摘要:
The present invention relates to a compound represented by the general formula (I): wherein m1 and m2 are 1, 2, or 3; n1 and n2 are 0 or 1; i is an integer of any of 1 to m1; j is an integer of 1 to m2; R is aryl, heteroaryl, or cycloalkyl any of which may be substituted; Rai and Rai′ is hydrogen atom, etc. and Rbj and Rbj′ is hydrogen atom, etc.; Rc, Rd, and Re are hydrogen atom, etc; X1 is CH, CX1a, or N; X2 is CH, N, etc.; X3 is CH, N, etc.; X4 is CH or N; Y1, Y2, and Y3 are each independently CH or N; Z1 and Z2 are each independently CH or N; W is a 5-membered aromatic heterocyclic group such as pyrazolyl, thiazolyl, etc., or a pharmaceutically acceptable salt or ester thereof; a pharmaceutical composition or antitumor agent containing the same; and combinations of the antitumor agent with other antitumor agent(s).
摘要翻译:本发明涉及由通式(I)表示的化合物:其中m 1和m 2是1,2或3; n 1和n 2是0或1; i是1〜m1的任一个的整数; j为1〜m 2的整数; R是芳基,杂芳基或环烷基,其中任一个可以被取代; R a a和R a'是氢原子等,R bj和R b'是氢原子 等等 R c,R d和R e是氢原子等; X 1是CH,CX 1a,或N; X 2是CH,N等; X 3是CH,N等; X 4是CH或N; Y 1,Y 2和Y 3各自独立地为CH或N; Z 1和Z 2各自独立地为CH或N; W是5元芳族杂环基,例如吡唑基,噻唑基等,或其药学上可接受的盐或酯; 含有它们的药物组合物或抗肿瘤剂; 以及抗肿瘤剂与其它抗肿瘤剂的组合。
摘要:
An organic electroluminescent device comprising a light-emitting layer between a pair of electrodes, the light-emitting layer comprising a mixture of a hole-transporting material consisting of a tertiary amine compound, an electron-transporting material and a light-emitting additive material, in which the tertiary amine compound has two or more oxidation potentials determined by a cyclic voltammetry wherein a potential difference between the first oxidation potential and the second oxidation potential in the oxidation potentials is 0.22V or more, and a glass transition temperature of at least 100° C., and the electron-transporting material has a glass transition temperature of at least 100° C.
摘要:
Provided are cycloalkanopyridine derivatives of formula [I]: [wherein the symbols are the same as those stated in the description]. The compounds act as a nociceptin receptor antagonist, and are useful as medicines for diseases associated with a nociceptin receptor, for example, as a reliever against tolerance to a narcotic analgesic; a reliever against dependence on or addiction to a narcotic analgesic; an analgesic enhancer; an antiobesitic or appetite suppressor; a treating or prophylactic agent for cognitive impairment and dementia/amnesia; an agent for treating developmental cognitive abnormality; a remedy for schizophrenia; an agent for treating neurodegenerative diseases; an anti-depressant or treating agent for affective disorder; a treating or prophylactic agent for diabetes insipidus; a treating or prophylactic agent for polyuria; or a remedy for hypotension.
摘要:
Buffer control means and output control means are included within a buffering apparatus. Data longer than the width of data bus is read by single access from buffer means. Rather than signal line control for each bus width, signal line control for each data group is performed by a method wherein address administration means holds address information in relationship with each group of a series of data written in the buffer means and data is output from the buffer means.
摘要:
An image reading apparatus includes: a reading table having a transparent plate having an exposed area which constitutes a part of an outer surface of the table exposed to the exterior, and on which a document with an image thereon is placed; a document holding member movable relative to the table and between a closed and an open position, and thus holding the document and covering the plate; a scanning device disposed on a side of the plate opposite to the side on which the document is placed on the plate, the scanning device being reciprocated in a direction along the plate; an image reading device mounted in the scanning device and including a light source, the reading device emitting light from the light source toward the document on the plate, and receiving the reflected light from the document, to read the image thereby; a control unit controlling reading by the reading device, and a reciprocating movement of the scanning device; a reference member disposed within the exposed area, and used as a reference when an amount of the light emitted from the light source is adjusted; and an external-light detector determining whether external light is entering the table, based on at least one value obtained as a result of reading the reference member.
摘要:
An evaporated fuel adsorbing apparatus for an engine intake passage includes a layer of activated carbon disposed in the engine intake passage for adsorbing evaporated fuel. The activated carbon includes activated carbon pellets having pores. At least one of an average pellet size and an average pore size of the activated carbon is varied in an intake gas flow direction of the engine intake passage. More particularly, an average pore size of a first portion of the activated carbon located in an atmosphere side portion of the layer is greater than an average pore size of a second portion of the activated carbon located in an engine side of the layer. An average pellet size of the first portion of the activated carbon is smaller than an average pellet size of the second portion of the activated carbon.
摘要:
An organic electroluminescent device comprising a light-emitting layer between a pair of electrodes, the light-emitting layer comprising a mixture of a hole-transporting material consisting of a tertiary amine compound, an electron-transporting material and a light-emitting additive material, in which the tertiary amine compound has two or more oxidation potentials determined by a cyclic voltammetry wherein a potential difference between the first oxidation potential and the second oxidation potential in the oxidation potentials is 0.22V or more, and a glass transition temperature of at least 100° C., and the electron-transporting material has a glass transition temperature of at least 100° C.
摘要:
A facsimile apparatus capable of preventing the loss received information even if there is a possibility of a print failure. The facsimile apparatus has a reception memory that stores the data received, a print executing unit that prints, on a recording sheet, the data stored in the reception memory, and a print-failure determining unit that determines whether there is a possibility that a print failure will occur if the print executing unit performs printing. If it is determined that there is the possibility of the print failure, a print stopping unit stops execution of printing by the print executing unit, and a data retaining unit retains the data stored in the reception memory, even after the data has been printed out by a forced printing function. More specifically, if a determination cannot be made regarding a paper jam or an ink shortage due to, for example, strong external light coming in, or if it is determined that there is a print failure, the apparatus does not start printing, but displays a message “RECEIVED . . . ”, and retains the received data in the reception memory. The forced-printing of the data can be performed by operating a start switch. The received data thus retained can be maintained even after the forced printing, and is erased only when a reset instruction is input.
摘要:
An engine-driven breaker which is capable of providing a breaking force equal to that of a hydraulic or pneumatic breaker even with a small engine and which is small and light and easy to handle and has a simple construction enabling it to be manufactured cheaply. The engine-driven breaker has a breaker main body and a cylinder fixed inside the breaker main body and inside the cylinder an upper air chamber of variable volume is provided between an operating piston and a hammer piston and a lower air chamber of variable volume is provided below the hammer piston. An annular air passage connected by way of a throttling passage to a crank chamber housing a crank mechanism driving the operating piston is provided between the outer peripheral wall of the cylinder and the inside wall of the breaker main body, and first air holes and second air holes are provided in the cylinder wall passing through to the annular air passage in a position corresponding to a bottom dead center position of the hammer piston and in a position below that respectively. Upper air holes for connecting the upper air chamber and the crank chamber are also provided in the cylinder wall in the crank chamber just below a top dead center position of the operating piston.
摘要:
A controller of a base station supervises radio communication between the base station and a plurality of personal stations of which a respective one has preset functions of which a description data is stored in a registering section of the base station so that, when an arbitrary personal station is operated into an off-hook state in response to a call it has received from a call sending station, the controller reads the description data of the functions of the personal station in the off-hook state and sends the read data to the call sending station, where it is processed to display a description of the functions before sending back a message of a complete display to the base station, where the controller responds thereto for connecting the personal station in the off-hook state for a talk with the call sending station.