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公开(公告)号：US20050085408A1
公开(公告)日：2005-04-21
申请号：US10492482
申请日：2002-10-11
申请人： Shinji Yokoyama , Reijiro Arakawa
发明人： Shinji Yokoyama , Reijiro Arakawa
IPC分类号： A61K31/00 , A61K38/00 , A61K38/05 , A61K38/55 , A61K38/56 , A61K38/57 , A61P3/06 , A61P9/10 , A61P43/00 , A61K38/04
摘要： The present invention is to provide an agent for low HDL-cholesterolemia, a prophylactic and/or therapeutic antiarteriosclerosis agent as well as a method for preventing and treating low HDL-cholesterolemia, arteriosclerosis and their related diseases or disorders, with emphasis given to improvement in HDL, without resorting to genetic engineering technology. Further, the present invention is to provide a clinically effective agent for low HDL-cholesterolemia and a prophylactic and/or therapeutic antiarteriosclerosis agent, comprising at least one cysteine protease inhibitor as an active ingredient, thereby increasing a quantity of expressed ABCA1 and elevating blood HDL levels, without using the genetic engineering technology.
摘要翻译： 本发明提供低HDL-胆固醇血症药物，预防和/或治疗性抗动脉硬化药物以及预防和治疗低HDL-胆固醇血症，动脉硬化及其相关疾病或病症的方法，其重点在于改善 HDL，而不诉诸基因工程技术。 此外，本发明提供一种低HDL-胆固醇血症的临床有效药剂和包含至少一种半胱氨酸蛋白酶抑制剂作为活性成分的预防和/或治疗性抗动脉硬化剂，从而增加表达的ABCA1的量和提高血液HDL 水平，不使用遗传工程技术。
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12.发明授权1.alpha.,25-dihydroxyvitamin D4 compounds, ergosta-5,7-diene compounds and processes for the preparation thereof 失效1（ALPHA），25-二羟基维生素D4化合物，ERGOSTA-5,7-二烯化合物及其制备方法
公开(公告)号：US5157135A
公开(公告)日：1992-10-20
申请号：US496862
申请日：1990-03-21
申请人： Masahiro Tsuji , Yoji Tachibana , Shinji Yokoyama , Nobuo Ikekawa
发明人： Masahiro Tsuji , Yoji Tachibana , Shinji Yokoyama , Nobuo Ikekawa
IPC分类号： A61K31/59 , A61P3/02 , C07C401/00 , C07J9/00 , C07J71/00
CPC分类号： C07J9/00 , C07C401/00 , C07J71/0042
摘要： (24S)- and (24R)-1.alpha.,25-Dihydroxyvitamin D.sub.4 compounds and processes for preparing same. Ergosta-5,7-diene compounds which are useful intermediates in the synthesis of the 1.alpha.,25-dihydroxyvitamin D.sub.4 compounds. The D.sub.4 compounds are expected to possess an interesting pharmacological activity in association with the active-type vitamins D.sub.3 and D.sub.2.
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公开(公告)号：US20130317832A1
公开(公告)日：2013-11-28
申请号：US13983132
申请日：2012-01-24
申请人： Shinji Yokoyama
发明人： Shinji Yokoyama
IPC分类号： G10L19/00
CPC分类号： G10L19/0017 , G10L19/00 , H04J3/0632 , H04J3/0685 , H04W52/029 , Y02D70/00
摘要： An audio frame timing correction method and a wireless device are provided. A controller generates a reference clock for audio coding/decoding such that the reference clock runs fast and moved forward within an audio data sampling interval with the remaining time becoming a margin of the interval. An audio codec decodes demodulated data based on the reference clock, and codes an audio signal based on the reference clock. A demodulator detects wireless frame deviation and determines an adjustment timing whereat the wireless frame symbol timing and the audio frame timing are corrected based on the deviation and the margin. Upon the adjustment timing, the controller synchronizes audio sampling timing with the wireless frame symbol timing.
摘要翻译： 提供了音频帧定时校正方法和无线设备。 控制器生成用于音频编码/解码的参考时钟，使得参考时钟在音频数据采样间隔内快速运行并向前移动，其余时间成为间隔的余量。 音频编解码器基于参考时钟解码解调数据，并且基于参考时钟对音频信号进行编码。 解调器检测无线帧偏差，并且基于偏差和余量确定校正无线帧符号定时和音频帧定时的调整定时。 在调整定时时，控制器将音频采样定时与无线帧符号定时同步。
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公开(公告)号：US08554449B2
公开(公告)日：2013-10-08
申请号：US12912271
申请日：2010-10-26
CPC分类号： F02D41/345 , F02D41/0025 , F02D41/009 , F02M69/044 , Y02T10/44
摘要： A fuel injection control apparatus for controlling a fuel injection valve including an arithmetic processing section that determines whether a necessary fuel amount is injectable or not within a fuel injectable range from a first fuel injection start timing, computes a second fuel injection start timing in which the necessary fuel amount is injectable within the fuel injectable range in the case that it is not injectable, and controls the fuel injection valve at the computed second fuel injection start timing so as to start fuel injection.
摘要翻译： 一种燃料喷射控制装置，用于控制包括运算处理部分的燃料喷射阀，所述运算处理部根据第一燃料喷射开始定时确定在燃料可喷射范围内是否可喷射必要的燃料量，计算第二燃料喷射开始定时， 在不可喷射的情况下，在燃料可喷射范围内注入必要的燃料量，并且在所计算的第二燃料喷射开始时刻控制燃料喷射阀以开始燃料喷射。
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公开(公告)号：US07976262B2
公开(公告)日：2011-07-12
申请号：US11359531
申请日：2006-02-23
申请人： Shinji Yokoyama
发明人： Shinji Yokoyama
IPC分类号： B65B21/02
CPC分类号： H01L21/67772
摘要： This invention relates to a FOUP opener in which a FOUP is placed and the FOUP door of the FOUP can be detached so as to allow access to the interior of the FOUP. The FOUP opener includes a port door having an attaching/detaching mechanism for attaching and detaching the FOUP door and a holding mechanism for holding the FOUP door to be detached, and a port door moving unit for moving said port door holding the FOUP door so as that the FOUP is opened. The port door has a main structure in which said attaching/detaching mechanism is arranged and a surface panel to cover said main structure. The surface panel is detachable from said main structure at a front side of the FOUP opener.
摘要翻译： 本发明涉及一种FOUP开启装置，其中FOUP被放置并且FOUP的FOUP门可以被拆卸，以允许进入FOUP的内部。 该FOUP开启装置包括具有用于安装和拆卸FOUP门的安装/拆卸机构的端口门和用于保持要拆卸的FOUP门的保持机构，以及用于移动保持FOUP门的端口门的端口门移动单元，以便 FOUP打开了。 端口门具有安装/拆卸机构布置的主要结构和覆盖所述主体结构的表面板。 在FOUP开启器的前侧，表面板可从所述主结构拆卸。
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公开(公告)号：US07666900B2
公开(公告)日：2010-02-23
申请号：US10586338
申请日：2004-12-22
申请人： Shinji Yokoyama , Maki Tsujita , Reijiro Arakawa , Tomoji Aotsuka
发明人： Shinji Yokoyama , Maki Tsujita , Reijiro Arakawa , Tomoji Aotsuka
CPC分类号： A61K31/385 , A61K31/05 , A61K31/122 , Y10S514/824
摘要： To provide a pharmaceutically effective prophylactic/preventive agent for low-HDL cholesterolemia, focusing on an HDL-generating mechanism. The ABCA1 stabilizer of the present invention contains a bisphenol-type compound selected form probucol spiroquinone, probucol diphenoquinone, and probucol bisphenol as an effective ingredient. The ABCA1 stabilizer can continuously and stably express ABCA1 by a mechanism quite different from that of conventional processes, and thus is useful as prophylactic/preventive agent for low-HDL cholesterolemia or arteriosclerosis.
摘要翻译： 提供用于低HDL胆固醇血症的药学上有效的预防/预防药物，重点是HDL生成机制。 本发明的ABCA1稳定剂含有选自普罗布考螺醌，普罗布考二苯醌和普罗布考双酚作为有效成分的双酚型化合物。 ABCA1稳定剂可以通过与常规方法完全不同的机制连续稳定地表达ABCA1，因此可用作低HDL胆固醇血症或动脉硬化的预防/预防剂。
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公开(公告)号：US20070010456A1
公开(公告)日：2007-01-11
申请号：US11520626
申请日：2006-09-14
申请人： Shinji Yokoyama , Reijiro Arakawa
发明人： Shinji Yokoyama , Reijiro Arakawa
摘要： The present invention is to provide an agent for low HDL-cholesterolemia, a prophylactic and/or therapeutic antiarteriosclerosis agent as well as a method for preventing and treating low HDL-cholesterolemia, arteriosclerosis and their related diseases or disorders, with emphasis given to improvement in HDL, without resorting to genetic engineering technology. Further, the present invention is to provide a clinically effective agent for low HDL-cholesterolemia and a prophylactic and/or therapeutic antiarteriosclerosis agent, comprising at least one cysteine protease inhibitor as an active ingredient, thereby increasing a quantity of expressed ABCA1 and elevating blood HDL levels, without using the genetic engineering technology.
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公开(公告)号：US20060245849A1
公开(公告)日：2006-11-02
申请号：US11359531
申请日：2006-02-23
申请人： Shinji Yokoyama
发明人： Shinji Yokoyama
IPC分类号： H01L21/677
CPC分类号： H01L21/67772
摘要： This invention relates to a FOUP opener in which a FOUP is placed and the FOUP door of the FOUP can be detached so as to allow access to the interior of the FOUP. The FOUP opener includes a port door having an attaching/detaching mechanism for attaching and detaching the FOUP door and a holding mechanism for holding the FOUP door to be detached, and a port door moving unit for moving said port door holding the FOUP door so as that the FOUP is opened. The port door has a main structure in which said attaching/detaching mechanism is arranged and a surface panel to cover said main structure. The surface panel is detachable from said main structure at a front side of the FOUP opener.
摘要翻译： 本发明涉及一种FOUP开启装置，其中FOUP被放置并且FOUP的FOUP门可以被拆卸，以允许进入FOUP的内部。 该FOUP开启装置包括具有用于安装和拆卸FOUP门的安装/拆卸机构的端口门和用于保持要拆卸的FOUP门的保持机构，以及用于移动保持FOUP门的端口门的端口门移动单元，以便 FOUP打开了。 端口门具有安装/拆卸机构布置的主要结构和覆盖所述主体结构的表面板。 在FOUP开启器的前侧，表面板可从所述主结构拆卸。
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公开(公告)号：US20060128003A1
公开(公告)日：2006-06-15
申请号：US11337446
申请日：2006-01-24
申请人： Shinji Yokoyama , Reijiro Arakawa
发明人： Shinji Yokoyama , Reijiro Arakawa
摘要： The present invention is to provide an agent for low HDL-cholesterolemia, a prophylactic and/or therapeutic antiarteriosclerosis agent as well as a method for preventing and treating low HDL-cholesterolemia, arteriosclerosis and their related diseases or disorders, with emphasis given to improvement in HDL, without resorting to genetic engineering technology. Further, the present invention is to provide a clinically effective agent for low HDL-cholesterolemia and a prophylactic and/or therapeutic antiarteriosclerosis agent, comprising at least one cysteine protease inhibitor as an active ingredient, thereby increasing a quantity of expressed ABCA1 and elevating blood HDL levels, without using the genetic engineering technology.
摘要翻译： 本发明提供低HDL-胆固醇血症药物，预防和/或治疗性抗动脉硬化药物以及预防和治疗低HDL-胆固醇血症，动脉硬化及其相关疾病或病症的方法，其重点在于改善 HDL，而不诉诸基因工程技术。 此外，本发明提供一种低HDL-胆固醇血症的临床有效药剂和包含至少一种半胱氨酸蛋白酶抑制剂作为活性成分的预防和/或治疗性抗动脉硬化剂，从而增加表达的ABCA1的量和提高血液HDL 水平，不使用遗传工程技术。
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20.发明授权
公开(公告)号：US4262779A
公开(公告)日：1981-04-21
申请号：US830875
申请日：1977-09-06
申请人： Teiji Katsumori , Shinji Yokoyama , Tetuo Kato
发明人： Teiji Katsumori , Shinji Yokoyama , Tetuo Kato
摘要： A shock absorber and suspension strut unit having an outer cylinder containing a predetermined amount of a damping liquid. An inner cylinder is mounted rigidly and concentrically in the outer cylinder and is arranged so as to form an intermediate concentric space between the cylinders. A movable piston rod assembly is movable relative to the double-cylinder assembly and has a piston slidably arranged within the inner cylinder for movement therealong. Check valves are provided in the piston for permitting selective fluid flow from one side of the piston to the other. Further, one or more communication passages are provided in an end of the inner cylinder which abuts the enclosed and the outer cylinder for allowing fluid passage therethrough mutually between a liquid chamber formed below the piston within the inner cylinder and lower part of the annular space formed by and between the cylinders. Thus, these spaces are a substantially unified liquid chamber. A first gas-filled chamber formed at the upper part of the further liquid chamber above the piston within the inner cylinder, while a second gas-filled chamber is formed at the upper part of the annular space. The resulting unit is characterized by the first and second gas-filled chambers being so arranged that either one of them is caused to expand during the contracting or expanding stroke of the unit, while the remaining one of the chambers is caused to simultaneously contract. A fluid flow-limiting passage is provided through the wall of the inner cylinder for allowing free fluid flow passage between the two gas-filled chambers.
摘要翻译： 一种减震器和悬架支柱单元，其具有包含预定量的阻尼液体的外筒。 内筒刚性地并且同心地安装在外筒中并且被布置成在气缸之间形成中间的同心空间。 可动活塞杆组件相对于双气缸组件是可移动的，并且具有可滑动地布置在内筒内的活塞，用于沿其移动。 止回阀设置在活塞中，以允许选择性流体从活塞的一侧流到另一侧。 此外，一个或多个连通通道设置在内筒的端部，其邻接封闭的外筒和外筒，用于允许流体在形成于内筒内的活塞下方形成的液室与形成的环形空间的下部相通 在气缸之间和之间。 因此，这些空间是基本统一的液体室。 第一气体填充室，形成在所述内筒内的所述活塞上方的所述另外的液体室的上部，而在所述环形空间的上部形成有第二充气室。 所得到的单元的特征在于，第一和第二充气室被布置成使得在单元的收缩或膨胀行程期间使其中的一个在其中一个被使得在该单元的收缩或膨胀行程期间膨胀，同时使剩余的一个室同时收缩。 通过内筒的壁设置流体限流通道，用于允许两个充气室之间的自由流体流通。
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