公开(公告)号：US20110121199A1

公开(公告)日：2011-05-26

申请号：US12952387

申请日：2010-11-23

申请人： Yoshihisa TANIKAWA ,  Masahiro Oba ,  Yoshihiro Shimada

发明人： Yoshihisa TANIKAWA ,  Masahiro Oba ,  Yoshihiro Shimada

IPC分类号： G01J1/58

CPC分类号： G01J3/02 ,  G01J3/0208 ,  G01J3/4406 ,  G01N21/6456 ,  G01N21/763 ,  G02B13/22 ,  G02B21/16

摘要： An imaging apparatus for low-light sample comprises: an image-forming optical system which includes an objective lens and an image-forming lens and forms the sample image of an sample having a point light source, where the point light source emits weak light including fluorescence; an illumination optical system which radiates light from an illumination light source to the sample to make the sample emit fluorescence; and an image capturing means which includes a plurality of pixels and captures the image corresponding to the sample image. The illumination optical system radiates light from the illumination light source to the sample with the light not traveling via the objective lens, the image-forming optical system is approximately telecentric and is provided with a filter which is arranged between the objective lens and the image forming lens and wavelength-selectively extracts fluorescence from the sample, and the image-forming optical system is formed in such a way that the image-forming optical system collects weak light from the point light source to form airy disks the sizes of which are is approximately the same as or smaller than the sizes of the pixels.

摘要翻译： 一种用于低光样本的成像装置，包括：成像光学系统，其包括物镜和图像形成透镜，并形成具有点光源的样本的样本图像，其中点光源发射弱光，包括 荧光; 照明光学系统，其将来自照明光源的光辐射到样品以使样品发射荧光; 以及包括多个像素并且捕获与样本图像相对应的图像的图像捕获装置。 照明光学系统以不经由物镜行进的光将照明光源的光照射到样品，图像形成光学系统近似为远心，并且设置有设置在物镜和图像形成之间的滤光器 透镜和波长选择性地从样品中提取荧光，并且成像光学系统以这样的方式形成，使得成像光学系统收集来自点光源的弱光，以形成其大小近似的通风盘 与像素的尺寸相同或小于像素的尺寸。

公开(公告)号：US20090263328A1

公开(公告)日：2009-10-22

申请号：US12424069

申请日：2009-04-15

申请人： Chika NAKAJIMA ,  Yoshihisa TANIKAWA ,  Nobuyuki NAGASAWA

发明人： Chika NAKAJIMA ,  Yoshihisa TANIKAWA ,  Nobuyuki NAGASAWA

IPC分类号： A61K49/00 ,  C12M1/34 ,  A61P35/00

CPC分类号： G01N21/6456

摘要： A site of interest to be observed is clearly observed in an image during fluoroscopy of a small laboratory animal, even when the fluorescence is extremely low. The invention provides a fluorescence observation apparatus including a light source that emits excitation light; an optical system that irradiates an image-acquisition site on a small laboratory animal with the excitation light from the light source; a light-blocking unit that blocks light in a prescribed region of the small laboratory animal or in an image of the prescribed region; an image-acquisition unit that acquires a fluorescence image of the small laboratory animal; and a control unit configured to identify a high-fluorescence region having a prescribed fluorescence level or above in the fluorescence image of the small laboratory animal acquired by the image-acquisition unit and to control the light-blocking unit so as to block light at the identified high-fluorescence region.

摘要翻译： 即使荧光极低，在小型实验室动物的荧光检查中，也可以在图像中观察到需要观察的位置。 本发明提供了一种荧光观察装置，其包括发射激发光的光源; 光学系统，其利用来自光源的激发光照射小实验动物的图像采集部位; 遮光单元，其阻挡小实验室动物的规定区域或规定区域的图像中的光; 获取小型实验室动物的荧光图像的图像获取单元; 以及控制单元，被配置为在由所述图像获取单元获取的所述小型实验动物的荧光图像中识别具有规定的荧光水平以上的高荧光区域，并且控制所述遮光单元以阻挡所述 鉴定出高荧光区。

公开(公告)号：US20080049309A1

公开(公告)日：2008-02-28

申请号：US11840449

申请日：2007-08-17

申请人： Yoshihisa TANIKAWA ,  Tomoaki SATO ,  Ikuko SAKAI

发明人： Yoshihisa TANIKAWA ,  Tomoaki SATO ,  Ikuko SAKAI

IPC分类号： G02B21/36

CPC分类号： G02B21/367

摘要： The invention provides an examination apparatus that is capable of observing a specimen in a stationary state while suppressing blurring caused by a control delay. The examination apparatus includes a first optical system and a second optical system for imaging light produced in a specimen, a first image-acquisition unit provided with a plurality of first image-acquisition devices for detecting an image formed by the first optical system, a second image-acquisition unit provided with a second image-acquisition device for acquiring an image formed by the second optical system, and a driving unit configured to cause the images to be formed at substantially the same position in the second image-acquisition unit based on a detection signal of the first image-acquisition unit. The value obtained by dividing the pixel size Y of the first image-acquisition devices by the magnification X of the first optical system is smaller than the value obtained by dividing the pixel size Y′ of the second image-acquisition device by the magnification X′ of the second optical system.

摘要翻译： 本发明提供一种能够在抑制由控制延迟引起的模糊的同时在静止状态下观察样本的检查装置。 检查装置包括第一光学系统和用于对样本中产生的光成像的第二光学系统，第一图像获取单元，设置有用于检测由第一光学系统形成的图像的多个第一图像获取装置，第二光学系统 图像获取单元，其具有用于获取由第二光学系统形成的图像的第二图像获取装置，以及驱动单元，被配置为基于第二图像获取单元基于相同的位置在第二图像获取单元中形成基本相同的位置 第一图像采集单元的检测信号。 通过将第一图像采集装置的像素大小Y除以第一光学系统的倍率X而获得的值小于通过将第二图像获取装置的像素尺寸Y'除以倍率X'而获得的值， 的第二光学系统。

公开(公告)号：US20080239477A1

公开(公告)日：2008-10-02

申请号：US11945713

申请日：2007-11-27

申请人： Takeshi MINAMIDE ,  Yoshihisa TANIKAWA ,  Seiya TAKAHASHI ,  Tomoaki SATO

发明人： Takeshi MINAMIDE ,  Yoshihisa TANIKAWA ,  Seiya TAKAHASHI ,  Tomoaki SATO

IPC分类号： G02B21/24 ,  G02B21/30

CPC分类号： G02B21/0004 ,  G02B21/30 ,  G02B21/34

摘要： A suitable clear image is obtained in observation of a specimen exhibiting dynamic motion, for example, during in vivo observation. The invention provides an observation system including an optical apparatus including an objective unit that is positioned close to a specimen; and a stabilizer adhered to the specimen, at least around an observation region of the optical apparatus, to restrain motion of the specimen, wherein a heat-transfer preventing member for preventing transfer of heat between the stabilizer and the specimen is provided on the stabilizer.

摘要翻译： 在观察动态运动的样本时，例如在体内观察期间，可以获得合适的清晰图像。 本发明提供了一种观察系统，包括：光学装置，其包括位于靠近样本的目标单元; 以及至少在光学装置的观察区域附近附着于试样的稳定剂，以抑制试样的运动，其中在稳定器上设置有用于防止稳定剂和试样之间的热传递的传热防止构件。

公开(公告)号：US20080043323A1

公开(公告)日：2008-02-21

申请号：US11923138

申请日：2007-10-24

申请人： Hiroya FUKUYAMA ,  Yoshihisa TANIKAWA ,  Tadashi HIRATA ,  Seiya TAKAHASHI

发明人： Hiroya FUKUYAMA ,  Yoshihisa TANIKAWA ,  Tadashi HIRATA ,  Seiya TAKAHASHI

IPC分类号： G02B21/00

CPC分类号： G02B21/24 ,  G02B21/26 ,  G02B27/646

摘要： The invention provides a microscope examination apparatus including a light source; an illumination optical system configured to guide light from the light source to a specimen; an objective lens configured to collimate return light from the specimen, the objective lens being provided in such a manner as to be displaceable at least in a direction intersecting an optical axis of the objective lens; an image-forming lens configured to image the return light from the specimen, which is collimated by the objective lens; an optical detector configured to detect the return light imaged by the image-forming lens; a microscope main body including the image-forming lens and the optical detector; and an objective-lens driving mechanism configured to drive the objective lens in a direction correcting image blur due to a displacement of the specimen.

摘要翻译： 本发明提供一种包括光源的显微镜检查装置; 照明光学系统，被配置为将来自所述光源的光引导到样本; 物镜，被配置为准直来自所述样本的返回光，所述物镜以至少在与所述物镜的光轴相交的方向可位移的方式设置; 成像透镜，被配置为对由所述物镜准直的来自所述样本的返回光进行成像; 光学检测器，被配置为检测由图像形成透镜成像的返回光; 包括图像形成透镜和光学检测器的显微镜主体; 以及物镜驱动机构，被配置为在校正由于样本的位移造成的图像模糊的方向上驱动物镜。