公开(公告)号：US20170183336A1

公开(公告)日：2017-06-29

申请号：US15460103

申请日：2017-03-15

Applicant: Senomyx, Inc.

Inventor： Catherine Tachdjian ,  Donald Karanewsky ,  Sara Werner ,  Vincent Darmohusodo ,  Jeff Yamamoto

IPC: C07D417/12 ,  C07D417/14 ,  A23L27/00

CPC classification number: C07D417/12 ,  A23L2/56 ,  A23L2/60 ,  A23L5/00 ,  A23L7/00 ,  A23L27/88 ,  A23L29/30 ,  A23L29/35 ,  A23V2002/00 ,  C07D417/14 ,  C07D471/04

Abstract: The present invention includes compounds having structural formula (Ia): or salts or solvates thereof. These compounds are useful as sweet flavor modifiers. The present invention also includes compositions comprising the present compounds and methods of modulating the sweet taste of compositions.

公开(公告)号：US20160331013A1

公开(公告)日：2016-11-17

申请号：US15224421

申请日：2016-07-29

Applicant: Senomyx, Inc.

Inventor： Catherine Tachdjian ,  Donald Karanewsky ,  Sara Werner ,  Vincent Darmohusodo ,  Jeff Yamamoto

IPC: A23L27/00 ,  C07D417/14 ,  C07D471/04 ,  C07D417/12

CPC classification number: C07D417/12 ,  A23L2/56 ,  A23L2/60 ,  A23L5/00 ,  A23L7/00 ,  A23L27/88 ,  A23L29/30 ,  A23L29/35 ,  A23V2002/00 ,  C07D417/14 ,  C07D471/04

Abstract: The present invention includes compounds having structural formula (Ia): or salts or solvates thereof. These compounds are useful as sweet flavor modifiers. The present invention also includes compositions comprising the present compounds and methods of modulating the sweet taste of compositions.

Abstract translation: 或其盐或溶剂合物。 这些化合物可用作甜味调味剂。 本发明还包括包含本发明化合物的组合物和调节组合物甜味的方法。

公开(公告)号：US09475803B2

公开(公告)日：2016-10-25

申请号：US14768167

申请日：2014-02-19

Applicant: Senomyx, Inc.

Inventor： Sara Adamski-Werner ,  Vincent Darmohusodo ,  Catherine Tachdjian ,  Donald Karanewsky ,  Goran Petrovic ,  Rachel Kimmich ,  Joseph Fotsing

IPC: C07D417/14 ,  C07D417/12 ,  A23L1/226 ,  A23L1/302 ,  C07D471/04 ,  C07D473/00 ,  C07D498/04

CPC classification number: C07D417/12 ,  A23L27/2056 ,  A23L33/15 ,  A23V2002/00 ,  C07D417/14 ,  C07D471/04 ,  C07D473/00 ,  C07D498/04

Abstract: The present invention includes compounds having structural formula (Ia): or salts or solvates thereof. These compounds are useful as sweet flavor modifiers. The present invention also includes compositions comprising the present compounds and methods of enhancing the sweet taste of compositions.

公开(公告)号：US20160251372A1

公开(公告)日：2016-09-01

申请号：US15059142

申请日：2016-03-02

Applicant: SENOMYX, INC.

Inventor： Catherine Tachdjian ,  Xiao Qing Tang ,  Donald S. Karanewsky ,  Guy Servant ,  Xiaodong Li ,  Feng Zhang ,  Qing Chen ,  Hong Zhang ,  Timothy Davis ,  Vincent Darmohusodo ,  Melissa Wong ,  Victor Selchau

IPC: C07D495/04 ,  A61K47/22 ,  A23L2/56 ,  C07D401/12 ,  C07D405/12 ,  C07D215/54 ,  C07D471/04

CPC classification number: C07D495/04 ,  A23L2/56 ,  A23L27/2054 ,  A23L27/88 ,  A23V2002/00 ,  A61K47/22 ,  C07D215/54 ,  C07D215/60 ,  C07D401/12 ,  C07D405/12 ,  C07D471/04 ,  C07D491/048

Abstract: The present invention includes compounds having structural formula (I), or pharmaceutically acceptable salts, solvate, and/or ester thereof. These compounds are useful as sweet flavor modifiers. The present invention also includes compositions comprising the present compounds and methods of enhancing the sweet taste of ingestible compositions. Furthermore, the present invention provides methods for preparing the compounds.

公开(公告)号：US20150265711A1

公开(公告)日：2015-09-24

申请号：US14731224

申请日：2015-06-04

Applicant: SENOMYX, INC.

Inventor： Catherine Tachdjian ,  Xiao Qing Tang ,  Donald S. Karanewsky ,  Guy Servant ,  Xiaodong Li ,  Feng Zhang ,  Qing Chen ,  Hong Zhang ,  Timothy Davis ,  Vincent Darmohusodo ,  Melissa Wong ,  Victor Selchau

IPC: A61K47/22 ,  A23L2/56 ,  A23L1/226

CPC classification number: C07D495/04 ,  A23L2/56 ,  A23L27/2054 ,  A23L27/88 ,  A23V2002/00 ,  A61K47/22 ,  C07D215/54 ,  C07D215/60 ,  C07D401/12 ,  C07D405/12 ,  C07D471/04 ,  C07D491/048

Abstract: The present invention includes compounds having structural formula (I), or pharmaceutically acceptable salts, solvate, and/or ester thereof. These compounds are useful as sweet flavor modifiers. The present invention also includes compositions comprising the present compounds and methods of enhancing the sweet taste of ingestible compositions. Furthermore, the present invention provides methods for preparing the compounds.

Abstract translation: 本发明包括具有结构式（I）的化合物或其药学上可接受的盐，溶剂化物和/或酯。 这些化合物可用作甜味调味剂。 本发明还包括包含本发明化合物的组合物和增强可摄入组合物的甜味的方法。 此外，本发明提供了制备化合物的方法。

公开(公告)号：US10392371B2

公开(公告)日：2019-08-27

申请号：US15764204

申请日：2016-09-21

Applicant: Senomyx, Inc.

Inventor： Andrew P. Patron ,  Alain Noncovich ,  Timothy Davis ,  Chad Priest ,  Joseph R. Fotsing ,  Jane Ung ,  Catherine Tachdjian

IPC: C07D409/12 ,  A61K9/00 ,  A61K31/4155 ,  A23L33/10 ,  A23L2/52 ,  B65D65/38 ,  B65D81/18

Abstract: Provided herein are compounds which are useful as cooling sensation compounds.

公开(公告)号：US20190177308A9

公开(公告)日：2019-06-13

申请号：US15764204

申请日：2016-09-21

Applicant: Senomyx, Inc.

Inventor： Andrew P. Patron ,  Alain Noncovich ,  Timothy Davis ,  Chad Priest ,  Joseph R. Fotsing ,  Jane Ung ,  Catherine Tachdjian

IPC: C07D409/12 ,  A23L33/10 ,  A23L2/52 ,  B65D81/18 ,  B65D65/38

CPC classification number: C07D409/12 ,  A23L2/52 ,  A23L33/10 ,  A23V2002/00 ,  A61K9/0014 ,  A61K31/4155 ,  B65D65/38 ,  B65D81/18

Abstract: The present disclosure relates to compounds which are useful as cooling sensation compounds.

公开(公告)号：US10308621B2

公开(公告)日：2019-06-04

申请号：US16119380

申请日：2018-08-31

Applicant: Senomyx, Inc.

Inventor： Catherine Tachdjian ,  Donald S. Karanewsky ,  Xiao-Qing Tang ,  Qing Chen ,  Peter Leeming ,  Tayyab Rashid ,  Daniel Levin

IPC: C07D285/16 ,  C01B21/096 ,  C07C235/20 ,  C07C237/44 ,  C07C255/54 ,  C07C255/59 ,  C07C307/10 ,  C07C231/02 ,  C07C231/14 ,  C07C253/30 ,  C07C255/57 ,  C07C303/40

Abstract: The present invention includes methods/processes and intermediates for preparing sulfamoyl chloride:

公开(公告)号：US09834544B2

公开(公告)日：2017-12-05

申请号：US14337764

申请日：2014-07-22

Applicant: SENOMYX, INC.

Inventor： Catherine Tachdjian ,  Xiao Qing Tang ,  Donald S. Karanewsky ,  Guy Servant ,  Xiaodong Li ,  Feng Zhang ,  Qing Chen ,  Hong Zhang ,  Timothy James Davis ,  Vincent Darmohusodo ,  Melissa S. Wong ,  Victor Selchau

IPC: C07D405/12 ,  A23L2/60 ,  C07D401/12 ,  C07D215/54 ,  C07D451/06 ,  A61K47/22 ,  C07D215/42 ,  A23L27/00

CPC classification number: C07D405/12 ,  A23L2/60 ,  A23L27/88 ,  A23V2002/00 ,  A61K47/22 ,  C07D215/42 ,  C07D215/54 ,  C07D401/12 ,  C07D451/06

Abstract: The present invention includes compounds having structural formula (I), or salts or solvates thereof. These compounds are useful as sweet flavor modifiers. The present invention also includes compositions comprising the present compounds and methods of enhancing the sweet taste of compositions.

公开(公告)号：US20170327479A1

公开(公告)日：2017-11-16

申请号：US15664179

申请日：2017-07-31

Applicant: Senomyx, Inc.

Inventor： Catherine Tachdjian ,  Donald S. Karanewsky ,  Xiao-Qing Tang ,  Qing Chen ,  Peter Leeming ,  Tayyab Rashid ,  Daniel Levin

IPC: C07D285/16 ,  C07C303/40 ,  C07C255/59 ,  C07C255/57 ,  C07C253/30 ,  C01B21/096 ,  C07C237/44 ,  C07C235/20 ,  C07C231/14 ,  C07C231/02 ,  C07C307/10 ,  C07C255/54

CPC classification number: C07D285/16 ,  C01B21/096 ,  C07C231/02 ,  C07C231/14 ,  C07C235/20 ,  C07C237/44 ,  C07C253/30 ,  C07C255/54 ,  C07C255/57 ,  C07C255/59 ,  C07C303/40 ,  C07C307/10

Abstract: The present invention includes methods/processes and intermediates for preparing compounds having structural Formula (I): wherein X is alkyl, substituted alkyl, alkenyl, substituted alkenyl, heteroalkyl, substituted heteroalkyl, heteroalkenyl, or substituted heteroalkenyl.