公开(公告)号：US20240360080A1

公开(公告)日：2024-10-31

申请号：US18520037

申请日：2023-11-27

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Yasushi HATTORI ,  Yuhei MIYANOHANA ,  Yuichi KAJITA ,  Tatsuki KOIKE ,  Yasutaka HOASHI ,  Norihito TOKUNAGA ,  Alexander Martin PAWLICZEK ,  Tsuneo ODA ,  Tohru MIYAZAKI ,  Yoshiteru ITO ,  Kohei TAKEUCHI ,  Keisuke IMAMURA ,  Takahiro SUGIMOTO

IPC: C07D207/14 ,  C07D403/06 ,  C07D407/08 ,  C07D417/06

CPC classification number: C07D207/14 ,  C07D403/06 ,  C07D407/08 ,  C07D417/06

Abstract: The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.
A compound represented by the formula (I):




wherein each symbol is as described in the specification, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.

公开(公告)号：US20220098180A1

公开(公告)日：2022-03-31

申请号：US17426971

申请日：2020-01-29

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Masahiro ITO ,  Takeshi YAMAMOTO ,  Keiko KAKEGAWA ,  Hideyuki SUGIYAMA ,  Tohru MIYAZAKI ,  Yasuyoshi ARIKAWA ,  Tomohiro OKAWA ,  Jinichi YONEMORI ,  Osamu KUBO ,  Akinori TOITA ,  Takuto KOJIMA ,  Fumiaki KIKUCHI ,  Minoru SASAKI ,  Misaki HOMMA ,  Yasuhiro IMAEDA ,  Hironobu MAEZAKI ,  Shiinobu SASAKI ,  Ayumu SATO ,  Hirotaka KAMITANI ,  Yasutomi ASANO ,  Hironori KOKUBO ,  Masato YOSHIKAWA

IPC: C07D413/10 ,  C07D271/06 ,  C07D413/14 ,  C07D417/14

Abstract: The present invention provides a heterocyclic compound having a HDAC inhibitory action, which is useful for the treatment of central nervous system diseases including neurodegenerative diseases, and the like, and a medicament comprising the compound.
The present invention relates to a compound represented by the formula (I): wherein each symbol is as described in the description, or a salt thereof.

公开(公告)号：US20210269420A1

公开(公告)日：2021-09-02

申请号：US17256330

申请日：2019-06-27

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Tatsuhiko FUJIMOTO ,  Koichiro FUKUDA ,  Hiromichi SUGIMOTO ,  Kentaro RIKIMARU ,  Yoshihiro BANNO ,  Takahiro MATSUMOTO ,  Norihito TOKUNAGA ,  Yoshihide TOMATA ,  Yuji ISHICHI ,  Shogo MARUI ,  Tsuneo ODA ,  Tohru MIYAZAKI ,  Yasutaka HOASHI ,  Yasushi HATTORI ,  Yuichi KAJITA ,  Yuhei MIYANOHANA ,  Tatsuki KOIKE

IPC: C07D401/14 ,  C07D405/14 ,  C07D211/56

Abstract: The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.
A compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.

公开(公告)号：US20210198240A1

公开(公告)日：2021-07-01

申请号：US16973320

申请日：2019-06-27

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Tsuneo ODA ,  Yoshiteru ITO ,  Tohru MIYAZAKI ,  Kohei TAKEUCHI ,  Norihito TOKUNAGA ,  Yasutaka HOASHI ,  Yasushi HATTORI ,  Keisuke IMAMURA ,  Yuichi KAJITA ,  Yuhei MIYANOHANA ,  Takahiro SUGIMOTO ,  Tatsuki KOIKE ,  Dilhumar UYGHUR

IPC: C07D405/12 ,  C07D207/14 ,  C07D401/14 ,  C07D401/06 ,  C07D417/14 ,  C07D417/06 ,  C07D405/14 ,  C07D211/56 ,  C07D405/06 ,  C07D403/06

Abstract: The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.
A compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.