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    Disposable cartridge for microfluidics system
    1.
    发明授权
    Disposable cartridge for microfluidics system 有权
    微流体系一次性墨盒

    公开(公告)号：US09377439B2

    公开(公告)日：2016-06-28

    申请号：US13737656

    申请日：2013-01-09

    Applicant: TECAN TRADING AG

    Inventor： Travis Lee ,  Tiffany Lay ,  Bruce Richardson ,  S. Nicholas Reimitz

    IPC: G01N27/447 ,  B01L3/00

    CPC classification number: G01N27/44791 ,  B01L3/502715 ,  B01L3/502792 ,  B01L3/505 ,  B01L2200/027 ,  B01L2200/0673 ,  B01L2300/043 ,  B01L2300/044 ,  B01L2300/089 ,  B01L2300/123 ,  B01L2400/0427

    Abstract: A disposable cartridge had body, bottom layer with first hydrophobic surface, top layer with a second hydrophobic surface, and gap between. The bottom layer is a flexible film sealingly attached at its circumference to the top layer. No spacer is between the layers. The top layer has loading sites for transferring processing liquids into the gap. In use, the bottom layer is a working film for manipulating samples in liquid droplets and is placed on an electrode array of a digital microfluidics system having base unit with cartridge accommodation site and electrode array at the site. The electrode array is supported by a bottom substrate that extends in a first plane and has individual electrodes. The system also includes a central control unit for controlling selection of the electrodes and for providing these electrodes with individual voltage pulses for manipulating liquid droplets within the gap by electrowetting.

    Abstract translation: 一次性药筒具有主体，底层具有第一疏水性表面，顶层具有第二疏水性表面，并且之间具有间隙。 底层是在其周围密封地附接到顶层的柔性膜。 层之间没有间隔物。 顶层具有用于将处理液体转移到间隙中的装载位置。 在使用中，底层是用于操作液滴中的样品的工作薄膜，并且放置在具有基座单元的数字微流体系统的电极阵列上，该基座具有筒位置和位置处的电极阵列。 电极阵列由在第一平面中延伸并具有单独电极的底部基底支撑。 该系统还包括一个中央控制单元，用于控制电极的选择，并为这些电极提供单独的电压脉冲，用于通过电润湿来操纵间隙内的液滴。

    DISPOSABLE CARTRIDGE FOR MICROFLUIDICS SYSTEM
    2.
    发明申请
    DISPOSABLE CARTRIDGE FOR MICROFLUIDICS SYSTEM 有权
    用于微流控系统的可拆卸墨盒

    公开(公告)号：US20140353157A1

    公开(公告)日：2014-12-04

    申请号：US14361556

    申请日：2014-01-06

    Applicant: TECAN TRADING AG

    Inventor： Daniel Hoffmeyer ,  Tiffany Lay ,  Travis Lee

    IPC: G01N27/447

    CPC classification number: G01N27/44791 ,  B01L3/502715 ,  B01L3/502792 ,  B01L3/505 ,  B01L2200/027 ,  B01L2200/04 ,  B01L2300/044 ,  B01L2300/123 ,  B01L2400/0427 ,  B81B1/00 ,  G01N27/44756

    Abstract: A digital microfluidics system for manipulating samples in liquid droplets within a gap between a first hydrophobic surface of a bottom layer and a second hydrophobic surface of at least one disposable cartridge. Disposable cartridges comprise a body and/or a rigid cover plate. The bottom layer of each disposable cartridge is a flexible film that is sealingly attached to the body or plate. The cartridge has no spacer between the first and second hydrophobic surfaces. When using these cartridges, the bottom layers configured as a working film for manipulating samples in liquid droplets thereon, is placed on an electrode array of a digital microfluidics system. The array has individual electrodes. The digital microfluidics system also comprises a central control unit for controlling the selection of the individual electrodes of the electrode array and for providing these electrodes with individual voltage pulses for manipulating liquid droplets by electrowetting.

    Abstract translation: 一种数字微流体系统，用于在底层的第一疏水表面和至少一个一次性盒的第二疏水表面之间的间隙内操作液滴中的样品。 一次性盒包括主体和/或刚性盖板。 每个一次性盒的底层是密封地附接到主体或板上的柔性膜。 墨盒在第一和第二疏水表面之间没有间隔物。 当使用这些盒时，将配置为工作膜的底层用于操作其上液滴的样品放置在数字微流体系统的电极阵列上。 该阵列具有单独的电极。 数字微流体系统还包括一个中央控制单元，用于控制电极阵列的各个电极的选择，并为这些电极提供单独的电压脉冲，用于通过电润湿来操纵液滴。

    System for manipulating samples in liquid droplets
    4.
    发明授权
    System for manipulating samples in liquid droplets 有权

    公开(公告)号：US11543383B2

    公开(公告)日：2023-01-03

    申请号：US15818428

    申请日：2017-11-20

    Applicant: TECAN TRADING AG

    Inventor： Travis Lee ,  Michael Benjamin Franklin ,  Kailiang Wang ,  Anne R. Kopf-Sill

    IPC: B01L3/00 ,  G01N27/447 ,  B01L7/00

    Abstract: A liquid droplet manipulation system has a substrate with at least one electrode array and a central control unit for controlling selection of individual electrodes of the electrode array and for providing the electrodes with individual voltage pulses for manipulating liquid droplets by electrowetting. A working film is placed on top of the electrodes for manipulating samples in liquid droplets with the electrode array. At least one selected individual electrode of the electrode array is configured to be penetrated by light of an optical detection system for the optical inspection or analysis of samples in liquid droplets that are located on the working film. Also disclosed is working film that is to be placed on the electrode array and a cartridge that includes such a working film for manipulating samples in liquid droplets.

    Disposable cartridge for microfluidics system
    5.
    发明授权
    Disposable cartridge for microfluidics system 有权

    公开(公告)号：US09915631B2

    公开(公告)日：2018-03-13

    申请号：US14361556

    申请日：2014-01-06

    Applicant: TECAN TRADING AG

    Inventor： Daniel Hoffmeyer ,  Tiffany Lay ,  Travis Lee

    IPC: G01N27/447 ,  B01L3/00 ,  B81B1/00

    CPC classification number: G01N27/44791 ,  B01L3/502715 ,  B01L3/502792 ,  B01L3/505 ,  B01L2200/027 ,  B01L2200/04 ,  B01L2300/044 ,  B01L2300/123 ,  B01L2400/0427 ,  B81B1/00 ,  G01N27/44756

    Abstract: A digital microfluidics system for manipulating samples in liquid droplets within a gap between a first hydrophobic surface of a bottom layer and a second hydrophobic surface of at least one disposable cartridge. Disposable cartridges comprise a body and/or a rigid cover plate. The bottom layer of each disposable cartridge is a flexible film that is sealingly attached to the body or plate. The cartridge has no spacer between the first and second hydrophobic surfaces. When using these cartridges, the bottom layers configured as a working film for manipulating samples in liquid droplets thereon, is placed on an electrode array of a digital microfluidics system. The array has individual electrodes. The digital microfluidics system also comprises a central control unit for controlling the selection of the individual electrodes of the electrode array and for providing these electrodes with individual voltage pulses for manipulating liquid droplets by electrowetting.

    DISPOSABLE CARTRIDGE FOR MICROFLUIDICS SYSTEMS
    8.
    发明申请
    DISPOSABLE CARTRIDGE FOR MICROFLUIDICS SYSTEMS 有权
    用于微流控系统的可替代墨盒

    公开(公告)号：US20150144489A1

    公开(公告)日：2015-05-28

    申请号：US14402717

    申请日：2014-01-06

    Applicant: TECAN TRADING AG

    Inventor： Daniel Hoffmeyer ,  Tiffany Lay ,  Travis Lee ,  Marc N. Feiglin ,  Werner Halg ,  Anne R. Kopf-Sill

    IPC: G01N27/447

    CPC classification number: G01N27/44791 ,  B01L3/502715 ,  B01L3/502792 ,  B01L3/505 ,  B01L2200/027 ,  B01L2200/04 ,  B01L2300/044 ,  B01L2300/123 ,  B01L2400/0427 ,  B81B1/00 ,  G01N27/44756

    Abstract: A disposable cartridge used in a digital microfluidics system has a bottom layer with first hydrophobic surface, a rigid cover plate with second hydrophobic surface, and a gap there-between. The bottom layer is a flexible film on an uppermost surface of a cartridge accommodation site of a system, attracted to and spread over the uppermost surface by an underpressure. A lower surface of the plate and the flexible bottom layer are sealed to each other. The assembled cartridge is removed from the cartridge accommodation site in one piece and potentially includes samples and processing fluids. The system has a base unit and a cartridge accommodation site with an electrode array of individual electrodes and a central control unit for controlling selection of individual electrodes and for providing these electrodes with individual voltage pulses for manipulating liquid droplets within the gap by electrowetting.

    Abstract translation: 在数字微流体系统中使用的一次性盒具有具有第一疏水表面的底层，具有第二疏水表面的刚性盖板及其间的间隙。 底层是在系统的盒容纳位置的最上表面上的柔性膜，通过负压吸引并分布在最上表面上。 板的下表面和柔性底层彼此密封。 将组装的墨盒从墨盒容纳部位一体地取出，并且可能包括样品和处理流体。 该系统具有基本单元和具有单独电极的电极阵列的中心控制单元和用于控制各个电极的选择的中心控制单元和用于通过电润湿来操纵间隙内的液滴的单独电压脉冲的中心控制单元。

    DISPOSABLE CARTRIDGE FOR MICROFLUIDICS SYSTEM
    9.
    发明申请
    DISPOSABLE CARTRIDGE FOR MICROFLUIDICS SYSTEM 有权
    用于微流控系统的可拆卸墨盒

    公开(公告)号：US20130134040A1

    公开(公告)日：2013-05-30

    申请号：US13737656

    申请日：2013-01-09

    Applicant: TECAN TRADING AG

    Inventor： Travis Lee ,  Tiffany Lay ,  Bruce Richardson ,  S. Nicholas Reimitz

    IPC: G01N27/447

    CPC classification number: G01N27/44791 ,  B01L3/502715 ,  B01L3/502792 ,  B01L3/505 ,  B01L2200/027 ,  B01L2200/0673 ,  B01L2300/043 ,  B01L2300/044 ,  B01L2300/089 ,  B01L2300/123 ,  B01L2400/0427

    Abstract: A disposable cartridge had body, bottom layer with first hydrophobic surface, top layer with a second hydrophobic surface, and gap between. The bottom layer is a flexible film sealingly attached at its circumference to the top layer. No spacer is between the layers. The top layer has loading sites for transferring processing liquids into the gap. In use, the bottom layer is a working film for manipulating samples in liquid droplets and is placed on an electrode array of a digital microfluidics system having base unit with cartridge accommodation site and electrode array at the site. The electrode array is supported by a bottom substrate that extends in a first plane and has individual electrodes. The system also includes a central control unit for controlling selection of the electrodes and for providing these electrodes with individual voltage pulses for manipulating liquid droplets within the gap by electrowetting.

    Abstract translation: 一次性药筒具有主体，底层具有第一疏水性表面，顶层具有第二疏水性表面，并且之间具有间隙。 底层是在其周围密封地附接到顶层的柔性膜。 层之间没有间隔物。 顶层具有用于将处理液体转移到间隙中的装载位置。 在使用中，底层是用于操作液滴中的样品的工作薄膜，并且放置在具有基座单元的数字微流体系统的电极阵列上，该基座具有筒位置和位置处的电极阵列。 电极阵列由在第一平面中延伸并具有单独电极的底部基底支撑。 该系统还包括一个中央控制单元，用于控制电极的选择，并为这些电极提供单独的电压脉冲，用于通过电润湿来操纵间隙内的液滴。

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