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    CARTRIDGE, ELECTROWETTING SAMPLE PROCESSING SYSTEM AND DROPLET FORMATION
    1.
    发明申请
    CARTRIDGE, ELECTROWETTING SAMPLE PROCESSING SYSTEM AND DROPLET FORMATION 有权

    公开(公告)号：US20230003685A1

    公开(公告)日：2023-01-05

    申请号：US17901634

    申请日：2022-09-01

    Applicant: TECAN TRADING AG

    Inventor： Patrick KINNEY ,  Tin Ngo ,  Sujata Iyer ,  Daniel Hoffmeyer ,  Manjeet Dhindsa ,  Tiffany Ding (Lay)

    IPC: G01N27/447 ,  B01L3/00

    Abstract: A cartridge for use in an electrowetting sample processing system, the cartridge having at least one inlet port for introducing an input liquid in an internal gap of the cartridge, wherein the gap has at least one hydrophobic surface and is configured to provide an electrowetting induced movement of a microfluidic droplet of input liquid, wherein the input liquid has a carrier liquid and a processing liquid and the gap has a capture zone that is configured to capture at least a part of the processing liquid as a microfluidic droplet by use of electrowetting force and the gap further has a transfer zone that is configured to provide a passage for the carrier liquid next to the microfluidic droplet, while processing liquid is captured in the capture zone.

    Magnetic conduits in microfluidics
    2.
    发明授权
    Magnetic conduits in microfluidics 有权

    公开(公告)号：US11148138B2

    公开(公告)日：2021-10-19

    申请号：US15756176

    申请日：2015-09-02

    Applicant: TECAN TRADING AG ,  Thomas Perroud ,  Dan Tran ,  Daniel Hoffmeyer ,  Tiffany Lay ,  Manjeet Dhindsa

    Inventor： Thomas Perroud ,  Dan Tran ,  Daniel Hoffmeyer ,  Tiffany Lay ,  Manjeet Dhindsa

    IPC: B01L3/00

    Abstract: A digital microfluidics system with electrodes attached to a substrate and covered by a hydrophobic surface, and a control unit for manipulating liquid droplets by electrowetting; providing in close proximity to electrodes a magnetic conduit for directing a magnetic field of a backing magnet to the first hydrophobic surface; providing on the hydrophobic surface a liquid droplet that has magnetically responsive beads; moving by electrowetting the liquid droplet with the magnetically responsive beads until a part of which is placed atop of the magnetic conduit; actuating the backing magnet of the magnetic conduit and attracting/concentrating magnetically responsive beads; and while actuating the backing magnet, moving by electrowetting the liquid droplet with decreased number of magnetically responsive beads away from the specific magnetic conduit. Also disclosed are a method for suspending magnetically responsive beads in liquid portions or droplets in digital microfluidics and a disposable cartridge to carry out the methods.

    Microfluidics cartridge with pipetting guide
    5.
    发明授权
    Microfluidics cartridge with pipetting guide 有权

    公开(公告)号：US10137450B2

    公开(公告)日：2018-11-27

    申请号：US14335027

    申请日：2014-07-18

    Applicant: Tecan Trading AG

    Inventor： Tiffany Lay ,  Daniel Hoffmeyer ,  Anne R. Kopf-Sill

    IPC: B01L3/00 ,  B01L3/02

    Abstract: A disposable cartridge configured as a digital microfluidics system for manipulating samples in liquid portions having a cartridge accommodation site and a central control unit for controlling selection of individual electrodes of an electrode array located at the site and for providing plural electrodes with individual voltage pulses for manipulating liquid portions by electrowetting. The cartridge has a hydrophobic working surface and a rigid cover with a second hydrophobic surface, the hydrophobic surfaces facing each other and being separated in parallel planes by a gap. The cartridge has plural pipetting guides for safe entering/withdrawing liquids into/from the gap with a pipette tip. At least one of the pipetting guides provides an abutting surface sealingly admittable by a counter surface of a pipette tip, located at a pipetting orifice that reaches through the rigid cover, and configured to prevent a pipette tip from touching the hydrophobic working surface.

    Disposable cartridge for microfluidics system
    6.
    发明授权
    Disposable cartridge for microfluidics system 有权

    公开(公告)号：US09915631B2

    公开(公告)日：2018-03-13

    申请号：US14361556

    申请日：2014-01-06

    Applicant: TECAN TRADING AG

    Inventor： Daniel Hoffmeyer ,  Tiffany Lay ,  Travis Lee

    IPC: G01N27/447 ,  B01L3/00 ,  B81B1/00

    CPC classification number: G01N27/44791 ,  B01L3/502715 ,  B01L3/502792 ,  B01L3/505 ,  B01L2200/027 ,  B01L2200/04 ,  B01L2300/044 ,  B01L2300/123 ,  B01L2400/0427 ,  B81B1/00 ,  G01N27/44756

    Abstract: A digital microfluidics system for manipulating samples in liquid droplets within a gap between a first hydrophobic surface of a bottom layer and a second hydrophobic surface of at least one disposable cartridge. Disposable cartridges comprise a body and/or a rigid cover plate. The bottom layer of each disposable cartridge is a flexible film that is sealingly attached to the body or plate. The cartridge has no spacer between the first and second hydrophobic surfaces. When using these cartridges, the bottom layers configured as a working film for manipulating samples in liquid droplets thereon, is placed on an electrode array of a digital microfluidics system. The array has individual electrodes. The digital microfluidics system also comprises a central control unit for controlling the selection of the individual electrodes of the electrode array and for providing these electrodes with individual voltage pulses for manipulating liquid droplets by electrowetting.

    Magnetic conduits in microfluidics
    7.
    发明授权
    Magnetic conduits in microfluidics 有权

    公开(公告)号：US11819845B2

    公开(公告)日：2023-11-21

    申请号：US17469656

    申请日：2021-09-08

    Applicant: TECAN TRADING AG

    Inventor： Thomas Perroud ,  Dan Tran ,  Daniel Hoffmeyer ,  Tiffany Lay ,  Manjeet Dhindsa

    IPC: B01L3/00

    CPC classification number: B01L3/502715 ,  B01L3/508 ,  B01L3/50273 ,  B01L3/502761 ,  B01L3/502792 ,  B01L2200/025 ,  B01L2200/0668 ,  B01L2300/0816 ,  B01L2300/123 ,  B01L2400/043 ,  B01L2400/0427

    Abstract: A digital microfluidics system with electrodes attached to a substrate and covered by a hydrophobic surface and a control unit for manipulating liquid droplets by electrowetting, providing in close proximity to electrodes a magnetic conduit for directing a magnetic field of a backing magnet to the first hydrophobic surface, providing on the hydrophobic surface a liquid droplet that has magnetically responsive beads moving by electrowetting the liquid droplet with the magnetically responsive beads until a part of which is placed atop of the magnetic conduit, actuating the backing magnet of the magnetic conduit and attracting/concentrating magnetically responsive beads while actuating the backing magnet, moving by electrowetting the liquid droplet with decreased number of magnetically responsive beads away from the specific magnetic conduit. Also disclosed are a method for suspending magnetically responsive beads in liquid portions or droplets in digital microfluidics and a disposable cartridge to carry out the methods.

    DISPOSABLE CARTRIDGE FOR MICROFLUIDICS SYSTEM
    9.
    发明申请
    DISPOSABLE CARTRIDGE FOR MICROFLUIDICS SYSTEM 有权
    用于微流控系统的可拆卸墨盒

    公开(公告)号：US20140353157A1

    公开(公告)日：2014-12-04

    申请号：US14361556

    申请日：2014-01-06

    Applicant: TECAN TRADING AG

    Inventor： Daniel Hoffmeyer ,  Tiffany Lay ,  Travis Lee

    IPC: G01N27/447

    CPC classification number: G01N27/44791 ,  B01L3/502715 ,  B01L3/502792 ,  B01L3/505 ,  B01L2200/027 ,  B01L2200/04 ,  B01L2300/044 ,  B01L2300/123 ,  B01L2400/0427 ,  B81B1/00 ,  G01N27/44756

    Abstract: A digital microfluidics system for manipulating samples in liquid droplets within a gap between a first hydrophobic surface of a bottom layer and a second hydrophobic surface of at least one disposable cartridge. Disposable cartridges comprise a body and/or a rigid cover plate. The bottom layer of each disposable cartridge is a flexible film that is sealingly attached to the body or plate. The cartridge has no spacer between the first and second hydrophobic surfaces. When using these cartridges, the bottom layers configured as a working film for manipulating samples in liquid droplets thereon, is placed on an electrode array of a digital microfluidics system. The array has individual electrodes. The digital microfluidics system also comprises a central control unit for controlling the selection of the individual electrodes of the electrode array and for providing these electrodes with individual voltage pulses for manipulating liquid droplets by electrowetting.

    Abstract translation: 一种数字微流体系统，用于在底层的第一疏水表面和至少一个一次性盒的第二疏水表面之间的间隙内操作液滴中的样品。 一次性盒包括主体和/或刚性盖板。 每个一次性盒的底层是密封地附接到主体或板上的柔性膜。 墨盒在第一和第二疏水表面之间没有间隔物。 当使用这些盒时，将配置为工作膜的底层用于操作其上液滴的样品放置在数字微流体系统的电极阵列上。 该阵列具有单独的电极。 数字微流体系统还包括一个中央控制单元，用于控制电极阵列的各个电极的选择，并为这些电极提供单独的电压脉冲，用于通过电润湿来操纵液滴。

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