公开(公告)号：US20110121199A1

公开(公告)日：2011-05-26

申请号：US12952387

申请日：2010-11-23

申请人： Yoshihisa TANIKAWA ,  Masahiro Oba ,  Yoshihiro Shimada

发明人： Yoshihisa TANIKAWA ,  Masahiro Oba ,  Yoshihiro Shimada

IPC分类号： G01J1/58

CPC分类号： G01J3/02 ,  G01J3/0208 ,  G01J3/4406 ,  G01N21/6456 ,  G01N21/763 ,  G02B13/22 ,  G02B21/16

摘要： An imaging apparatus for low-light sample comprises: an image-forming optical system which includes an objective lens and an image-forming lens and forms the sample image of an sample having a point light source, where the point light source emits weak light including fluorescence; an illumination optical system which radiates light from an illumination light source to the sample to make the sample emit fluorescence; and an image capturing means which includes a plurality of pixels and captures the image corresponding to the sample image. The illumination optical system radiates light from the illumination light source to the sample with the light not traveling via the objective lens, the image-forming optical system is approximately telecentric and is provided with a filter which is arranged between the objective lens and the image forming lens and wavelength-selectively extracts fluorescence from the sample, and the image-forming optical system is formed in such a way that the image-forming optical system collects weak light from the point light source to form airy disks the sizes of which are is approximately the same as or smaller than the sizes of the pixels.

摘要翻译： 一种用于低光样本的成像装置，包括：成像光学系统，其包括物镜和图像形成透镜，并形成具有点光源的样本的样本图像，其中点光源发射弱光，包括 荧光; 照明光学系统，其将来自照明光源的光辐射到样品以使样品发射荧光; 以及包括多个像素并且捕获与样本图像相对应的图像的图像捕获装置。 照明光学系统以不经由物镜行进的光将照明光源的光照射到样品，图像形成光学系统近似为远心，并且设置有设置在物镜和图像形成之间的滤光器 透镜和波长选择性地从样品中提取荧光，并且成像光学系统以这样的方式形成，使得成像光学系统收集来自点光源的弱光，以形成其大小近似的通风盘 与像素的尺寸相同或小于像素的尺寸。

公开(公告)号：US07616292B2

公开(公告)日：2009-11-10

申请号：US11648638

申请日：2007-01-03

申请人： Susumu Kikuchi ,  Yoshihiro Kawano ,  Masahiro Oba

发明人： Susumu Kikuchi ,  Yoshihiro Kawano ,  Masahiro Oba

IPC分类号： G01C11/12

CPC分类号： G01N21/6458 ,  A61B5/14556 ,  G01N21/6428 ,  G01N21/6486 ,  G01N2021/1787 ,  G02B21/365

摘要： The invention provides an examination apparatus including an objective optical system for positioning a focal point inside a specimen mounted on a stage; an image-acquisition apparatus for detecting light emitted in different optical-axis directions from the vicinity of the focal point inside the specimen and collected by the objective optical system to acquire a plurality of pieces of image information; and a three-dimensional image forming unit for forming a three-dimensional image of a light-emitting site in the vicinity of the focal point based on the plurality of pieces of image information acquired by the image-acquiring apparatus.

摘要翻译： 本发明提供了一种检查装置，其包括用于将焦点定位在安装在台架上的样本内的物镜光学系统; 用于从所述物体光学系统收集的，从所述样本内的所述焦点附近检测在不同的光轴方向上发出的光的摄像装置，以获取多张图像信息; 以及三维图像形成单元，用于基于由图像获取装置获取的多条图像信息，在焦点附近形成发光位置的三维图像。

公开(公告)号：US20070247523A1

公开(公告)日：2007-10-25

申请号：US11648638

申请日：2007-01-03

申请人： Susumu Kikuchi ,  Yoshihiro Kawano ,  Masahiro Oba

发明人： Susumu Kikuchi ,  Yoshihiro Kawano ,  Masahiro Oba

IPC分类号： H04N13/02

CPC分类号： G01N21/6458 ,  A61B5/14556 ,  G01N21/6428 ,  G01N21/6486 ,  G01N2021/1787 ,  G02B21/365

摘要： The invention provides an examination apparatus including an objective optical system for positioning a focal point inside a specimen mounted on a stage; an image-acquisition apparatus for detecting light emitted in different optical-axis directions from the vicinity of the focal point inside the specimen and collected by the objective optical system to acquire a plurality of pieces of image information; and a three-dimensional image forming unit for forming a three-dimensional image of a light-emitting site in the vicinity of the focal point based on the plurality of pieces of image information acquired by the image-acquiring apparatus.

摘要翻译： 本发明提供了一种检查装置，其包括用于将焦点定位在安装在台架上的样本内的物镜光学系统; 用于从所述物体光学系统收集的，从所述样本内的所述焦点附近检测在不同的光轴方向上发出的光的摄像装置，以获取多张图像信息; 以及三维图像形成单元，用于基于由图像获取装置获取的多条图像信息，在焦点附近形成发光位置的三维图像。

公开(公告)号：US5175797A

公开(公告)日：1992-12-29

申请号：US575951

申请日：1990-08-31

申请人： Motohisa Funabashi ,  Takushi Nishiya ,  Masahiro Oba ,  Mikio Yoda ,  Kazuo Kera ,  Kiyomi Mori

发明人： Motohisa Funabashi ,  Takushi Nishiya ,  Masahiro Oba ,  Mikio Yoda ,  Kazuo Kera ,  Kiyomi Mori

IPC分类号： G06F15/18 ,  G06F9/44 ,  G06F19/00 ,  G06N3/00 ,  G06N3/04 ,  G06N5/04 ,  G06N7/02 ,  G06N99/00

CPC分类号： G06N3/0436 ,  Y10S706/90

摘要： A method and apparatus of a learning type decision support system are provided for improved acquisition of a priori knowledge from the system object and expression of non-linear structures in the object. The system is comprised of a learning module and an executing module for outputting advice and process manipulate command values to system users by receiving input data comprising on-line data and file data. The learning module comprises (1) a symbolized dictionary unit for generating a symbolized dictionary for giving a symbolic name in accordance with a pattern comprised of a combination of the values of the input data by giving examples of a pair of the pattern and the symbolic name; (2) a preprocessing unit for transforming at least a portion of the input data into the symbolic name with reference to the symbolic dictionary generated; and, (3) a model generating unit for determining an unknown parameter contained in a predetermined skeleton model to transform the preprocessed results into desired advice and manipulation command values. The executing module arithmetically processes the input data to output the advice and the manipulation command values by using the symbolized dictionary generated by the learning module and the generated model.

摘要翻译： 提供了一种学习型决策支持系统的方法和装置，用于从系统对象中改进对先验知识的获取和对象中非线性结构的表达。 该系统包括学习模块和执行模块，用于通过接收包括在线数据和文件数据的输入数据来向系统用户输出建议和处理操作命令值。 学习模块包括：（1）符号字典单元，用于通过给出一对图案和符号名称的示例来生成符号字典，用于根据包括输入数据的值的组合的图案来给出符号名称 ; （2）预处理单元，用于参照所生成的符号字典将输入数据的至少一部分变换为符号名称; （3）模型生成单元，用于确定包含在预定骨架模型中的未知参数，以将预处理结果转换为期望的建议和操作命令值。 执行模块通过使用由学习模块和生成的模型生成的符号化字典来对输入数据进行算术处理以输出建议和操作命令值。