公开(公告)号：US06313201B1

公开(公告)日：2001-11-06

申请号：US09218892

申请日：1998-12-22

申请人： Satoshi Nanba ,  Tomomi Suzuki ,  Syunsuke Ohhashi ,  Tohru Yasukohchi

发明人： Satoshi Nanba ,  Tomomi Suzuki ,  Syunsuke Ohhashi ,  Tohru Yasukohchi

IPC分类号： C08L8900

CPC分类号： C12N9/0065 ,  A61K47/60

摘要： A composition is provided which comprises catalase modified with a copolymer (A) and a second copolymer, i.e., copolymer (B). The copolymer (A) comprises an alkenyl ether, maleic anhydride, and at least one monomer selected from the group consisting of unsaturated carboxylic acid, vinyl compound and olefin, and copolymer (B) consists of an ethylenically unsaturated monomer and a monomer selected from the group consisting of a monomer having a carboxyl group and a monomer having an acid anhydride group, or a salt of the copolymer (B).

摘要翻译： 提供了包含用共聚物（A）和第二共聚物（即共聚物（B））改性的过氧化氢酶的组合物。 共聚物（A）包含链烯基醚，马来酸酐和至少一种选自不饱和羧酸，乙烯基化合物和烯烃的单体，共聚物（B）由烯键式不饱和单体和选自 由具有羧基的单体和具有酸酐基的单体组成的组，或共聚物（B）的盐组成的组。

公开(公告)号：US5872191A

公开(公告)日：1999-02-16

申请号：US867985

申请日：1997-06-03

申请人： Kouzoh Sanchika ,  Tohru Yasukohchi ,  Kei-ichi Maruyama ,  Syunsuke Ohhashi

发明人： Kouzoh Sanchika ,  Tohru Yasukohchi ,  Kei-ichi Maruyama ,  Syunsuke Ohhashi

IPC分类号： C07D207/46 ,  C08G65/32 ,  C08G65/329 ,  C08G65/332 ,  C08G65/333 ,  C08L71/02

CPC分类号： C08G65/329 ,  C08G65/33337

摘要： A process for producing a polyoxyalkylene derivative substituted with succinimidyl group which comprises reacting a polyoxyalkylene compound having carboxyl group at ends with N-hydroxysuccinimide in an inert solvent in the presence of dicyclohexylcarbodiimide; dissolving an obtained reaction product into chloroform, an amount by weight of chloroform being 0.5 to 10 times as much as an amount by weight of the polyoxyalkylene compound having carboxyl group at ends; and crystallizing the polyoxyalkylene derivative substituted with succinimidyl group by adding an aliphatic hydrocarbon having 5 to 8 carbon atoms to a resultant solution, an amount by weight of the aliphatic hydrocarbon being 2 to 10 times as much as an amount by weight of chloroform. Materials can be handled with safety, and a highly pure polyoxyalkylene derivative substituted with succinimidyl group which does not cause turbidity in an aqueous solution and has an excellent quality as a material for drugs can be produced.

摘要翻译： 一种制备被琥珀酰亚胺基取代的聚氧化烯衍生物的方法，包括在二环己基碳二亚胺的存在下，在惰性溶剂中使具有羧基的聚氧化烯化合物与N-羟基琥珀酰亚胺反应; 将得到的反应产物溶解在氯仿中，氯仿的重量为末端具有羧基的聚氧化烯化合物的重量的0.5〜10倍; 并通过向所得溶液中加入碳原子数为5〜8的脂肪族烃而使被琥珀酰亚胺基取代的聚氧化烯衍生物结晶化，所述脂肪族烃的重量比为氯仿的2〜10倍。 可以安全地处理材料，并且可以制备用琥珀酰亚胺基取代的高纯度聚氧化烯衍生物，其不会在水溶液中引起浊度并且具有作为药物的材料的优良品质。

公开(公告)号：US5767284A

公开(公告)日：1998-06-16

申请号：US868261

申请日：1997-06-03

申请人： Kouzoh Sanchika ,  Tohru Yasukohchi ,  Kei-ichi Maruyama ,  Syunsuke Ohhashi

发明人： Kouzoh Sanchika ,  Tohru Yasukohchi ,  Kei-ichi Maruyama ,  Syunsuke Ohhashi

IPC分类号： C08G65/32 ,  A61K47/48 ,  C07D207/46 ,  C08G65/30 ,  C08G65/329 ,  C08G65/332 ,  C08G65/333 ,  C07D207/12

CPC分类号： A61K47/48215 ,  C08G65/30 ,  C08G65/329 ,  C08G65/33337

摘要： A process for producing a polyoxyalkylene derivative substituted with succinimidyl group which comprises reacting a polyoxyalkylene compound having carboxyl group at ends with N-hydroxysuccinimide in an inert solvent in the presence of dicyclohexylcarbodiimide; filtering an obtained reaction product; and crystallizing the polyoxyalkylene derivative substituted with succinimidyl group by adding isopropyl alcohol to a filtrate obtained by the filtration, an amount by weight of isopropyl alcohol being 1 to 100 times as much as an amount by weight of the polyoxyalkylene compound having carboxyl group at ends. Materials can be handled with safety in the process of the present invention, and a highly pure polyoxyalkylene derivative substituted with succinimidyl group which does not cause turbidity in an aqueous solution and has an excellent quality as a material for drugs can be produced.

摘要翻译： 一种制备被琥珀酰亚胺基取代的聚氧化烯衍生物的方法，包括在二环己基碳二亚胺的存在下，在惰性溶剂中使具有羧基的聚氧化烯化合物与N-羟基琥珀酰亚胺反应; 过滤得到的反应产物; 并将通过过滤得到的滤液中加入异丙醇使用琥珀酰亚胺基取代的聚氧化烯衍生物结晶，异丙醇的重量比在末端具有羧基的聚氧化烯化合物的重量的1〜100倍。 可以在本发明的方法中安全地处理材料，并且可以制备用琥珀酰亚胺基取代的高纯度聚氧化烯衍生物，其不会在水溶液中引起浊度并且具有作为药物的材料的优良品质。

公开(公告)号：US08828373B2

公开(公告)日：2014-09-09

申请号：US11142683

申请日：2005-06-02

申请人： Ken-ichiro Nakamoto ,  Syunsuke Ohashi ,  Yuji Yamamoto ,  Kenji Sakanoue ,  Chika Itoh ,  Tohru Yasukohchi

发明人： Ken-ichiro Nakamoto ,  Syunsuke Ohashi ,  Yuji Yamamoto ,  Kenji Sakanoue ,  Chika Itoh ,  Tohru Yasukohchi

IPC分类号： A61K31/765 ,  C08F283/00 ,  C08G65/329 ,  C08G65/333 ,  C08G65/26 ,  A61K47/48

CPC分类号： C08G65/2609 ,  A61K47/48215 ,  A61K47/60 ,  C08G65/329 ,  C08G65/333

摘要： A polyalkylene glycol derivative containing a compound of the formula (1): wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OA1 and OA2 are each an oxyalkylene group having 2 to 4 carbon atoms, the groups represented by R are the same or different from each other in one molecule, the groups represented by OA2 are the same or different from each other in one molecule, m is an average number of moles of the above oxyalkylene group added, m represents 10 to 1000, X represents a functional group capable of chemically reacting with a bio-related substance, and Y is a linker and represents an ether bond, an amide bond, a urethane bond, an ester bond, a secondary amino group, a carbonate bond, or an alkylene group containing these bonds, polydispersity Mw/Mn of the above polyalkylene glycol derivative in gel permeation chromatography satisfying the following relationship: Mw/Mn≦1.08 wherein Mw represents a weight average molecular weight and Mn represents a number average molecular weight.

摘要翻译： 含有式（1）化合物的聚亚烷基二醇衍生物：其中R为碳原子数为1〜24的烃基，OA1和OA2分别为碳原子数2〜4的氧化烯基，由R表示的基团相同 或在一个分子中彼此不同，在一个分子中由OA2表示的基团相同或不同，m为上述加成的氧化烯基的平均摩尔数，m表示10〜1000，X表示官能团 能够与生物相关物质进行化学反应的基团，Y为连接基，表示醚键，酰胺键，氨基甲酸酯键，酯键，仲氨基，碳酸酯键或含有这些基团的亚烷基 键，多分散性上述聚亚烷基二醇衍生物的Mw / Mn满足以下关系式：Mw / Mn＆nlE 1.08其中Mw表示重均分子量，Mn表示数均mol 精神重量

公开(公告)号：US20090192320A1

公开(公告)日：2009-07-30

申请号：US12399249

申请日：2009-03-06

申请人： Ken-ichiro NAKAMOTO ,  Syunsuke Ohashi ,  Yuji Yamamoto ,  Kenji Sakanoue ,  Chika Itoh ,  Tohru Yasukohchi

发明人： Ken-ichiro NAKAMOTO ,  Syunsuke Ohashi ,  Yuji Yamamoto ,  Kenji Sakanoue ,  Chika Itoh ,  Tohru Yasukohchi

IPC分类号： C07D207/404 ,  C07C43/13 ,  C07C309/68

CPC分类号： C08G65/329 ,  A61K47/60 ,  C08G65/2609

摘要： A modified bio-related substance, wherein at least one poly(alkylene glycol)oxy group represented by the following formula (1) is combined in a molecule: wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OA1 and OA2 are each an oxyalkylene group having 2 to 4 carbon atoms, the groups represented by R are the same or different from each other in one molecule, and the groups represented by OA2 are the same or different from each other in one molecule, n and m are each average number of moles of the oxyalkylene group added, n represents 0 to 1000, and m represents 10 to 1000.

摘要翻译： 一种改性的生物相关物质，其中至少一种由下式（1）表示的聚（亚烷基二醇）氧基在分子中组合：其中R是具有1至24个碳原子的烃基，OA1和OA2各自 具有2至4个碳原子的氧化烯基，由一个分子中由R表示的基团彼此相同或不同，并且由OA2表示的基团在一个分子中彼此相同或不同，n和m各自为 氧化烯基的平均加成摩尔数，n表示0〜1000，m表示10〜1000。

公开(公告)号：US08034981B2

公开(公告)日：2011-10-11

申请号：US12942554

申请日：2010-11-09

申请人： Ken-ichiro Nakamoto ,  Syunsuke Ohashi ,  Yuji Yamamoto ,  Kenji Sakanoue ,  Chika Itoh ,  Tohru Yasukohchi

发明人： Ken-ichiro Nakamoto ,  Syunsuke Ohashi ,  Yuji Yamamoto ,  Kenji Sakanoue ,  Chika Itoh ,  Tohru Yasukohchi

IPC分类号： C07D249/18

CPC分类号： C08G65/329 ,  A61K47/60 ,  C08G65/2609

摘要： A modified bio-related substance, wherein at least one poly(alkylene glycol)oxy group represented by the following formula (1) is combined in a molecule: wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OA1 and OA2 are each an oxyalkylene group having 2 to 4 carbon atoms, the groups represented by R are the same or different from each other in one molecule, and the groups represented by OA2 are the same or different from each other in one molecule, n and m are each average number of moles of the oxyalkylene group added, n represents 0 to 1000, and m represents 10 to 1000.

摘要翻译： 一种改性的生物相关物质，其中至少一种由下式（1）表示的聚（亚烷基二醇）氧基在分子中组合：其中R是具有1至24个碳原子的烃基，OA1和OA2各自 具有2至4个碳原子的氧化烯基，由一个分子中由R表示的基团彼此相同或不同，并且由OA2表示的基团在一个分子中彼此相同或不同，n和m各自为 氧化烯基的平均加成摩尔数，n表示0〜1000，m表示10〜1000。

公开(公告)号：US07524875B2

公开(公告)日：2009-04-28

申请号：US11142255

申请日：2005-06-02

申请人： Ken-ichiro Nakamoto ,  Syunsuke Ohashi ,  Yuji Yamamoto ,  Kenji Sakanoue ,  Chika Itoh ,  Tohru Yasukohchi

发明人： Ken-ichiro Nakamoto ,  Syunsuke Ohashi ,  Yuji Yamamoto ,  Kenji Sakanoue ,  Chika Itoh ,  Tohru Yasukohchi

IPC分类号： A61K31/075 ,  A61K31/4015 ,  A61K31/4164 ,  A61K31/4192 ,  C07C43/11 ,  C07D207/444 ,  C07D233/64 ,  C07D249/04 ,  C07D487/06

CPC分类号： C08G65/329 ,  A61K47/60 ,  C08G65/2609

摘要： A modified bio-related substance, wherein at least one poly(alkylene glycol)oxy group represented by the following formula (1) is combined in a molecule: wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OA1 and OA2 are each an oxyalkylene group having 2 to 4 carbon atoms, the groups represented by R are the same or different from each other in one molecule, and the groups represented by OA2 are the same or different from each other in one molecule, n and m are each average number of moles of the oxyalkylene group added, n represents 0 to 1000, and m represents 10 to 1000.

摘要翻译： 一种改性的生物相关物质，其中至少一种由下式（1）表示的聚（亚烷基二醇）氧基在分子中组合：其中R是具有1至24个碳原子的烃基，OA1和OA2各自 具有2至4个碳原子的氧化烯基，由一个分子中由R表示的基团彼此相同或不同，并且由OA2表示的基团在一个分子中彼此相同或不同，n和m各自为 氧化烯基的平均加成摩尔数，n表示0〜1000，m表示10〜1000。

公开(公告)号：US20060115450A1

公开(公告)日：2006-06-01

申请号：US11142683

申请日：2005-06-02

申请人： Ken-ichiro Nakamoto ,  Syunsuke Ohashi ,  Yuji Yamamoto ,  Kenji Sakanoue ,  Chika Itoh ,  Tohru Yasukohchi

发明人： Ken-ichiro Nakamoto ,  Syunsuke Ohashi ,  Yuji Yamamoto ,  Kenji Sakanoue ,  Chika Itoh ,  Tohru Yasukohchi

IPC分类号： A61K31/765 ,  C08F283/00

CPC分类号： C08G65/2609 ,  A61K47/48215 ,  A61K47/60 ,  C08G65/329 ,  C08G65/333

摘要： A polyalkylene glycol derivative containing a compound of the formula (1): wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OA1 and OA2 are each an oxyalkylene group having 2 to 4 carbon atoms, the groups represented by R are the same or different from each other in one molecule, the groups represented by OA2 are the same or different from each other in one molecule, m is an average number of moles of the above oxyalkylene group added, m represents 10 to 1000, X represents a functional group capable of chemically reacting with a bio-related substance, and Y is a linker and represents an ether bond, an amide bond, a urethane bond, an ester bond, a secondary amino group, a carbonate bond, or an alkylene group containing these bonds, polydispersity Mw/Mn of the above polyalkylene glycol derivative in gel permeation chromatography satisfying the following relationship: Mw/Mn≦1.08 wherein Mw represents a weight average molecular weight and Mn represents a number average molecular weight.

摘要翻译： 含有式（1）化合物的聚亚烷基二醇衍生物：其中R为碳原子数为1〜24的烃基，OA 1和O 2各自为氧化烯 具有2至4个碳原子的基团，由R表示的基团在一个分子中彼此相同或不同，在一个分子中由OA 2表示的基团彼此相同或不同， m是上述氧化烯基的平均加成摩尔数，m表示10〜1000，X表示与生物相关物质发生化学反应的官能团，Y为连接基，表示醚键，酰胺键 氨基甲酸酯键，酯键，仲氨基，碳酸酯键或含有这些键的亚烷基，上述聚亚烷基二醇衍生物在凝胶渗透色谱中的多分散性Mw / Mn满足以下关系： -formulae description =“In-line Formulas”end =“lead”？> Mw / Mn <= 1.08 < in-line-formula description =“In-line Formulas”end =“tail”？>其中Mw表示重均分子量，Mn表示数均分子量。

公开(公告)号：US08003117B2

公开(公告)日：2011-08-23

申请号：US11142678

申请日：2005-06-02

申请人： Ken-ichiro Nakamoto ,  Syunsuke Ohashi ,  Yuji Yamamoto ,  Kenji Sakanoue ,  Chika Itoh ,  Tohru Yasukohchi

发明人： Ken-ichiro Nakamoto ,  Syunsuke Ohashi ,  Yuji Yamamoto ,  Kenji Sakanoue ,  Chika Itoh ,  Tohru Yasukohchi

IPC分类号： C07C41/00 ,  C07C43/00

CPC分类号： C08G65/333 ,  C08G65/2609 ,  C08G65/329

摘要： A polyalkylene glycol derivative containing a compound of the formula (1): wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OA2 is an oxyalkylene group having 2 to 4 carbon atoms, the groups represented by R are the same or different from each other in one molecule, the groups represented by OA2 are the same or different from each other in one molecule, m is an average number of moles of the oxyalkylene group added, m represents 10 to 1000, and X represents a functional group capable of chemically reactive with a bio-related substance, polydispersity Mw/Mn of the above polyalkylene glycol derivative in gel permeation chromatography satisfying the following relationship: Mw/Mn≦1.07 wherein Mw represents a weight average molecular weight and Mn represents a number average molecular weight.

摘要翻译： 含有式（1）化合物的聚亚烷基二醇衍生物：其中R为碳原子数1〜24的烃基，OA2为碳原子数2〜4的氧化烯基，由R表示的基团相同或不同， 在一个分子中，由一个分子表示的基团彼此相同或不同，m是加成的氧化烯基的平均摩尔数，m表示10〜1000，X表示能够 与生物相关物质化学反应，上述聚亚烷基二醇衍生物的多分散性Mw / Mn在凝胶渗透色谱中满足以下关系式：Mw / Mn＆nlE 1.07其中Mw表示重均分子量，Mn表示数均分子量。

公开(公告)号：US07851491B2

公开(公告)日：2010-12-14

申请号：US12399249

申请日：2009-03-06

申请人： Ken-ichiro Nakamoto ,  Syunsuke Ohashi ,  Yuji Yamamoto ,  Kenji Sakanoue ,  Chika Itoh ,  Tohru Yasukohchi

发明人： Ken-ichiro Nakamoto ,  Syunsuke Ohashi ,  Yuji Yamamoto ,  Kenji Sakanoue ,  Chika Itoh ,  Tohru Yasukohchi

IPC分类号： A61K31/4192 ,  C07D249/18

CPC分类号： C08G65/329 ,  A61K47/60 ,  C08G65/2609

摘要： A modified bio-related substance, wherein at least one poly(alkylene glycol)oxy group represented by the following formula (1) is combined in a molecule: wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OA1 and OA2 are each an oxyalkylene group having 2 to 4 carbon atoms, the groups represented by R are the same or different from each other in one molecule, and the groups represented by OA2 are the same or different from each other in one molecule, n and m are each average number of moles of the oxyalkylene group added, n represents 0 to 1000, and m represents 10 to 1000.

摘要翻译： 一种改性的生物相关物质，其中至少一种由下式（1）表示的聚（亚烷基二醇）氧基在分子中组合：其中R是具有1至24个碳原子的烃基，OA1和OA2各自 具有2至4个碳原子的氧化烯基，由一个分子中由R表示的基团彼此相同或不同，并且由OA2表示的基团在一个分子中彼此相同或不同，n和m各自为 氧化烯基的平均加成摩尔数，n表示0〜1000，m表示10〜1000。