公开(公告)号：US12187846B2

公开(公告)日：2025-01-07

申请号：US17042711

申请日：2019-03-29

Applicant: NOF CORPORATION ,  TOKYO INSTITUTE OF TECHNOLOGY

Inventor： Hiroki Yoshioka ,  Masaki Kamiya ,  Yuji Yamamoto ,  Midori Hirai ,  Akiko Sasaki ,  Nobuhiro Nishiyama ,  Makoto Matsui ,  Hiroyasu Takemoto ,  Kazuki Miyauchi ,  Takahiro Nomoto ,  Keishiro Tomoda

IPC: C08G65/333 ,  A61K47/60 ,  A61K47/62 ,  A61K47/65 ,  C08G65/325 ,  C08L71/02

Abstract: The invention provides a high-molecular-weight polyethylene glycol derivative that does not cause vacuolation of cells. The degradable polyethylene glycol derivative is represented by the following formula (1): wherein m is 1-7, n1 and n2 are each independently 45-682, p is 1-4, R is an alkyl group having 1-4 carbon atoms, Z is an oligopeptide with 2-8 residues composed of neutral amino acids excluding cysteine, Q is a residue of a compound having 2-5 active hydrogens, X is a functional group capable of reacting with a bio-related substance, and L1, L2, L3, L4 and L5 are each independently a single bond or a divalent spacer.

公开(公告)号：US20220265836A1

公开(公告)日：2022-08-25

申请号：US17613912

申请日：2020-05-29

Applicant: TOKYO INSTITUTE OF TECHNOLOGY ,  KAWASAKI INSTITUTE OF INDUSTRIAL PROMOTION

Inventor： Nobuhiro Nishiyama ,  Yuto Honda ,  Takahiro Nomoto ,  Hiroyasu Takemoto ,  Makoto Matsui ,  Hiroaki Kinoh ,  Kazunori Kataoka ,  Xueying Liu ,  Anjaneyulu Dirisala

IPC: A61K47/64 ,  A61K47/69 ,  A61K47/59 ,  A61K47/54 ,  A61K47/60 ,  A61P35/00

Abstract: A complex is provided comprising a conjugate in which a polymer having a boronic acid group and a compound having a diol structure are bonded, and a substance that is complexed with the conjugate.

公开(公告)号：US20220380533A1

公开(公告)日：2022-12-01

申请号：US17763498

申请日：2020-09-25

Applicant: NOF CORPORATION ,  TOKYO INSTITUTE OF TECHNOLOGY

Inventor： Hiroki Yoshioka ,  Ken Hamura ,  Kazuki Osakama ,  Nobuhiro Nishiyama

IPC: C08G65/333 ,  C08G83/00 ,  C07K5/103 ,  C07K14/46 ,  C07K7/06

Abstract: A multi-arm, degradable polyethylene glycol derivative with a high molecular weight that does not cause vacuolation of cells is provided. A degradable polyethylene glycol derivative represented by the following formula (1): wherein n1 and n2 are each independently 45-950, W1 and W2 are each independently an oligopeptide of 2-47 residues, a1 and a2 are each independently 1-8, Q is a hydrocarbon chain having 2-12 carbon atoms and optionally containing an oxygen atom and/or a nitrogen atom, X1 and X2 are each independently a functional group capable of reacting with a bio-related substance, and L1, L2, L3, L4, L5 and L6 are each independently a divalent spacer.