US13896913

申请日：2013-05-17

Applicant: SENOMYX, INC.

Inventor： Donald S. Karanewsky ,  Joseph R. Fotsing ,  Catherine Tachdjian ,  Melissa Arellano

IPC: C07D261/06 ,  C07D413/14 ,  A61K31/44 ,  A61K31/42 ,  A23L1/22 ,  A23L1/226 ,  A61K31/135 ,  A61K31/4439 ,  A61K31/485 ,  A61K31/60 ,  A61K31/704 ,  A61K45/06 ,  A23F5/46

CPC classification number: A23L1/22083 ,  A23F5/465 ,  A23L27/2056 ,  A23L27/86 ,  A61K31/135 ,  A61K31/4439 ,  A61K31/485 ,  A61K31/60 ,  A61K31/704 ,  A61K45/06 ,  A61K2300/00

Abstract: The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds present in, e.g., coffee. Also, the invention relates to the discovery of specific compounds and compositions containing that function as bitter taste blockers and the use thereof as bitter taste blockers or flavor modulators in, e.g., coffee and coffee flavored foods, beverages and medicaments. Also, the present invention relates to the discovery of a compound that antagonizes numerous different human T2Rs and the use thereof in assays and as a bitter taste blocker in compositions for ingestion by humans and animals.

Abstract translation: 本发明涉及T2R味觉受体家族中的特定人味受体对存在于例如咖啡中的特定苦味化合物的反应的发现。 此外，本发明涉及含有作为苦味抑制剂的特定化合物和组合物的发现，以及其作为例如咖啡和咖啡风味食品，饮料和药物中的苦味抑制剂或风味调节剂的用途。 此外，本发明涉及一种拮抗多种不同人类T2R的化合物的发现及其在测定中的用途以及用于摄取人类和动物的组合物中的苦味阻滞剂。