公开(公告)号：US20230382920A1

公开(公告)日：2023-11-30

申请号：US18027648

申请日：2021-09-23

Applicant: The Trustees of Princeton University

Inventor： Hahn Kim ,  Joshua D. Rabinowitz

IPC: C07D491/052 ,  A61K45/06

CPC classification number: C07D491/052 ,  A61K45/06

Abstract: Provided herein is a compound of the following structural formula: or a pharmaceutically acceptable salt thereof, wherein values for the variables are as described herein. Also provided herein are compositions comprising a compound of structural formula (I), or a pharmaceutically acceptable salt thereof, and methods of treating a disease, disorder or condition associated with serine hydroxymethyl transferase (SHMT) activity, e.g., cancer, an autoimmune disorder, fibrosis and/or a fibrotic disease, in a subject in need thereof with a compound of structural formula (I), or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20230255997A1

公开(公告)日：2023-08-17

申请号：US18003753

申请日：2021-07-15

Applicant: The Trustees of Princeton University

Inventor： Joshua D. Rabinowitz ,  Lifeng Yang

IPC: A61K31/7068 ,  A61K31/337 ,  A61K31/519 ,  A61K33/243 ,  A61P1/18 ,  A61P35/04 ,  A61P1/00 ,  A61P35/00 ,  A61K45/06 ,  A23L33/00

CPC classification number: A61K31/7068 ,  A61K31/337 ,  A61K31/519 ,  A61K33/243 ,  A61P1/18 ,  A61P35/04 ,  A61P1/00 ,  A61P35/00 ,  A61K45/06 ,  A23L33/30

Abstract: Disclosed herein are methods for treating cancer, particularly gastrointestinal cancers, such as pancreatic cancer and colon cancer, with chemotherapeutic agent(s) in subjects on a ketogenic diet or a ketone supplement or both.

公开(公告)号：US20200237725A1

公开(公告)日：2020-07-30

申请号：US16842513

申请日：2020-04-07

Applicant: The Trustees of Princeton University

Inventor： Joshua D. Rabinowitz ,  Hahn Kim ,  Gregory S. Ducker ,  Jonathan M. Ghergurovich

IPC: A61K31/4162 ,  A61K45/06 ,  A61K31/19 ,  A61P35/00 ,  A61P37/00 ,  A61K31/519

Abstract: The disclosure provides compounds. In certain embodiments, compounds of the disclosure are capable of inhibiting a mammalian SHMT, such as human SMHT1 and/or SHMT2. Compounds of the disclosure have numerous uses.

公开(公告)号：US20140113353A1

公开(公告)日：2014-04-24

申请号：US14112824

申请日：2012-04-18

Applicant: THE TRUSTEES OF PRINCETON UNIVERSITY

Inventor： Thomas Shenk ,  Emre Koyuncu ,  Joshua D. Rabinowitz

IPC: C12N7/00

CPC classification number: C12N7/00 ,  C12N2710/16151 ,  C12N2710/16751

Abstract: A method for improving virus production in a host cell infected with the virus is provided.

Abstract translation: 提供了用于改善感染病毒的宿主细胞中病毒产生的方法。

公开(公告)号：US10584132B2

公开(公告)日：2020-03-10

申请号：US16103375

申请日：2018-08-14

Applicant: The Trustees of Princeton University

Inventor： Joshua D. Rabinowitz ,  Hahn Kim ,  Gregory S. Ducker ,  Jonathan M. Ghergurovich

IPC: A61K31/4162 ,  C07D491/052 ,  A61K31/19 ,  A61K31/496 ,  A61K31/198 ,  A61K45/06

Abstract: The disclosure provides compounds of Formulae (I)-(IX). The disclosed compounds are capable of inhibiting a mammalian SHMT. Compounds of the disclosure have numerous uses, such as for treatment of cancer or autoimmue disorders.

公开(公告)号：US20160374971A1

公开(公告)日：2016-12-29

申请号：US14901859

申请日：2014-07-01

Applicant: THE TRUSTEES OF PRINCETON UNIVERSITY ,  MEMORIAL SLOAN-KETTERING CANCER CENTER

Inventor： Joshua D. Rabinowitz ,  Craig B. Thompson ,  Jianbin Ye ,  Jing Fan ,  Jurre Kamphorst

IPC: A61K31/198 ,  A23L33/175 ,  A61K9/00 ,  A61K31/7068 ,  A61K45/06

CPC classification number: A61K31/198 ,  A23L33/175 ,  A23V2002/00 ,  A61K9/0056 ,  A61K31/519 ,  A61K31/7068 ,  A61K45/06 ,  A61K2300/00

Abstract: Methods and compositions for treating cancer and other disorders associated with undesired cellular proliferation are provided comprising administering to a subject in need thereof an amino acid mixture, wherein the amino acid mixture comprises glycine, optionally comprising at least a 2:1 molar ratio of glycine to serine.

Abstract translation: 提供了用于治疗癌症和与不期望的细胞增殖相关的其它病症的方法和组合物，包括向有需要的受试者施用氨基酸混合物，其中所述氨基酸混合物包含甘氨酸，任选地包含至少2:1摩尔比的甘氨酸与 丝氨酸

公开(公告)号：US10934305B2

公开(公告)日：2021-03-02

申请号：US16773765

申请日：2020-01-27

Applicant: The Trustees of Princeton University

Inventor： Joshua D. Rabinowitz ,  Hahn Kim ,  Gregory S. Ducker ,  Jonathan M. Ghergurovich

IPC: C07D491/052 ,  A61K31/4162 ,  A61K45/06 ,  A61K31/496 ,  A61K31/198 ,  A61K31/19

Abstract: The disclosure provides compounds of Formulae (I)-(IX). The disclosed compounds are capable of inhibiting a mammalian SHMT. Compounds of the disclosure have numerous uses, such as for treatment of cancer or autoimmune disorders.

公开(公告)号：US10646475B2

公开(公告)日：2020-05-12

申请号：US15552442

申请日：2016-03-10

Applicant: The Trustees of Princeton University

Inventor： Joshua D. Rabinowitz ,  Hahn Kim ,  Gregory S. Ducker ,  Jonathan M. Ghergurovich

IPC: A61K31/519 ,  A61K45/06 ,  A61P37/00 ,  A61P35/00 ,  A61K31/19 ,  A61K31/4162

Abstract: The present invention relates to a method for the treatment of cancer or an autoimmune disorder, comprising the administration of a serine hydroxymethyltransferase (SHMT) inhibitor, and in particular the administration of pyrazolopyran compounds of Formula (VI) as presently described, wherein the compounds are capable of inhibiting a mammalian SHMT, such as human SHMT1 and/or SHMT2. The treatment method further comprises the optional administration of an additional agent as a rescue therapy to reduce toxicity, wherein said agent may be chosen from formate, a formate salt, folinic acid, formate ester, or leucovorin.

公开(公告)号：US20180354964A1

公开(公告)日：2018-12-13

申请号：US16103375

申请日：2018-08-14

Applicant: The Trustees of Princeton University

Inventor： Joshua D. Rabinowitz ,  Hahn Kim ,  Gregory S. Ducker ,  Jonathan M. Ghergurovich

IPC: C07D491/052 ,  A61K45/06 ,  A61K31/4162 ,  A61K31/19 ,  A61K31/198 ,  A61K31/496

CPC classification number: C07D491/052 ,  A61K31/19 ,  A61K31/198 ,  A61K31/4162 ,  A61K31/496 ,  A61K45/06

Abstract: The disclosure provides compounds of Formulae (I)-(IX). The disclosed compounds are capable of inhibiting a mammalian SHMT. Compounds of the disclosure have numerous uses, such as for treatment of cancer or autoimmue disorders.

公开(公告)号：US10077273B2

公开(公告)日：2018-09-18

申请号：US15705200

申请日：2017-09-14

Applicant: The Trustees of Princeton University

Inventor： Joshua D. Rabinowitz ,  Hahn Kim ,  Gregory S. Ducker ,  Jonathan M. Ghergurovich

IPC: C07D491/052 ,  A61K31/4162 ,  A61K31/19 ,  A61K31/496 ,  A61K31/198 ,  A61K45/06

CPC classification number: C07D491/052 ,  A61K31/19 ,  A61K31/198 ,  A61K31/4162 ,  A61K31/496 ,  A61K45/06

Abstract: The disclosure provides compounds of Formulae (I)-(IX). The disclosed compounds are capable of inhibiting a mammalian SHMT. Compounds of the disclosure have numerous uses, such as for treatment of cancer or autoimmune disorders.