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17 条记录 (耗时 0.031 秒)

    DNA coding for a human vasoconstrictive peptide and use thereof
    11.
    发明授权
    DNA coding for a human vasoconstrictive peptide and use thereof 失效
    编码人血管收缩肽的DNA及其用途

    公开(公告)号：US06365725B1

    公开(公告)日：2002-04-02

    申请号：US07728169

    申请日：1991-07-10

    申请人： Haruo Onda ,  Shoichi Ohkubo

    发明人： Haruo Onda ,  Shoichi Ohkubo

    IPC分类号： C12N1512

    CPC分类号： C07K14/57536 ,  A61K38/00

    摘要： Disclosed are (1) a DNA containing a cDNA segment coding for human endothelin-2 (SEQ ID NO:1), (2) a precursor of human endothelin-2 (SEQ ID NO:2), (3) a transformant carrying a DNA containing a cDNA segment coding for human endothelin-2, and (4) a method for preparing mature human endothelin-2 which comprises culturing the transformant described in (3), accumulating a protein in a culture medium, and collecting the same, whereby human endothelin-2 and the precursors thereof can be produced in large amounts.

    摘要翻译： 公开了（1）含有编码人内皮素-2（SEQ ID NO：1）的cDNA片段的DNA，（2）人内皮素-2（SEQ ID NO：2）的前体，（3）携带 含有编码人内皮素-2的cDNA片段的DNA，（4）成熟人内皮素-2的制备方法，其包括培养（3）所述的转化体，在培养基中积聚蛋白质，收集培养基，由此 人内皮素-2及其前体可以大量生产。

    DNA coding for a human vasoconstrictive peptide and use thereof
    12.
    发明授权
    DNA coding for a human vasoconstrictive peptide and use thereof 失效
    编码人血管收缩肽的DNA及其用途

    公开(公告)号：US5756344A

    公开(公告)日：1998-05-26

    申请号：US673269

    申请日：1996-06-28

    申请人： Haruo Onda ,  Shoichi Ohkubo ,  Takuo Kosaka

    发明人： Haruo Onda ,  Shoichi Ohkubo ,  Takuo Kosaka

    IPC分类号： A61K38/00 ,  C07K14/00 ,  C07K14/575 ,  C12N1/21 ,  C12N15/09 ,  C12N15/12 ,  C12N15/16 ,  C12P21/02

    CPC分类号： C07K14/57536 ,  A61K38/00

    摘要： Disclosed are (1) a DNA containing a cDNA segment coding for human endothelin-2 (SEQ ID NO:1), (2) a precursor of human endothelin-2 (SEQ ID NO:2), (3) a transformant carrying a DNA containing a cDNA segment coding for human endothelin-2, and (4) a method for preparing mature human endothelin-2 which comprises culturing the transformant described in (3), accumulating a protein in a culture medium, and collecting the same, whereby human endothelin-2 and the precursors thereof can be produced in large amounts.

    摘要翻译： 公开了（1）含有编码人内皮素-2（SEQ ID NO：1）的cDNA片段的DNA，（2）人内皮素-2（SEQ ID NO：2）的前体，（3）携带 含有编码人内皮素-2的cDNA片段的DNA，（4）成熟人内皮素-2的制备方法，其包括培养（3）所述的转化体，在培养基中积聚蛋白质，收集培养基，由此 人内皮素-2及其前体可以大量生产。

    Genomic DNA exons having exons encoding human pituitary adenylate cyclase activity peptide with 38 amino acids residues(PACAP38) and a promoter thereof
    14.
    发明授权
    Genomic DNA exons having exons encoding human pituitary adenylate cyclase activity peptide with 38 amino acids residues(PACAP38) and a promoter thereof 失效
    具有编码具有38个氨基酸残基的人垂体腺苷酸环化酶活性肽（PACAP38）的外显子的基因组DNA外显子及其启动子

    公开(公告)号：US5521069A

    公开(公告)日：1996-05-28

    申请号：US76011

    申请日：1993-06-11

    申请人： Haruo Onda ,  Chiharu Kimura ,  Shoichi Ohkubo

    发明人： Haruo Onda ,  Chiharu Kimura ,  Shoichi Ohkubo

    IPC分类号： C07K14/575 ,  C12N15/85 ,  C12N5/10

    CPC分类号： C07K14/57563

    摘要： Disclosed are (1) a genomic DNA of human PACAP38; (2) a DNA containing a DNA segment coding for human PACAP38; (3) a DNA of human PACAP 38 promotor; (4) a transformant carrying a vector which contains a DNA of (3) or further contains a DNA coding for a protein downstream from the promotor; and (5) a method for preparing a protein comprising cultivating the transformant described in the above (4), accumulating the protein in a culture product, and collecting the resulting protein such as mature PACAP 38. The DNA gives human PACAP 38 effectively and makes it possible to screen the chemical substance necessary for production of PACAP and is applied to experimental animals to understand their brain functions, which serves to elucidate human brain functions. Human PACAP38 can also be utilized as therapeutic agents about growth and maintenance of human brain nerves.

    摘要翻译： 公开的是（1）人PACAP38的基因组DNA; （2）含有编码人PACAP38的DNA片段的DNA; （3）人PACAP 38启动子的DNA; （4）携带载体的转化体，其含有（3）的DNA或进一步含有编码来自启动子下游的蛋白质的DNA; （5）一种制备蛋白质的方法，包括培养上述（4）中所述的转化体，将蛋白质积聚在培养产物中，并收集所得蛋白质如成熟PACAP 38.该DNA有效地给予人PACAP 38，并使 可以筛选生产PACAP所需的化学物质，并将其应用于实验动物，以了解其大脑功能，从而阐明人脑功能。 人类PACAP38也可以用作关于人脑神经生长和维持的治疗剂。

    Process for preparing smoke-retardant polyisocyanurate foam
    15.
    发明授权
    Process for preparing smoke-retardant polyisocyanurate foam 失效
    制备阻燃聚异氰脲酸酯泡沫的方法

    公开(公告)号：US4514525A

    公开(公告)日：1985-04-30

    申请号：US665527

    申请日：1976-03-10

    申请人： Kaneyoshi Ashida ,  Masaaki Ohtani ,  Shoichi Ohkubo

    发明人： Kaneyoshi Ashida ,  Masaaki Ohtani ,  Shoichi Ohkubo

    IPC分类号： C08G18/00 ,  C08G18/02 ,  C08G18/10 ,  C08J9/00 ,  C08G18/14

    CPC分类号： C08G18/022 ,  C08G18/10 ,  C08J9/0061 ,  C08J2379/04 ,  C08J2443/00 ,  C08J2483/00 ,  Y10S521/902

    摘要： In a process for preparing a smoke-retardant polyisocyanurate foam by reacting an organic polyisocyanate in the presence of a blowing agent and an isocyanate-trimerization catalyst, the improvement comprising conducting the reaction by adding 0.5 to 6 wt. % as Si to the total components of the foam of an organosilicone surfactant having a Si content of 4-22%, and selected from an organopolysiloxane-poly-oxyalkylene copolymer, polyvinylsilane having polyoxyalkylene side chain or modified products thereof wherein the mole % of the ethylene oxide units of the polyoxyalkylene moiety of the organosilicone surfactant is greater than 40 mole % based on the total number of ethylene oxide and propylene oxide units in said polyoxyalkylene moiety.

    摘要翻译： 在有机多异氰酸酯在发泡剂和异氰酸酯 - 三聚催化剂存在下反应制备阻燃聚异氰脲酸酯泡沫的方法，其改进包括通过加入0.5至6wt。 Si为Si含量为4〜22％的有机硅氧烷表面活性剂的总成分的Si，选自有机聚硅氧烷 - 聚 - 氧化烯共聚物，具有聚氧化烯侧链的聚乙烯基硅烷或其改性产物，其中摩尔％ 基于所述聚氧化烯部分中的环氧乙烷和环氧丙烷单元的总数，有机硅氧烷表面活性剂的聚氧化烯部分的环氧乙烷单元大于40摩尔％。

    Process for preparing smoke-retardant polyisocyanurate foam
    16.
    发明授权
    Process for preparing smoke-retardant polyisocyanurate foam 失效
    制备阻燃聚异氰脲酸酯泡沫的方法

    公开(公告)号：US4072636A

    公开(公告)日：1978-02-07

    申请号：US663503

    申请日：1976-03-03

    申请人： Kaneyoshi Ashida ,  Masaaki Ohtani ,  Shoichi Ohkubo

    发明人： Kaneyoshi Ashida ,  Masaaki Ohtani ,  Shoichi Ohkubo

    IPC分类号： C08G18/02 ,  C08J9/00 ,  C08G18/14

    CPC分类号： C08J9/0042 ,  C08G18/022 ,  C08J2379/04 ,  Y10S521/902

    摘要： In a process for preparing a smoke-retardant polyisocyanurate foam by reacting an organic polyisocyanate in the presence of a blowing agent and an isocyanate-trimerization catalyst, an improvement is characterized in that the reaction is conducted in the presence of an organosilicate having the formula Si(OR).sub.4 or R.sub.n Si(OR').sub.4-n wherein R and R' are the same or different and represent aliphatic, alicyclic and aromatic hydrocarbon groups having 1-12 carbon atoms or substituted derivatives thereof and n is an integer of 1 to 3.

    摘要翻译： 在有机多异氰酸酯存在下，在发泡剂和异氰酸酯 - 三聚催化剂存在下，通过使有机多异氰酸酯反应来制备阻燃性聚异氰脲酸酯泡沫体的方法，其特征在于反应在具有式Si的有机硅酸盐存在下进行 （OR）4或RnSi（OR'）4-n其中R和R'相同或不同，表示具有1-12个碳原子的脂族，脂环族和芳族烃基或其取代的衍生物，n是1〜 3。