公开(公告)号：US09701740B2

公开(公告)日：2017-07-11

申请号：US14009327

申请日：2012-04-02

申请人： James E. Hansen ,  Peter M. Glazer ,  Richard H. Weisbart ,  Robert N. Nishimura ,  Grace Chan

发明人： James E. Hansen ,  Peter M. Glazer ,  Richard H. Weisbart ,  Robert N. Nishimura ,  Grace Chan

IPC分类号： C07K16/18 ,  A61K39/00 ,  A61K39/395 ,  C07K16/44 ,  A61K31/704 ,  A61K45/06 ,  A61K31/337 ,  A61K31/475 ,  A61K31/513 ,  A61K31/7068 ,  A61K33/24

CPC分类号： C07K16/18 ,  A61K31/337 ,  A61K31/475 ,  A61K31/513 ,  A61K31/704 ,  A61K31/7068 ,  A61K33/24 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/44 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/77 ,  A61K2300/00

摘要： Antibodies that penetrate cell nuclei and inhibit DNA repair or interfere with DNA metabolism are provided for treatment of cancer (both directly and by sensitizing cancer cells to DNA-damaging treatments) or inhibiting or preventing viral infection, proliferation or metabolism. The method involves treating cells with a composition containing cell-penetrating anti-DNA antibodies or derivatives thereof, alone or in combination with treatment that induces DNA damage such as DNA-damaging chemotherapy or radiation. The impact of the cell-penetrating anti-DNA antibodies or derivatives thereof is potentiated in cancer cells that are deficient in DNA repair, and the cell-penetrating anti-DNA antibodies or derivatives thereof are synthetically lethal to cancer cells with DNA repair deficiencies.

公开(公告)号：US07250748B2

公开(公告)日：2007-07-31

申请号：US10711746

申请日：2004-10-01

申请人： Jerome K. Hastings ,  Dale L. Gass ,  Birger Pahl ,  Davin R. Lee ,  James E. Hansen

发明人： Jerome K. Hastings ,  Dale L. Gass ,  Birger Pahl ,  Davin R. Lee ,  James E. Hansen

IPC分类号： G01R33/06

CPC分类号： G01R15/202 ,  G01R15/207

摘要： The present invention is directed to a system for current sensing including a first Hall effect sensor and a second Hall effect sensor constructed to provide feedback indicating current flow through a conductor susceptible to external magnetic flux. A housing is configured to position the first Hall effect sensor and the second Hall effect sensor about the conductor to provide generally magnitude equal feedback of the current flow through the conductor and generally polarity opposite feedback of the external magnetic flux.

摘要翻译： 本发明涉及一种用于电流检测的系统，其包括第一霍尔效应传感器和第二霍尔效应传感器，该传感器被构造成提供指示通过容易受到外部磁通量的导体的电流的反馈。 壳体被配置为将第一霍尔效应传感器和第二霍尔效应传感器定位在导体周围，以提供通过导体的电流的大致相等的反馈，并且大体上极性地反映外部磁通的极性反馈。

公开(公告)号：US06771074B2

公开(公告)日：2004-08-03

申请号：US10060107

申请日：2002-01-31

申请人： Lian Q. Zou ,  James E. Hansen ,  Victor E. Shtaida

发明人： Lian Q. Zou ,  James E. Hansen ,  Victor E. Shtaida

IPC分类号： G01N2702

CPC分类号： G01N27/226

摘要： A probe assembly for use in monitoring fluid conditions in real time in a transducer utilizing impedance spectroscopy and having two closely spaced tubular concentric electrodes. The electrodes have a surface area of about 8.1 to 10.8 cm2 spaced in the range of about 0.1 to 0.55 mm. In one embodiment a concentric outer tubular Faraday shield is employed for monitoring fluid in a non-metallic vessel. The probe assembly is particularly suitable for monitoring hydraulic fluid including automatic transmission fluid and mineral based engine oil for diesel and gasoline engines.

摘要翻译： 探头组件，用于利用阻抗光谱仪实时监测流体条件，并具有两个紧密间隔的管状同心电极。 电极具有在约0.1至0.55mm范围内的约8.1至10.8cm 2的表面积。 在一个实施例中，使用同心的外管法拉第屏蔽来监测非金属容器中的流体。 探头组件特别适用于监测液压流体，包括用于柴油和汽油发动机的自动变速器油和矿物基发动机油。

公开(公告)号：US5425166A

公开(公告)日：1995-06-20

申请号：US277403

申请日：1994-07-19

申请人： Jerome K. Hastings ,  Bruce C. Beihoff ,  James E. Hansen ,  Mark A. Juds ,  Steven C. Kaishian ,  Charles J. Tennies

发明人： Jerome K. Hastings ,  Bruce C. Beihoff ,  James E. Hansen ,  Mark A. Juds ,  Steven C. Kaishian ,  Charles J. Tennies

IPC分类号： H01F1/00 ,  H01F17/00 ,  H01F41/16 ,  H01F41/02

CPC分类号： H01F41/16 ,  H01F1/0027 ,  H01F17/0033 ,  H01F2027/2814 ,  H01F2038/305 ,  Y10T29/4902 ,  Y10T29/49073 ,  Y10T29/49078 ,  Y10T29/4981

摘要： A current transformer device is formed on a ceramic substrate which is provided with a plurality of planar conductive tracks formed on a surface of the substrate where the conductive tracks extend substantially radially from an imaginary point on the surface of the substrate. A structure of permeable material is then tape cast or epitaxially formed by vapor deposition of a thick film of magnetic ceramic over the major portion of each of the conductive tracks to form a permeable toroidal core. A lead frame is then placed over the core and a plurality of metal conductors are soldered to each of the respective exposed ends of the metal conductive tracks on the substrate. The required electrical elements to complete the current transformer device are mounted to a second side of the ceramic substrate and electrically connected to the toroidal coil for powering and/or receiving signals therefrom.

摘要翻译： 电流互感器装置形成在陶瓷基片上，该陶瓷基片上设有形成在基片表面上的多个平面导电迹线，导电迹线从基片表面的假想点基本径向延伸。 然后通过在每个导电轨道的主要部分上蒸镀一层厚厚的磁性陶瓷，将可渗透材料的结构胶带或外延形成，以形成可渗透的环形芯。 然后将引线框架放置在芯上，并且将多个金属导体焊接到衬底上的金属导电轨道的相应的暴露端中的每一个。 完成电流互感器装置的所需电气元件安装在陶瓷基片的第二侧上，并电连接到环形线圈，用于向其提供和/或接收信号。

公开(公告)号：US5174389A

公开(公告)日：1992-12-29

申请号：US729224

申请日：1991-07-12

申请人： James E. Hansen

发明人： James E. Hansen

IPC分类号： E21B19/14

CPC分类号： E21B19/146

摘要： A well work-over drilling rig uses a single cylindrical column forming a mast for assembly and disassembly of a casing, pipe or rod forming a well string in a well bore.The mast supports a hydraulic ram for elevating a crown block having arms radially extending equal distances from the axis of the ram. Cables are supported by sheaves at the outer ends of the arms to permit equal and opposite forces (moments) to be applied to the column by the weight of pipe sections or the complete well string. The column is stabilized by racking pipe sections, including up to the full length of a well string, annularly around the column mast on a rotatable fingerboard, with substantially the full weight of pipe sections on the lower annular support. This avoids the need for lateral guy wires to stabilize the column mast.

摘要翻译： 一个井井平井钻机使用一个单柱柱形柱，用于组装和拆卸在井眼中形成井柱的套管，管或杆。 桅杆支撑液压柱塞，用于升高具有径向延伸距离压头轴线等距离的臂的表冠块。 电缆在臂的外端由滑轮支撑，以允许通过管段或整个井串的重量施加到柱上的相等和相反的力（力矩）。 通过在可旋转的指板上围绕柱桅杆环形地围绕管柱的整个长度，包括直径为整个长度的管段来稳定柱，并且在下环形支撑件上具有基本上全部重量的管段。 这避免了需要外侧电线来稳定柱桅杆。

公开(公告)号：US4490659A

公开(公告)日：1984-12-25

申请号：US540738

申请日：1983-10-11

申请人： James E. Hansen

发明人： James E. Hansen

IPC分类号： G05D3/18 ,  G05D3/10 ,  G01C21/18 ,  H01H43/00

CPC分类号： G05D3/18

摘要： A pair of interval timer units including a lower right timer (LRT) and a lower left timer (LLT) for controlling a pair of D.C. motors (RM, LM) to drive a pair of load devices accurately and consistently a predetermined lowering distance. The load devices are raised together until stopped by limit switches (LS1, LS2) but can be lowered individually under the interval timer (IT) control. Each timer unit (LRT) includes a voltage regulator (ZD1, ZR1) to provide a constant voltage to a ramp voltage generator (RG) and a reference voltage to a voltage inverter (VI). The ramp voltage is applied through a buffer (IC1B) to one input of a comparator (IC1C). The variable supply voltage is also applied to the voltage inverter (VI) that provides a time reference voltage that varies inversely with respect to variation in the supply voltage. This time reference voltage is applied to the comparator (IC1C) upon closure of a "lower" switch to close a motor control switch (Q3) to start the motor time interval and when the ramp voltage rises to the level of the time reference voltage, the comparator (IC1C) opens the motor control switch (Q3) to stop the motor time interval. As a result, since the motor speed changes with change in supply voltage, the interval timer varies inversely the motor operating time for constant load driving distance.

摘要翻译： 一对间隔定时器单元，包括用于控制一对直流电动机（RM，LM）的右下定时器（LRT）和左下定时器（LLT），以精确地和一致地驱动一对负载装置预定的下降距离。 负载设备一起升高，直到限位开关（LS1，LS2）停止，但可以在间隔定时器（IT）控制下单独降低负载。 每个定时器单元（LRT）包括电压调节器（ZD1，ZR1），以向斜坡电压发生器（RG）提供恒定电压，并将参考电压提供给电压逆变器（VI）。 斜坡电压通过缓冲器（IC1B）施加到比较器（IC1C）的一个输入端。 可变电源电压也被施加到电压逆变器（VI），其提供相对于电源电压的变化而反向变化的时间参考电压。 在“下”开关闭合时，该参考电压施加到比较器（IC1C），以关闭电动机控制开关（Q3）以启动电动机时间间隔，并且当斜坡电压上升到时间参考电压的电平时， 比较器（IC1C）打开电机控制开关（Q3）以停止电机时间间隔。 结果，由于电机速度随着电源电压的变化而变化，间隔定时器反向变化恒定负载驱动距离的电动机工作时间。

公开(公告)号：US4477613A

公开(公告)日：1984-10-16

申请号：US519451

申请日：1983-08-01

申请人： James M. Evans ,  Kenneth E. Krajca ,  Keijo A. Ukkonen ,  James E. Hansen

发明人： James M. Evans ,  Kenneth E. Krajca ,  Keijo A. Ukkonen ,  James E. Hansen

IPC分类号： C08L1/00 ,  C08L7/00 ,  C08L21/00 ,  C08L23/00 ,  C08L27/00 ,  C08L33/00 ,  C08L33/02 ,  C08L93/00 ,  C08L93/04 ,  C08L101/00 ,  C09F1/00 ,  C09F7/00

CPC分类号： C08L93/04

摘要： There is provided a stabilized aqueous base tackifier composition characterized by the presence in an aqueous medium of a resinous tackifier composition having an acid number in the range from 30 to 150 and a softening point in the range of from -40.degree. to 150.degree. C., a minor amount of a nonionic or anionic surfactant and a minor amount of an elastomeric latex. There is also provided a method of stabilizing an emulsifiable tackifier composition which comprises adding to such composition, a minor amount of a surfactant and a minor amount of an elastomer.

摘要翻译： 提供一种稳定的水性基础增粘剂组合物，其特征在于在水性介质中存在酸值为30至150，软化点为-40至150℃的树脂增粘剂组合物。 ，少量的非离子或阴离子表面活性剂和少量弹性体胶乳。 还提供了一种稳定可乳化增粘剂组合物的方法，其包括向该组合物中加入少量表面活性剂和少量弹性体。

公开(公告)号：US4346424A

公开(公告)日：1982-08-24

申请号：US123593

申请日：1980-02-22

申请人： James E. Hansen

发明人： James E. Hansen

IPC分类号： H02H3/087 ,  H02H3/093

CPC分类号： H02H3/087

摘要： An electronic remote control D.C. power control and overload circuit breaker for the cockpit controlled D.C. power system of an aircraft or the like. Electronic sensing of overcurrent conditions provides better accuracy, stability and reliability and easier adjustment or adaptation to specific applications. These are attained by using a combination of a shunt resistor in the D.C. line feeding a transient suppressing input bridge and an instrumentation amplifier with common mode rejection followed by a trip time delay network, a threshold comparator and logic and relay control circuitry, as well as supply voltage regulation plus secondary regulation of the comparator reference voltage. A remote cockpit unit affords control and indication. Modifications afford bidirectional sensing of the D.C. bus overload as well as different trip time delays for the two polarities of overload currents.

摘要翻译： 用于飞机等的驾驶舱控制的直流电力系统的电子遥控器D.C.功率控制和过载断路器。 过电流条件的电子感应提供更好的精度，稳定性和可靠性，并且更容易调整或适应特定应用。 这些通过使用馈送瞬态抑制输入桥的DC线路中的分流电阻和具有共模抑制，后跟跳闸时间延迟网络，阈值比较器和逻辑和继电器控制电路的仪表放大器的组合来实现，以及 电源电压调节加二次调节比较器参考电压。 遥控驾驶舱单元提供控制和指示。 修改提供双向感测直流母线过载以及两个过载电流极性的不同跳闸时间延迟。

公开(公告)号：US4161331A

公开(公告)日：1979-07-17

申请号：US799140

申请日：1977-05-23

申请人： James E. Hansen

发明人： James E. Hansen

IPC分类号： F16L27/08 ,  B05B15/00 ,  F16L27/02 ,  F16L27/06 ,  F16L55/00

CPC分类号： F16L27/0853

摘要： In accordance with the present invention, irrigation pipe couplings for movable irrigation systems may include a spherical coupling structure that allows articulation of sections of the irrigation pipe during operation of the irrigation system. A sealing element is provided that maintains a positive seal when the various sections of irrigation pipe of the irrigation system are static or are moving. The internal and external components of the coupling structure and the sealing element of each of the couplings cooperate in such manner that the sealing elements are easily and quickly replaceable should they become worn or damaged. It is not necessary to cause longitudinal separation of the sections of irrigation pipe to which the coupling structures are affixed in order to achieve replacement of the sealing element. A portion of the external part of the coupling structure provides support for one extremity of one of the pipe sections that are coupled, both in normal operation and during replacement of the sealing element.

摘要翻译： 根据本发明，用于可移动灌溉系统的灌溉管接头可以包括球形联接结构，其允许在灌溉系统的操作期间铰接灌溉管道的部分。 提供一种密封元件，当灌溉系统的灌溉管道的各个部分是静止的或正在移动时，该密封元件保持正密封。 联接结构的内部和外部部件以及每个联轴器的密封元件以这样的方式配合，使得密封元件在它们被磨损或损坏时容易且快速地可更换。 为了实现更换密封元件，不需要将连接结构固定的冲洗管的部分纵向分离。 耦合结构的外部部分的一部分为正常操作和更换密封元件期间连接的一个管段的一个末端提供支撑。

公开(公告)号：US06433560B1

公开(公告)日：2002-08-13

申请号：US09944897

申请日：2001-08-31

申请人： James E. Hansen ,  Edward F. Buck ,  Lian Q. Zou ,  Victor E. Shtaida ,  Peter J. McGinnis ,  Birger Pahl

发明人： James E. Hansen ,  Edward F. Buck ,  Lian Q. Zou ,  Victor E. Shtaida ,  Peter J. McGinnis ,  Birger Pahl

IPC分类号： G01R2726

CPC分类号： G01F23/268 ,  G01F23/265 ,  G01F23/266 ,  G01N33/2888

摘要： A combination fluid condition monitor and fluid level sensor having an excitation electrode divided into two segments disposed closely spaced and parallel to current sensing electrode. For the fluid condition monitoring mode function both segments of the excitation electrode are commonly excited sequentially at high and low frequencies and the currents sensed in the sensing electrode employed to compute the difference in impedance for determining the fluid condition. For the level sensing mode function a mode switching circuit grounds one of the excitation electrode segments and excites the other then grounds the other segment and excites the one segment and the resultant currents ratioed to determine the amount of electrode immersed in fluid and hence the fluid level.

摘要翻译： 一种组合流体状态监测器和液位传感器，其具有被分成与电流感测电极紧密隔开并平行设置的两个段的激励电极。 对于流体状况监测模式功能，激励电极的两个部分通常在高频和低频下顺序地被激励，并且感测电极中检测到的电流用于计算阻抗差以确定流体状况。 对于电平感测模式功能，模式切换电路接地一个激励电极段并激励另一个激励，然后使另一个部分接地，并激励一个部分，并将所得到的电流比值确定浸入流体中的电极的量，从而确定液位 。