公开(公告)号：US10913062B2

公开(公告)日：2021-02-09

申请号：US15756209

申请日：2016-09-01

Applicant: TECAN TRADING AG

Inventor： Thomas Perroud ,  Daniel Tran ,  Daniel Hoffmeyer ,  Tiffany Lay ,  Manjeet Dhindsa

IPC: B01L3/00

Abstract: Digital microfluidics system with electrodes attached to a PCB has control unit for manipulating liquid droplets by electrowetting, cartridge accommodation site for taking up a disposable cartridge having a working gap in-between two hydrophobic surfaces, and magnetic conduit/backing combination. A barrier element on an individual electrode of the PCB for narrowing the working gap. A disposable cartridge is positioned at the cartridge accommodation site, its flexible working film touching there and of the barrier element an uppermost surface. In the working gap and above a path of selected electrodes a liquid portion or liquid droplet with magnetically responsive beads moves by electrowetting on the electrode path until a magnetic field of the magnetic conduit is reached. The backing magnet is activated before and during the moving to thereby attract and remove magnetically responsive beads therefrom.

公开(公告)号：US20190331639A1

公开(公告)日：2019-10-31

申请号：US15962945

申请日：2018-04-25

Applicant: TECAN TRADING AG

Inventor： PATRICK KINNEY ,  Tin Ngo ,  Sujata Iyer ,  Daniel Hoffmeyer ,  Manjeet Dhindsa ,  Tiffany Ding (Lay)

IPC: G01N27/447 ,  B01L3/00

Abstract: A cartridge for use in an electrowetting sample processing system, the cartridge having at least one inlet port for introducing an input liquid in an internal gap of the cartridge, wherein the gap has at least one hydrophobic surface and is configured to provide an electrowetting induced movement of a microfluidic droplet of input liquid, wherein the input liquid has a carrier liquid and a processing liquid and the gap has a capture zone that is configured to capture at least a part of the processing liquid as a microfluidic droplet by use of electrowetting force and the gap further has a transfer zone that is configured to provide a passage for the carrier liquid next to the microfluidic droplet, while processing liquid is captured in the capture zone.

公开(公告)号：US20150144489A1

公开(公告)日：2015-05-28

申请号：US14402717

申请日：2014-01-06

Applicant: TECAN TRADING AG

Inventor： Daniel Hoffmeyer ,  Tiffany Lay ,  Travis Lee ,  Marc N. Feiglin ,  Werner Halg ,  Anne R. Kopf-Sill

IPC: G01N27/447

CPC classification number: G01N27/44791 ,  B01L3/502715 ,  B01L3/502792 ,  B01L3/505 ,  B01L2200/027 ,  B01L2200/04 ,  B01L2300/044 ,  B01L2300/123 ,  B01L2400/0427 ,  B81B1/00 ,  G01N27/44756

Abstract: A disposable cartridge used in a digital microfluidics system has a bottom layer with first hydrophobic surface, a rigid cover plate with second hydrophobic surface, and a gap there-between. The bottom layer is a flexible film on an uppermost surface of a cartridge accommodation site of a system, attracted to and spread over the uppermost surface by an underpressure. A lower surface of the plate and the flexible bottom layer are sealed to each other. The assembled cartridge is removed from the cartridge accommodation site in one piece and potentially includes samples and processing fluids. The system has a base unit and a cartridge accommodation site with an electrode array of individual electrodes and a central control unit for controlling selection of individual electrodes and for providing these electrodes with individual voltage pulses for manipulating liquid droplets within the gap by electrowetting.

Abstract translation: 在数字微流体系统中使用的一次性盒具有具有第一疏水表面的底层，具有第二疏水表面的刚性盖板及其间的间隙。 底层是在系统的盒容纳位置的最上表面上的柔性膜，通过负压吸引并分布在最上表面上。 板的下表面和柔性底层彼此密封。 将组装的墨盒从墨盒容纳部位一体地取出，并且可能包括样品和处理流体。 该系统具有基本单元和具有单独电极的电极阵列的中心控制单元和用于控制各个电极的选择的中心控制单元和用于通过电润湿来操纵间隙内的液滴的单独电压脉冲的中心控制单元。