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公开(公告)号：US20230063805A1
公开(公告)日：2023-03-02
申请号：US17846830
申请日：2022-06-22
发明人： Yuichi KAJITA , Yuhei MIYANOHANA , Tatsuki KOIKE , Kohei TAKEUCHI , Yoshiteru ITO , Norihito TOKUNAGA , Takahiro SUGIMOTO , Tohru MIYAZAKI , Tsuneo ODA , Yasutaka HOASHI , Yasushi HATTORI , Keisuke IMAMURA
IPC分类号： C07D211/56 , C07D211/36 , C07D405/06 , A61P25/26 , C07D409/10 , A61P25/00 , C07D205/04 , C07D207/14 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/06 , C07D405/10 , C07D405/12 , C07D413/06 , C07D417/06 , C07D417/14
摘要： The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.
A compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof, is useful as an agent for the prophylaxis or treatment of narcolepsy.-
公开(公告)号：US20230042358A1
公开(公告)日：2023-02-09
申请号：US17413469
申请日：2019-12-11
发明人： Yuhei MIYANOHANA , Yuichi KAJITA , Tatsuki KOIKE , Yasutaka HOASHI , Yasushi HATTORI , Norihito TOKUNAGA , Tsuneo ODA , Tohru MIYAZAKI , Dilhumar UYGHUR , Yoshiteru ITO , Kohei TAKEUCHI , Keisuke IMAMURA , Takahiro SUGIMOTO , Koichiro FUKUDA , Yasuhisa KOHARA , Rei OKAMOTO , Taiichi OHRA , Naoki MIYAMOTO , Jun CHIBA , Yoshito TERAO , Masanori KAWASAKI
IPC分类号： C07D455/02 , A61P25/26 , C07D471/04 , C07D217/24 , C07D239/90 , C07D237/32 , C07D401/10 , C07D403/10 , C07D498/04 , C07D417/06 , C07D401/06
摘要： The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.
A compound represented by the formula (I): wherein each symbol is as described in the description, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.-
公开(公告)号：US20210009572A1
公开(公告)日：2021-01-14
申请号：US17038917
申请日：2020-09-30
发明人： Masami YAMADA , Shinkichi SUZUKI , Takahiro SUGIMOTO , Minoru NAKAMURA , Hiroki SAKAMOTO , Makoto KAMATA
IPC分类号： C07D405/14 , C07D209/46 , C07D401/10 , C07D401/14 , C07D403/04 , C07D403/10 , C07D401/06 , C07D405/04 , A61K31/4035 , A61K31/4155 , A61K31/4439 , A61K31/13 , A61K31/325 , A61K31/445 , A61K31/55 , A61K31/045 , A61K31/4406
摘要： The present invention provides a compound having a cholinergic muscarinic Ml receptor positive allosteric modulator activity and useful as an agent for the prophylaxis or treatment of Alzheimer's disease, schizophrenia, pain, sleep disorder, Parkinson's disease dementia, dementia with Lewy bodies, and the like.
The present invention relates to a compound represented by the formula (I) or a salt thereof. wherein each symbol is as described in the specification, or a salt thereof.-
公开(公告)号：US20190040010A1
公开(公告)日：2019-02-07
申请号：US16052967
申请日：2018-08-02
发明人： Yuichi Kajita , Satoshi MIKAMI , Yuhei MIYANOHANA , Tatsuki KOIKE , Masaki DAINI , Norio OHYABU , Masaki OGINO , Kohei TAKEUCHI , Yoshiteru ITO , Norihito TOKUNAGA , Takahiro SUGIMOTO , Tohru MIYAZAKI , Tsuneo ODA , Yasutaka HOASHI , Yasushi HATTORI , Keisuke IMAMURA
IPC分类号： C07D211/56 , C07D401/10 , C07D401/06 , C07D207/14 , C07D405/10 , C07D417/06 , C07D405/12 , C07D413/06 , C07D401/14 , C07D205/04 , C07D403/06 , C07D417/14 , A61P25/00
摘要： The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.A compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof, is useful as an agent for the prophylaxis or treatment of narcolepsy.
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公开(公告)号：US20170266162A1
公开(公告)日：2017-09-21
申请号：US15608557
申请日：2017-05-30
发明人： Masami YAMADA , Shinkichi SUZUKI , Takahiro SUGIMOTO , Minoru NAKAMURA , Hiroki SAKAMOTO , Makoto KAMATA
IPC分类号： A61K31/4035 , A61K31/55 , A61K31/13 , A61K31/325 , A61K31/4155 , A61K31/445 , A61K31/4439
CPC分类号： C07D405/14 , A61K31/045 , A61K31/13 , A61K31/325 , A61K31/4035 , A61K31/4155 , A61K31/4406 , A61K31/4439 , A61K31/445 , A61K31/55 , C07D209/46 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/04 , C07D471/04
摘要： The present invention provides a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity and useful as an agent for the prophylaxis or treatment of Alzheimer's disease, schizophrenia, pain, sleep disorder, Parkinson's disease dementia, dementia with Lewy bodies, and the like.The present invention relates to a compound represented by the formula (I) or a salt thereof. wherein each symbol is as described in the specification, or a salt thereof.
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公开(公告)号：US20150307451A1
公开(公告)日：2015-10-29
申请号：US14693342
申请日：2015-04-22
发明人： Masami YAMADA , Shinkichi SUZUKI , Takahiro SUGIMOTO , Minoru NAKAMURA , Hiroki SAKAMOTO , Makoto KAMATA
IPC分类号： C07D209/46 , C07D401/14 , C07D403/04 , C07D401/10 , C07D403/10 , C07D405/14
CPC分类号： C07D405/14 , A61K31/045 , A61K31/13 , A61K31/325 , A61K31/4035 , A61K31/4155 , A61K31/4406 , A61K31/4439 , A61K31/445 , A61K31/55 , C07D209/46 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/04 , C07D471/04
摘要： The present invention provides a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity and useful as an agent for the prophylaxis or treatment of Alzheimer's disease, schizophrenia, pain, sleep disorder, Parkinson's disease dementia, dementia with Lewy bodies, and the like.The present invention relates to a compound represented by the formula (I) or a salt thereof. wherein each symbol is as described in the specification, or a salt thereof.
摘要翻译： 本发明提供具有胆碱能毒蕈碱M1受体阳性变构调节剂活性的化合物，可用作预防或治疗阿尔茨海默病，精神分裂症，疼痛，睡眠障碍，帕金森病痴呆，路易体痴呆等。 本发明涉及由式（I）表示的化合物或其盐。 其中每个符号如说明书中所述或其盐。
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公开(公告)号：US20240360080A1
公开(公告)日：2024-10-31
申请号：US18520037
申请日：2023-11-27
发明人： Yasushi HATTORI , Yuhei MIYANOHANA , Yuichi KAJITA , Tatsuki KOIKE , Yasutaka HOASHI , Norihito TOKUNAGA , Alexander Martin PAWLICZEK , Tsuneo ODA , Tohru MIYAZAKI , Yoshiteru ITO , Kohei TAKEUCHI , Keisuke IMAMURA , Takahiro SUGIMOTO
IPC分类号： C07D207/14 , C07D403/06 , C07D407/08 , C07D417/06
CPC分类号： C07D207/14 , C07D403/06 , C07D407/08 , C07D417/06
摘要： The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.
A compound represented by the formula (I):
wherein each symbol is as described in the specification, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.-
公开(公告)号：US20210198240A1
公开(公告)日：2021-07-01
申请号：US16973320
申请日：2019-06-27
发明人： Tsuneo ODA , Yoshiteru ITO , Tohru MIYAZAKI , Kohei TAKEUCHI , Norihito TOKUNAGA , Yasutaka HOASHI , Yasushi HATTORI , Keisuke IMAMURA , Yuichi KAJITA , Yuhei MIYANOHANA , Takahiro SUGIMOTO , Tatsuki KOIKE , Dilhumar UYGHUR
IPC分类号： C07D405/12 , C07D207/14 , C07D401/14 , C07D401/06 , C07D417/14 , C07D417/06 , C07D405/14 , C07D211/56 , C07D405/06 , C07D403/06
摘要： The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.
A compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.-
9.发明申请公开(公告)号：US20180162850A1
公开(公告)日：2018-06-14
申请号：US15735418
申请日：2016-06-23
发明人： Takahiro SUGIMOTO , Shinkichi SUZUKI , Hiroki SAKAMOTO , Masami YAMADA , Minoru NAKAMURA , Makoto KAMATA , Kenichiro SHIMOKAWA , Masaki OGINO , Eiji KIMURA , Masataka MURAKAMI , Jinichi YONEMORI , Takuto KOJIMA
IPC分类号： C07D413/14 , C07D413/10 , C07D265/22 , C07D417/10 , C07F7/08 , C07D491/107 , A61P25/28
CPC分类号： C07D265/22 , A61P25/28 , C07B2200/07 , C07D413/04 , C07D413/06 , C07D413/10 , C07D413/14 , C07D417/06 , C07D417/10 , C07D471/04 , C07D491/107 , C07F7/02 , C07F7/0814
摘要： The present invention provides a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity, which may be useful as a prophylactic or therapeutic drug for Alzheimer's disease, schizophrenia, pain, sleep disorder, Parkinson's disease dementia, dementia with Lewy bodies and the like. The present invention relates to a compound represented by the formula (I) or a salt thereof: wherein each symbol is as defined in the attached DESCRIPTION.
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公开(公告)号：US20180000780A1
公开(公告)日：2018-01-04
申请号：US15685800
申请日：2017-08-24
发明人： Masami YAMADA , Shinkichi SUZUKI , Takahiro SUGIMOTO , Minoru NAKAMURA , Hiroki SAKAMOTO , Makoto KAMATA
IPC分类号： A61K31/4035 , A61K31/045 , A61K31/4406 , C07D471/04
CPC分类号： C07D405/14 , A61K31/045 , A61K31/13 , A61K31/325 , A61K31/4035 , A61K31/4155 , A61K31/4406 , A61K31/4439 , A61K31/445 , A61K31/55 , C07D209/46 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/04 , C07D471/04
摘要： The present invention provides a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity and useful as an agent for the prophylaxis or treatment of Alzheimer's disease, schizophrenia, pain, sleep disorder, Parkinson's disease dementia, dementia with Lewy bodies, and the like.The present invention relates to a compound represented by the formula (I) or a salt thereof. wherein each symbol is as described in the specification, or a salt thereof.
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