公开(公告)号：US11318164B2

公开(公告)日：2022-05-03

申请号：US16490443

申请日：2018-03-01

Applicant: Nektar Therapeutics ,  The Regents of the University of California

Inventor： Deborah H. Charych ,  Antoni Ribas ,  Giulia Parisi

IPC: A61K38/20 ,  A61K35/17 ,  A61K47/60 ,  A61P35/04

Abstract: Provided are methods and compositions directed towards the treatment of an individual having cancer by providing adoptive cell transfer therapy and administering to the individual a long-acting IL-2Rβ-biased agonist.

公开(公告)号：US20200016206A1

公开(公告)日：2020-01-16

申请号：US16490443

申请日：2018-03-01

Applicant: Nektar Therapeutics ,  The Regents of the University of California

Inventor： Deborah H. Charych ,  Antoni Ribas ,  Giulia Parisi

IPC: A61K35/17 ,  A61P35/04 ,  A61K38/20 ,  A61K47/60

Abstract: Provided are methods and compositions directed towards the treatment of an individual having cancer by providing adoptive cell transfer therapy and administering to the individual a long acting IL-2Rαβ-biased agonist.

公开(公告)号：US20180051347A1

公开(公告)日：2018-02-22

申请号：US15648423

申请日：2017-07-12

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Antoni Ribas ,  Jesse Zaretsky ,  Daniel Shin ,  Angel Garcia-Diaz ,  Blanca Homet Moreno

IPC: C12Q1/68 ,  C07K16/28

CPC classification number: C12Q1/6886 ,  A61K2039/505 ,  A61K2039/55 ,  C07K16/2818 ,  C07K2317/24 ,  C07K2317/76 ,  C12Q2600/106 ,  C12Q2600/156

Abstract: Disclosed herein are methods of treating or assessing cancer in a subject wherein it has been determined whether the cancer comprises a loss of function mutation or disruption in an immune pathway. The loss of function mutation or disruption can be in JAK1 or JAK2. The loss of function mutation or disruption can be in B2M. The methods can include administering an immune checkpoint therapy such as anti-PD1 or anti-PDL1. The methods can include administering an alternative therapy to an immune checkpoint therapy. In some aspects, the method includes determining whether the cancer comprises a loss of function mutation or disruption in an immune pathway.

公开(公告)号：US11590171B2

公开(公告)日：2023-02-28

申请号：US17725478

申请日：2022-04-20

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Theodore Lee Roth ,  Eric Shifrut ,  Alexander Marson ,  Cristina Puig Saus ,  Antoni Ribas

IPC: A61K35/17 ,  C07K14/725 ,  C12N9/22 ,  C12N15/113 ,  C12N15/85 ,  C12N15/90

Abstract: Provided herein are methods and compositions for editing the genome of a human T cell. In some embodiments, a heterologous T cell receptor (TCR)-β chain and a heterologous TCR-α chain are inserted into exon 1 of a TCR subunit constant gene in the genome of the T cell.

公开(公告)号：US20220138939A1

公开(公告)日：2022-05-05

申请号：US17431138

申请日：2020-02-14

Applicant: The Regents of the University of California

Inventor： Bahram Jalali ,  Madhuri Suthar ,  Cejo Konuparamban Lonappan ,  Antoni Ribas ,  Theodore Scott Nowicki ,  Jia Ming Chen

IPC: G06T7/00 ,  G06V20/69 ,  G06V10/25 ,  G06V10/40 ,  G02B21/36 ,  G16H10/40 ,  G16H70/60 ,  G16H30/40

Abstract: Systems and methods for digital pathology in accordance with embodiments of the invention obtain a whole slide image of a microscope slide that includes a registration mark, wherein the registration mark is associated with a coordinate system. The method inputs the whole slide image into a region identification (RI) model to extract features of the whole slide image and generate feature vectors for the extracted features, detects a presence of a region of interest (ROI) based on the feature vectors, determines a set of coordinates of the ROI in the coordinate system, and translates a microscope stage of a microscope holding the microscope slide to a position corresponding to the coordinates of the ROI. The method captures a field of view (FOV) image with the microscope and inputs the FOV image into a grading model to determine a pathology score that indicates a likelihood of a presence of a disease.

公开(公告)号：US11033584B2

公开(公告)日：2021-06-15

申请号：US16568116

申请日：2019-09-11

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Theodore Lee Roth ,  Eric Shifrut ,  Alexander Marson ,  Cristina Puig Saus ,  Antoni Ribas

IPC: A61K35/17 ,  C07K14/725 ,  C12N9/22 ,  C12N15/113 ,  C12N15/85 ,  C12N15/90

Abstract: Provided herein are methods and compositions for editing the genome of a human T cell. In some embodiments, a heterologous T cell receptor (TCR)-β chain and a heterologous TCR-α chain are inserted into exon 1 of a TCR subunit constant gene in the genome of the T cell.