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公开(公告)号：US20230063805A1
公开(公告)日：2023-03-02
申请号：US17846830
申请日：2022-06-22
发明人： Yuichi KAJITA , Yuhei MIYANOHANA , Tatsuki KOIKE , Kohei TAKEUCHI , Yoshiteru ITO , Norihito TOKUNAGA , Takahiro SUGIMOTO , Tohru MIYAZAKI , Tsuneo ODA , Yasutaka HOASHI , Yasushi HATTORI , Keisuke IMAMURA
IPC分类号： C07D211/56 , C07D211/36 , C07D405/06 , A61P25/26 , C07D409/10 , A61P25/00 , C07D205/04 , C07D207/14 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/06 , C07D405/10 , C07D405/12 , C07D413/06 , C07D417/06 , C07D417/14
摘要： The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.
A compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof, is useful as an agent for the prophylaxis or treatment of narcolepsy.-
公开(公告)号：US20230042358A1
公开(公告)日：2023-02-09
申请号：US17413469
申请日：2019-12-11
发明人： Yuhei MIYANOHANA , Yuichi KAJITA , Tatsuki KOIKE , Yasutaka HOASHI , Yasushi HATTORI , Norihito TOKUNAGA , Tsuneo ODA , Tohru MIYAZAKI , Dilhumar UYGHUR , Yoshiteru ITO , Kohei TAKEUCHI , Keisuke IMAMURA , Takahiro SUGIMOTO , Koichiro FUKUDA , Yasuhisa KOHARA , Rei OKAMOTO , Taiichi OHRA , Naoki MIYAMOTO , Jun CHIBA , Yoshito TERAO , Masanori KAWASAKI
IPC分类号： C07D455/02 , A61P25/26 , C07D471/04 , C07D217/24 , C07D239/90 , C07D237/32 , C07D401/10 , C07D403/10 , C07D498/04 , C07D417/06 , C07D401/06
摘要： The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.
A compound represented by the formula (I): wherein each symbol is as described in the description, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.-
公开(公告)号：US20210276949A1
公开(公告)日：2021-09-09
申请号：US17239191
申请日：2021-04-23
发明人： Yasushi HATTORI , Yuhei MIYANOHANA , Yuichi KAJITA , Tatsuki KOIKE , Yasutaka HOASHI , Norihito TOKUNAGA , Alexander Martin PAWLICZEK , Tsuneo ODA , Tohru MIYAZAKI , Yoshiteru ITO , Kohei TAKEUCHI , Keisuke IMAMURA , Takahiro SUGIMOTO
IPC分类号： C07D207/14 , C07D407/08 , C07D417/06
摘要： The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.
A compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.-
公开(公告)号：US20200017444A1
公开(公告)日：2020-01-16
申请号：US16577449
申请日：2019-09-20
发明人： Yuichi KAJITA , Satoshi MIKAMI , Yuhei MIYANOHANA , Tatsuki KOIKE , Masaki DAINI , Norio OYABU , Masaki OGINO , Kohei TAKEUCHI , Yoshiteru ITO , Norihito TOKUNAGA , Takahiro SUGIMOTO , Tohru MIYAZAKI , Tsuneo ODA , Yasutaka HOASHI , Yasushi HATTORI , Keisuke IMAMURA
IPC分类号： C07D211/56 , A61P25/00 , C07D205/04 , C07D207/14 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/06 , C07D405/10 , C07D405/12 , C07D413/06 , C07D417/06 , C07D417/14 , C07D211/36 , C07D405/06
摘要： The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.A compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof, is useful as an agent for the prophylaxis or treatment of narcolepsy.
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公开(公告)号：US20160024049A1
公开(公告)日：2016-01-28
申请号：US14781963
申请日：2014-04-03
发明人： Tatsuki KOIKE , Masato YOSHIKAWA , Haruhi ANDO , William John FARNABY , Shuhei IKEDA , Yuichi KAJITA , Toshiya NISHI
IPC分类号： C07D401/10 , C07D213/56 , C07D401/14 , C07D403/12 , C07D239/26 , C07D213/42 , C07D405/14 , C07D417/14 , C07D401/12 , C07D413/14
CPC分类号： C07D401/10 , C07D213/34 , C07D213/42 , C07D213/56 , C07D239/26 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14
摘要： The present invention relates to a compound represented by the formula (I), which is useful as an agent for the prophylaxis or treatment of epilepsy, neurodegenerative disease and the like. In the formula (I), each symbol is as defined in the specification.
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公开(公告)号：US20240309016A1
公开(公告)日：2024-09-19
申请号：US18606857
申请日：2024-03-15
发明人： Mitsunori KONO , Yusuke SASAKI , Yuya OGURO , Zenichi IKEDA , Osamu KUBO , Masaki SETO , Toru YAMASHITA , Makoto KAMATA , Kenjiro SATO , Matthew Thomas REYNOLDS , Kazuaki TAKAMI , Asato KINA , Takafumi YUKAWA , Minoru NAKAMURA , Taku KAMEI , Hiroyuki KAKEI , Fumie YAMAGUCHI , Tomohiro OHASHI , Keiko KAKEGAWA , Takuto KOJIMA , Florian PÜNNER , Masataka MURAKAMI , Takahiko TANIGUCHI , Tatsuki KOIKE , Yuichi KAJITA , Yuhei MIYANOHANA , Kohei TAKEUCHI , Yoshiteru ITO , Norihito TOKUNAGA , Yasushi HATTORI , Eiji KIMURA , Martin Alexander PAWLICZEK , Marilena PIRA , Shuhei IKEDA , Noriyuki TEZUKA , Yoshikazu WATANABE , Kevin CURRAN , Nicolle DOERING , Maria HOPKINS , Ben JOHNSON , Andre KIRYANOV , Jon LAM , Sean MURPHY , Natasha O'ROURKE , Holly REICHARD , Paul TANIS , Yunlong ZHANG
IPC分类号： C07D498/14 , A61K31/407 , A61K31/437 , A61P25/26 , C07D498/04
CPC分类号： C07D498/14 , A61K31/407 , A61K31/437 , A61P25/26 , C07D498/04
摘要： The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.
A compound represented by the formula (I):
wherein each symbol is as described in the specification, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.-
公开(公告)号：US20170197983A1
公开(公告)日：2017-07-13
申请号：US15467548
申请日：2017-03-23
发明人： Tatsuki KOIKE , Yuichi KAJITA , Masato YOSHIKAWA , Shuhei IKEDA , Eiji KIMURA , Tomoaki HASUI , Toshiya NISHI , Hiromi FUKUDA
IPC分类号： C07D498/08 , C07D413/14 , C07D417/14 , C07D471/08 , C07D471/10 , C07D405/14 , C07D213/74 , C07D239/42 , C07D401/04 , C07D401/14 , C07D487/18
CPC分类号： C07D498/08 , A61K9/2018 , A61K9/4858 , C07D213/12 , C07D213/72 , C07D213/74 , C07D239/42 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D451/02 , C07D451/04 , C07D471/08 , C07D471/10 , C07D487/08 , C07D487/10 , C07D487/18 , C07D491/08 , C07D491/18 , C12N9/99
摘要： An object of the present invention is to provide a compound having a superior CH24H inhibitory action, which is useful as an agent for the prophylaxis or treatment of epilepsy, neurodegenerative disease and the like. The present invention relates to a compound represented by the formula: wherein each symbol is as defined in the specification, or a salt thereof.
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公开(公告)号：US20160264536A1
公开(公告)日：2016-09-15
申请号：US15031505
申请日：2014-10-22
发明人： Masaki SETO , Yoshihiro BANNO , Toshihiro IMAEDA , Yuichi KAJITA , Tomoko ASHIZAWA , Masanori KAWASAKI , Shinji NAKAMURA , Satoshi MIKAMI , Izumi NOMURA , Takahiko TANIGUCHI , Shogo MARUI
IPC分类号： C07D277/56 , C07D403/12 , C07D239/28 , C07D403/04 , C07D239/47 , C07D239/36 , C07D239/52 , C07D241/24 , C07D498/08 , C07D413/04 , C07D405/04 , C07D401/04 , C07D417/04 , C07D409/04 , C07D401/12 , C07D239/42
CPC分类号： C07D277/56 , C07D239/28 , C07D239/36 , C07D239/42 , C07D239/47 , C07D239/48 , C07D239/52 , C07D239/54 , C07D239/56 , C07D241/24 , C07D241/26 , C07D277/20 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D409/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D498/04 , C07D498/08
摘要： The problem of the present invention is to provide a compound having a PDE2A inhibitory action, and useful as a prophylactic or therapeutic drug for schizophrenia, Alzheimer's disease and the like. The present invention relates to a compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof.
摘要翻译： 其中每个符号如说明书中所述或其盐。
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公开(公告)号：US20230037557A1
公开(公告)日：2023-02-09
申请号：US17780125
申请日：2020-11-26
发明人： Yoshiteru ITO , Yuhei MIYANOHANA , Yuichi KAJITA , Yasutaka HOASHI , Yasushi HATTORI , Tatsuki KOIKE , Norihito TOKUNAGA , Eiji KIMURA , Alexander Martin PAWLICZEK , Marilena PIRA , Javier MIGUELEZ-RAMOS
IPC分类号： C07D471/04 , A61P25/00
摘要： The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.
A compound represented by the formula (I): wherein each symbol is as described in the description, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.-
公开(公告)号：US20220017514A1
公开(公告)日：2022-01-20
申请号：US17413473
申请日：2019-12-11
发明人： Yuichi KAJITA , Yuhei MIYANOHANA , Tatsuki KOIKE , Yasutaka HOASHI , Yasushi HATTORI , Norihito TOKUNAGA , Tsuneo ODA , Tohru MIYAZAKI , Dilhumar UYGHUR , Yoshiteru ITO , Kohei TAKEUCHI , Keisuke IMAMURA , Takahiro SUGIMOTO , Koichiro FUKUDA , Yasuhisa KOHARA , Rei OKAMOTO , Taiichi OHRA , Naoki MIYAMOTO , Yoshito TERAO , Masanori KAWASAKI
IPC分类号： C07D471/04 , C07D231/56 , C07D277/64 , C07D215/38 , C07D401/14
摘要： The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.
A compound represented by the formula (I): wherein each symbol is as described in the description, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.
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