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    Apparatus and method of reacting polymers passing through metal ion chelated resin matrix to produce injectable medical devices
    2.
    发明授权
    Apparatus and method of reacting polymers passing through metal ion chelated resin matrix to produce injectable medical devices 有权
    使通过金属离子螯合树脂基质的聚合物反应产生可注射医疗器械的装置和方法

    公开(公告)号：US09550164B2

    公开(公告)日：2017-01-24

    申请号：US14692776

    申请日：2015-04-22

    Applicant: Sofradim Production

    Inventor： Sébastien Ladet ,  Philippe Gravagna

    IPC: B01J19/00 ,  B01J19/18 ,  A61B17/00 ,  B01F5/06 ,  B01F13/00 ,  B01J14/00 ,  C08G63/66 ,  B01J23/72 ,  B01J35/04

    CPC classification number: B01J19/18 ,  A61B17/00491 ,  A61B2017/00495 ,  B01F5/0615 ,  B01F5/0683 ,  B01F5/0688 ,  B01F13/002 ,  B01F13/0023 ,  B01J14/005 ,  B01J19/0053 ,  B01J19/0066 ,  B01J23/72 ,  B01J35/04 ,  B01J2219/00761 ,  C08G63/66

    Abstract: The present disclosure relates to an apparatus and process for forming medical devices from an injectable composition. The apparatus includes a supply assembly configured to maintain and selective dispense a first precursor and a second precursor, a mixing assembly configured to mix the first and second precursors, and at least one catalyzing element including a transition metal ion to aid in the polymerization of the first and second precursors. The process includes dispensing a volume of the first precursor and a volume of the second precursor into a mixing assembly and mixing the first and second precursors. The first and second precursors each possess a core and at least one functional group known to have click reactivity with each other. The mixed precursors are contacted with a transition metal catalyst to produce a flowable composition for use as a medical device.

    Abstract translation: 本公开涉及一种用于从可注射组合物形成医疗装置的装置和方法。 该设备包括供应组件，其被配置为维持和选择性地分配第一前体和第二前体，配置成混合第一和第二前体的混合组件和包含过渡金属离子的至少一个催化元素以有助于聚合 第一和第二前体。 该方法包括将体积的第一前体和体积的第二前体分配到混合组件中并混合第一和第二前体。 第一和第二前体各自具有核心和至少一个已知具有彼此具有点击反应性的官能团。 混合的前体与过渡金属催化剂接触以产生用作医疗装置的可流动组合物。

    Medical devices incorporating functional adhesives
    4.
    发明授权
    Medical devices incorporating functional adhesives 有权

    公开(公告)号：US09510810B2

    公开(公告)日：2016-12-06

    申请号：US14026149

    申请日：2013-09-13

    Applicant: Sofradim Production

    Inventor： Sébastien Ladet ,  Philippe Gravagna

    IPC: A61B17/08 ,  A61B17/00 ,  A61L15/22 ,  A61L15/58 ,  A61L31/04 ,  A61L31/14

    CPC classification number: A61B17/00491 ,  A61L15/22 ,  A61L15/58 ,  A61L31/04 ,  A61L31/14 ,  Y10T156/10

    Abstract: A method for bonding a polymeric medical device to tissue is provided which includes providing a polymeric medical device having a plurality of reactive members of a specific binding pair attached on a surface of the medical device, and providing tissue with a plurality of complementary reactive members of the specific binding pair, wherein upon contact of the reactive members on the surface of the medical device with the complimentary reactive members on the tissue, covalent bonds are formed between the reactive members and the complementary reactive members, thus adhering the device to the tissue. A kit is provided including a polymeric medical device such as a patch or mesh having a plurality of reactive members of a specific binding pair attached to a surface of the device and an applicator containing a solution or suspension of complementary reactive members of the specific binding pair, the complementary reactive members having a functionality that will adhere them to biological tissue upon contact, said applicator adapted to deliver the solution or suspension to biological tissue.

    APPARATUS AND METHOD OF REACTING POLYMERS PASSING THROUGH METAL ION CHELATED RESIN MATRIX TO PRODUCE INJECTABLE MEDICAL DEVICES
    5.
    发明申请
    APPARATUS AND METHOD OF REACTING POLYMERS PASSING THROUGH METAL ION CHELATED RESIN MATRIX TO PRODUCE INJECTABLE MEDICAL DEVICES 有权
    通过金属离子螯合树脂基质反应聚合物生产注射用医疗装置的装置和方法

    公开(公告)号：US20150290617A1

    公开(公告)日：2015-10-15

    申请号：US14692776

    申请日：2015-04-22

    Applicant: Sofradim Production

    Inventor： Sébastien Ladet ,  Philippe Gravagna

    IPC: B01J19/18 ,  C08G63/66 ,  B01J19/00

    CPC classification number: B01J19/18 ,  A61B17/00491 ,  A61B2017/00495 ,  B01F5/0615 ,  B01F5/0683 ,  B01F5/0688 ,  B01F13/002 ,  B01F13/0023 ,  B01J14/005 ,  B01J19/0053 ,  B01J19/0066 ,  B01J23/72 ,  B01J35/04 ,  B01J2219/00761 ,  C08G63/66

    Abstract: The present disclosure relates to an apparatus and process for forming medical devices from an injectable composition. The apparatus includes a supply assembly configured to maintain and selective dispense a first precursor and a second precursor, a mixing assembly configured to mix the first and second precursors, and at least one catalyzing element including a transition metal ion to aid in the polymerization of the first and second precursors. The process includes dispensing a volume of the first precursor and a volume of the second precursor into a mixing assembly and mixing the first and second precursors. The first and second precursors each possess a core and at least one functional group known to have click reactivity with each other. The mixed precursors are contacted with a transition metal catalyst to produce a flowable composition for use as a medical device.

    Abstract translation: 本公开涉及一种用于从可注射组合物形成医疗装置的装置和方法。 该设备包括供应组件，其被配置为维持和选择性地分配第一前体和第二前体，配置成混合第一和第二前体的混合组件和包含过渡金属离子的至少一个催化元素以有助于聚合 第一和第二前体。 该方法包括将体积的第一前体和体积的第二前体分配到混合组件中并混合第一和第二前体。 第一和第二前体各自具有核心和至少一个已知具有彼此具有点击反应性的官能团。 混合的前体与过渡金属催化剂接触以产生用作医疗装置的可流动组合物。

    PROCESS FOR PREPARING A POROUS LAYER
    6.
    发明申请
    PROCESS FOR PREPARING A POROUS LAYER 审中-公开
    制备多孔层的方法

    公开(公告)号：US20150240046A1

    公开(公告)日：2015-08-27

    申请号：US14423150

    申请日：2013-09-26

    Applicant: Sofradim Production

    Inventor： Sébastien Ladet ,  Nicolas Prost

    IPC: C08J9/28 ,  A61L31/14 ,  A61L31/04

    CPC classification number: C08J9/28 ,  A61L27/20 ,  A61L31/042 ,  A61L31/146 ,  A61L2400/18 ,  C08J5/18 ,  C08J2201/048 ,  C08J2207/10 ,  C08J2305/04 ,  C08J2305/08 ,  C08L5/04 ,  C08L5/08

    Abstract: The present invention relates to a process for preparing a porous layer of biocompatible polymer, having a uniform density and porosity, comprising the following steps: —a) a quantity Qp of solution of the said polymer, having a viscosity Vp, is poured into a mould in order to form a first sublayer, the surface of the first sublayer being left to the open air; —b) a quantity Qs of solvent, having a viscosity Vs, lower than Vp, is spread uniformly over the surface of the first sublayer so as to form a second sublayer; —c) the first and second sublayers are subjected to a step of lyophilisation, in which the said polymer is a polysaccharide chosen from hyaluronic acid, alginic acid and chitosan, salts thereof and mixtures thereof.

    Abstract translation: 本发明涉及制备具有均匀密度和孔隙率的生物相容性聚合物多孔层的方法，包括以下步骤：a）将具有粘度Vp的所述聚合物溶液的量Qp倒入 模具以形成第一子层，第一子层的表面留在露天; -b），粘度Vs低于Vp的溶剂量Qs均匀地分散在第一子层的表面上，形成第二子层; -c）第一和第二子层进行冻干的步骤，其中所述聚合物是选自透明质酸，藻酸和壳聚糖的多糖，其盐及其混合物。

    HERNIA PROSTHESIS WITH MARKING MEANS
    7.
    发明申请
    HERNIA PROSTHESIS WITH MARKING MEANS 有权
    HERNIA具有标志性意义

    公开(公告)号：US20140364878A1

    公开(公告)日：2014-12-11

    申请号：US14366403

    申请日：2012-12-27

    Applicant: Sofradim Production

    Inventor： Sébastien Ladet ,  Sébastien Francois ,  Nicolas Prost

    IPC: A61F2/00

    CPC classification number: A61F2/0063 ,  A61F2250/0097

    Abstract: Prosthesis (1) comprising a patch (2) made of biocompatible material, said patch having a generally plane geometric shape that defines two opposite faces, a centre, a length and a width of said patch, characterized in that said patch is provided, on one (2a) of its faces, with a single marking means (3) designed to indicate both the centre (C) of the patch and also the longitudinal direction of said patch.

    Abstract translation: 假体（1）包括由生物相容性材料制成的贴片（2），所述贴片具有大致平面的几何形状，其限定两个相对的面，所述贴片的中心，长度和宽度，其特征在于，所述贴片设置在 一个（2a）的面，具有设计成指示贴片的中心（C）以及所述贴片的纵向方向的单个标记装置（3）。

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