利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

11 条记录 (耗时 0.082 秒)

    Two cyclic cinnamide compound
    7.
    发明授权
    Two cyclic cinnamide compound 失效
    两种环状肉桂酰胺化合物

    公开(公告)号：US08048878B2

    公开(公告)日：2011-11-01

    申请号：US12403565

    申请日：2009-03-13

    申请人： Teiji Kimura ,  Koki Kawano ,  Eriko Doi ,  Noritaka Kitazawa ,  Mamoru Takaishi ,  Koichi Ito ,  Toshihiko Kaneko ,  Takeo Sasaki ,  Takehiko Miyagawa ,  Hiroaki Hagiwara ,  Yu Yoshida

    发明人： Teiji Kimura ,  Koki Kawano ,  Eriko Doi ,  Noritaka Kitazawa ,  Mamoru Takaishi ,  Koichi Ito ,  Toshihiko Kaneko ,  Takeo Sasaki ,  Takehiko Miyagawa ,  Hiroaki Hagiwara ,  Yu Yoshida

    IPC分类号： C07D491/02 ,  C07D265/36 ,  C07D498/02 ,  C07D295/00 ,  A61K31/535 ,  A61K31/50 ,  A61K31/44 ,  A01N43/60

    CPC分类号： C07D471/04 ,  C07D487/04

    摘要： The present invention relates to a novel two cyclic cinnamide compound and a pharmaceutical agent comprising the compound as an active ingredient. The two cyclic cinnamide compound represented by the general formula (I): wherein represents a single bond or a double bond; Ar1 represents a phenyl group or pyridinyl group that may be substituted with 1 to 3 substituents; R1 and R2 each represent a C1-6 alkyl group, a hydroxyl group, or the like; Z1 represents a methylene group or vinylene group, which may be substituted with 1 or 2 substituents selected from Substituent Group A1, an oxygen atom, or an imino group that may be substituted with a substituent selected from Substituent Group A1; and p, q, and r each represent an integer of 0 to 2, which has an effect of reducing Aβ40 and Aβ42 production, and thus is particularly useful as a prophylactic or therapeutic agent for a neurodegenerative disease caused by Aβ such as Alzheimer's disease or Down's syndrome.

    摘要翻译： 本发明涉及一种新型的两种环状肉桂酰胺化合物和包含该化合物作为活性成分的药剂。 由通式（I）表示的两个环状肉桂酰胺化合物：其中表示单键或双键; Ar 1表示可被1〜3个取代基取代的苯基或吡啶基; R1和R2各自表示C1-6烷基，羟基等; Z1表示亚甲基或亚乙烯基，其可以被1或2个选自取代基组A1，氧原子或可被选自取代基组A1的取代基取代的亚氨基取代基取代; p，q和r各自表示0〜2的整数，其具有降低A＆bgr 40和A＆bgr 42生成的效果，因此特别可用作由A＆bgr引起的神经变性疾病的预防或治疗剂。 如阿尔茨海默病或唐氏综合症。

    Two cyclic cinnamide compound
    8.
    发明申请
    Two cyclic cinnamide compound 审中-公开
    两种环状肉桂酰胺化合物

    公开(公告)号：US20070117839A1

    公开(公告)日：2007-05-24

    申请号：US11594150

    申请日：2006-11-08

    申请人： Teiji Kimura ,  Koki Kawano ,  Eriko Doi ,  Noritaka Kitazawa ,  Mamoru Takaishi ,  Koichi Ito ,  Toshihiko Kaneko ,  Takeo Sasaki ,  Takehiko Miyagawa ,  Hiroaki Hagiwara ,  Yu Yoshida

    发明人： Teiji Kimura ,  Koki Kawano ,  Eriko Doi ,  Noritaka Kitazawa ,  Mamoru Takaishi ,  Koichi Ito ,  Toshihiko Kaneko ,  Takeo Sasaki ,  Takehiko Miyagawa ,  Hiroaki Hagiwara ,  Yu Yoshida

    IPC分类号： C07D455/02 ,  A61K31/4745

    CPC分类号： C07D471/04 ,  C07D487/04

    摘要： The present invention relates to a novel two cyclic cinnamide compound and a pharmaceutical agent comprising the compound as an active ingredient. The two cyclic cinnamide compound represented by the general formula (I): wherein represents a single bond or a double bond; Ar1 represents a phenyl group or pyridinyl group that may be substituted with 1 to 3 substituents; R1 and R2 each represent a C1-6 alkyl group, a hydroxyl group, or the like; Z1 represents a methylene group or vinylene group, which may be substituted with 1 or 2 substituents selected from Substituent Group A1, an oxygen atom, or an imino group that may be substituted with a substituent selected from Substituent Group A1; and p, q, and r each represent an integer of 0 to 2, which has an effect of reducing Aβ40 and Aβ42 production, and thus is particularly useful as a prophylactic or therapeutic agent for a neurodegenerative disease caused by Aβ such as Alzheimer's disease or Down's syndrome.

    摘要翻译： 本发明涉及一种新型的两种环状肉桂酰胺化合物和包含该化合物作为活性成分的药剂。 由通式（I）表示的两种环状肉桂酰胺化合物：其中表示单键或双键; Ar 1代表可被1至3个取代基取代的苯基或吡啶基; R 1和R 2各自表示C 1-6烷基，羟基等; Z 1表示亚甲基或亚乙烯基，其可以被1或2个选自取代基组A1，氧原子或亚氨基的取代基取代，所述取代基可以被选自取代基 A1组; 并且p，q和r各自表示0〜2的整数，其具有降低Abeta40和Abeta42产生的作用，因此特别可用作由Abeta如阿尔茨海默病或阿尔茨海默病引起的神经变性疾病的预防或治疗剂 唐氏综合症。

    Cyclopropane compound
    10.
    发明授权
    Cyclopropane compound 有权
    环丙烷化合物

    公开(公告)号：US08268848B2

    公开(公告)日：2012-09-18

    申请号：US13237205

    申请日：2011-09-20

    申请人： Taro Terauchi ,  Ayumi Takemura ,  Takashi Doko ,  Yu Yoshida ,  Toshiaki Tanaka ,  Keiichi Sorimachi ,  Yoshimitsu Naoe ,  Carsten Beuckmann ,  Yuji Kazuta

    发明人： Taro Terauchi ,  Ayumi Takemura ,  Takashi Doko ,  Yu Yoshida ,  Toshiaki Tanaka ,  Keiichi Sorimachi ,  Yoshimitsu Naoe ,  Carsten Beuckmann ,  Yuji Kazuta

    IPC分类号： A01N43/54 ,  A61K31/505

    CPC分类号： C07D401/12 ,  C07D239/34

    摘要： A cyclopropane compound represented by the following formula (A) or a pharmaceutically acceptable salt thereof has orexin receptor antagonism, and therefore has a potencial of usefulness for the treatment of sleep disorder for which orexin receptor antagonism is effective, for example, insomnia: wherein Q represents —CH— or a nitrogen atom, R1a and R1b each independently represent a C1-6 alkyl group and the like, R1c represents a hydrogen atom and the like, R2a, R2b, R2c and R2d each independently represent a hydrogen atom, a halogen atom, a C1-6 alkyl group and the like, R3a, R3b and R3c each independently represent a hydrogen atom, a halogen atom and the like, and R3d represents a hydrogen atom and the like.

    摘要翻译： 由下式（A）表示的环丙烷化合物或其药学上可接受的盐具有食欲肽受体拮抗作用，因此具有治疗食欲肽受体拮抗作用有效的睡眠障碍的潜在用途，例如失眠症：其中Q表示 -CH-或氮原子，R1a和R1b各自独立地表示C1-6烷基等，R1c表示氢原子等，R2a，R2b，R2c和R2d各自独立地表示氢原子，卤素原子 C 1-6烷基等，R 3a，R 3b和R 3c各自独立地表示氢原子，卤素原子等，R 3d表示氢原子等。