公开(公告)号：US20160100926A1

公开(公告)日：2016-04-14

申请号：US14970655

申请日：2015-12-16

Applicant: Sofradim Production

Inventor： Yves Bayon ,  Philippe Gravagna ,  Alfredo Meneghin

IPC: A61F2/00

CPC classification number: A61F2/0063 ,  A61F2/0077 ,  A61F2002/0068 ,  A61F2002/0081 ,  A61L27/24 ,  A61L27/26 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/404 ,  A61L2300/602 ,  D04B21/12 ,  D10B2509/08 ,  C08L5/08

Abstract: An implant and a process for preparing such an implant are disclosed. The implant includes a porous layer including collagen, a non-porous layer including a collagenic constituent, and a reinforcement component. The non-porous layer is joined to the porous layer and the reinforcement member is embedded into the non-porous layer. The porous layer has a three dimensional density ranging from about 20 mg collagen/cm3 to about 200 mg collagen/cm3.

Abstract translation: 公开了一种植入物和用于制备这种植入物的方法。 植入物包括包括胶原的多孔层，包括胶原成分的无孔层和增强组分。 无孔层与多孔层接合，加强构件嵌入到无孔层中。 多孔层具有约20mg胶原/ cm 3至约200mg胶原/ cm 3的三维密度。

公开(公告)号：US09216226B2

公开(公告)日：2015-12-22

申请号：US14612353

申请日：2015-02-03

Applicant: Sofradim Production

Inventor： Sébastien Ladet ,  Philippe Gravagna

IPC: A61K47/48 ,  A61K47/30 ,  A61L27/26 ,  A61L27/48 ,  A61L27/50 ,  A61L27/54 ,  A61L31/14 ,  A61L31/16

CPC classification number: A61K47/4823 ,  A61K47/30 ,  A61K47/48038 ,  A61K47/48092 ,  A61K47/48238 ,  A61K47/542 ,  A61K47/549 ,  A61K47/61 ,  A61K47/62 ,  A61L27/26 ,  A61L27/48 ,  A61L27/50 ,  A61L27/54 ,  A61L31/14 ,  A61L31/16 ,  A61L2300/00 ,  C08L101/02

Abstract: The present disclosure relates to compounds and medical devices activated with a solvophobic material functionalized with a first reactive member and methods of making such compounds and devices.

Abstract translation: 本公开涉及通过用第一反应性成员功能化的抗溶性疏料材料活化的化合物和医疗装置以及制备这种化合物和装置的方法。

公开(公告)号：US20140128497A1

公开(公告)日：2014-05-08

申请号：US14154338

申请日：2014-01-14

Applicant: SOFRADIM PRODUCTION

Inventor： Sebastien Ladet ,  Philippe Gravagna

IPC: A61L24/00

CPC classification number: A61L24/0031 ,  A61K9/06 ,  A61L24/046 ,  C08L101/02

Abstract: A bioadherent substrate includes a medical gel or medical gel precursor having a plurality of reactive members of a specific binding pair attached on or adapted to be attached to a surface of the medical gel, said reactive members being capable of forming covalent bonds with a plurality of complementary reactive members of the specific binding pair via a reaction selected from a Huisgen cycloaddition reaction, a Diels-Alder reaction and a thiol-ene reaction. A method for adhering a medical gel to biological tissue includes providing a medical gel or a medical gel precursor having a plurality of reactive members of a specific binding pair attached on or adapted to be attached to a surface of the medical gel and providing tissue with a plurality of complementary reactive members of the specific binding pair, wherein upon contact of the reactive members on the medical gel with the complimentary reactive members on the tissue, covalent bonds are formed between the reactive members and the complementary reactive members, thus adhering the medical gel to the tissue.

Abstract translation: 生物粘附底物包括医学凝胶或医用凝胶前体，其具有连接在或适于附着在医用凝胶表面上的特定结合对的多个反应性成员，所述反应性成员能够与多个 通过选自Huisgen环加成反应，Diels-Alder反应和硫醇 - 烯反应的反应的特异性结合对的互补反应性成员。 将医用凝胶粘附到生物组织上的方法包括提供具有多个特异性结合对的反应性成员的医用凝胶或医用凝胶前体，所述多个反应性成员附着于或适于附着在医用凝胶的表面上， 多个特异性结合对的互补反应性成员，其中当在医用凝胶上的反应性成员与组织上的互补反应性成员接触时，在反应性部件和互补的反应性部件之间形成共价键，从而粘附医用凝胶 到组织。

公开(公告)号：US20140018849A1

公开(公告)日：2014-01-16

申请号：US14026149

申请日：2013-09-13

Applicant: Sofradim Production

Inventor： Sébastien Ladet ,  Philippe Gravagna

IPC: A61B17/00

CPC classification number: A61B17/00491 ,  A61L15/22 ,  A61L15/58 ,  A61L31/04 ,  A61L31/14 ,  Y10T156/10

Abstract: A method for bonding a polymeric medical device to tissue is provided which includes providing a polymeric medical device having a plurality of reactive members of a specific binding pair attached on a surface of the medical device, and providing tissue with a plurality of complementary reactive members of the specific binding pair, wherein upon contact of the reactive members on the surface of the medical device with the complimentary reactive members on the tissue, covalent bonds are formed between the reactive members and the complementary reactive members, thus adhering the device to the tissue. A kit is provided including a polymeric medical device such as a patch or mesh having a plurality of reactive members of a specific binding pair attached to a surface of the device and an applicator containing a solution or suspension of complementary reactive members of the specific binding pair, the complementary reactive members having a functionality that will adhere them to biological tissue upon contact, said applicator adapted to deliver the solution or suspension to biological tissue.

Abstract translation: 提供了一种用于将聚合物医疗装置粘合到组织的方法，其包括提供聚合物医疗装置，其具有附着在医疗装置的表面上的特定结合对的多个反应性成员，并且向组织提供多个互补的反应性成员 特异性结合对，其中当在医疗装置的表面上的反应性构件与组织上的互补的反应性构件接触时，在反应性构件和互补的反应性构件之间形成共价键，从而将该装置粘附到组织上。 提供了一种试剂盒，其包括聚合物医疗装置，例如补片或网，其具有连接到装置的表面的特定结合对的多个反应性成员和包含特异性结合对的互补反应性成员的溶液或悬浮液的施用器 互补的活性成员具有在接触时将它们粘附到生物组织上的功能，所述施用器适于将溶液或悬浮液输送到生物组织。