公开(公告)号：US20180072751A1

公开(公告)日：2018-03-15

申请号：US15705200

申请日：2017-09-14

Applicant: The Trustees of Princeton University

Inventor： Joshua D. Rabinowitz ,  Hahn Kim ,  Gregory S. Ducker ,  Jonathan M. Ghergurovich

IPC: C07D491/052 ,  A61K31/4162 ,  A61K45/06 ,  A61K31/496 ,  A61K31/198 ,  A61K31/19

CPC classification number: C07D491/052 ,  A61K31/19 ,  A61K31/198 ,  A61K31/4162 ,  A61K31/496 ,  A61K45/06

Abstract: The disclosure provides compounds of Formulae (I)-(IX). The disclosed compounds are capable of inhibiting a mammalian SHMT. Compounds of the disclosure have numerous uses, such as for treatment of cancer or autoimmune disorders.

公开(公告)号：US20160130565A1

公开(公告)日：2016-05-12

申请号：US14935061

申请日：2015-11-06

Applicant: The Trustees of Princeton University

Inventor： Thomas Shenk ,  Emre Koyuncu ,  Joshua D. Rabinowitz

IPC: C12N7/00

CPC classification number: C12N7/00 ,  C12N2710/16151 ,  C12N2710/16751

Abstract: A method for improving virus production in a host cell infected with the virus is provided.

Abstract translation: 提供了用于改善感染病毒的宿主细胞中病毒产生的方法。

公开(公告)号：US20230416703A1

公开(公告)日：2023-12-28

申请号：US18167711

申请日：2023-02-10

Applicant: THE TRUSTEES OF PRINCETON UNIVERSITY

Inventor： Yi-Fan Xu ,  Joshua D. Rabinowitz ,  Fabien Letisse ,  Sarah Johnson

IPC: C12N9/16 ,  C12N1/16 ,  C12P7/18

CPC classification number: C12N9/16 ,  C12N1/16 ,  C12Y301/0305 ,  C12P7/18 ,  C12Y301/03048

Abstract: Methods and materials for producing polyols are provided comprising recombinant microorganisms expressing a Pyp1 polyol phosphatase. Also provided herein are methods and materials for producing electron rich compounds in recombinant microorganisms lacking the DET1 and/or PHO13 genes.

公开(公告)号：US20230348401A1

公开(公告)日：2023-11-02

申请号：US17758847

申请日：2021-01-15

Applicant: The Trustees of Princeton University

Inventor： Jonathan M. Ghergurovich ,  Hahn Kim ,  Joshua D. Rabinowitz

IPC: C07D239/84 ,  C07D409/12 ,  C07D239/70 ,  C07D405/12 ,  C07D417/12 ,  C07D403/12 ,  C07D495/04 ,  C07D401/12 ,  C07D471/04 ,  C07D413/12 ,  C07D409/14 ,  C07D498/06

CPC classification number: C07D239/84 ,  C07D239/70 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D495/04 ,  C07D498/06

Abstract: Provided herein are compounds having the following structural formula, wherein values for the variables are as described herein. Also provided are pharmaceutical compositions of the compounds, as well as methods of using the compounds to inhibit the oxidative pentose phosphate pathway, e.g, to treat cancer, malaria, an autoimmune disease, an inflammatory condition or asthma.

公开(公告)号：US11759453B2

公开(公告)日：2023-09-19

申请号：US16842513

申请日：2020-04-07

Applicant: The Trustees of Princeton University

Inventor： Joshua D. Rabinowitz ,  Hahn Kim ,  Gregory S. Ducker ,  Jonathan M. Ghergurovich

IPC: A61K31/519 ,  A61K45/06 ,  A61P37/00 ,  A61P35/00 ,  A61K31/19 ,  A61K31/4162

CPC classification number: A61K31/4162 ,  A61K31/19 ,  A61K31/519 ,  A61K45/06 ,  A61P35/00 ,  A61P37/00 ,  A61K31/519 ,  A61K2300/00 ,  A61K31/4162 ,  A61K2300/00

Abstract: The disclosure provides compounds. In certain embodiments, compounds of the disclosure are capable of inhibiting a mammalian SHMT, such as human SMHT1 and/or SHMT2. Compounds of the disclosure have numerous uses.

公开(公告)号：US20210002620A1

公开(公告)日：2021-01-07

申请号：US16851970

申请日：2020-04-17

Applicant: The Trustees of Princeton University

Inventor： Yi-Fan Xu ,  Joshua D. Rabinowitz ,  Fabien Letisse ,  Sarah Johnson

IPC: C12N9/16 ,  C12N1/16 ,  C12P7/18

Abstract: Methods and materials for producing polyols are provided comprising recombinant microorganisms expressing a Pyp1 polyol phosphatase. Also provided herein are methods and materials for producing electron rich compounds in recombinant microorganisms lacking the DET1 and/or PHO13 genes.

公开(公告)号：US20200239488A1

公开(公告)日：2020-07-30

申请号：US16773765

申请日：2020-01-27

Applicant: The Trustees of Princeton University

Inventor： Joshua D. Rabinowitz ,  Hahn Kim ,  Gregory S. Ducker ,  Jonathan M. Ghergurovich

IPC: C07D491/052 ,  A61K31/4162 ,  A61K31/19 ,  A61K31/496 ,  A61K31/198 ,  A61K45/06

Abstract: The disclosure provides compounds of Formulae (I)-(IX). The disclosed compounds are capable of inhibiting a mammalian SHMT. Compounds of the disclosure have numerous uses, such as for treatment of cancer or autoimmue disorders.

公开(公告)号：US20170000769A1

公开(公告)日：2017-01-05

申请号：US15266596

申请日：2016-09-15

Applicant: The Trustees of Princeton University

Inventor： Joshua D. Rabinowitz ,  Jing Fan ,  Gregory S. Ducker

IPC: A61K31/4162 ,  A61K31/513

CPC classification number: A61K31/4162 ,  A61K31/198 ,  A61K31/513 ,  A61K31/517 ,  A61K31/519 ,  A61K45/06 ,  A61K2300/00

Abstract: A 10-formyl-THF pathway for producing NADPH is useful in the diagnosis and treatment of cancer and metabolic disease, in the development of new antineoplastic agents and/or regimens, in the development of new methods for measuring metabolic pathway activity, and in the development of new therapeutics for treating metabolic disease.

Abstract translation: 用于产生NADPH的10-formyl-THF途径可用于诊断和治疗癌症和代谢疾病，在开发新的抗肿瘤药物和/或方案时，开发新的测量代谢途径活性的方法，并且在 开发用于治疗代谢疾病的新疗法。

公开(公告)号：US20240285683A1

公开(公告)日：2024-08-29

申请号：US18413717

申请日：2024-01-16

Applicant: The Trustees of Princeton University

Inventor： Joshua D. Rabinowitz

IPC: A61K35/17 ,  C07K16/28 ,  C07K16/30 ,  C12N5/0783 ,  C12N9/02 ,  C12N15/113

CPC classification number: A61K35/17 ,  C07K16/2818 ,  C07K16/3084 ,  C12N5/0636 ,  C12N9/0036 ,  C12N15/1138 ,  C12N2310/14 ,  C12N2500/02 ,  C12N2501/71

Abstract: The present invention provides, in some embodiments, methods of promoting an immune response in a subject in need thereof, comprising administering to a subject a population of immune cells that express an exogenous enzyme that facilitates immune cell function in a nutrient-poor environment. Other embodiments of the invention include methods of promoting an immune response to a tumor in a subject in need thereof, comprising administering to the subject an effective amount of an agent that provides a one-carbon unit (e.g., formate) and an agent that promotes an anti-tumor response, and methods of promoting an immune response to a tumor in a subject in need thereof, comprising administering to a subject an effective amount of an agent that inhibits consumption of metabolic fuels by tumor cells. The invention also provides, in other embodiments, compositions comprising an ex vivo population of immune cells expressing an exogenous enzyme that enhances immune cell function in nutrient poor environments, and compositions comprising a nucleic acid expression construct encoding an inhibitor of glucose metabolism, and a pharmaceutically acceptable carrier or excipient.

公开(公告)号：US20230100559A1

公开(公告)日：2023-03-30

申请号：US17790702

申请日：2021-01-07

Applicant: The Trustees of Princeton University

Inventor： Joshua D. Rabinowitz ,  Lifeng Yang

IPC: A61K31/155 ,  A61K31/454 ,  A61K31/352 ,  A61K31/365 ,  A61P9/10

Abstract: The present disclosure relates, in various embodiments, to methods of treating various NADH-mediated diseases and disorders in a subject, such as disorders characterized by excess NADH, for example, by inhibiting serine catabolism in the subject.