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公开(公告)号：US07622500B2
公开(公告)日：2009-11-24
申请号：US12034429
申请日：2008-02-20
IPC分类号： A61K31/343 , C07D307/78
CPC分类号： C07D307/81
摘要： The present invention relates to compounds of the formula (I) and pharmaceutically acceptable salts thereof, compositions containing such compounds and the uses of such compounds as antiparasitic agents.
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐，含有这些化合物的组合物以及这些化合物作为抗寄生虫剂的用途。
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![3-azabicyclo[3.1.0]hexane derivatives useful in therapy](/abs-image/US/2006/05/23/US07049444B2/abs.jpg.150x150.jpg)
公开(公告)号：US07049444B2
公开(公告)日：2006-05-23
申请号：US10214658
申请日：2002-08-07
申请人： Bernard Joseph Banks , Robert James Crook , Stephen Paul Gibson , Graham Lunn , Alan John Pettman
发明人： Bernard Joseph Banks , Robert James Crook , Stephen Paul Gibson , Graham Lunn , Alan John Pettman
IPC分类号： C07D209/52
CPC分类号： C07D401/04 , C07D209/52 , C07D401/06 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/06 , C07D409/06 , C07D409/10 , C07D413/12 , C07D417/06
摘要： Compounds of formula (I), their salts and prodrugs thereof, where the substituents are as defined herein are disclosed as opiate binding agents useful in the treatment of opiate-mediated conditions. Also described are processes for making such substances.
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公开(公告)号：US20100035980A1
公开(公告)日：2010-02-11
申请号：US12579809
申请日：2009-10-15
IPC分类号： A61K31/343 , C07D307/77
CPC分类号： C07D307/81
摘要： The present invention relates to compounds of the formula (I) and pharmaceutically acceptable salts thereof, compositions containing such compounds and the uses of such compounds as antiparasitic agents.
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐，含有这些化合物的组合物以及这些化合物作为抗寄生虫剂的用途。
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公开(公告)号：US5665708A
公开(公告)日：1997-09-09
申请号：US617740
申请日：1996-03-08
申请人： Constantine Sklavounos , Thomas Charles Crawford , Neil Demers , Stephen Paul Gibson , Charles William Murtiashaw, deceased
发明人： Constantine Sklavounos , Thomas Charles Crawford , Neil Demers , Stephen Paul Gibson , Charles William Murtiashaw, deceased
IPC分类号： A01N43/90 , A01N47/06 , A01P3/00 , A61K31/70 , A61K31/7042 , A61K31/7048 , A61P33/00 , C07H17/08 , C07H19/01
摘要： Intermediates and a process for preparing doramectin, the compound of formula (I), semisynthetically from by-product in the fermentation procedure which also yields the compound of formula (I). The intermediates prepared by the process of this invention also have utility as antiparasitic agents. The process of this invention utilizes continuous reaction inert gas sparging during the pyrolysis step, resulting in a significant improvement in the overall yield of this conversion. ##STR1##
摘要翻译： PCT No.PCT / IB94 / 00283 Sec。 371日期：1996年3月8日 102（e）1996年3月8日PCT PCT 1994年9月19日PCT公布。 公开号WO95 / 09863 日期1995年04月13日中间体和制备多拉菌素的方法，式（I）化合物在发酵过程中半合成来自副产物，其也产生式（I）化合物。 通过本发明方法制备的中间体也可用作抗寄生虫剂。 本发明的方法在热解步骤期间利用连续反应惰性气体喷射，导致该转化率的总收率显着提高。 （一）
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