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公开(公告)号:US07713993B2
公开(公告)日:2010-05-11
申请号:US11715440
申请日:2007-03-08
申请人: Teiji Kimura , Noritaka Kitazawa , Toshihiko Kaneko , Nobuaki Sato , Koki Kawano , Koichi Ito , Eriko Doi , Mamoru Takaishi , Takeo Sasaki , Takehiko Miyagawa , Hiroaki Hagiwara , Takashi Doko
发明人: Teiji Kimura , Noritaka Kitazawa , Toshihiko Kaneko , Nobuaki Sato , Koki Kawano , Koichi Ito , Eriko Doi , Mamoru Takaishi , Takeo Sasaki , Takehiko Miyagawa , Hiroaki Hagiwara , Takashi Doko
IPC分类号: C07D471/04 , C07D498/04 , A61K31/5383 , A61K31/5025
CPC分类号: C07D403/10 , C07D471/04 , C07D498/04
摘要: The present invention provides a compound represented by the formula (I): or a pharmacologically acceptable salt thereof, wherein Ar1 represents an imidazolyl group that may be substituted with a C1-6 alkyl group, or the like, Ar2 represents a phenyl group that may be substituted with a C1-6 alkoxy group, or the like, X1 represents a double bond or the like, and Het represents an imidazolyl group that may be substituted with a C1-6 alkyl group, or the like, which is effective as a therapeutic or prophylactic agent for a disease caused by Aβ.
摘要翻译: 本发明提供由式(I)表示的化合物或其药理学上可接受的盐,其中Ar 1表示可被C 1-6烷基取代的咪唑基等,Ar 2表示可以 被C 1-6烷氧基等取代,X 1表示双键等,Het表示可被C 1-6烷基取代的咪唑基等,其作为式 由A&Bgr引起的疾病的治疗或预防剂。
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公开(公告)号:US20100113773A1
公开(公告)日:2010-05-06
申请号:US12522281
申请日:2008-02-27
申请人: Teiji Kimura , Koki Kawano , Eriko Doi , Noritaka Kitazawa , Mamoru Takaishi , Koichi Ito , Toshihiko Kaneko , Takeo Sasaki , Nobuaki Sato , Takehiko Miyagawa , Hiroaki Hagiwara
发明人: Teiji Kimura , Koki Kawano , Eriko Doi , Noritaka Kitazawa , Mamoru Takaishi , Koichi Ito , Toshihiko Kaneko , Takeo Sasaki , Nobuaki Sato , Takehiko Miyagawa , Hiroaki Hagiwara
IPC分类号: C07D498/04
CPC分类号: C07D498/04
摘要: The present invention relates to a compound represented by formula (I): wherein R1 represents a C1-3 alkyl group, R2 represents a hydrogen atom or a C1-3 alkyl group, Ar represents a phenyl group or the like which may be substituted with 1 to 3 substituents, X represents an oxygen atom or the like, n and m are the same or different and integers of 0 to 2, or a pharmacologically acceptable salt, and use thereof as a medicament.
摘要翻译: 本发明涉及由式(I)表示的化合物:其中R1表示C1-3烷基,R2表示氢原子或C1-3烷基,Ar表示可被基团取代的苯基等 1〜3个取代基,X表示氧原子等,n和m相同或不同,为0〜2的整数,或药理学上可接受的盐及其作为药物的用途。
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公开(公告)号:US20090181945A1
公开(公告)日:2009-07-16
申请号:US12403565
申请日:2009-03-13
申请人: Teiji Kimura , Koki Kawano , Eriko Doi , Noritaka Kitazawa , Mamoru Takaishi , Koichi Ito , Toshihiko Kaneko , Takeo Sasaki , Takehiko Miyagawa , Hiroaki Hagiwara , Yu Yoshida
发明人: Teiji Kimura , Koki Kawano , Eriko Doi , Noritaka Kitazawa , Mamoru Takaishi , Koichi Ito , Toshihiko Kaneko , Takeo Sasaki , Takehiko Miyagawa , Hiroaki Hagiwara , Yu Yoshida
IPC分类号: A61K31/4375 , C07D455/02 , C07D471/04 , C07D487/04 , C07D498/04 , A61K31/437 , A61K31/55 , A61K31/4178 , A61K31/5365 , A61K31/4985 , A61P25/00
CPC分类号: C07D471/04 , C07D487/04
摘要: The present invention relates to a novel two cyclic cinnamide compound and a pharmaceutical agent comprising the compound as an active ingredient. The two cyclic cinnamide compound represented by the general formula (I): wherein represents a single bond or a double bond; Ar1 represents a phenyl group or pyridinyl group that may be substituted with 1 to 3 substituents; R1 and R2 each represent a C1-6 alkyl group, a hydroxyl group, or the like; Z1 represents a methylene group or vinylene group, which may be substituted with 1 or 2 substituents selected from Substituent Group A1, an oxygen atom, or an imino group that may be substituted with a substituent selected from Substituent Group A1; and p, q, and r each represent an integer of 0 to 2, which has an effect of reducing Aβ40 and Aβ42 production, and thus is particularly useful as a prophylactic or therapeutic agent for a neurodegenerative disease caused by Aβ such as Alzheimer's disease or Down's syndrome.
摘要翻译: 本发明涉及一种新型的两种环状肉桂酰胺化合物和包含该化合物作为活性成分的药剂。 由通式(I)表示的两种环状肉桂酰胺化合物:其中表示单键或双键; Ar 1表示可被1〜3个取代基取代的苯基或吡啶基; R1和R2各自表示C1-6烷基,羟基等; Z1表示亚甲基或亚乙烯基,其可以被1或2个选自取代基组A1,氧原子或可被选自取代基组A1的取代基取代的亚氨基取代基取代; 并且p,q和r各自表示0〜2的整数,其具有降低Abeta40和Abeta42产生的作用,因此特别可用作由Abeta如阿尔茨海默病或阿尔茨海默病引起的神经变性疾病的预防或治疗剂 唐氏综合症。
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公开(公告)号:US08048878B2
公开(公告)日:2011-11-01
申请号:US12403565
申请日:2009-03-13
申请人: Teiji Kimura , Koki Kawano , Eriko Doi , Noritaka Kitazawa , Mamoru Takaishi , Koichi Ito , Toshihiko Kaneko , Takeo Sasaki , Takehiko Miyagawa , Hiroaki Hagiwara , Yu Yoshida
发明人: Teiji Kimura , Koki Kawano , Eriko Doi , Noritaka Kitazawa , Mamoru Takaishi , Koichi Ito , Toshihiko Kaneko , Takeo Sasaki , Takehiko Miyagawa , Hiroaki Hagiwara , Yu Yoshida
IPC分类号: C07D491/02 , C07D265/36 , C07D498/02 , C07D295/00 , A61K31/535 , A61K31/50 , A61K31/44 , A01N43/60
CPC分类号: C07D471/04 , C07D487/04
摘要: The present invention relates to a novel two cyclic cinnamide compound and a pharmaceutical agent comprising the compound as an active ingredient. The two cyclic cinnamide compound represented by the general formula (I): wherein represents a single bond or a double bond; Ar1 represents a phenyl group or pyridinyl group that may be substituted with 1 to 3 substituents; R1 and R2 each represent a C1-6 alkyl group, a hydroxyl group, or the like; Z1 represents a methylene group or vinylene group, which may be substituted with 1 or 2 substituents selected from Substituent Group A1, an oxygen atom, or an imino group that may be substituted with a substituent selected from Substituent Group A1; and p, q, and r each represent an integer of 0 to 2, which has an effect of reducing Aβ40 and Aβ42 production, and thus is particularly useful as a prophylactic or therapeutic agent for a neurodegenerative disease caused by Aβ such as Alzheimer's disease or Down's syndrome.
摘要翻译: 本发明涉及一种新型的两种环状肉桂酰胺化合物和包含该化合物作为活性成分的药剂。 由通式(I)表示的两个环状肉桂酰胺化合物:其中表示单键或双键; Ar 1表示可被1〜3个取代基取代的苯基或吡啶基; R1和R2各自表示C1-6烷基,羟基等; Z1表示亚甲基或亚乙烯基,其可以被1或2个选自取代基组A1,氧原子或可被选自取代基组A1的取代基取代的亚氨基取代基取代; p,q和r各自表示0〜2的整数,其具有降低A&bgr 40和A&bgr 42生成的效果,因此特别可用作由A&bgr引起的神经变性疾病的预防或治疗剂。 如阿尔茨海默病或唐氏综合症。
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公开(公告)号:US08008293B2
公开(公告)日:2011-08-30
申请号:US12522281
申请日:2008-02-27
申请人: Teiji Kimura , Koki Kawano , Eriko Doi , Noritaka Kitazawa , Mamoru Takaishi , Koichi Ito , Toshihiko Kaneko , Takeo Sasaki , Nobuaki Sato , Takehiko Miyagawa , Hiroaki Hagiwara
发明人: Teiji Kimura , Koki Kawano , Eriko Doi , Noritaka Kitazawa , Mamoru Takaishi , Koichi Ito , Toshihiko Kaneko , Takeo Sasaki , Nobuaki Sato , Takehiko Miyagawa , Hiroaki Hagiwara
IPC分类号: C07D498/04 , A61K31/5375
CPC分类号: C07D498/04
摘要: The present invention relates to a compound represented by formula (I): wherein R1 represents a C1-3 alkyl group, R2 represents a hydrogen atom or a C1-3 alkyl group, Ar represents a phenyl group or the like which may be substituted with 1 to 3 substituents, X represents an oxygen atom or the like, n and m are the same or different and integers of 0 to 2, or a pharmacologically acceptable salt, and use thereof as a medicament.
摘要翻译: 本发明涉及由式(I)表示的化合物:其中R1表示C1-3烷基,R2表示氢原子或C1-3烷基,Ar表示可被基团取代的苯基等 1〜3个取代基,X表示氧原子等,n和m相同或不同,为0〜2的整数,或药理学上可接受的盐及其作为药物的用途。
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公开(公告)号:US07973033B2
公开(公告)日:2011-07-05
申请号:US13005064
申请日:2011-01-12
申请人: Teiji Kimura , Noritaka Kitazawa , Toshihiko Kaneko , Nobuaki Sato , Koki Kawano , Koichi Ito , Eriko Doi , Mamoru Takaishi , Takeo Sasaki , Takehiko Miyagawa , Hiroaki Hagiwara , Takashi Doko
发明人: Teiji Kimura , Noritaka Kitazawa , Toshihiko Kaneko , Nobuaki Sato , Koki Kawano , Koichi Ito , Eriko Doi , Mamoru Takaishi , Takeo Sasaki , Takehiko Miyagawa , Hiroaki Hagiwara , Takashi Doko
IPC分类号: C07D471/04 , C07D498/04 , A61K31/5383 , A61K31/5025
CPC分类号: C07D403/10 , C07D471/04 , C07D498/04
摘要: The present invention provides a compound represented by the formula (I): or a pharmacologically acceptable salt thereof, wherein Ar1 represents an imidazolyl group that may be substituted with a C1-6 alkyl group, or the like, Ar2 represents a phenyl group that may be substituted with a C1-6 alkoxy group, or the like, X1 represents a double bond or the like, and Het represents an imidazolyl group that may be substituted with a C1-6 alkyl group, or the like, which is effective as a therapeutic or prophylactic agent for a disease caused by Aβ.
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公开(公告)号:US20070117839A1
公开(公告)日:2007-05-24
申请号:US11594150
申请日:2006-11-08
申请人: Teiji Kimura , Koki Kawano , Eriko Doi , Noritaka Kitazawa , Mamoru Takaishi , Koichi Ito , Toshihiko Kaneko , Takeo Sasaki , Takehiko Miyagawa , Hiroaki Hagiwara , Yu Yoshida
发明人: Teiji Kimura , Koki Kawano , Eriko Doi , Noritaka Kitazawa , Mamoru Takaishi , Koichi Ito , Toshihiko Kaneko , Takeo Sasaki , Takehiko Miyagawa , Hiroaki Hagiwara , Yu Yoshida
IPC分类号: C07D455/02 , A61K31/4745
CPC分类号: C07D471/04 , C07D487/04
摘要: The present invention relates to a novel two cyclic cinnamide compound and a pharmaceutical agent comprising the compound as an active ingredient. The two cyclic cinnamide compound represented by the general formula (I): wherein represents a single bond or a double bond; Ar1 represents a phenyl group or pyridinyl group that may be substituted with 1 to 3 substituents; R1 and R2 each represent a C1-6 alkyl group, a hydroxyl group, or the like; Z1 represents a methylene group or vinylene group, which may be substituted with 1 or 2 substituents selected from Substituent Group A1, an oxygen atom, or an imino group that may be substituted with a substituent selected from Substituent Group A1; and p, q, and r each represent an integer of 0 to 2, which has an effect of reducing Aβ40 and Aβ42 production, and thus is particularly useful as a prophylactic or therapeutic agent for a neurodegenerative disease caused by Aβ such as Alzheimer's disease or Down's syndrome.
摘要翻译: 本发明涉及一种新型的两种环状肉桂酰胺化合物和包含该化合物作为活性成分的药剂。 由通式(I)表示的两种环状肉桂酰胺化合物:其中表示单键或双键; Ar 1代表可被1至3个取代基取代的苯基或吡啶基; R 1和R 2各自表示C 1-6烷基,羟基等; Z 1表示亚甲基或亚乙烯基,其可以被1或2个选自取代基组A1,氧原子或亚氨基的取代基取代,所述取代基可以被选自取代基 A1组; 并且p,q和r各自表示0〜2的整数,其具有降低Abeta40和Abeta42产生的作用,因此特别可用作由Abeta如阿尔茨海默病或阿尔茨海默病引起的神经变性疾病的预防或治疗剂 唐氏综合症。
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公开(公告)号:US20070117798A1
公开(公告)日:2007-05-24
申请号:US11594130
申请日:2006-11-08
申请人: Teiji Kimura , Koki Kawano , Eriko Doi , Noritaka Kitazawa , Mamoru Takaishi , Koichi Ito , Toshihiko Kaneko , Takeo Sasaki , Nobuaki Sato , Takehiko Miyagawa , Hiroaki Hagiwara
发明人: Teiji Kimura , Koki Kawano , Eriko Doi , Noritaka Kitazawa , Mamoru Takaishi , Koichi Ito , Toshihiko Kaneko , Takeo Sasaki , Nobuaki Sato , Takehiko Miyagawa , Hiroaki Hagiwara
IPC分类号: A61K31/538 , A61K31/5377 , A61K31/454 , C07D413/04
CPC分类号: C07D413/10 , C07D401/10 , C07D401/14 , C07D405/14 , C07D413/14
摘要: The present invention relates to a compound represented by the formula (I): or a pharmacologically acceptable salt thereof, wherein R1, R2, R3, and R4 are the same or different and each represent a hydrogen atom or a C1-6 alkyl group; X1 represents a C1-6 alkylene group that may be substituted; Xa represents a methoxy group or a fluorine atom; Xb represents an oxygen atom or a methylene group, provided that Xb is only an oxygen atom when Xa is a methoxy group; and Ar1 represents an aryl group, pyridinyl group, aryloxy group, or pyridinyloxy group that may have a substituent such as a halogen atom; and to use of the compound or salt as a pharmaceutical agent.
摘要翻译: 本发明涉及由式(I)表示的化合物或其药理学上可接受的盐,其中R 1,R 2,R 3, SUP>和R 4相同或不同,各自表示氢原子或C 1-6烷基; X 1表示可以被取代的C 1-6亚烷基; X a a表示甲氧基或氟原子; X B表示氧原子或亚甲基,条件是当X a a为甲氧基时,X B b仅为氧原子; 和Ar 1表示可以具有卤素原子等取代基的芳基,吡啶基,芳氧基或吡啶氧基; 并使用化合物或盐作为药剂。
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公开(公告)号:US20110009619A1
公开(公告)日:2011-01-13
申请号:US12671873
申请日:2008-08-28
申请人: Teiji Kimura , Noritaka Kitazawa , Toshihiko Kaneko , Nobuaki Sato , Koki Kawano , Koichi Ito , Mamoru Takaishi , Takeo Sasaki , Yu Yoshida , Toshiyuki Uemura , Takashi Doko , Daisuke Shinmyo , Daiju Hasegawa , Takehiko Miyagawa , Hiroaki Hagiwara
发明人: Teiji Kimura , Noritaka Kitazawa , Toshihiko Kaneko , Nobuaki Sato , Koki Kawano , Koichi Ito , Mamoru Takaishi , Takeo Sasaki , Yu Yoshida , Toshiyuki Uemura , Takashi Doko , Daisuke Shinmyo , Daiju Hasegawa , Takehiko Miyagawa , Hiroaki Hagiwara
IPC分类号: C07D487/04 , C07D471/04 , C07D498/04
CPC分类号: C07D403/10 , C07D471/04 , C07D487/04 , C07D498/04
摘要: Disclosed is a compound represented by the formula (I): or a pharmacologically acceptable salt thereof, which is effective as a therapeutic or prophylactic agent for a disease induced by Aβ, wherein Ar1 represents an imidazolyl group which may be substituted with a C1-6 alkyl group, or the like; Ar2 represents a phenyl group which may be substituted with a C1-6 alkoxy group, or the like; X1 represents a double bond, or the like; and Het represents a triazolyl group or the like which may be substituted with a C1-6 alkyl group or the like, or the like.
摘要翻译: 公开了由式(I)表示的化合物或其药理学上可接受的盐,其作为由A&bgr诱导的疾病的治疗或预防剂是有效的,其中Ar1表示可被C1- 6烷基等; Ar 2表示可被C 1-6烷氧基取代的苯基等; X1表示双键等; Het表示可以被C 1-6烷基等取代的三唑基等。
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公开(公告)号:US07935815B2
公开(公告)日:2011-05-03
申请号:US12200731
申请日:2008-08-28
申请人: Teiji Kimura , Noritaka Kitazawa , Toshihiko Kaneko , Nobuaki Sato , Koki Kawano , Koichi Ito , Mamoru Takaishi , Takeo Sasaki , Yu Yoshida , Toshiyuki Uemura , Takashi Doko , Daisuke Shinmyo , Daiju Hasegawa , Takehiko Miyagawa , Hiroaki Hagiwara
发明人: Teiji Kimura , Noritaka Kitazawa , Toshihiko Kaneko , Nobuaki Sato , Koki Kawano , Koichi Ito , Mamoru Takaishi , Takeo Sasaki , Yu Yoshida , Toshiyuki Uemura , Takashi Doko , Daisuke Shinmyo , Daiju Hasegawa , Takehiko Miyagawa , Hiroaki Hagiwara
IPC分类号: C07D491/00 , C07D513/00 , C07D515/00 , C07D265/36 , C07D498/02 , C07D487/00 , C07D513/02 , C07D515/02 , C07D401/00
CPC分类号: C07D403/10 , C07D401/14 , C07D403/14 , C07D409/14
摘要: A compound represented by the formula (I): or a pharmacologically acceptable salt thereof, wherein Ar1 represents an imidazolyl group or the like which may be substituted with a C1-6 alkyl group, Ar2 represents a phenyl group or the like which may be substituted with a C1-6 alkoxy group, X1 represents a double bond or the like and Het represents a triazolyl group or the like which may be substituted with a C1-6 alkyl group or the like, is effective as a therapeutic or prophylactic agent for a disease caused by Aβ.
摘要翻译: 由式(I)表示的化合物或其药理学上可接受的盐,其中Ar 1表示可被C 1-6烷基取代的咪唑基等,Ar 2表示可被取代的苯基等 具有C 1-6烷氧基,X 1表示双键等,Het表示可以被C 1-6烷基等取代的三唑基等,作为治疗或预防药物是有效的 A&BGR引起的疾病
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